Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_066124                                                              19     869
XP_006717999                                                           19     869
NP_001265371                                                           16    5631
NP_004508                                                              16    5631
NP_001014795                                                           16    5631
NP_001014794                                                           16    5631
NP_055861                                                              16    5631
NP_055730                                                              16    5631
NP_001265370                                                           16    5631
NP_001242982                                                           16    5631
XP_005252962                                                           16    5631
XP_005252961                                                           16    5631
XP_006717495                                                           16    5631
XP_006717492                                                           16    5631
XP_006717491                                                           16    5631
XP_006717489                                                           16    5631
XP_006717488                                                           16    5631
XP_006717487                                                           16    5631
XP_006717486                                                           16    5631
XP_005272230                                                           16    5631
XP_005272229                                                           16    5631
XP_005272228                                                           16    5631
NP_001177                                                              16    7355
NP_996749                                                              16    7355
NP_001278296                                                           16    7355
NP_001278295                                                           16    7355
NP_001043                                                              16    7355
NP_055423                                                              16    7355
NP_001274739                                                           16    7355
NP_001032409                                                           16    7355
NP_003491                                                              16    7355
XP_006724097                                                           16    7355
XP_005261071                                                           16    7355
XP_005261070                                                           16    7355
XP_005261069                                                           16    7355
XP_006723818                                                           16    7355
XP_005272600                                                           16    7355
XP_006713403                                                           16    7355
XP_005265563                                                           16    7355
XP_005265562                                                           16    7355
NP_001032410                                                           16    7355
NP_055191                                                              16    7355
NP_001185617                                                           15    9605
NP_001003680                                                           15    9605
NP_001185616                                                           15    9605
NP_002294                                                              15    9605
NP_001003679                                                           15    9605
NP_001185618                                                           15    9605
NP_055986                                                              15    9605
NP_001257869                                                           15    9605
XP_005255255                                                           15    9605
XP_005255254                                                           15    9605
XP_005255252                                                           15    9605
XP_006719294                                                           15    9605
NP_001138947                                                           15    9605
NP_001135780                                                           15    9605
>NP_066124
          Length = 1114

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LSPSVAKLM 9
            LSPS AKLM
Sbjct: 1101 LSPSAAKLM 1109
>XP_006717999
          Length = 1207

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LSPSVAKLM 9
            LSPS AKLM
Sbjct: 1194 LSPSAAKLM 1202
>NP_001265371
          Length = 318

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSPSVAKLM 9
           +SP V KLM
Sbjct: 283 ISPHVCKLM 291
>NP_004508
          Length = 452

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSPSVAKLM 9
           +SP V KLM
Sbjct: 417 ISPHVCKLM 425
>NP_001014795
          Length = 452

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSPSVAKLM 9
           +SP V KLM
Sbjct: 417 ISPHVCKLM 425
>NP_001014794
          Length = 452

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSPSVAKLM 9
           +SP V KLM
Sbjct: 417 ISPHVCKLM 425
>NP_055861
          Length = 2677

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    SPSVAKL 8
            SPSVAK+
Sbjct: 1952 SPSVAKI 1958
>NP_055730
          Length = 1710

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   PSVAKLM 9
           PS+AKLM
Sbjct: 276 PSLAKLM 282
>NP_001265370
          Length = 391

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSPSVAKLM 9
           +SP V KLM
Sbjct: 356 ISPHVCKLM 364
>NP_001242982
          Length = 1709

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   PSVAKLM 9
           PS+AKLM
Sbjct: 276 PSLAKLM 282
>XP_005252962
          Length = 318

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSPSVAKLM 9
           +SP V KLM
Sbjct: 283 ISPHVCKLM 291
>XP_005252961
          Length = 452

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSPSVAKLM 9
           +SP V KLM
Sbjct: 417 ISPHVCKLM 425
>XP_006717495
          Length = 1037

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   PSVAKLM 9
           PS+AKLM
Sbjct: 276 PSLAKLM 282
>XP_006717492
          Length = 1635

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   PSVAKLM 9
           PS+AKLM
Sbjct: 276 PSLAKLM 282
>XP_006717491
          Length = 1677

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   PSVAKLM 9
           PS+AKLM
Sbjct: 276 PSLAKLM 282
>XP_006717489
          Length = 1945

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   PSVAKLM 9
           PS+AKLM
Sbjct: 276 PSLAKLM 282
>XP_006717488
          Length = 2031

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   PSVAKLM 9
           PS+AKLM
Sbjct: 276 PSLAKLM 282
>XP_006717487
          Length = 2071

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   PSVAKLM 9
           PS+AKLM
Sbjct: 276 PSLAKLM 282
>XP_006717486
          Length = 2072

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   PSVAKLM 9
           PS+AKLM
Sbjct: 276 PSLAKLM 282
>XP_005272230
          Length = 2706

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    SPSVAKL 8
            SPSVAK+
Sbjct: 1952 SPSVAKI 1958
>XP_005272229
          Length = 2706

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    SPSVAKL 8
            SPSVAK+
Sbjct: 1952 SPSVAKI 1958
>XP_005272228
          Length = 2706

