Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_612449                                                              18    1135
NP_733751                                                              18    1482
XP_006716142                                                           18    1482
XP_005250088                                                           18    1482
XP_006716141                                                           18    1482
XP_005250085                                                           18    1482
XP_006716140                                                           18    1482
XP_005250084                                                           18    1482
XP_005250083                                                           18    1482
XP_005250082                                                           18    1482
NP_112174                                                              18    1935
NP_001271215                                                           17    3301
NP_001271214                                                           17    3301
NP_001175                                                              17    4312
XP_006722374                                                           17    4312
XP_006722373                                                           17    4312
XP_006722370                                                           17    4312
XP_006722365                                                           17    4312
NP_004235                                                              16    5631
NP_981961                                                              16    5631
NP_001137139                                                           16    5631
NP_067034                                                              16    5631
NP_001245259                                                           16    5631
XP_005253586                                                           16    5631
XP_005253585                                                           16    5631
NP_001239312                                                           16    7355
NP_116277                                                              16    7355
NP_061923                                                              16    7355
NP_001074003                                                           16    7355
NP_940947                                                              16    7355
XP_005254452                                                           16    7355
XP_005254451                                                           16    7355
XP_006717372                                                           16    7355
XP_006717371                                                           16    7355
XP_005263135                                                           16    7355
XP_005263134                                                           16    7355
XP_005263133                                                           16    7355
XP_005263132                                                           16    7355
XP_005263131                                                           16    7355
XP_005263130                                                           16    7355
NP_001124456                                                           15    9605
NP_001124459                                                           15    9605
NP_001124455                                                           15    9605
NP_001124450                                                           15    9605
NP_001124449                                                           15    9605
NP_001124453                                                           15    9605
NP_079415                                                              15    9605
NP_001258395                                                           15    9605
NP_008944                                                              15    9605
NP_002379                                                              15    9605
NP_001257401                                                           15    9605
NP_777593                                                              15    9605
NP_114110                                                              15    9605
NP_955452                                                              15    9605
XP_005274406                                                           15    9605
XP_005250818                                                           15    9605
XP_005250817                                                           15    9605
XP_006713543                                                           15    9605
XP_005264642                                                           15    9605
XP_005264641                                                           15    9605
XP_005271185                                                           15    9605
XP_005271183                                                           15    9605
XP_005271182                                                           15    9605
NP_001129475                                                           15    9605
NP_073611                                                              15    9605
YP_003024032                                                           15    9605
>NP_612449
          Length = 673

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   LSSSLAPT 8
           LSSSLAPT
Sbjct: 371 LSSSLAPT 378
>NP_733751
          Length = 4911

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LSSSLAPTK 9
            LSSS APTK
Sbjct: 1412 LSSSSAPTK 1420
>XP_006716142
          Length = 4927

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LSSSLAPTK 9
            LSSS APTK
Sbjct: 1413 LSSSSAPTK 1421
>XP_005250088
          Length = 4928

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LSSSLAPTK 9
            LSSS APTK
Sbjct: 1413 LSSSSAPTK 1421
>XP_006716141
          Length = 4959

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LSSSLAPTK 9
            LSSS APTK
Sbjct: 1413 LSSSSAPTK 1421
>XP_005250085
          Length = 4979

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LSSSLAPTK 9
            LSSS APTK
Sbjct: 1413 LSSSSAPTK 1421
>XP_006716140
          Length = 4982

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LSSSLAPTK 9
            LSSS APTK
Sbjct: 1413 LSSSSAPTK 1421
>XP_005250084
          Length = 4982

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LSSSLAPTK 9
            LSSS APTK
Sbjct: 1413 LSSSSAPTK 1421
>XP_005250083
          Length = 4982

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LSSSLAPTK 9
            LSSS APTK
Sbjct: 1412 LSSSSAPTK 1420
>XP_005250082
          Length = 4983

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LSSSLAPTK 9
            LSSS APTK
Sbjct: 1413 LSSSSAPTK 1421
>NP_112174
          Length = 551

