Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006209                                                              18    1482
XP_006713721                                                           18    1482
NP_115970                                                              16    5631
NP_064627                                                              16    5631
NP_006416                                                              16    5631
NP_001139806                                                           16    5631
XP_006724421                                                           16    5631
XP_006715862                                                           16    5631
XP_006715737                                                           16    5631
XP_005249373                                                           16    5631
XP_005265850                                                           16    5631
XP_006713328                                                           16    5631
XP_006713327                                                           16    5631
XP_006713326                                                           16    5631
XP_006713325                                                           16    5631
XP_006713324                                                           16    5631
XP_005265385                                                           16    5631
NP_115921                                                              16    7355
NP_115590                                                              16    7355
NP_778252                                                              16    7355
NP_001988                                                              16    7355
XP_005260629                                                           16    7355
XP_005267222                                                           16    7355
NP_000029                                                              15    9605
NP_001120983                                                           15    9605
NP_001120982                                                           15    9605
NP_003256                                                              15    9605
NP_892006                                                              15    9605
NP_149062                                                              15    9605
NP_071361                                                              15    9605
NP_060681                                                              15    9605
XP_006715488                                                           15    9605
XP_006715487                                                           15    9605
XP_006715486                                                           15    9605
XP_006715485                                                           15    9605
XP_006715484                                                           15    9605
XP_006715483                                                           15    9605
XP_006715482                                                           15    9605
XP_006715481                                                           15    9605
XP_006715480                                                           15    9605
XP_006715479                                                           15    9605
XP_006715478                                                           15    9605
XP_006715477                                                           15    9605
XP_006715476                                                           15    9605
XP_006715475                                                           15    9605
XP_006715474                                                           15    9605
XP_006715473                                                           15    9605
XP_006715472                                                           15    9605
XP_006715471                                                           15    9605
XP_006715470                                                           15    9605
XP_006714357                                                           15    9605
XP_006710801                                                           15    9605
NP_055040                                                              15    9605
>NP_006209
          Length = 1068

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LSEITGQEK 9
           LSEIT QEK
Sbjct: 540 LSEITEQEK 548
>XP_006713721
          Length = 1068

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LSEITGQEK 9
           LSEIT QEK
Sbjct: 540 LSEITEQEK 548
>NP_115970
          Length = 521

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SEITGQEK 9
           +E+TGQE+
Sbjct: 333 TELTGQEE 340
>NP_064627
          Length = 1388

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SEITGQEK 9
           SEI+G EK
Sbjct: 552 SEISGMEK 559
>NP_006416
          Length = 586

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LSEITGQE 8
           ++EITG+E
Sbjct: 471 INEITGEE 478
>NP_001139806
          Length = 1562

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSEITGQE 8
           +SEI GQE
Sbjct: 532 ISEILGQE 539
>XP_006724421
          Length = 667

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EITGQEK 9
           E+TG+EK
Sbjct: 651 EVTGKEK 657
>XP_006715862
          Length = 346

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SEITGQEK 9
           +E+TGQE+
Sbjct: 158 TELTGQEE 165
>XP_006715737
          Length = 1349

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSEITGQE 8
           +SEI GQE
Sbjct: 532 ISEILGQE 539
>XP_005249373
          Length = 7723

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SEITGQEK 9
           SEIT QEK
Sbjct: 166 SEITFQEK 173
>XP_005265850
          Length = 596

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LSEITGQE 8
           ++EITG+E
Sbjct: 481 INEITGEE 488
>XP_006713328
          Length = 992

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SEITGQEK 9
           SEI+G EK
Sbjct: 552 SEISGMEK 559
>XP_006713327
          Length = 1023

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SEITGQEK 9
           SEI+G EK
Sbjct: 187 SEISGMEK 194
>XP_006713326
          Length = 1037

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SEITGQEK 9
           SEI+G EK
Sbjct: 552 SEISGMEK 559
>XP_006713325
          Length = 1195

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SEITGQEK 9
           SEI+G EK
Sbjct: 552 SEISGMEK 559
>XP_006713324
          Length = 1285

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SEITGQEK 9
           SEI+G EK
Sbjct: 552 SEISGMEK 559
>XP_005265385
          Length = 1291

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SEITGQEK 9
           SEI+G EK
Sbjct: 455 SEISGMEK 462
>NP_115921
          Length = 1894

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SEITGQEK 9
           +EITG+E+
Sbjct: 538 TEITGEEE 545
>NP_115590
          Length = 261

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LSEITGQE 8
          LSE++G+E
Sbjct: 72 LSEVSGRE 79
>NP_778252
          Length = 210

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LSEITGQE 8
          LSE++G+E
Sbjct: 72 LSEVSGRE 79
>NP_001988
          Length = 133

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  EITGQE 8
          E+TGQE
Sbjct: 14 EVTGQE 19
>XP_005260629
          Length = 214

