Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_115803                                                              20     390
XP_006710239                                                           19     869
NP_031376                                                              18    1482
NP_891550                                                              17    2528
XP_005265386                                                           17    2528
NP_001269869                                                           17    3301
NP_001034934                                                           17    3301
XP_005246372                                                           17    3301
NP_001121371                                                           17    4312
NP_001269092                                                           17    4312
NP_001121370                                                           17    4312
NP_000075                                                              17    4312
NP_001107604                                                           17    4312
NP_005711                                                              17    4312
XP_006715889                                                           17    4312
XP_006715888                                                           17    4312
XP_005246845                                                           17    4312
XP_006712765                                                           17    4312
XP_006712764                                                           17    4312
XP_005246844                                                           17    4312
XP_006712763                                                           17    4312
XP_006712762                                                           17    4312
XP_006712761                                                           17    4312
NP_995318                                                              16    5631
NP_001035362                                                           16    5631
NP_892005                                                              16    5631
NP_612501                                                              16    5631
NP_065863                                                              16    5631
XP_005260057                                                           16    5631
XP_006722867                                                           16    5631
XP_006722866                                                           16    5631
XP_006722865                                                           16    5631
XP_005260058                                                           16    5631
XP_006712965                                                           16    5631
NP_000913                                                              15    9605
NP_055475                                                              15    9605
NP_004144                                                              15    9605
NP_001177748                                                           15    9605
NP_001229769                                                           15    9605
NP_001177747                                                           15    9605
XP_006725395                                                           15    9605
XP_006722056                                                           15    9605
XP_005254346                                                           15    9605
XP_005254347                                                           15    9605
XP_006718312                                                           15    9605
XP_005253029                                                           15    9605
XP_005249968                                                           15    9605
XP_005249967                                                           15    9605
XP_005249966                                                           15    9605
XP_006715864                                                           15    9605
XP_005249965                                                           15    9605
XP_005273163                                                           15    9605
XP_005273162                                                           15    9605
XP_005273160                                                           15    9605
XP_005270390                                                           15    9605
XP_006711823                                                           15    9605
NP_733843                                                              15    9605
NP_001017434                                                           15    9605
>NP_115803
          Length = 1156

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  LRTRIAVCR 9
          LR RIAVCR
Sbjct: 40 LRARIAVCR 48
>XP_006710239
          Length = 485

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LRTRIAVCR 9
           LR+R++VCR
Sbjct: 339 LRSRVSVCR 347
>NP_031376
          Length = 401

 Score = 18.1 bits (35), Expect =  1482
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  LRTRIAVCR 9
          +RTR+++CR
Sbjct: 73 IRTRLSLCR 81
>NP_891550
          Length = 1935

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    LRTRIAVCR 9
            +RTR+ VC+
Sbjct: 1402 IRTRLVVCQ 1410
>XP_005265386
          Length = 1907

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    LRTRIAVCR 9
            +RTR+ VC+
Sbjct: 1374 IRTRLVVCQ 1382
>NP_001269869
          Length = 517

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LRTRIAVCR 9
           LR+R+ +CR
Sbjct: 229 LRSRVPLCR 237
>NP_001034934
          Length = 518

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LRTRIAVCR 9
           LR+R+ +CR
Sbjct: 229 LRSRVPLCR 237
>XP_005246372
          Length = 420

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LRTRIAVCR 9
           LR+R+ +CR
Sbjct: 131 LRSRVPLCR 139
>NP_001121371
          Length = 816

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LRTRIAVCR 9
           +RT IA CR
Sbjct: 407 IRTNIAWCR 415
>NP_001269092
          Length = 766

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LRTRIAVCR 9
           +RT IA CR
Sbjct: 357 IRTNIAWCR 365
>NP_001121370
          Length = 816

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LRTRIAVCR 9
           +RT IA CR
Sbjct: 407 IRTNIAWCR 415
>NP_000075
          Length = 746

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LRTRIAVCR 9
           +RT IA CR
Sbjct: 337 IRTNIAWCR 345
>NP_001107604
          Length = 2694

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    LRTRIAVCR 9
            +  R+A+CR
Sbjct: 1233 INVRVAICR 1241
>NP_005711
          Length = 372

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  RTRIAVC 8
          RT+IA+C
Sbjct: 20 RTQIAIC 26
>XP_006715889
          Length = 372

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  RTRIAVC 8
          RT+IA+C
Sbjct: 20 RTQIAIC 26
>XP_006715888
          Length = 372

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  RTRIAVC 8
          RT+IA+C
Sbjct: 20 RTQIAIC 26
>XP_005246845
          Length = 1624

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   LRTRIAVCR 9
           +  R+A+CR
Sbjct: 150 INVRVAICR 158
>XP_006712765
          Length = 2679

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    LRTRIAVCR 9
            +  R+A+CR
Sbjct: 1205 INVRVAICR 1213
>XP_006712764
          Length = 2697

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    LRTRIAVCR 9
            +  R+A+CR
Sbjct: 1262 INVRVAICR 1270
>XP_005246844
          Length = 2707

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    LRTRIAVCR 9
            +  R+A+CR
Sbjct: 1233 INVRVAICR 1241
>XP_006712763
          Length = 2716

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    LRTRIAVCR 9
            +  R+A+CR
Sbjct: 1262 INVRVAICR 1270
>XP_006712762
          Length = 2723

