Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

XP_005260825                                                           17    2528
XP_006723661                                                           17    2528
NP_001128558                                                           17    3301
NP_003240                                                              17    4312
NP_056466                                                              16    5631
NP_001273769                                                           16    5631
NP_005711                                                              16    5631
XP_006717111                                                           16    5631
XP_006717110                                                           16    5631
XP_006717109                                                           16    5631
XP_006717108                                                           16    5631
XP_005251963                                                           16    5631
XP_006715889                                                           16    5631
XP_006715888                                                           16    5631
NP_000266                                                              16    7355
NP_001191055                                                           16    7355
NP_006143                                                              16    7355
NP_001191056                                                           16    7355
NP_055872                                                              16    7355
NP_067614                                                              16    7355
NP_001191197                                                           16    7355
NP_001671                                                              16    7355
NP_542172                                                              16    7355
XP_006720943                                                           16    7355
XP_005268316                                                           16    7355
XP_006719852                                                           16    7355
XP_005266357                                                           16    7355
XP_006719851                                                           16    7355
XP_006719850                                                           16    7355
XP_006719849                                                           16    7355
XP_006719848                                                           16    7355
XP_005266356                                                           16    7355
XP_006719847                                                           16    7355
XP_006719846                                                           16    7355
XP_006719845                                                           16    7355
XP_006719844                                                           16    7355
XP_006719843                                                           16    7355
XP_006719842                                                           16    7355
XP_005253431                                                           16    7355
XP_006719140                                                           16    7355
XP_006719139                                                           16    7355
XP_005253429                                                           16    7355
XP_006719138                                                           16    7355
XP_005253428                                                           16    7355
XP_005253427                                                           16    7355
XP_006718465                                                           16    7355
NP_758857                                                              15    9605
NP_001231293                                                           15    9605
NP_001073948                                                           15    9605
NP_056380                                                              15    9605
NP_683721                                                              15    9605
NP_001171164                                                           15    9605
NP_004195                                                              15    9605
XP_005248625                                                           15    9605
XP_006714732                                                           15    9605
>XP_005260825
          Length = 1923

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    RLSRSYRC 9
            R+SR +RC
Sbjct: 1906 RISRKFRC 1913
>XP_006723661
          Length = 1970

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    RLSRSYRC 9
            R+SR +RC
Sbjct: 1953 RISRKFRC 1960
>NP_001128558
          Length = 318

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LRLSRSYRC 9
          LRL R +RC
Sbjct: 72 LRLRRRHRC 80
>NP_003240
          Length = 689

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LRLSRSYR 8
           LR+SR YR
Sbjct: 519 LRMSRHYR 526
>NP_056466
          Length = 580

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LRLSRSYRC 9
           LR+ + YRC
Sbjct: 208 LRMLQCYRC 216
>NP_001273769
          Length = 599

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LRLSRSYRC 9
           LR+ + YRC
Sbjct: 227 LRMLQCYRC 235
>NP_005711
          Length = 372

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LRLSRSYRC 9
           LR++R+ RC
Sbjct: 93  LRINRAARC 101
>XP_006717111
          Length = 369

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LRLSRSYRC 9
           LR+ + YRC
Sbjct: 208 LRMLQCYRC 216
>XP_006717110
          Length = 403

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LRLSRSYRC 9
           LR+ + YRC
Sbjct: 208 LRMLQCYRC 216
>XP_006717109
          Length = 407

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  LRLSRSYRC 9
          LR+ + YRC
Sbjct: 35 LRMLQCYRC 43
>XP_006717108
          Length = 580

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LRLSRSYRC 9
           LR+ + YRC
Sbjct: 208 LRMLQCYRC 216
>XP_005251963
          Length = 580

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LRLSRSYRC 9
           LR+ + YRC
Sbjct: 208 LRMLQCYRC 216
>XP_006715889
          Length = 372

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LRLSRSYRC 9
           LR++R+ RC
Sbjct: 93  LRINRAARC 101
>XP_006715888
          Length = 372

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LRLSRSYRC 9
           LR++R+ RC
Sbjct: 93  LRINRAARC 101
>NP_000266
          Length = 838

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LRLSRSYRC 9
           LRLS+  RC
Sbjct: 166 LRLSKLRRC 174
>NP_001191055
          Length = 499

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LRLSRSYRC 9
           LRLS  ++C
Sbjct: 159 LRLSLGFKC 167
>NP_006143
          Length = 499

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LRLSRSYRC 9
           LRLS  ++C
Sbjct: 159 LRLSLGFKC 167
>NP_001191056
          Length = 499

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LRLSRSYRC 9
           LRLS  ++C
Sbjct: 159 LRLSLGFKC 167
>NP_055872
          Length = 4678

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    LRLSRSYRC 9
            LRL R Y C
Sbjct: 1467 LRLLRVYTC 1475
>NP_067614
          Length = 64

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  LSRSYRC 9
          LSR +RC
Sbjct: 44 LSRRFRC 50
>NP_001191197
          Length = 144

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LSRSYRC 9
           LSR +RC
Sbjct: 124 LSRRFRC 130
>NP_001671
          Length = 66

