Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005091                                                              20     509
NP_653080                                                              20     509
XP_005267292                                                           20     509
XP_005267291                                                           20     509
XP_005267290                                                           20     509
NP_055444                                                              17    2528
XP_006725174                                                           17    2528
XP_006725173                                                           17    2528
XP_006725172                                                           17    2528
XP_006725171                                                           17    2528
XP_006725170                                                           17    2528
XP_006725169                                                           17    2528
XP_006725168                                                           17    2528
XP_006725167                                                           17    2528
XP_005266099                                                           17    2528
XP_006716304                                                           17    2528
XP_006716303                                                           17    2528
XP_006716302                                                           17    2528
XP_005266098                                                           17    2528
XP_005266097                                                           17    2528
XP_005266096                                                           17    2528
XP_006716301                                                           17    2528
NP_055299                                                              17    4312
NP_004583                                                              16    5631
NP_001248340                                                           16    5631
NP_001135444                                                           16    5631
NP_065075                                                              16    5631
XP_006719621                                                           16    5631
XP_005246749                                                           16    5631
XP_005246746                                                           16    5631
NP_001120729                                                           16    5631
NP_002652                                                              16    7355
NP_071349                                                              16    7355
NP_004288                                                              16    7355
NP_002058                                                              16    7355
NP_002063                                                              16    7355
NP_001099038                                                           16    7355
NP_001099037                                                           16    7355
NP_001099036                                                           16    7355
NP_071396                                                              16    7355
XP_005257625                                                           16    7355
XP_005257624                                                           16    7355
XP_006715230                                                           16    7355
XP_006715229                                                           16    7355
XP_005249350                                                           16    7355
XP_005249349                                                           16    7355
XP_005249348                                                           16    7355
XP_005249347                                                           16    7355
XP_005249346                                                           16    7355
NP_061720                                                              16    7355
NP_055873                                                              15    9605
NP_689805                                                              15    9605
XP_006720130                                                           15    9605
XP_006720128                                                           15    9605
XP_006720127                                                           15    9605
XP_006720126                                                           15    9605
XP_005267433                                                           15    9605
XP_005267434                                                           15    9605
XP_006719854                                                           15    9605
XP_006719853                                                           15    9605
>NP_005091
          Length = 1782

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   LSEYDAVE 8
           LSEYDAVE
Sbjct: 849 LSEYDAVE 856
>NP_653080
          Length = 1684

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   LSEYDAVE 8
           LSEYDAVE
Sbjct: 751 LSEYDAVE 758
>XP_005267292
          Length = 1677

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   LSEYDAVE 8
           LSEYDAVE
Sbjct: 744 LSEYDAVE 751
>XP_005267291
          Length = 1684

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   LSEYDAVE 8
           LSEYDAVE
Sbjct: 751 LSEYDAVE 758
>XP_005267290
          Length = 1782

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   LSEYDAVE 8
           LSEYDAVE
Sbjct: 849 LSEYDAVE 856
>NP_055444
          Length = 1344

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LSEYDAVEM 9
           +SE+D+VEM
Sbjct: 464 VSEWDSVEM 472
>XP_006725174
          Length = 1306

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LSEYDAVEM 9
           +SE+D+VEM
Sbjct: 426 VSEWDSVEM 434
>XP_006725173
          Length = 1328

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LSEYDAVEM 9
           +SE+D+VEM
Sbjct: 489 VSEWDSVEM 497
>XP_006725172
          Length = 1329

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LSEYDAVEM 9
           +SE+D+VEM
Sbjct: 449 VSEWDSVEM 457
>XP_006725171
          Length = 1330

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LSEYDAVEM 9
           +SE+D+VEM
Sbjct: 450 VSEWDSVEM 458
>XP_006725170
          Length = 1345

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LSEYDAVEM 9
           +SE+D+VEM
Sbjct: 465 VSEWDSVEM 473
>XP_006725169
          Length = 1368

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LSEYDAVEM 9
           +SE+D+VEM
Sbjct: 489 VSEWDSVEM 497
>XP_006725168
          Length = 1368

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LSEYDAVEM 9
           +SE+D+VEM
Sbjct: 488 VSEWDSVEM 496
>XP_006725167
          Length = 1369

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LSEYDAVEM 9
           +SE+D+VEM
Sbjct: 489 VSEWDSVEM 497
>XP_005266099
          Length = 1306

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LSEYDAVEM 9
           +SE+D+VEM
Sbjct: 426 VSEWDSVEM 434
>XP_006716304
          Length = 1328

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LSEYDAVEM 9
           +SE+D+VEM
Sbjct: 489 VSEWDSVEM 497
>XP_006716303
          Length = 1329

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LSEYDAVEM 9
           +SE+D+VEM
Sbjct: 449 VSEWDSVEM 457
>XP_006716302
          Length = 1330

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LSEYDAVEM 9
           +SE+D+VEM
Sbjct: 450 VSEWDSVEM 458
>XP_005266098
          Length = 1345

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LSEYDAVEM 9
           +SE+D+VEM
Sbjct: 465 VSEWDSVEM 473
>XP_005266097
          Length = 1368

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LSEYDAVEM 9
           +SE+D+VEM
Sbjct: 489 VSEWDSVEM 497
>XP_005266096
          Length = 1368

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LSEYDAVEM 9
           +SE+D+VEM
Sbjct: 488 VSEWDSVEM 496
>XP_006716301
          Length = 1369

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LSEYDAVEM 9
           +SE+D+VEM
Sbjct: 489 VSEWDSVEM 497
>NP_055299
          Length = 460

