Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_075259                                                              20     299
NP_001138391                                                           20     299
NP_001138385                                                           20     299
XP_006717775                                                           20     299
XP_006717774                                                           20     299
XP_006717773                                                           20     299
XP_006717771                                                           20     299
NP_065733                                                              17    3301
NP_001265519                                                           17    4312
NP_919433                                                              17    4312
NP_006850                                                              17    4312
NP_001091678                                                           17    4312
NP_001091677                                                           17    4312
NP_001091676                                                           17    4312
NP_001091675                                                           17    4312
NP_001091674                                                           17    4312
NP_005476                                                              17    4312
NP_004957                                                              17    4312
NP_060439                                                              17    4312
NP_775922                                                              17    4312
XP_006714053                                                           17    4312
XP_006712977                                                           17    4312
XP_005264836                                                           17    4312
XP_006712689                                                           17    4312
XP_005263764                                                           17    4312
NP_001003931                                                           17    4312
NP_037518                                                              16    5631
NP_998816                                                              16    5631
XP_006719245                                                           16    5631
XP_006719244                                                           16    5631
XP_006717822                                                           16    5631
XP_006717821                                                           16    5631
XP_005269749                                                           16    5631
XP_006717820                                                           16    5631
XP_005271295                                                           16    5631
NP_065081                                                              16    5631
NP_005471                                                              16    5631
NP_112227                                                              16    5631
NP_001138578                                                           16    7355
NP_116232                                                              16    7355
NP_071738                                                              16    7355
NP_001273940                                                           16    7355
NP_001273942                                                           16    7355
NP_001273939                                                           16    7355
NP_004738                                                              16    7355
XP_006725186                                                           16    7355
XP_006725185                                                           16    7355
XP_006725184                                                           16    7355
XP_006725183                                                           16    7355
XP_006718120                                                           16    7355
XP_006718119                                                           16    7355
XP_006718118                                                           16    7355
XP_005270333                                                           16    7355
NP_055302                                                              16    7355
NP_001180413                                                           15    9605
NP_004949                                                              15    9605
NP_112192                                                              15    9605
NP_001027565                                                           15    9605
NP_001171760                                                           15    9605
NP_062543                                                              15    9605
NP_001093901                                                           15    9605
NP_005511                                                              15    9605
NP_001244222                                                           15    9605
XP_006714926                                                           15    9605
XP_006714925                                                           15    9605
XP_005265952                                                           15    9605
XP_005265953                                                           15    9605
XP_005264005                                                           15    9605
XP_005263496                                                           15    9605
XP_005263495                                                           15    9605
>NP_075259
          Length = 822

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LRVLKHSGI 9
           L+VLKHSGI
Sbjct: 309 LKVLKHSGI 317
>NP_001138391
          Length = 680

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LRVLKHSGI 9
           L+VLKHSGI
Sbjct: 220 LKVLKHSGI 228
>NP_001138385
          Length = 769

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LRVLKHSGI 9
           L+VLKHSGI
Sbjct: 309 LKVLKHSGI 317
>XP_006717775
          Length = 726

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LRVLKHSGI 9
           L+VLKHSGI
Sbjct: 213 LKVLKHSGI 221
>XP_006717774
          Length = 752

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LRVLKHSGI 9
           L+VLKHSGI
Sbjct: 239 LKVLKHSGI 247
>XP_006717773
          Length = 807

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LRVLKHSGI 9
           L+VLKHSGI
Sbjct: 328 LKVLKHSGI 336
>XP_006717771
          Length = 839

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LRVLKHSGI 9
           L+VLKHSGI
Sbjct: 328 LKVLKHSGI 336
>NP_065733
          Length = 375

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RVLKHSG 8
           RVLKH G
Sbjct: 173 RVLKHGG 179
>NP_001265519
          Length = 329

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LRVLKHS 7
           LRVLKH+
Sbjct: 216 LRVLKHA 222
>NP_919433
          Length = 322

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LRVLKHS 7
           LRVLKH+
Sbjct: 259 LRVLKHA 265
>NP_006850
          Length = 372

