Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001261                                                              19     665
XP_005271924                                                           19     665
XP_005271923                                                           19     665
NP_000882                                                              17    4312
NP_001035810                                                           17    4312
NP_000393                                                              17    4312
XP_005274715                                                           17    4312
XP_005274714                                                           17    4312
NP_001009899                                                           16    5631
NP_001241872                                                           16    5631
NP_001129069                                                           16    5631
NP_060554                                                              16    5631
NP_653317                                                              16    5631
NP_001264003                                                           16    5631
NP_775794                                                              16    5631
XP_005247266                                                           16    5631
XP_005247265                                                           16    5631
XP_006713054                                                           16    5631
XP_005264484                                                           16    5631
XP_005264483                                                           16    5631
XP_005264480                                                           16    5631
XP_005264478                                                           16    5631
XP_005264475                                                           16    5631
NP_002461                                                              16    7355
NP_001136087                                                           16    7355
NP_009120                                                              16    7355
NP_056140                                                              16    7355
NP_001136086                                                           16    7355
NP_689658                                                              16    7355
NP_001803                                                              16    7355
NP_001001669                                                           16    7355
NP_005683                                                              16    7355
XP_006721591                                                           16    7355
XP_006715887                                                           16    7355
XP_005249988                                                           16    7355
XP_005268505                                                           16    7355
XP_006714848                                                           16    7355
XP_005268504                                                           16    7355
XP_006714847                                                           16    7355
XP_006714128                                                           16    7355
XP_006714127                                                           16    7355
XP_006712034                                                           16    7355
XP_005264284                                                           16    7355
XP_005264283                                                           16    7355
XP_005264282                                                           16    7355
NP_001136088                                                           16    7355
NP_758455                                                              16    7355
NP_056067                                                              16    7355
NP_689845                                                              15    9605
NP_000691                                                              15    9605
XP_005257093                                                           15    9605
XP_005257092                                                           15    9605
XP_005257091                                                           15    9605
XP_005257090                                                           15    9605
XP_005275805                                                           15    9605
NP_859058                                                              15    9605
>NP_001261
          Length = 1710

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LSRDLAKKK 9
            LSRDLAKK+
Sbjct: 1313 LSRDLAKKE 1321
>XP_005271924
          Length = 1710

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LSRDLAKKK 9
            LSRDLAKK+
Sbjct: 1313 LSRDLAKKE 1321
>XP_005271923
          Length = 1798

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LSRDLAKKK 9
            LSRDLAKK+
Sbjct: 1313 LSRDLAKKE 1321
>NP_000882
          Length = 427

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SRDLAKKK 9
           +RDLA+KK
Sbjct: 358 ARDLAEKK 365
>NP_001035810
          Length = 515

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  SRDLAKKK 9
          S DLAKKK
Sbjct: 40 SGDLAKKK 47
>NP_000393
          Length = 545

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  SRDLAKKK 9
          S DLAKKK
Sbjct: 70 SGDLAKKK 77
>XP_005274715
          Length = 516

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  SRDLAKKK 9
          S DLAKKK
Sbjct: 40 SGDLAKKK 47
>XP_005274714
          Length = 546

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  SRDLAKKK 9
          S DLAKKK
Sbjct: 70 SGDLAKKK 77
>NP_001009899
          Length = 2245

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LSRDLAKKK 9
            L  DLAKKK
Sbjct: 1007 LLSDLAKKK 1015
>NP_001241872
          Length = 1796

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSRDLAKKK 9
           LS+DL K+K
Sbjct: 527 LSKDLMKEK 535
>NP_001129069
          Length = 1870

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSRDLAKKK 9
           LS+DL K+K
Sbjct: 527 LSKDLMKEK 535
>NP_060554
          Length = 1843

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSRDLAKKK 9
           LS+DL K+K
Sbjct: 527 LSKDLMKEK 535
>NP_653317
          Length = 179

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSRDLAKK 8
           L RD+AKK
Sbjct: 129 LKRDVAKK 136
>NP_001264003
          Length = 166

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSRDLAKK 8
           L RD+AKK
Sbjct: 116 LKRDVAKK 123
>NP_775794
          Length = 407

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSRDLAKKK 9
           LS+D  KKK
Sbjct: 190 LSKDAVKKK 198
>XP_005247266
          Length = 2189

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LSRDLAKKK 9
           L  DLAKKK
Sbjct: 951 LLSDLAKKK 959
>XP_005247265
          Length = 2211

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LSRDLAKKK 9
           L  DLAKKK
Sbjct: 973 LLSDLAKKK 981
>XP_006713054
          Length = 211

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSRDLAKK 8
           L RD+AKK
Sbjct: 129 LKRDVAKK 136
>XP_005264484
          Length = 955

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSRDLAKKK 9
           LS+DL K+K
Sbjct: 527 LSKDLMKEK 535
>XP_005264483
          Length = 1311

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSRDLAKKK 9
           LS+DL K+K
Sbjct: 527 LSKDLMKEK 535
>XP_005264480
          Length = 1842

