Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_733751                                                              19     869
XP_006716142                                                           19     869
XP_005250088                                                           19     869
XP_006716141                                                           19     869
XP_005250085                                                           19     869
XP_006716140                                                           19     869
XP_005250084                                                           19     869
XP_005250083                                                           19     869
XP_005250082                                                           19     869
NP_037407                                                              17    2528
NP_001243112                                                           17    2528
NP_001243111                                                           17    2528
XP_006721247                                                           17    2528
XP_006721246                                                           17    2528
XP_006721245                                                           17    2528
XP_006721244                                                           17    2528
NP_079194                                                              17    4312
NP_001138790                                                           17    4312
NP_001138788                                                           17    4312
NP_001138789                                                           17    4312
NP_001138787                                                           17    4312
XP_006723939                                                           17    4312
XP_005260616                                                           17    4312
XP_005260615                                                           17    4312
NP_001091873                                                           16    5631
NP_001091872                                                           16    5631
NP_065778                                                              16    5631
XP_005261180                                                           16    5631
XP_005261178                                                           16    5631
XP_005251808                                                           16    5631
NP_619639                                                              16    7355
NP_733842                                                              16    7355
NP_002470                                                              16    7355
NP_085143                                                              16    7355
NP_006763                                                              16    7355
NP_689413                                                              16    7355
NP_055241                                                              16    7355
NP_004411                                                              16    7355
XP_005253545                                                           16    7355
XP_006719218                                                           16    7355
NP_001258931                                                           15    9605
NP_212132                                                              15    9605
NP_001258929                                                           15    9605
NP_001258930                                                           15    9605
NP_001258928                                                           15    9605
NP_006648                                                              15    9605
NP_996848                                                              15    9605
XP_006724025                                                           15    9605
XP_006724024                                                           15    9605
XP_006724023                                                           15    9605
XP_005271350                                                           15    9605
XP_005271349                                                           15    9605
NP_689764                                                              15    9605
>NP_733751
          Length = 4911

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LRRSVSVDI 9
            LRRSVSVD+
Sbjct: 2514 LRRSVSVDM 2522
>XP_006716142
          Length = 4927

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LRRSVSVDI 9
            LRRSVSVD+
Sbjct: 2531 LRRSVSVDM 2539
>XP_005250088
          Length = 4928

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LRRSVSVDI 9
            LRRSVSVD+
Sbjct: 2531 LRRSVSVDM 2539
>XP_006716141
          Length = 4959

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LRRSVSVDI 9
            LRRSVSVD+
Sbjct: 2531 LRRSVSVDM 2539
>XP_005250085
          Length = 4979

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LRRSVSVDI 9
            LRRSVSVD+
Sbjct: 2531 LRRSVSVDM 2539
>XP_006716140
          Length = 4982

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LRRSVSVDI 9
            LRRSVSVD+
Sbjct: 2531 LRRSVSVDM 2539
>XP_005250084
          Length = 4982

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LRRSVSVDI 9
            LRRSVSVD+
Sbjct: 2531 LRRSVSVDM 2539
>XP_005250083
          Length = 4982

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LRRSVSVDI 9
            LRRSVSVD+
Sbjct: 2530 LRRSVSVDM 2538
>XP_005250082
          Length = 4983

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LRRSVSVDI 9
            LRRSVSVD+
Sbjct: 2531 LRRSVSVDM 2539
>NP_037407
          Length = 2663

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LRRSVSVDI 9
            L RSVSVDI
Sbjct: 1787 LYRSVSVDI 1795
>NP_001243112
          Length = 2663

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LRRSVSVDI 9
            L RSVSVDI
Sbjct: 1787 LYRSVSVDI 1795
>NP_001243111
          Length = 2663

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LRRSVSVDI 9
            L RSVSVDI
Sbjct: 1787 LYRSVSVDI 1795
>XP_006721247
          Length = 2564

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LRRSVSVDI 9
            L RSVSVDI
Sbjct: 1688 LYRSVSVDI 1696
>XP_006721246
          Length = 2620

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LRRSVSVDI 9
            L RSVSVDI
Sbjct: 1744 LYRSVSVDI 1752
>XP_006721245
          Length = 2629

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LRRSVSVDI 9
            L RSVSVDI
Sbjct: 1753 LYRSVSVDI 1761
>XP_006721244
          Length = 2629

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LRRSVSVDI 9
            L RSVSVDI
Sbjct: 1753 LYRSVSVDI 1761
>NP_079194
          Length = 356

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LRRSVSVDI 9
           L RS+SVD+
Sbjct: 120 LSRSISVDL 128
>NP_001138790
          Length = 340

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LRRSVSVDI 9
           L RS+SVD+
Sbjct: 104 LSRSISVDL 112
>NP_001138788
          Length = 356

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LRRSVSVDI 9
           L RS+SVD+
Sbjct: 120 LSRSISVDL 128
>NP_001138789
          Length = 249