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   SSSLAPTK 9
           SSSL+PTK
Sbjct: 317 SSSLSPTK 324
>NP_001271215
          Length = 939

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2  SSSLAPT 8
          SSSLAPT
Sbjct: 36 SSSLAPT 42
>NP_001271214
          Length = 1006

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   SSSLAPT 8
           SSSLAPT
Sbjct: 103 SSSLAPT 109
>NP_001175
          Length = 2644

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LSSSLAPTK 9
           LSSSL P+K
Sbjct: 434 LSSSLNPSK 442
>XP_006722374
          Length = 944

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LSSSLAPTK 9
           LS SLAP K
Sbjct: 831 LSESLAPIK 839
>XP_006722373
          Length = 948

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LSSSLAPTK 9
           LS SLAP K
Sbjct: 835 LSESLAPIK 843
>XP_006722370
          Length = 956

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LSSSLAPTK 9
           LS SLAP K
Sbjct: 843 LSESLAPIK 851
>XP_006722365
          Length = 981

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LSSSLAPTK 9
           LS SLAP K
Sbjct: 868 LSESLAPIK 876
>NP_004235
          Length = 1156

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SSSLAPTK 9
           SSSL PT+
Sbjct: 695 SSSLGPTR 702
>NP_981961
          Length = 1121

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SSSLAPTK 9
           SSSL PT+
Sbjct: 695 SSSLGPTR 702
>NP_001137139
          Length = 693

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SSSLAPTK 9
           +SSLAP+K
Sbjct: 141 NSSLAPSK 148
>NP_067034
          Length = 693

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SSSLAPTK 9
           +SSLAP+K
Sbjct: 141 NSSLAPSK 148
>NP_001245259
          Length = 701

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LSSSLAPTK 9
          L+ SLAPT+
Sbjct: 16 LAESLAPTE 24
>XP_005253586
          Length = 1124

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SSSLAPTK 9
           SSSL PT+
Sbjct: 695 SSSLGPTR 702
>XP_005253585
          Length = 1154

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SSSLAPTK 9
           SSSL PT+
Sbjct: 728 SSSLGPTR 735
>NP_001239312
          Length = 147

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  LSSSLAPTK 9
          LSSS  PTK
Sbjct: 44 LSSSNPPTK 52
>NP_116277
          Length = 1860

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LSSSLAPT 8
           LSSS APT
Sbjct: 487 LSSSPAPT 494
>NP_061923
          Length = 1073

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  SLAPTK 9
          SLAPTK
Sbjct: 25 SLAPTK 30
>NP_001074003
          Length = 2214

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SSSLAPTK 9
           SSSLAP++
Sbjct: 157 SSSLAPSE 164
>NP_940947
          Length = 349

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SSSLAPT 8
           S+SLAPT
Sbjct: 181 STSLAPT 187
>XP_005254452
          Length = 2188

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SSSLAPTK 9
           SSSLAP++
Sbjct: 157 SSSLAPSE 164
>XP_005254451
          Length = 2214

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SSSLAPTK 9
           SSSLAP++
Sbjct: 157 SSSLAPSE 164
>XP_006717372
          Length = 1842

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LSSSLAPT 8
           LSSS APT
Sbjct: 487 LSSSPAPT 494
>XP_006717371
          Length = 1842

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LSSSLAPT 8
           LSSS APT
Sbjct: 487 LSSSPAPT 494
>XP_005263135
          Length = 488

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  SLAPTK 9
          SLAPTK
Sbjct: 25 SLAPTK 30
>XP_005263134
          Length = 800

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  SLAPTK 9
          SLAPTK
Sbjct: 25 SLAPTK 30
>XP_005263133
          Length = 1022

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  SLAPTK 9
          SLAPTK
Sbjct: 25 SLAPTK 30
>XP_005263132
          Length = 1023

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  SLAPTK 9
          SLAPTK
Sbjct: 25 SLAPTK 30
>XP_005263131
          Length = 1073