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LSEITGQE 8
          LSE++G+E
Sbjct: 72 LSEVSGRE 79
>XP_005267222
          Length = 1819

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SEITGQEK 9
           +EITG+E+
Sbjct: 463 TEITGEEE 470
>NP_000029
          Length = 2843

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    SEITGQEK 9
            SEI+GQ K
Sbjct: 2207 SEISGQMK 2214
>NP_001120983
          Length = 2825

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    SEITGQEK 9
            SEI+GQ K
Sbjct: 2189 SEISGQMK 2196
>NP_001120982
          Length = 2843

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    SEITGQEK 9
            SEI+GQ K
Sbjct: 2207 SEISGQMK 2214
>NP_003256
          Length = 904

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   EITGQE 8
           E+TGQE
Sbjct: 446 ELTGQE 451
>NP_892006
          Length = 8797

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LSEITGQEK 9
            + E+T QEK
Sbjct: 4521 MKEVTEQEK 4529
>NP_149062
          Length = 8749

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LSEITGQEK 9
            + E+T QEK
Sbjct: 4450 MKEVTEQEK 4458
>NP_071361
          Length = 525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   EITGQEK 9
           ++TGQE+
Sbjct: 309 DVTGQER 315
>NP_060681
          Length = 678

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   SEITGQEK 9
           SE+TG  K
Sbjct: 176 SEVTGHSK 183
>XP_006715488
          Length = 8721

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LSEITGQEK 9
            + E+T QEK
Sbjct: 4528 MKEVTEQEK 4536
>XP_006715487
          Length = 8744

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LSEITGQEK 9
            + E+T QEK
Sbjct: 4528 MKEVTEQEK 4536
>XP_006715486
          Length = 8758

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LSEITGQEK 9
            + E+T QEK
Sbjct: 4528 MKEVTEQEK 4536
>XP_006715485
          Length = 8793

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LSEITGQEK 9
            + E+T QEK
Sbjct: 4475 MKEVTEQEK 4483
>XP_006715484
          Length = 8794

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LSEITGQEK 9
            + E+T QEK
Sbjct: 4476 MKEVTEQEK 4484
>XP_006715483
          Length = 8795

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LSEITGQEK 9
            + E+T QEK
Sbjct: 4528 MKEVTEQEK 4536
>XP_006715482
          Length = 8797

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LSEITGQEK 9
            + E+T QEK
Sbjct: 4521 MKEVTEQEK 4529
>XP_006715481
          Length = 8799

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LSEITGQEK 9
            + E+T QEK
Sbjct: 4481 MKEVTEQEK 4489
>XP_006715480
          Length = 8799

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LSEITGQEK 9
            + E+T QEK
Sbjct: 4528 MKEVTEQEK 4536
>XP_006715479
          Length = 8804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LSEITGQEK 9
            + E+T QEK
Sbjct: 4528 MKEVTEQEK 4536
>XP_006715478
          Length = 8809

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LSEITGQEK 9
            + E+T QEK
Sbjct: 4528 MKEVTEQEK 4536
>XP_006715477
          Length = 8822

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LSEITGQEK 9
            + E+T QEK
Sbjct: 4504 MKEVTEQEK 4512
>XP_006715476
          Length = 8823

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LSEITGQEK 9
            + E+T QEK
Sbjct: 4528 MKEVTEQEK 4536
>XP_006715475
          Length = 8827

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LSEITGQEK 9
            + E+T QEK
Sbjct: 4528 MKEVTEQEK 4536
>XP_006715474
          Length = 8829

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LSEITGQEK 9
            + E+T QEK
Sbjct: 4511 MKEVTEQEK 4519
>XP_006715473
          Length = 8832

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LSEITGQEK 9
            + E+T QEK
Sbjct: 4528 MKEVTEQEK 4536
>XP_006715472
          Length = 8839

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LSEITGQEK 9
            + E+T QEK
Sbjct: 4521 MKEVTEQEK 4529
>XP_006715471
          Length = 8842

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LSEITGQEK 9
            + E+T QEK
Sbjct: 4528 MKEVTEQEK 4536
>XP_006715470
          Length = 8846

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LSEITGQEK 9
            + E+T QEK
Sbjct: 4528 MKEVTEQEK 4536
>XP_006714357
          Length = 904

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   EITGQE 8
           E+TGQE
Sbjct: 446 ELTGQE 451
>XP_006710801
          Length = 647

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   SEITGQEK 9
           SE+TG  K
Sbjct: 132 SEVTGHSK 139
>NP_055040
          Length = 589

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LSEITGQE 8
           LSE+ GQ+
Sbjct: 508 LSEVCGQD 515
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.293    0.119    0.282 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 593,500
Number of extensions: 908
Number of successful extensions: 53
Number of sequences better than 10000.0: 53
Number of HSP's gapped: 53
Number of HSP's successfully gapped: 53
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.9 bits)
S2: 28 (15.4 bits)

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