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSRDLAKKK 9
           LS+DL K+K
Sbjct: 527 LSKDLMKEK 535
>XP_005264478
          Length = 1844

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSRDLAKKK 9
           LS+DL K+K
Sbjct: 527 LSKDLMKEK 535
>XP_005264475
          Length = 2027

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSRDLAKKK 9
           LS+DL K+K
Sbjct: 527 LSKDLMKEK 535
>NP_002461
          Length = 1940

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DLAKKK 9
           DLAKKK
Sbjct: 204 DLAKKK 209
>NP_001136087
          Length = 1160

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DLAKKK 9
           DLAKKK
Sbjct: 738 DLAKKK 743
>NP_009120
          Length = 623

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4 DLAKKK 9
         DLAKKK
Sbjct: 4 DLAKKK 9
>NP_056140
          Length = 2266

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSRDLAKKK 9
           LSR+L K+K
Sbjct: 588 LSRELEKEK 596
>NP_001136086
          Length = 1196

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DLAKKK 9
           DLAKKK
Sbjct: 738 DLAKKK 743
>NP_689658
          Length = 710

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LSRDLAKKK 9
           +++DLAKK+
Sbjct: 616 VAKDLAKKE 624
>NP_001803
          Length = 943

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DLAKKK 9
           DLAKKK
Sbjct: 624 DLAKKK 629
>NP_001001669
          Length = 675

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSRDLAKK 8
           L RDLAK+
Sbjct: 427 LQRDLAKQ 434
>NP_005683
          Length = 634

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4 DLAKKK 9
         DLAKKK
Sbjct: 4 DLAKKK 9
>XP_006721591
          Length = 1940

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DLAKKK 9
           DLAKKK
Sbjct: 204 DLAKKK 209
>XP_006715887
          Length = 634

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4 DLAKKK 9
         DLAKKK
Sbjct: 4 DLAKKK 9
>XP_005249988
          Length = 634

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4 DLAKKK 9
         DLAKKK
Sbjct: 4 DLAKKK 9
>XP_005268505
          Length = 461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSRDLAKK 8
           L RDLAK+
Sbjct: 213 LQRDLAKQ 220
>XP_006714848
          Length = 638

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSRDLAKK 8
           L RDLAK+
Sbjct: 390 LQRDLAKQ 397
>XP_005268504
          Length = 675

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSRDLAKK 8
           L RDLAK+
Sbjct: 427 LQRDLAKQ 434
>XP_006714847
          Length = 675

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSRDLAKK 8
           L RDLAK+
Sbjct: 427 LQRDLAKQ 434
>XP_006714128
          Length = 730

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DLAKKK 9
           DLAKKK
Sbjct: 411 DLAKKK 416
>XP_006714127
          Length = 935

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DLAKKK 9
           DLAKKK
Sbjct: 624 DLAKKK 629
>XP_006712034
          Length = 1195

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DLAKKK 9
           DLAKKK
Sbjct: 773 DLAKKK 778
>XP_005264284
          Length = 1196

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DLAKKK 9
           DLAKKK
Sbjct: 738 DLAKKK 743
>XP_005264283
          Length = 1231

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DLAKKK 9
           DLAKKK
Sbjct: 773 DLAKKK 778
>XP_005264282
          Length = 1231

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DLAKKK 9
           DLAKKK
Sbjct: 773 DLAKKK 778
>NP_001136088
          Length = 1160

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DLAKKK 9
           DLAKKK
Sbjct: 738 DLAKKK 743
>NP_758455
          Length = 138

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LSRDLAKK 8
          L+RD AKK
Sbjct: 31 LARDYAKK 38
>NP_056067
          Length = 1231

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DLAKKK 9
           DLAKKK
Sbjct: 773 DLAKKK 778
>NP_689845
          Length = 976

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RDLAKKK 9
           +DLAK+K
Sbjct: 549 KDLAKRK 555
>NP_000691
          Length = 346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LSRDLAK 7
           L RDLAK
Sbjct: 160 LKRDLAK 166
>XP_005257093
          Length = 246

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LSRDLAKKK 9
          L RDL +KK
Sbjct: 68 LPRDLPQKK 76
>XP_005257092
          Length = 209

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LSRDLAKKK 9
          L RDL +KK
Sbjct: 31 LPRDLPQKK 39
>XP_005257091
          Length = 269

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSRDLAKKK 9
           L RDL +KK
Sbjct: 101 LPRDLPQKK 109
>XP_005257090
          Length = 279

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSRDLAKKK 9
           L RDL +KK
Sbjct: 101 LPRDLPQKK 109
>XP_005275805
          Length = 309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSRDLAKK 8
           +SRD AKK
Sbjct: 218 ISRDNAKK 225
>NP_859058
          Length = 236

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LSRDLAKKK 9
          L RDL +KK
Sbjct: 68 LPRDLPQKK 76
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.310    0.125    0.300 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 522,207
Number of extensions: 1141
Number of successful extensions: 56
Number of sequences better than 10000.0: 56
Number of HSP's gapped: 56
Number of HSP's successfully gapped: 56
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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