Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001275701                                                           20     509
NP_004561                                                              20     509
NP_001275703                                                           20     509
XP_005253450                                                           20     509
XP_006719151                                                           20     509
XP_005251896                                                           18    1135
XP_005251895                                                           18    1135
XP_005251894                                                           18    1135
NP_055925                                                              18    1135
NP_001487                                                              18    1935
NP_689957                                                              16    5631
NP_001005161                                                           16    5631
XP_006721879                                                           16    5631
XP_006721878                                                           16    5631
XP_006721877                                                           16    5631
XP_006721876                                                           16    5631
XP_005257269                                                           16    5631
XP_006721875                                                           16    5631
XP_005257264                                                           16    5631
NP_056469                                                              16    5631
NP_001136067                                                           16    7355
NP_001017962                                                           16    7355
NP_005782                                                              16    7355
NP_640337                                                              16    7355
NP_001121187                                                           16    7355
NP_001258867                                                           16    7355
NP_055795                                                              16    7355
NP_001401                                                              16    7355
XP_005250166                                                           16    7355
XP_006715402                                                           16    7355
XP_005247964                                                           16    7355
XP_006713889                                                           16    7355
XP_006713888                                                           16    7355
NP_057576                                                              15    9605
NP_001171272                                                           15    9605
NP_055054                                                              15    9605
NP_001005191                                                           15    9605
NP_653191                                                              15    9605
NP_061130                                                              15    9605
XP_006718995                                                           15    9605
XP_005274425                                                           15    9605
XP_006718994                                                           15    9605
XP_006718993                                                           15    9605
XP_005274424                                                           15    9605
XP_005274423                                                           15    9605
NP_203753                                                              15    9605
NP_443187                                                              15    9605
>NP_001275701
          Length = 1486

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LRRLTFSQP 9
           LRR TFSQP
Sbjct: 754 LRRWTFSQP 762
>NP_004561
          Length = 1445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LRRLTFSQP 9
           LRR TFSQP
Sbjct: 713 LRRWTFSQP 721
>NP_001275703
          Length = 1264

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LRRLTFSQP 9
           LRR TFSQP
Sbjct: 532 LRRWTFSQP 540
>XP_005253450
          Length = 1486

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LRRLTFSQP 9
           LRR TFSQP
Sbjct: 754 LRRWTFSQP 762
>XP_006719151
          Length = 1486

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LRRLTFSQP 9
           LRR TFSQP
Sbjct: 754 LRRWTFSQP 762
>XP_005251896
          Length = 1063

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    RRLTFSQP 9
            RR+TF+QP
Sbjct: 1055 RRITFTQP 1062
>XP_005251895
          Length = 1077

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    RRLTFSQP 9
            RR+TF+QP
Sbjct: 1069 RRITFTQP 1076
>XP_005251894
          Length = 1086

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    RRLTFSQP 9
            RR+TF+QP
Sbjct: 1078 RRITFTQP 1085
>NP_055925
          Length = 1101

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    RRLTFSQP 9
            RR+TF+QP
Sbjct: 1093 RRITFTQP 1100
>NP_001487
          Length = 400

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LRRLTFSQP 9
           LRRL FS P
Sbjct: 251 LRRLCFSDP 259
>NP_689957
          Length = 2213

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RRLTFSQP 9
           RRLT S P
Sbjct: 345 RRLTISNP 352
>NP_001005161
          Length = 314

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LRRLTFSQ 8
           L+RLTF Q
Sbjct: 165 LKRLTFCQ 172
>XP_006721879
          Length = 112

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LRRLTFSQP 9
          L+RLT S+P
Sbjct: 36 LQRLTASEP 44
>XP_006721878
          Length = 134

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LRRLTFSQP 9
          L+RLT S+P
Sbjct: 36 LQRLTASEP 44
>XP_006721877
          Length = 135

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LRRLTFSQP 9
          L+RLT S+P
Sbjct: 37 LQRLTASEP 45
>XP_006721876
          Length = 176

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LRRLTFSQP 9
          L+RLT S+P
Sbjct: 6  LQRLTASEP 14
>XP_005257269
          Length = 176

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LRRLTFSQP 9
          L+RLT S+P
Sbjct: 6  LQRLTASEP 14
>XP_006721875
          Length = 206

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LRRLTFSQP 9
          L+RLT S+P
Sbjct: 36 LQRLTASEP 44
>XP_005257264
          Length = 206

