Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001138389                                                           19     665
NP_001138390                                                           19     665
NP_001138386                                                           19     665
NP_001138387                                                           19     665
NP_000132                                                              19     665
NP_075259                                                              19     665
NP_001138388                                                           19     665
NP_001138391                                                           19     665
NP_001138385                                                           19     665
NP_075418                                                              19     665
XP_006717776                                                           19     665
XP_006717775                                                           19     665
XP_006717774                                                           19     665
XP_006717773                                                           19     665
XP_006717772                                                           19     665
XP_006717771                                                           19     665
NP_002572                                                              17    3301
NP_071397                                                              17    3301
NP_001121631                                                           17    3301
XP_006721617                                                           17    3301
XP_005256773                                                           17    3301
XP_005256772                                                           17    3301
XP_006717192                                                           17    3301
XP_006710877                                                           17    3301
XP_005244829                                                           17    3301
NP_001068567                                                           17    4312
NP_003717                                                              17    4312
XP_005257812                                                           17    4312
NP_619639                                                              16    5631
NP_733842                                                              16    5631
NP_001245348                                                           16    5631
NP_065980                                                              16    5631
XP_005276458                                                           16    5631
XP_005275762                                                           16    5631
NP_054859                                                              16    7355
NP_001120679                                                           16    7355
NP_065871                                                              16    7355
XP_006726572                                                           16    7355
XP_006726571                                                           16    7355
XP_006726570                                                           16    7355
XP_003960511                                                           16    7355
XP_005260528                                                           16    7355
XP_006717414                                                           16    7355
XP_006712620                                                           16    7355
XP_005246688                                                           16    7355
XP_005246689                                                           16    7355
XP_001718723                                                           16    7355
XP_006710283                                                           16    7355
XP_006710282                                                           16    7355
NP_689737                                                              15    9605
NP_001153518                                                           15    9605
NP_001153505                                                           15    9605
NP_003039                                                              15    9605
XP_005246402                                                           15    9605
XP_006712393                                                           15    9605
XP_005246401                                                           15    9605
NP_005273                                                              15    9605
>NP_001138389
          Length = 705

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LSLTADTPM 9
           LS TADTPM
Sbjct: 335 LSSTADTPM 343
>NP_001138390
          Length = 704

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LSLTADTPM 9
           LS TADTPM
Sbjct: 334 LSSTADTPM 342
>NP_001138386
          Length = 709

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LSLTADTPM 9
           LS TADTPM
Sbjct: 339 LSSTADTPM 347
>NP_001138387
          Length = 707

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LSLTADTPM 9
           LS TADTPM
Sbjct: 362 LSSTADTPM 370
>NP_000132
          Length = 821

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LSLTADTPM 9
           LS TADTPM
Sbjct: 451 LSSTADTPM 459
>NP_075259
          Length = 822

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LSLTADTPM 9
           LS TADTPM
Sbjct: 452 LSSTADTPM 460
>NP_001138388
          Length = 706

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LSLTADTPM 9
           LS TADTPM
Sbjct: 336 LSSTADTPM 344
>NP_001138391
          Length = 680

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LSLTADTPM 9
           LS TADTPM
Sbjct: 363 LSSTADTPM 371
>NP_001138385
          Length = 769

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LSLTADTPM 9
           LS TADTPM
Sbjct: 452 LSSTADTPM 460
>NP_075418
          Length = 732

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LSLTADTPM 9
           LS TADTPM
Sbjct: 362 LSSTADTPM 370
>XP_006717776
          Length = 806

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LSLTADTPM 9
           LS TADTPM
Sbjct: 470 LSSTADTPM 478
>XP_006717775
          Length = 726

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LSLTADTPM 9
           LS TADTPM
Sbjct: 356 LSSTADTPM 364
>XP_006717774
          Length = 752

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LSLTADTPM 9
           LS TADTPM
Sbjct: 382 LSSTADTPM 390
>XP_006717773
          Length = 807

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LSLTADTPM 9
           LS TADTPM
Sbjct: 471 LSSTADTPM 479
>XP_006717772
          Length = 838

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LSLTADTPM 9
           LS TADTPM
Sbjct: 468 LSSTADTPM 476
>XP_006717771
          Length = 839

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LSLTADTPM 9
           LS TADTPM
Sbjct: 469 LSSTADTPM 477
>NP_002572
          Length = 1627

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSLTADTPM 9
           L+ TADTP+
Sbjct: 869 LTSTADTPL 877
>NP_071397
          Length = 1276

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LSLTADTPM 9
            LSL+ DTP+
Sbjct: 1238 LSLSEDTPL 1246
>NP_001121631
          Length = 832

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LSLTADTP 8
           LSLTA TP
Sbjct: 807 LSLTAPTP 814
>XP_006721617
          Length = 641

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LSLTADTP 8
           LSLTA TP
Sbjct: 616 LSLTAPTP 623
>XP_005256773
          Length = 641

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LSLTADTP 8
           LSLTA TP
Sbjct: 616 LSLTAPTP 623
>XP_005256772
          Length = 803