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  LSRSYRC 9
          LSR +RC
Sbjct: 46 LSRRFRC 52
>NP_542172
          Length = 329

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LRLSRSY 7
           LRLSR Y
Sbjct: 228 LRLSRDY 234
>XP_006720943
          Length = 1208

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3  LSRSYRC 9
          LSR Y C
Sbjct: 36 LSREYHC 42
>XP_005268316
          Length = 814

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LRLSRSYRC 9
           LRLS+  RC
Sbjct: 166 LRLSKLRRC 174
>XP_006719852
          Length = 4752

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    LRLSRSYRC 9
            LRL R Y C
Sbjct: 1467 LRLLRVYTC 1475
>XP_005266357
          Length = 4600

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    LRLSRSYRC 9
            LRL R Y C
Sbjct: 1467 LRLLRVYTC 1475
>XP_006719851
          Length = 4689

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    LRLSRSYRC 9
            LRL R Y C
Sbjct: 1467 LRLLRVYTC 1475
>XP_006719850
          Length = 4697

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    LRLSRSYRC 9
            LRL R Y C
Sbjct: 1467 LRLLRVYTC 1475
>XP_006719849
          Length = 4703

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    LRLSRSYRC 9
            LRL R Y C
Sbjct: 1467 LRLLRVYTC 1475
>XP_006719848
          Length = 4737

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    LRLSRSYRC 9
            LRL R Y C
Sbjct: 1467 LRLLRVYTC 1475
>XP_005266356
          Length = 4755

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    LRLSRSYRC 9
            LRL R Y C
Sbjct: 1467 LRLLRVYTC 1475
>XP_006719847
          Length = 4761

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    LRLSRSYRC 9
            LRL R Y C
Sbjct: 1431 LRLLRVYTC 1439
>XP_006719846
          Length = 4763

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    LRLSRSYRC 9
            LRL R Y C
Sbjct: 1467 LRLLRVYTC 1475
>XP_006719845
          Length = 4772

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    LRLSRSYRC 9
            LRL R Y C
Sbjct: 1467 LRLLRVYTC 1475
>XP_006719844
          Length = 4789

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    LRLSRSYRC 9
            LRL R Y C
Sbjct: 1467 LRLLRVYTC 1475
>XP_006719843
          Length = 4794

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    LRLSRSYRC 9
            LRL R Y C
Sbjct: 1467 LRLLRVYTC 1475
>XP_006719842
          Length = 4797

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    LRLSRSYRC 9
            LRL R Y C
Sbjct: 1467 LRLLRVYTC 1475
>XP_005253431
          Length = 499

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LRLSRSYRC 9
           LRLS  ++C
Sbjct: 159 LRLSLGFKC 167
>XP_006719140
          Length = 446

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LRLSRSYRC 9
           LRLS  ++C
Sbjct: 106 LRLSLGFKC 114
>XP_006719139
          Length = 499

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LRLSRSYRC 9
           LRLS  ++C
Sbjct: 159 LRLSLGFKC 167
>XP_005253429
          Length = 499

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LRLSRSYRC 9
           LRLS  ++C
Sbjct: 159 LRLSLGFKC 167
>XP_006719138
          Length = 499

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LRLSRSYRC 9
           LRLS  ++C
Sbjct: 159 LRLSLGFKC 167
>XP_005253428
          Length = 499

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LRLSRSYRC 9
           LRLS  ++C
Sbjct: 159 LRLSLGFKC 167
>XP_005253427
          Length = 499

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LRLSRSYRC 9
           LRLS  ++C
Sbjct: 159 LRLSLGFKC 167
>XP_006718465
          Length = 258

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RLSRSY 7
           RLSRSY
Sbjct: 233 RLSRSY 238
>NP_758857
          Length = 519

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  LRLSRSY 7
          LRL RSY
Sbjct: 88 LRLCRSY 94
>NP_001231293
          Length = 1392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   SRSYRC 9
           SRSY C
Sbjct: 241 SRSYSC 246
>NP_001073948
          Length = 1731

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   SRSYRC 9
           SRSY C
Sbjct: 554 SRSYSC 559
>NP_056380
          Length = 1812

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    RLSRSYRC 9
            RLS +Y C
Sbjct: 1020 RLSLNYEC 1027
>NP_683721
          Length = 760

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LRLSRSYR 8
           LRL R YR
Sbjct: 501 LRLCRPYR 508
>NP_001171164
          Length = 1705

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   SRSYRC 9
           SRSY C
Sbjct: 554 SRSYSC 559
>NP_004195
          Length = 581

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LRLSRSYR 8
           LRL R YR
Sbjct: 501 LRLCRPYR 508
>XP_005248625
          Length = 1418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   SRSYRC 9
           SRSY C
Sbjct: 241 SRSYSC 246
>XP_006714732
          Length = 1633

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   SRSYRC 9
           SRSY C
Sbjct: 456 SRSYSC 461
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.341    0.142    0.462 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 495,331
Number of extensions: 695
Number of successful extensions: 55
Number of sequences better than 10000.0: 55
Number of HSP's gapped: 55
Number of HSP's successfully gapped: 55
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.6 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package