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LRRLTFSQP 9
          L+RLT S+P
Sbjct: 36 LQRLTASEP 44
>NP_056469
          Length = 207

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LRRLTFSQP 9
          L+RLT S+P
Sbjct: 37 LQRLTASEP 45
>NP_001136067
          Length = 534

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LRRLTFSQP 9
           LRR T S P
Sbjct: 360 LRRATISNP 368
>NP_001017962
          Length = 534

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LRRLTFSQP 9
           LRR T S P
Sbjct: 360 LRRATISNP 368
>NP_005782
          Length = 681

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LRRLTFSQP 9
           L+R+TF+ P
Sbjct: 328 LKRVTFALP 336
>NP_640337
          Length = 1115

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LRRLTFSQ 8
           ++RLT+SQ
Sbjct: 977 IQRLTYSQ 984
>NP_001121187
          Length = 1151

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    LRRLTFSQ 8
            ++RLT+SQ
Sbjct: 1013 IQRLTYSQ 1020
>NP_001258867
          Length = 2845

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LRRLTFSQP 9
           L  LTF QP
Sbjct: 683 LHLLTFQQP 691
>NP_055795
          Length = 1186

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    LRRLTFSQ 8
            ++RLT+SQ
Sbjct: 1048 IQRLTYSQ 1055
>NP_001401
          Length = 2778

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LRRLTFSQP 9
           L  LTF QP
Sbjct: 683 LHLLTFQQP 691
>XP_005250166
          Length = 127

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RRLTFS 7
           RRLTFS
Sbjct: 112 RRLTFS 117
>XP_006715402
          Length = 1135

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    LRRLTFSQ 8
            ++RLT+SQ
Sbjct: 997  IQRLTYSQ 1004
>XP_005247964
          Length = 1162

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    LRRLTFSQ 8
            ++RLT+SQ
Sbjct: 1024 IQRLTYSQ 1031
>XP_006713889
          Length = 1186

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    LRRLTFSQ 8
            ++RLT+SQ
Sbjct: 1048 IQRLTYSQ 1055
>XP_006713888
          Length = 1186

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    LRRLTFSQ 8
            ++RLT+SQ
Sbjct: 1048 IQRLTYSQ 1055
>NP_057576
          Length = 186

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LTFSQP 9
           LTF+QP
Sbjct: 140 LTFNQP 145
>NP_001171272
          Length = 146

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LTFSQP 9
           LTF+QP
Sbjct: 140 LTFNQP 145
>NP_055054
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  RRLTFSQP 9
          RR+T +QP
Sbjct: 66 RRMTAAQP 73
>NP_001005191
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LRRLTFS 7
           ++RLTFS
Sbjct: 163 MKRLTFS 169
>NP_653191
          Length = 191

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RRLTFSQ 8
           RRL FSQ
Sbjct: 176 RRLKFSQ 182
>NP_061130
          Length = 513

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RRLTFSQP 9
           R L+FS+P
Sbjct: 446 RSLSFSEP 453
>XP_006718995
          Length = 2382

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RRLTFSQP 9
           +RL+ SQP
Sbjct: 715 KRLSLSQP 722
>XP_005274425
          Length = 2566

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RRLTFSQP 9
           +RL+ SQP
Sbjct: 948 KRLSLSQP 955
>XP_006718994
          Length = 2567

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RRLTFSQP 9
           +RL+ SQP
Sbjct: 948 KRLSLSQP 955
>XP_006718993
          Length = 2602

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RRLTFSQP 9
           +RL+ SQP
Sbjct: 935 KRLSLSQP 942
>XP_005274424
          Length = 2614

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RRLTFSQP 9
           +RL+ SQP
Sbjct: 948 KRLSLSQP 955
>XP_005274423
          Length = 2615

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RRLTFSQP 9
           +RL+ SQP
Sbjct: 948 KRLSLSQP 955
>NP_203753
          Length = 2601

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RRLTFSQP 9
           +RL+ SQP
Sbjct: 935 KRLSLSQP 942
>NP_443187
          Length = 710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  RLTFSQP 9
          RL+FS+P
Sbjct: 44 RLSFSRP 50
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.334    0.142    0.417 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 589,497
Number of extensions: 1234
Number of successful extensions: 47
Number of sequences better than 10000.0: 47
Number of HSP's gapped: 47
Number of HSP's successfully gapped: 47
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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