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSEYDAVEM 9
           L +YD VEM
Sbjct: 111 LVDYDVVEM 119
>NP_004583
          Length = 951

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  LSEYDA 6
          LSEYDA
Sbjct: 83 LSEYDA 88
>NP_001248340
          Length = 1003

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  LSEYDA 6
          LSEYDA
Sbjct: 83 LSEYDA 88
>NP_001135444
          Length = 165

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LSEYDAVEM 9
           L+EYDA+ +
Sbjct: 112 LAEYDALNL 120
>NP_065075
          Length = 831

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LSEYDAV 7
           L EYDAV
Sbjct: 489 LEEYDAV 495
>XP_006719621
          Length = 874

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  LSEYDA 6
          LSEYDA
Sbjct: 83 LSEYDA 88
>XP_005246749
          Length = 381

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  LSEYDAV 7
          L EYDAV
Sbjct: 39 LEEYDAV 45
>XP_005246746
          Length = 898

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LSEYDAV 7
           L EYDAV
Sbjct: 556 LEEYDAV 562
>NP_001120729
          Length = 831

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LSEYDAV 7
           L EYDAV
Sbjct: 489 LEEYDAV 495
>NP_002652
          Length = 1265

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EYDAVEM 9
           +YDAV+M
Sbjct: 305 KYDAVDM 311
>NP_071349
          Length = 1292

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SEYDAVE 8
           S+YD+VE
Sbjct: 717 SDYDSVE 723
>NP_004288
          Length = 355

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LSEYDAV 7
           LSEYD V
Sbjct: 228 LSEYDQV 234
>NP_002058
          Length = 359

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LSEYDAV 7
           LSEYD V
Sbjct: 232 LSEYDQV 238
>NP_002063
          Length = 359

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LSEYDAV 7
           LSEYD V
Sbjct: 232 LSEYDQV 238
>NP_001099038
          Length = 1749

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LSEYDAVEM 9
            L EY AVE+
Sbjct: 1001 LGEYAAVEL 1009
>NP_001099037
          Length = 1757

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LSEYDAVEM 9
            L EY AVE+
Sbjct: 1001 LGEYAAVEL 1009
>NP_001099036
          Length = 1770

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LSEYDAVEM 9
            L EY AVE+
Sbjct: 1001 LGEYAAVEL 1009
>NP_071396
          Length = 1805

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LSEYDAVEM 9
            L EY AVE+
Sbjct: 1001 LGEYAAVEL 1009
>XP_005257625
          Length = 1268

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SEYDAVE 8
           S+YD+VE
Sbjct: 693 SDYDSVE 699
>XP_005257624
          Length = 1293

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SEYDAVE 8
           S+YD+VE
Sbjct: 718 SDYDSVE 724
>XP_006715230
          Length = 1734

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSEYDAVEM 9
           L EY AVE+
Sbjct: 930 LGEYAAVEL 938
>XP_006715229
          Length = 1782

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSEYDAVEM 9
           L EY AVE+
Sbjct: 978 LGEYAAVEL 986
>XP_005249350
          Length = 1810

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LSEYDAVEM 9
            L EY AVE+
Sbjct: 1041 LGEYAAVEL 1049
>XP_005249349
          Length = 1824

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LSEYDAVEM 9
            L EY AVE+
Sbjct: 1041 LGEYAAVEL 1049
>XP_005249348
          Length = 1832

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LSEYDAVEM 9
            L EY AVE+
Sbjct: 1041 LGEYAAVEL 1049
>XP_005249347
          Length = 1837

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LSEYDAVEM 9
            L EY AVE+
Sbjct: 1041 LGEYAAVEL 1049
>XP_005249346
          Length = 1845

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LSEYDAVEM 9
            L EY AVE+
Sbjct: 1041 LGEYAAVEL 1049
>NP_061720
          Length = 4024

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LSEYDAVE 8
           ++E+DAVE
Sbjct: 909 ITEWDAVE 916
>NP_055873
          Length = 1905

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    LSEYDA 6
            +SEYDA
Sbjct: 1632 MSEYDA 1637
>NP_689805
          Length = 975

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SEYDAVE 8
           +EYDAV+
Sbjct: 199 AEYDAVK 205
>XP_006720130
          Length = 491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SEYDAVE 8
           +EYDAV+
Sbjct: 199 AEYDAVK 205
>XP_006720128
          Length = 934

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SEYDAVE 8
           +EYDAV+
Sbjct: 199 AEYDAVK 205
>XP_006720127
          Length = 970

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SEYDAVE 8
           +EYDAV+
Sbjct: 199 AEYDAVK 205
>XP_006720126
          Length = 975

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SEYDAVE 8
           +EYDAV+
Sbjct: 199 AEYDAVK 205
>XP_005267433
          Length = 975

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SEYDAVE 8
           +EYDAV+
Sbjct: 199 AEYDAVK 205
>XP_005267434
          Length = 975

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SEYDAVE 8
           +EYDAV+
Sbjct: 199 AEYDAVK 205
>XP_006719854
          Length = 1550

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    LSEYDA 6
            +SEYDA
Sbjct: 1277 MSEYDA 1282
>XP_006719853
          Length = 1809

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    LSEYDA 6
            +SEYDA
Sbjct: 1536 MSEYDA 1541
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.307    0.124    0.307 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 427,719
Number of extensions: 433
Number of successful extensions: 60
Number of sequences better than 10000.0: 60
Number of HSP's gapped: 60
Number of HSP's successfully gapped: 60
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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