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LRVLKHS 7
           LRVLKH+
Sbjct: 259 LRVLKHA 265
>NP_001091678
          Length = 415

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VLKHSG 8
           VLKHSG
Sbjct: 96  VLKHSG 101
>NP_001091677
          Length = 415

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VLKHSG 8
           VLKHSG
Sbjct: 96  VLKHSG 101
>NP_001091676
          Length = 415

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VLKHSG 8
           VLKHSG
Sbjct: 96  VLKHSG 101
>NP_001091675
          Length = 415

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VLKHSG 8
           VLKHSG
Sbjct: 96  VLKHSG 101
>NP_001091674
          Length = 415

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VLKHSG 8
           VLKHSG
Sbjct: 96  VLKHSG 101
>NP_005476
          Length = 533

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LRVLKHSG 8
           LR++ HSG
Sbjct: 399 LRIMPHSG 406
>NP_004957
          Length = 415

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VLKHSG 8
           VLKHSG
Sbjct: 96  VLKHSG 101
>NP_060439
          Length = 819

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LKHSGI 9
           LKHSGI
Sbjct: 652 LKHSGI 657
>NP_775922
          Length = 6996

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    VLKHSG 8
            VLKHSG
Sbjct: 6349 VLKHSG 6354
>XP_006714053
          Length = 226

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LRVLKHS 7
           LRVLKH+
Sbjct: 113 LRVLKHA 119
>XP_006712977
          Length = 533

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LRVLKHSG 8
           LR++ HSG
Sbjct: 399 LRIMPHSG 406
>XP_005264836
          Length = 533

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LRVLKHSG 8
           LR++ HSG
Sbjct: 399 LRIMPHSG 406
>XP_006712689
          Length = 823

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LKHSGI 9
           LKHSGI
Sbjct: 657 LKHSGI 662
>XP_005263764
          Length = 824

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LKHSGI 9
           LKHSGI
Sbjct: 657 LKHSGI 662
>NP_001003931
          Length = 540

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LRVLKHSG 8
           LR++ HSG
Sbjct: 406 LRIMPHSG 413
>NP_037518
          Length = 477

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   RVLKHSGI 9
           ++LKH G+
Sbjct: 333 KILKHEGL 340
>NP_998816
          Length = 458

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   RVLKHSGI 9
           ++LKH G+
Sbjct: 314 KILKHEGL 321
>XP_006719245
          Length = 776

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VLKHSGI 9
           +LKHSG+
Sbjct: 492 LLKHSGL 498
>XP_006719244
          Length = 868

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VLKHSGI 9
           +LKHSG+
Sbjct: 494 LLKHSGL 500
>XP_006717822
          Length = 810

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LRVLKHSG 8
           LRVL++SG
Sbjct: 254 LRVLRNSG 261
>XP_006717821
          Length = 846

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LRVLKHSG 8
           LRVL++SG
Sbjct: 254 LRVLRNSG 261
>XP_005269749
          Length = 901

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LRVLKHSG 8
           LRVL++SG
Sbjct: 254 LRVLRNSG 261
>XP_006717820
          Length = 949

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LRVLKHSG 8
           LRVL++SG
Sbjct: 254 LRVLRNSG 261
>XP_005271295
          Length = 300

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LRVLKHSGI 9
           LRV+ HS I
Sbjct: 141 LRVIAHSSI 149
>NP_065081
          Length = 951

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LRVLKHSG 8
           LRVL++SG
Sbjct: 254 LRVLRNSG 261
>NP_005471
          Length = 778

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VLKHSGI 9
           +LKHSG+
Sbjct: 494 LLKHSGL 500
>NP_112227
          Length = 336

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LRVLKHSGI 9
           LRV+ HS I
Sbjct: 141 LRVIAHSSI 149
>NP_001138578
          Length = 461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VLKHSGI 9
           +LKHSG+
Sbjct: 379 LLKHSGM 385
>NP_116232
          Length = 461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VLKHSGI 9
           +LKHSG+
Sbjct: 379 LLKHSGM 385
>NP_071738
          Length = 154

