Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_733751                                                              20     390
XP_006716142                                                           20     390
XP_005250088                                                           20     390
XP_006716141                                                           20     390
XP_005250085                                                           20     390
XP_006716140                                                           20     390
XP_005250084                                                           20     390
XP_005250083                                                           20     390
XP_005250082                                                           20     390
NP_055061                                                              17    2528
XP_006724446                                                           17    2528
NP_001035521                                                           17    4312
NP_689681                                                              17    4312
NP_004426                                                              17    4312
NP_005348                                                              17    4312
NP_056284                                                              17    4312
XP_005258994                                                           17    4312
XP_006721788                                                           17    4312
NP_004930                                                              16    5631
NP_079350                                                              16    5631
NP_001129628                                                           16    5631
NP_078889                                                              16    5631
NP_000772                                                              16    5631
NP_001254514                                                           16    5631
NP_001254515                                                           16    5631
NP_001269469                                                           16    5631
NP_055725                                                              16    5631
XP_006723441                                                           16    5631
XP_005259313                                                           16    5631
XP_006721485                                                           16    5631
XP_006721484                                                           16    5631
XP_006721483                                                           16    5631
XP_006720468                                                           16    5631
XP_006720467                                                           16    5631
XP_006714380                                                           16    5631
XP_006714379                                                           16    5631
XP_006714378                                                           16    5631
XP_006714377                                                           16    5631
NP_006373                                                              16    5631
NP_077286                                                              16    5631
NP_001141                                                              16    7355
NP_004786                                                              16    7355
NP_001186127                                                           16    7355
NP_060779                                                              16    7355
XP_005259906                                                           16    7355
XP_005254949                                                           16    7355
XP_006719958                                                           16    7355
NP_001139627                                                           15    9605
NP_001139626                                                           15    9605
NP_001138820                                                           15    9605
NP_079049                                                              15    9605
NP_001263408                                                           15    9605
NP_001263409                                                           15    9605
NP_004784                                                              15    9605
NP_689657                                                              15    9605
XP_006721155                                                           15    9605
NP_076957                                                              15    9605
>NP_733751
          Length = 4911

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    SQERFLVP 9
            SQERFLVP
Sbjct: 2494 SQERFLVP 2501
>XP_006716142
          Length = 4927

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    SQERFLVP 9
            SQERFLVP
Sbjct: 2511 SQERFLVP 2518
>XP_005250088
          Length = 4928

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    SQERFLVP 9
            SQERFLVP
Sbjct: 2511 SQERFLVP 2518
>XP_006716141
          Length = 4959

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    SQERFLVP 9
            SQERFLVP
Sbjct: 2511 SQERFLVP 2518
>XP_005250085
          Length = 4979

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    SQERFLVP 9
            SQERFLVP
Sbjct: 2511 SQERFLVP 2518
>XP_006716140
          Length = 4982

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    SQERFLVP 9
            SQERFLVP
Sbjct: 2511 SQERFLVP 2518
>XP_005250084
          Length = 4982

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    SQERFLVP 9
            SQERFLVP
Sbjct: 2511 SQERFLVP 2518
>XP_005250083
          Length = 4982

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    SQERFLVP 9
            SQERFLVP
Sbjct: 2510 SQERFLVP 2517
>XP_005250082
          Length = 4983

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    SQERFLVP 9
            SQERFLVP
Sbjct: 2511 SQERFLVP 2518
>NP_055061
          Length = 3014

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LSQERFLVP 9
            +SQE+FL P
Sbjct: 1214 MSQEKFLSP 1222
>XP_006724446
          Length = 3019

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LSQERFLVP 9
            +SQE+FL P
Sbjct: 1214 MSQEKFLSP 1222
>NP_001035521
          Length = 106

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  LSQERFL 7
          +SQERFL
Sbjct: 79 ISQERFL 85
>NP_689681
          Length = 726

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSQERFLVP 9
           L +E FLVP
Sbjct: 464 LEREEFLVP 472
>NP_004426
          Length = 297

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ERFLVP 9
           ERFLVP
Sbjct: 261 ERFLVP 266
>NP_005348
          Length = 1076

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  SQERFLVP 9
          SQE FL P
Sbjct: 83 SQEEFLAP 90
>NP_056284
          Length = 247

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QERFLVP 9
           QE+FL+P
Sbjct: 110 QEQFLIP 116
>XP_005258994
          Length = 1000

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  SQERFLVP 9
          SQE FL P
Sbjct: 83 SQEEFLAP 90
>XP_006721788
          Length = 503

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSQERFLVP 9
           L +E FLVP
Sbjct: 241 LEREEFLVP 249
>NP_004930
          Length = 740

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LSQERFLV 8
           LSQ RFLV
Sbjct: 361 LSQVRFLV 368
>NP_079350
          Length = 4012

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    ERFLVP 9
            ERFL+P
Sbjct: 3641 ERFLIP 3646
>NP_001129628
          Length = 953