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  SLAPTK 9
          SLAPTK
Sbjct: 25 SLAPTK 30
>XP_005263130
          Length = 1073

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  SLAPTK 9
          SLAPTK
Sbjct: 25 SLAPTK 30
>NP_001124456
          Length = 2088

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    SSLAPT 8
            SSLAPT
Sbjct: 1463 SSLAPT 1468
>NP_001124459
          Length = 2119

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    SSLAPT 8
            SSLAPT
Sbjct: 1494 SSLAPT 1499
>NP_001124455
          Length = 2102

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    SSLAPT 8
            SSLAPT
Sbjct: 1477 SSLAPT 1482
>NP_001124450
          Length = 2101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    SSLAPT 8
            SSLAPT
Sbjct: 1476 SSLAPT 1481
>NP_001124449
          Length = 2087

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    SSLAPT 8
            SSLAPT
Sbjct: 1462 SSLAPT 1467
>NP_001124453
          Length = 2118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    SSLAPT 8
            SSLAPT
Sbjct: 1493 SSLAPT 1498
>NP_079415
          Length = 665

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSSSLAPTK 9
           L +SLAP K
Sbjct: 298 LRASLAPVK 306
>NP_001258395
          Length = 818

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSSSLAPTK 9
           L +SLAP K
Sbjct: 298 LRASLAPVK 306
>NP_008944
          Length = 922

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SSSLAPT 8
           SSS APT
Sbjct: 246 SSSFAPT 252
>NP_002379
          Length = 853

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SSSLAPTK 9
           SSS+ PTK
Sbjct: 215 SSSVYPTK 222
>NP_001257401
          Length = 818

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SSSLAPTK 9
           SSS+ PTK
Sbjct: 180 SSSVYPTK 187
>NP_777593
          Length = 297

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SSLAPT 8
           SSLAPT
Sbjct: 182 SSLAPT 187
>NP_114110
          Length = 464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SSSLAPTK 9
           SSSLAP +
Sbjct: 392 SSSLAPVQ 399
>NP_955452
          Length = 2590

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LSSSLAP 7
           LSSSL+P
Sbjct: 619 LSSSLSP 625
>XP_005274406
          Length = 430

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SSSLAPTK 9
           SSSLAP +
Sbjct: 358 SSSLAPVQ 365
>XP_005250818
          Length = 921

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SSSLAPT 8
           SSS APT
Sbjct: 245 SSSFAPT 251
>XP_005250817
          Length = 922

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SSSLAPT 8
           SSS APT
Sbjct: 246 SSSFAPT 252
>XP_006713543
          Length = 2591

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LSSSLAP 7
           LSSSL+P
Sbjct: 620 LSSSLSP 626
>XP_005264642
          Length = 2132

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    SSLAPT 8
            SSLAPT
Sbjct: 1507 SSLAPT 1512
>XP_005264641
          Length = 2133

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    SSLAPT 8
            SSLAPT
Sbjct: 1508 SSLAPT 1513
>XP_005271185
          Length = 373

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LSSSLAP 7
           LSS+LAP
Sbjct: 361 LSSTLAP 367
>XP_005271183
          Length = 373

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LSSSLAP 7
           LSS+LAP
Sbjct: 361 LSSTLAP 367
>XP_005271182
          Length = 373

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LSSSLAP 7
           LSS+LAP
Sbjct: 361 LSSTLAP 367
>NP_001129475
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SSLAPT 8
           SSLAPT
Sbjct: 344 SSLAPT 349
>NP_073611
          Length = 373

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LSSSLAP 7
           LSS+LAP
Sbjct: 361 LSSTLAP 367
>YP_003024032
          Length = 261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SSLAPT 8
           SSLAPT
Sbjct: 104 SSLAPT 109
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.293    0.106    0.252 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 693,303
Number of extensions: 1721
Number of successful extensions: 66
Number of sequences better than 10000.0: 66
Number of HSP's gapped: 66
Number of HSP's successfully gapped: 66
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package