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LRRSVSVDI 9
          L RS+SVD+
Sbjct: 13 LSRSISVDL 21
>NP_001138787
          Length = 356

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LRRSVSVDI 9
           L RS+SVD+
Sbjct: 120 LSRSISVDL 128
>XP_006723939
          Length = 249

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LRRSVSVDI 9
          L RS+SVD+
Sbjct: 13 LSRSISVDL 21
>XP_005260616
          Length = 334

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LRRSVSVDI 9
           L RS+SVD+
Sbjct: 98  LSRSISVDL 106
>XP_005260615
          Length = 441

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LRRSVSVDI 9
           L RS+SVD+
Sbjct: 205 LSRSISVDL 213
>NP_001091873
          Length = 865

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LRRSVSVD 8
           LRRS+S+D
Sbjct: 340 LRRSLSMD 347
>NP_001091872
          Length = 1066

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LRRSVSVD 8
           LRRS+S+D
Sbjct: 340 LRRSLSMD 347
>NP_065778
          Length = 1066

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LRRSVSVD 8
           LRRS+S+D
Sbjct: 340 LRRSLSMD 347
>XP_005261180
          Length = 865

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LRRSVSVD 8
           LRRS+S+D
Sbjct: 340 LRRSLSMD 347
>XP_005261178
          Length = 1066

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LRRSVSVD 8
           LRRS+S+D
Sbjct: 340 LRRSLSMD 347
>XP_005251808
          Length = 3075

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    RRSVSVDI 9
            +RSVS+D+
Sbjct: 3062 KRSVSIDL 3069
>NP_619639
          Length = 4074

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    RRSVSVDI 9
            RRSV VD+
Sbjct: 1418 RRSVRVDL 1425
>NP_733842
          Length = 3396

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    RRSVSVDI 9
            RRSV VD+
Sbjct: 1418 RRSVRVDL 1425
>NP_002470
          Length = 224

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  RRSVSVD 8
          R+SVSVD
Sbjct: 75 RKSVSVD 81
>NP_085143
          Length = 665

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LRRSVSVDI 9
           L+RS S+DI
Sbjct: 396 LKRSFSLDI 404
>NP_006763
          Length = 1343

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LRRSVSVDI 9
          LRR+VSV +
Sbjct: 82 LRRTVSVPV 90
>NP_689413
          Length = 404

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  RSVSVDI 9
          RSVSVD+
Sbjct: 19 RSVSVDL 25
>NP_055241
          Length = 404

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  RSVSVDI 9
          RSVSVD+
Sbjct: 19 RSVSVDL 25
>NP_004411
          Length = 625

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LRRSVSVDI 9
           L+RS S+DI
Sbjct: 390 LKRSFSLDI 398
>XP_005253545
          Length = 517

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LRRSVSVDI 9
           L+RS S+DI
Sbjct: 248 LKRSFSLDI 256
>XP_006719218
          Length = 665

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LRRSVSVDI 9
           L+RS S+DI
Sbjct: 396 LKRSFSLDI 404
>NP_001258931
          Length = 632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RRSVSVD 8
           RRS+S+D
Sbjct: 178 RRSMSID 184
>NP_212132
          Length = 2109

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RRSVSVD 8
           RRS+S+D
Sbjct: 178 RRSMSID 184
>NP_001258929
          Length = 2100

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RRSVSVD 8
           RRS+S+D
Sbjct: 178 RRSMSID 184
>NP_001258930
          Length = 2098

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RRSVSVD 8
           RRS+S+D
Sbjct: 178 RRSMSID 184
>NP_001258928
          Length = 2129

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RRSVSVD 8
           RRS+S+D
Sbjct: 178 RRSMSID 184
>NP_006648
          Length = 541

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LRRSVSVDI 9
           LRR+VSV +
Sbjct: 444 LRRAVSVPL 452
>NP_996848
          Length = 541

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LRRSVSVDI 9
           LRR+VSV +
Sbjct: 444 LRRAVSVPL 452
>XP_006724025
          Length = 635

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LRRSVSVDI 9
           LRR+VSV +
Sbjct: 487 LRRAVSVPL 495
>XP_006724024
          Length = 584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LRRSVSVDI 9
           LRR+VSV +
Sbjct: 487 LRRAVSVPL 495
>XP_006724023
          Length = 592

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LRRSVSVDI 9
           LRR+VSV +
Sbjct: 444 LRRAVSVPL 452
>XP_005271350
          Length = 1854

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RRSVSVD 8
           RRS+S+D
Sbjct: 178 RRSMSID 184
>XP_005271349
          Length = 2131

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RRSVSVD 8
           RRS+S+D
Sbjct: 178 RRSMSID 184
>NP_689764
          Length = 339

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RRSVSVD 8
           RRS SVD
Sbjct: 273 RRSASVD 279
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.329    0.141    0.339 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 365,786
Number of extensions: 703
Number of successful extensions: 53
Number of sequences better than 10000.0: 53
Number of HSP's gapped: 53
Number of HSP's successfully gapped: 53
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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