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    SPSVAKL 8
            SPSVAK+
Sbjct: 1952 SPSVAKI 1958
>NP_001177
          Length = 736

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LSPSVAK 7
           LSP+VAK
Sbjct: 416 LSPAVAK 422
>NP_996749
          Length = 736

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LSPSVAK 7
           LSP+VAK
Sbjct: 416 LSPAVAK 422
>NP_001278296
          Length = 696

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   SPSVAKLM 9
           SP  AKLM
Sbjct: 119 SPETAKLM 126
>NP_001278295
          Length = 790

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   SPSVAKLM 9
           SP  AKLM
Sbjct: 213 SPETAKLM 220
>NP_001043
          Length = 388

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   PSVAKLM 9
           PSVAKL+
Sbjct: 160 PSVAKLI 166
>NP_055423
          Length = 1253

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LSPSVAKLM 9
           L P V KLM
Sbjct: 115 LEPEVTKLM 123
>NP_001274739
          Length = 1253

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LSPSVAKLM 9
           L P V KLM
Sbjct: 115 LEPEVTKLM 123
>NP_001032409
          Length = 1253

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LSPSVAKLM 9
           L P V KLM
Sbjct: 115 LEPEVTKLM 123
>NP_003491
          Length = 681

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LSPSVAKL 8
           LSPSVA L
Sbjct: 470 LSPSVAYL 477
>XP_006724097
          Length = 623

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LSPSVAK 7
           LSP+VAK
Sbjct: 416 LSPAVAK 422
>XP_005261071
          Length = 736

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LSPSVAK 7
           LSP+VAK
Sbjct: 416 LSPAVAK 422
>XP_005261070
          Length = 736

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LSPSVAK 7
           LSP+VAK
Sbjct: 416 LSPAVAK 422
>XP_005261069
          Length = 736

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LSPSVAK 7
           LSP+VAK
Sbjct: 416 LSPAVAK 422
>XP_006723818
          Length = 1975

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    LSPSVAKLM 9
            L PS+AK++
Sbjct: 1960 LLPSIAKML 1968
>XP_005272600
          Length = 1253

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LSPSVAKLM 9
           L P V KLM
Sbjct: 115 LEPEVTKLM 123
>XP_006713403
          Length = 583

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LSPSVAKL 8
           LSPSVA L
Sbjct: 372 LSPSVAYL 379
>XP_005265563
          Length = 611

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LSPSVAKL 8
           LSPSVA L
Sbjct: 400 LSPSVAYL 407
>XP_005265562
          Length = 681

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LSPSVAKL 8
           LSPSVA L
Sbjct: 470 LSPSVAYL 477
>NP_001032410
          Length = 1253

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LSPSVAKLM 9
           L P V KLM
Sbjct: 115 LEPEVTKLM 123
>NP_055191
          Length = 1253

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LSPSVAKLM 9
           L P V KLM
Sbjct: 115 LEPEVTKLM 123
>NP_001185617
          Length = 906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LSPSVAKLM 9
           LSPS  KLM
Sbjct: 760 LSPSDYKLM 768
>NP_001003680
          Length = 958

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LSPSVAKLM 9
           LSPS  KLM
Sbjct: 760 LSPSDYKLM 768
>NP_001185616
          Length = 958

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LSPSVAKLM 9
           LSPS  KLM
Sbjct: 760 LSPSDYKLM 768
>NP_002294
          Length = 1165

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LSPSVAKLM 9
           LSPS  KLM
Sbjct: 760 LSPSDYKLM 768
>NP_001003679
          Length = 896

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LSPSVAKLM 9
           LSPS  KLM
Sbjct: 760 LSPSDYKLM 768
>NP_001185618
          Length = 896

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LSPSVAKLM 9
           LSPS  KLM
Sbjct: 760 LSPSDYKLM 768
>NP_055986
          Length = 1125

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SPSVAKLM 9
           SPS AKL+
Sbjct: 224 SPSSAKLL 231
>NP_001257869
          Length = 1111

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SPSVAKLM 9
           SPS AKL+
Sbjct: 210 SPSSAKLL 217
>XP_005255255
          Length = 951

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  SPSVAKLM 9
          SPS AKL+
Sbjct: 50 SPSSAKLL 57
>XP_005255254
          Length = 1051

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SPSVAKLM 9
           SPS AKL+
Sbjct: 150 SPSSAKLL 157
>XP_005255252
          Length = 1124

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SPSVAKLM 9
           SPS AKL+
Sbjct: 224 SPSSAKLL 231
>XP_006719294
          Length = 2348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    SPSVAK 7
            SPSVAK
Sbjct: 1948 SPSVAK 1953
>NP_001138947
          Length = 2351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    SPSVAK 7
            SPSVAK
Sbjct: 1948 SPSVAK 1953
>NP_001135780
          Length = 2156

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SPSVAKL 8
           SP VAKL
Sbjct: 530 SPGVAKL 536
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.314    0.122    0.306 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 762,159
Number of extensions: 882
Number of successful extensions: 56
Number of sequences better than 10000.0: 56
Number of HSP's gapped: 56
Number of HSP's successfully gapped: 56
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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