Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001261                                                              19     869
XP_005271924                                                           19     869
XP_005271923                                                           19     869
NP_689836                                                              16    5631
NP_001139206                                                           16    5631
NP_001163873                                                           16    5631
NP_653317                                                              16    5631
NP_036266                                                              16    5631
NP_001264003                                                           16    5631
XP_006713054                                                           16    5631
NP_001796                                                              16    7355
NP_057427                                                              16    7355
NP_001123361                                                           16    7355
NP_001913                                                              16    7355
NP_001001669                                                           16    7355
NP_005186                                                              16    7355
XP_006715629                                                           16    7355
XP_005268505                                                           16    7355
XP_006714848                                                           16    7355
XP_005268504                                                           16    7355
XP_006714847                                                           16    7355
NP_758455                                                              16    7355
NP_078970                                                              16    7355
NP_003633                                                              15    9605
NP_001274353                                                           15    9605
NP_001272758                                                           15    9605
NP_001274364                                                           15    9605
NP_004355                                                              15    9605
NP_060396                                                              15    9605
NP_001035810                                                           15    9605
NP_000393                                                              15    9605
NP_000691                                                              15    9605
NP_689658                                                              15    9605
NP_689632                                                              15    9605
NP_060442                                                              15    9605
NP_001107590                                                           15    9605
XP_005274715                                                           15    9605
XP_005274714                                                           15    9605
XP_006721619                                                           15    9605
XP_005256774                                                           15    9605
XP_006720255                                                           15    9605
XP_006720254                                                           15    9605
XP_005273469                                                           15    9605
XP_005273468                                                           15    9605
XP_005273467                                                           15    9605
XP_005273466                                                           15    9605
XP_006712871                                                           15    9605
XP_005275805                                                           15    9605
NP_982248                                                              15    9605
>NP_001261
          Length = 1710

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LSRDLAKK 8
            LSRDLAKK
Sbjct: 1313 LSRDLAKK 1320
>XP_005271924
          Length = 1710

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LSRDLAKK 8
            LSRDLAKK
Sbjct: 1313 LSRDLAKK 1320
>XP_005271923
          Length = 1798

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LSRDLAKK 8
            LSRDLAKK
Sbjct: 1313 LSRDLAKK 1320
>NP_689836
          Length = 515

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LSRDLAKKR 9
          LS+DL +KR
Sbjct: 28 LSKDLKQKR 36
>NP_001139206
          Length = 477

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LSRDLAKKR 9
          LS+DL +KR
Sbjct: 28 LSKDLKQKR 36
>NP_001163873
          Length = 519

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LSRDLAKKR 9
          LS+DL +KR
Sbjct: 28 LSKDLKQKR 36
>NP_653317
          Length = 179

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSRDLAKK 8
           L RD+AKK
Sbjct: 129 LKRDVAKK 136
>NP_036266
          Length = 600

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LSRDLAKKR 9
           LSRD  KKR
Sbjct: 200 LSRDKDKKR 208
>NP_001264003
          Length = 166

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSRDLAKK 8
           L RD+AKK
Sbjct: 116 LKRDVAKK 123
>XP_006713054
          Length = 211

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSRDLAKK 8
           L RD+AKK
Sbjct: 129 LKRDVAKK 136
>NP_001796
          Length = 281

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SRDLAKKR 9
           SRD AK+R
Sbjct: 221 SRDKAKRR 228
>NP_057427
          Length = 3114

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SRDLAKKR 9
           S+DL KKR
Sbjct: 570 SQDLLKKR 577
>NP_001123361
          Length = 552

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DLAKKR 9
           DLAKKR
Sbjct: 146 DLAKKR 151
>NP_001913
          Length = 519

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DLAKKR 9
           DLAKKR
Sbjct: 146 DLAKKR 151
>NP_001001669
          Length = 675

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSRDLAKK 8
           L RDLAK+
Sbjct: 427 LQRDLAKQ 434
>NP_005186
          Length = 269

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SRDLAKKR 9
           SRD AK+R
Sbjct: 208 SRDKAKRR 215
>XP_006715629
          Length = 1667

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SRDLAKKR 9
           +RD+ KKR
Sbjct: 367 ARDIGKKR 374
>XP_005268505
          Length = 461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSRDLAKK 8
           L RDLAK+
Sbjct: 213 LQRDLAKQ 220
>XP_006714848
          Length = 638