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LSQERFLV 8
           LSQ+RFL+
Sbjct: 409 LSQKRFLM 416
>NP_078889
          Length = 249

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SQERFLVP 9
           S++RFL+P
Sbjct: 187 SEKRFLLP 194
>NP_000772
          Length = 521

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   ERFLVP 9
           ERFL+P
Sbjct: 119 ERFLIP 124
>NP_001254514
          Length = 1052

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LSQERFLV 8
          +SQ RFLV
Sbjct: 51 ISQRRFLV 58
>NP_001254515
          Length = 999

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LSQERFLV 8
          +SQ RFLV
Sbjct: 51 ISQRRFLV 58
>NP_001269469
          Length = 714

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LSQERFLV 8
          +SQ RFLV
Sbjct: 51 ISQRRFLV 58
>NP_055725
          Length = 953

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LSQERFLV 8
           LSQ+RFL+
Sbjct: 409 LSQKRFLM 416
>XP_006723441
          Length = 279

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SQERFLVP 9
           S++RFL+P
Sbjct: 187 SRQRFLLP 194
>XP_005259313
          Length = 364

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SQERFLVP 9
           S++RFL+P
Sbjct: 272 SRQRFLLP 279
>XP_006721485
          Length = 805

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LSQERFLV 8
          +SQ RFLV
Sbjct: 51 ISQRRFLV 58
>XP_006721484
          Length = 997

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LSQERFLV 8
          +SQ RFLV
Sbjct: 51 ISQRRFLV 58
>XP_006721483
          Length = 1061

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LSQERFLV 8
          +SQ RFLV
Sbjct: 51 ISQRRFLV 58
>XP_006720468
          Length = 433

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  ERFLVP 9
          ERFL+P
Sbjct: 31 ERFLIP 36
>XP_006720467
          Length = 450

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  ERFLVP 9
          ERFL+P
Sbjct: 48 ERFLIP 53
>XP_006714380
          Length = 3897

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    ERFLVP 9
            ERFL+P
Sbjct: 3526 ERFLIP 3531
>XP_006714379
          Length = 3936

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    ERFLVP 9
            ERFL+P
Sbjct: 3565 ERFLIP 3570
>XP_006714378
          Length = 3965

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    ERFLVP 9
            ERFL+P
Sbjct: 3594 ERFLIP 3599
>XP_006714377
          Length = 4010

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    ERFLVP 9
            ERFL+P
Sbjct: 3639 ERFLIP 3644
>NP_006373
          Length = 752

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LSQERFLV 8
          +SQ RFLV
Sbjct: 51 ISQRRFLV 58
>NP_077286
          Length = 279

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SQERFLVP 9
           S++RFL+P
Sbjct: 187 SRQRFLLP 194
>NP_001141
          Length = 967

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSQERFLV 8
           LSQE FL+
Sbjct: 561 LSQEHFLL 568
>NP_004786
          Length = 1012

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LSQERFLVP 9
           LSQ++ L+P
Sbjct: 482 LSQDKMLLP 490
>NP_001186127
          Length = 699

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LSQERFLVP 9
           L+ ER+L+P
Sbjct: 669 LAIERYLIP 677
>NP_060779
          Length = 684

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LSQERFLVP 9
           L+ ER+L+P
Sbjct: 654 LAIERYLIP 662
>XP_005259906
          Length = 206

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  QERFLVP 9
          +ERFL+P
Sbjct: 28 RERFLLP 34
>XP_005254949
          Length = 967

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSQERFLV 8
           LSQE FL+
Sbjct: 561 LSQEHFLL 568
>XP_006719958
          Length = 705

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LSQERFLVP 9
           LSQ++ L+P
Sbjct: 175 LSQDKMLLP 183
>NP_001139627
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LSQERFLV 8
           +++ERFLV
Sbjct: 282 ITRERFLV 289
>NP_001139626
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LSQERFLV 8
           +++ERFLV
Sbjct: 282 ITRERFLV 289
>NP_001138820
          Length = 454

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QERFLVP 9
           +E+FLVP
Sbjct: 234 REQFLVP 240
>NP_079049
          Length = 416

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QERFLVP 9
           +E+FLVP
Sbjct: 196 REQFLVP 202
>NP_001263408
          Length = 895

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   ERFLVP 9
           ER+LVP
Sbjct: 607 ERYLVP 612
>NP_001263409
          Length = 763

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   ERFLVP 9
           ER+LVP
Sbjct: 475 ERYLVP 480
>NP_004784
          Length = 959

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   ERFLVP 9
           ER+LVP
Sbjct: 671 ERYLVP 676
>NP_689657
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LSQERFLV 8
           +++ERFLV
Sbjct: 282 ITRERFLV 289
>XP_006721155
          Length = 427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QERFLVP 9
           +E+FLVP
Sbjct: 207 REQFLVP 213
>NP_076957
          Length = 300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QERFLVP 9
           +E+FLVP
Sbjct: 236 KEQFLVP 242
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.328    0.144    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 533,504
Number of extensions: 979
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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