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    LRTRIAVCR 9
            +  R+A+CR
Sbjct: 1262 INVRVAICR 1270
>XP_006712761
          Length = 2736

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    LRTRIAVCR 9
            +  R+A+CR
Sbjct: 1262 INVRVAICR 1270
>NP_995318
          Length = 177

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  RTRIAVCR 9
          R RIA+C+
Sbjct: 53 RKRIAICQ 60
>NP_001035362
          Length = 1762

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RTRIAVCR 9
           +TR A+CR
Sbjct: 809 QTRSAICR 816
>NP_892005
          Length = 189

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  RTRIAVCR 9
          R RIA+C+
Sbjct: 53 RKRIAICQ 60
>NP_612501
          Length = 148

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  RTRIAVCR 9
          R RIA+C+
Sbjct: 24 RKRIAICQ 31
>NP_065863
          Length = 2047

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LRTRIAVC 8
            ++TRI VC
Sbjct: 1885 IKTRIRVC 1892
>XP_005260057
          Length = 2113

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LRTRIAVC 8
            ++TRI VC
Sbjct: 1951 IKTRIRVC 1958
>XP_006722867
          Length = 1159

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LRTRIAVC 8
            ++TRI VC
Sbjct: 997  IKTRIRVC 1004
>XP_006722866
          Length = 1778

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LRTRIAVC 8
            ++TRI VC
Sbjct: 1616 IKTRIRVC 1623
>XP_006722865
          Length = 2078

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LRTRIAVC 8
            ++TRI VC
Sbjct: 1916 IKTRIRVC 1923
>XP_005260058
          Length = 2082

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LRTRIAVC 8
            ++TRI VC
Sbjct: 1920 IKTRIRVC 1927
>XP_006712965
          Length = 423

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  LRTRIAVCR 9
          +RTR   CR
Sbjct: 46 IRTRTTACR 54
>NP_000913
          Length = 1112

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LRTRIAVC 8
           LRT ++VC
Sbjct: 108 LRTLLSVC 115
>NP_055475
          Length = 888

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   LRTRIAVCR 9
           LRT  A C+
Sbjct: 867 LRTECATCK 875
>NP_004144
          Length = 861

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LRTRIAVCR 9
           LRTRIA  +
Sbjct: 318 LRTRIAASK 326
>NP_001177748
          Length = 856

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LRTRIAVCR 9
           LRTRIA  +
Sbjct: 318 LRTRIAASK 326
>NP_001229769
          Length = 241

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RTRIAVC 8
           R R+AVC
Sbjct: 189 RLRLAVC 195
>NP_001177747
          Length = 861

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LRTRIAVCR 9
           LRTRIA  +
Sbjct: 318 LRTRIAASK 326
>XP_006725395
          Length = 1249

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    RTRIAVCR 9
            RTR  +CR
Sbjct: 1209 RTRAPLCR 1216
>XP_006722056
          Length = 1249

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    RTRIAVCR 9
            RTR  +CR
Sbjct: 1209 RTRAPLCR 1216
>XP_005254346
          Length = 483

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  RTRIAVCR 9
          +TR+ +CR
Sbjct: 13 KTRLRLCR 20
>XP_005254347
          Length = 483

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  RTRIAVCR 9
          +TR+ +CR
Sbjct: 13 KTRLRLCR 20
>XP_006718312
          Length = 735

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LRTRIAVC 8
           LRT ++VC
Sbjct: 108 LRTLLSVC 115
>XP_005253029
          Length = 1029

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LRTRIAVC 8
           LRT ++VC
Sbjct: 108 LRTLLSVC 115
>XP_005249968
          Length = 673

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   LRTRIAVCR 9
           LRT  A C+
Sbjct: 582 LRTECATCK 590
>XP_005249967
          Length = 892

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   LRTRIAVCR 9
           LRT  A C+
Sbjct: 867 LRTECATCK 875
>XP_005249966
          Length = 948

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   LRTRIAVCR 9
           LRT  A C+
Sbjct: 867 LRTECATCK 875
>XP_006715864
          Length = 957

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   LRTRIAVCR 9
           LRT  A C+
Sbjct: 867 LRTECATCK 875
>XP_005249965
          Length = 958

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   LRTRIAVCR 9
           LRT  A C+
Sbjct: 867 LRTECATCK 875
>XP_005273163
          Length = 220

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RTRIAVC 8
           R R+AVC
Sbjct: 168 RLRLAVC 174
>XP_005273162
          Length = 220

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RTRIAVC 8
           R R+AVC
Sbjct: 168 RLRLAVC 174
>XP_005273160
          Length = 286

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RTRIAVC 8
           R R+AVC
Sbjct: 234 RLRLAVC 240
>XP_005270390
          Length = 589

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RTRIAVC 8
           RTR A+C
Sbjct: 557 RTRCALC 563
>XP_006711823
          Length = 592

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RTRIAVC 8
           RTR A+C
Sbjct: 560 RTRCALC 566
>NP_733843
          Length = 592

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RTRIAVC 8
           RTR A+C
Sbjct: 560 RTRCALC 566
>NP_001017434
          Length = 341

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RTRIAVC 8
           RTR A+C
Sbjct: 309 RTRCALC 315
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.352    0.147    0.475 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 474,404
Number of extensions: 682
Number of successful extensions: 58
Number of sequences better than 10000.0: 58
Number of HSP's gapped: 58
Number of HSP's successfully gapped: 58
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (17.0 bits)
S2: 28 (15.4 bits)

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