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSRDLAKK 8
           L RDLAK+
Sbjct: 390 LQRDLAKQ 397
>XP_005268504
          Length = 675

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSRDLAKK 8
           L RDLAK+
Sbjct: 427 LQRDLAKQ 434
>XP_006714847
          Length = 675

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSRDLAKK 8
           L RDLAK+
Sbjct: 427 LQRDLAKQ 434
>NP_758455
          Length = 138

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LSRDLAKK 8
          L+RD AKK
Sbjct: 31 LARDYAKK 38
>NP_078970
          Length = 1667

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SRDLAKKR 9
           +RD+ KKR
Sbjct: 367 ARDIGKKR 374
>NP_003633
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RDLAKKR 9
           RDLAK R
Sbjct: 368 RDLAKMR 374
>NP_001274353
          Length = 393

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SRDLAKKR 9
           SRD AK+R
Sbjct: 334 SRDKAKQR 341
>NP_001272758
          Length = 239

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SRDLAKKR 9
           SRD AK+R
Sbjct: 180 SRDKAKQR 187
>NP_001274364
          Length = 344

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SRDLAKKR 9
           SRD AK+R
Sbjct: 285 SRDKAKQR 292
>NP_004355
          Length = 358

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SRDLAKKR 9
           SRD AK+R
Sbjct: 299 SRDKAKQR 306
>NP_060396
          Length = 482

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SRDLAKKR 9
           SRD+ +KR
Sbjct: 409 SRDIKRKR 416
>NP_001035810
          Length = 515

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  SRDLAKKR 9
          S DLAKK+
Sbjct: 40 SGDLAKKK 47
>NP_000393
          Length = 545

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  SRDLAKKR 9
          S DLAKK+
Sbjct: 70 SGDLAKKK 77
>NP_000691
          Length = 346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LSRDLAK 7
           L RDLAK
Sbjct: 160 LKRDLAK 166
>NP_689658
          Length = 710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LSRDLAKK 8
           +++DLAKK
Sbjct: 616 VAKDLAKK 623
>NP_689632
          Length = 635

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  RDLAKKR 9
          RDL KKR
Sbjct: 39 RDLDKKR 45
>NP_060442
          Length = 477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SRDLAKKR 9
           SRD+ +KR
Sbjct: 404 SRDIKRKR 411
>NP_001107590
          Length = 620

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LSRDLAKKR 9
           + RD+ KKR
Sbjct: 308 IQRDVIKKR 316
>XP_005274715
          Length = 516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  SRDLAKKR 9
          S DLAKK+
Sbjct: 40 SGDLAKKK 47
>XP_005274714
          Length = 546

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  SRDLAKKR 9
          S DLAKK+
Sbjct: 70 SGDLAKKK 77
>XP_006721619
          Length = 497

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LSRDLAKKR 9
           + RD+ KKR
Sbjct: 173 IQRDVIKKR 181
>XP_005256774
          Length = 632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LSRDLAKKR 9
           + RD+ KKR
Sbjct: 308 IQRDVIKKR 316
>XP_006720255
          Length = 438

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SRDLAKKR 9
           SRD+ +KR
Sbjct: 409 SRDIKRKR 416
>XP_006720254
          Length = 477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SRDLAKKR 9
           SRD+ +KR
Sbjct: 404 SRDIKRKR 411
>XP_005273469
          Length = 502

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  RDLAKKR 9
          RDL KKR
Sbjct: 39 RDLDKKR 45
>XP_005273468
          Length = 608

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  RDLAKKR 9
          RDL KKR
Sbjct: 39 RDLDKKR 45
>XP_005273467
          Length = 664

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  RDLAKKR 9
          RDL KKR
Sbjct: 39 RDLDKKR 45
>XP_005273466
          Length = 672

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  RDLAKKR 9
          RDL KKR
Sbjct: 39 RDLDKKR 45
>XP_006712871
          Length = 413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RDLAKKR 9
           RDLAK R
Sbjct: 362 RDLAKMR 368
>XP_005275805
          Length = 309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSRDLAKK 8
           +SRD AKK
Sbjct: 218 ISRDNAKK 225
>NP_982248
          Length = 164

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  LSRDLAKKR 9
          LSR L KKR
Sbjct: 81 LSRVLEKKR 89
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.320    0.131    0.324 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 479,670
Number of extensions: 966
Number of successful extensions: 49
Number of sequences better than 10000.0: 49
Number of HSP's gapped: 49
Number of HSP's successfully gapped: 49
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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