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LSLTADTP 8
           LSLTA TP
Sbjct: 778 LSLTAPTP 785
>XP_006717192
          Length = 929

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSLTADTPM 9
           L+ TADTP+
Sbjct: 171 LTSTADTPL 179
>XP_006710877
          Length = 1276

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LSLTADTPM 9
            LSL+ DTP+
Sbjct: 1238 LSLSEDTPL 1246
>XP_005244829
          Length = 1277

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LSLTADTPM 9
            LSL+ DTP+
Sbjct: 1239 LSLSEDTPL 1247
>NP_001068567
          Length = 358

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LSLTADTP 8
          LSLT+D P
Sbjct: 78 LSLTSDAP 85
>NP_003717
          Length = 359

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LSLTADTP 8
          LSLT+D P
Sbjct: 78 LSLTSDAP 85
>XP_005257812
          Length = 341

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LSLTADTP 8
          LSLT+D P
Sbjct: 78 LSLTSDAP 85
>NP_619639
          Length = 4074

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LSLTADTPM 9
            L+ TAD PM
Sbjct: 1509 LATTADEPM 1517
>NP_733842
          Length = 3396

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LSLTADTPM 9
            L+ TAD PM
Sbjct: 1509 LATTADEPM 1517
>NP_001245348
          Length = 640

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LTADTPM 9
           +T DTPM
Sbjct: 575 ITGDTPM 581
>NP_065980
          Length = 640

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LTADTPM 9
           +T DTPM
Sbjct: 575 ITGDTPM 581
>XP_005276458
          Length = 263

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSLTADTP 8
           L LTAD+P
Sbjct: 166 LCLTADSP 173
>XP_005275762
          Length = 263

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSLTADTP 8
           L LTAD+P
Sbjct: 166 LCLTADSP 173
>NP_054859
          Length = 954

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LSLTADTP 8
           LSLT D P
Sbjct: 414 LSLTPDVP 421
>NP_001120679
          Length = 954

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LSLTADTP 8
           LSLT D P
Sbjct: 414 LSLTPDVP 421
>NP_065871
          Length = 1659

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSLTADTPM 9
           LSL  D+PM
Sbjct: 833 LSLCEDSPM 841
>XP_006726572
          Length = 2066

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSLTADTP 8
           L+LTA TP
Sbjct: 774 LTLTAHTP 781
>XP_006726571
          Length = 3681

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LSLTADTP 8
            L+LTA TP
Sbjct: 2430 LTLTAHTP 2437
>XP_006726570
          Length = 3722

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LSLTADTP 8
            L+LTA TP
Sbjct: 2430 LTLTAHTP 2437
>XP_003960511
          Length = 3722

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LSLTADTP 8
            L+LTA TP
Sbjct: 2430 LTLTAHTP 2437
>XP_005260528
          Length = 956

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSLTADTPM 9
           LSL  D+PM
Sbjct: 130 LSLCEDSPM 138
>XP_006717414
          Length = 5100

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LSLTADTP 8
            L+LTA TP
Sbjct: 3808 LTLTAHTP 3815
>XP_006712620
          Length = 932

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LSLTADTP 8
           LSLT D P
Sbjct: 414 LSLTPDVP 421
>XP_005246688
          Length = 954

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LSLTADTP 8
           LSLT D P
Sbjct: 414 LSLTPDVP 421
>XP_005246689
          Length = 954

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LSLTADTP 8
           LSLT D P
Sbjct: 414 LSLTPDVP 421
>XP_001718723
          Length = 1091

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    SLTADTP 8
            SLTAD P
Sbjct: 1078 SLTADIP 1084
>XP_006710283
          Length = 2066

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSLTADTP 8
           L+LTA TP
Sbjct: 774 LTLTAHTP 781
>XP_006710282
          Length = 2621

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LSLTADTP 8
            L+LTA TP
Sbjct: 1329 LTLTAHTP 1336
>NP_689737
          Length = 1265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SLTADTP 8
           +L+ADTP
Sbjct: 284 NLSADTP 290
>NP_001153518
          Length = 1261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SLTADTP 8
           +L+ADTP
Sbjct: 284 NLSADTP 290
>NP_001153505
          Length = 1260

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SLTADTP 8
           +L+ADTP
Sbjct: 284 NLSADTP 290
>NP_003039
          Length = 812

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SLTADT 7
           SLTADT
Sbjct: 623 SLTADT 628
>XP_005246402
          Length = 1265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SLTADTP 8
           +L+ADTP
Sbjct: 284 NLSADTP 290
>XP_006712393
          Length = 1267

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SLTADTP 8
           +L+ADTP
Sbjct: 290 NLSADTP 296
>XP_005246401
          Length = 1271

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SLTADTP 8
           +L+ADTP
Sbjct: 290 NLSADTP 296
>NP_005273
          Length = 362

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SLTADTPM 9
           SLT +TP+
Sbjct: 320 SLTLETPL 327
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.312    0.122    0.327 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 593,234
Number of extensions: 864
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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