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  RVLKHS 7
          R+LKHS
Sbjct: 50 RILKHS 55
>NP_001273940
          Length = 104

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  RVLKHS 7
          R+LKHS
Sbjct: 50 RILKHS 55
>NP_001273942
          Length = 169

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  RVLKHS 7
          R+LKHS
Sbjct: 65 RILKHS 70
>NP_001273939
          Length = 128

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  RVLKHS 7
          R+LKHS
Sbjct: 50 RILKHS 55
>NP_004738
          Length = 1919

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RVLKHSG 8
           +VLKH+G
Sbjct: 288 QVLKHNG 294
>XP_006725186
          Length = 1342

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RVLKHSG 8
           +VLKH+G
Sbjct: 288 QVLKHNG 294
>XP_006725185
          Length = 1579

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RVLKHSG 8
           +VLKH+G
Sbjct: 288 QVLKHNG 294
>XP_006725184
          Length = 1907

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RVLKHSG 8
           +VLKH+G
Sbjct: 276 QVLKHNG 282
>XP_006725183
          Length = 1915

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RVLKHSG 8
           +VLKH+G
Sbjct: 284 QVLKHNG 290
>XP_006718120
          Length = 1342

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RVLKHSG 8
           +VLKH+G
Sbjct: 288 QVLKHNG 294
>XP_006718119
          Length = 1579

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RVLKHSG 8
           +VLKH+G
Sbjct: 288 QVLKHNG 294
>XP_006718118
          Length = 1907

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RVLKHSG 8
           +VLKH+G
Sbjct: 276 QVLKHNG 282
>XP_005270333
          Length = 1915

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RVLKHSG 8
           +VLKH+G
Sbjct: 284 QVLKHNG 290
>NP_055302
          Length = 320

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  VLKHSGI 9
          V+KH+G+
Sbjct: 83 VIKHAGV 89
>NP_001180413
          Length = 362

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  LRVLKHSGI 9
          L+ L HSG+
Sbjct: 6  LKELSHSGL 14
>NP_004949
          Length = 2549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LRVLKHSGI 9
           L  L+HSGI
Sbjct: 738 LTELEHSGI 746
>NP_112192
          Length = 597

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RVLKHSGI 9
           RVL+HS I
Sbjct: 427 RVLQHSWI 434
>NP_001027565
          Length = 449

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VLKHSG 8
           VLKH+G
Sbjct: 96  VLKHTG 101
>NP_001171760
          Length = 227

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LRVLKHS 7
           LRV KHS
Sbjct: 133 LRVQKHS 139
>NP_062543
          Length = 449

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VLKHSG 8
           VLKH+G
Sbjct: 96  VLKHTG 101
>NP_001093901
          Length = 305

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LRVLKHS 7
           LRV KHS
Sbjct: 133 LRVQKHS 139
>NP_005511
          Length = 449

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VLKHSG 8
           VLKH+G
Sbjct: 96  VLKHTG 101
>NP_001244222
          Length = 449

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VLKHSG 8
           VLKH+G
Sbjct: 96  VLKHTG 101
>XP_006714926
          Length = 429

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VLKHSG 8
           VLKH+G
Sbjct: 96  VLKHTG 101
>XP_006714925
          Length = 452

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VLKHSG 8
           VLKH+G
Sbjct: 96  VLKHTG 101
>XP_005265952
          Length = 472

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VLKHSG 8
           VLKH+G
Sbjct: 96  VLKHTG 101
>XP_005265953
          Length = 472

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VLKHSG 8
           VLKH+G
Sbjct: 96  VLKHTG 101
>XP_005264005
          Length = 373

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  LRVLKHSGI 9
          L+ L HSG+
Sbjct: 6  LKELSHSGL 14
>XP_005263496
          Length = 2322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LRVLKHSGI 9
           L  L+HSGI
Sbjct: 511 LTELEHSGI 519
>XP_005263495
          Length = 2549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LRVLKHSGI 9
           L  L+HSGI
Sbjct: 738 LTELEHSGI 746
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.331    0.148    0.417 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 597,062
Number of extensions: 840
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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