Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001120712                                                           19     665
NP_001139434                                                           18    1935
XP_005255636                                                           18    1935
NP_940880                                                              17    2528
NP_037507                                                              17    2528
NP_005306                                                              17    2528
NP_067544                                                              17    4312
NP_001172019                                                           17    4312
NP_001172020                                                           17    4312
NP_000823                                                              17    4312
NP_015566                                                              17    4312
NP_001274691                                                           17    4312
NP_001274690                                                           17    4312
NP_004204                                                              17    4312
NP_964014                                                              17    4312
XP_005255050                                                           17    4312
XP_005255048                                                           17    4312
XP_005255046                                                           17    4312
XP_005266130                                                           17    4312
XP_005266129                                                           17    4312
XP_005266128                                                           17    4312
NP_114072                                                              16    5631
NP_001136027                                                           16    5631
NP_079152                                                              16    5631
NP_003459                                                              16    5631
XP_005259331                                                           16    5631
XP_006723457                                                           16    5631
XP_006723456                                                           16    5631
XP_006723455                                                           16    5631
XP_005259330                                                           16    5631
XP_005259328                                                           16    5631
XP_005259329                                                           16    5631
XP_005259327                                                           16    5631
XP_006722922                                                           16    5631
NP_000264                                                              16    7355
NP_001454                                                              16    7355
NP_001273758                                                           16    7355
NP_660202                                                              16    7355
XP_006726824                                                           16    7355
XP_005274599                                                           16    7355
XP_005274598                                                           16    7355
XP_006722739                                                           16    7355
XP_006722738                                                           16    7355
XP_005259567                                                           16    7355
XP_006722329                                                           16    7355
XP_006710154                                                           16    7355
XP_006710096                                                           16    7355
NP_000398                                                              15    9605
NP_001025035                                                           15    9605
NP_114088                                                              15    9605
NP_061721                                                              15    9605
NP_660281                                                              15    9605
NP_115894                                                              15    9605
NP_003117                                                              15    9605
NP_002481                                                              15    9605
NP_061130                                                              15    9605
NP_001730                                                              15    9605
XP_006726620                                                           15    9605
XP_005276276                                                           15    9605
XP_006720857                                                           15    9605
XP_006720422                                                           15    9605
XP_005264828                                                           15    9605
XP_005263905                                                           15    9605
XP_006710939                                                           15    9605
XP_005271228                                                           15    9605
XP_006710938                                                           15    9605
XP_006710937                                                           15    9605
XP_005275986                                                           15    9605
>NP_001120712
          Length = 261

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  LRARAACRP 9
          LRAR  CRP
Sbjct: 74 LRARPGCRP 82
>NP_001139434
          Length = 1087

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1 LRARAACRP 9
         +RA  ACRP
Sbjct: 1 MRAGGACRP 9
>XP_005255636
          Length = 737

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  RAACRP 9
          RAACRP
Sbjct: 75 RAACRP 80
>NP_940880
          Length = 832

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  LRARAACRP 9
          LRA   CRP
Sbjct: 43 LRAHGPCRP 51
>NP_037507
          Length = 272

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LRARAACRP 9
           LRAR A RP
Sbjct: 220 LRARKAARP 228
>NP_005306
          Length = 205

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  LRARAACRP 9
          L ARAAC P
Sbjct: 34 LPARAACPP 42
>NP_067544
          Length = 901

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  ARAACRP 9
          ARAAC P
Sbjct: 18 ARAACDP 24
>NP_001172019
          Length = 943

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  ARAACRP 9
          ARAAC P
Sbjct: 18 ARAACDP 24
>NP_001172020
          Length = 906

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  ARAACRP 9
          ARAAC P
Sbjct: 18 ARAACDP 24
>NP_000823
          Length = 885

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  ARAACRP 9
          ARAAC P
Sbjct: 18 ARAACDP 24
>NP_015566
          Length = 938

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  ARAACRP 9
          ARAAC P
Sbjct: 18 ARAACDP 24
>NP_001274691
          Length = 649

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LRARAACR 8
          LRAR+ CR
Sbjct: 69 LRARSFCR 76
>NP_001274690
          Length = 483

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LRARAACR 8
          LRAR+ CR
Sbjct: 69 LRARSFCR 76
>NP_004204
          Length = 649

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LRARAACR 8
          LRAR+ CR
Sbjct: 69 LRARSFCR 76
>NP_964014
          Length = 175

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LRARAACR 8
          LRAR+ CR
Sbjct: 69 LRARSFCR 76
>XP_005255050
          Length = 623

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LRARAACR 8
          LRAR+ CR
Sbjct: 69 LRARSFCR 76
>XP_005255048
          Length = 649

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LRARAACR 8
          LRAR+ CR
Sbjct: 69 LRARSFCR 76
>XP_005255046
          Length = 649

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LRARAACR 8
          LRAR+ CR
Sbjct: 69 LRARSFCR 76
>XP_005266130
          Length = 959

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  ARAACRP 9
          ARAAC P
Sbjct: 18 ARAACDP 24
>XP_005266129
          Length = 922

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  ARAACRP 9
          ARAAC P
Sbjct: 18 ARAACDP 24
>XP_005266128
          Length = 922

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  ARAACRP 9
          ARAAC P
Sbjct: 18 ARAACDP 24
>NP_114072
          Length = 694

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   RARAACRP 9
           RA+A C P
Sbjct: 113 RAKAGCAP 120
>NP_001136027
          Length = 503

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LRARAACR 8
           LRA  ACR
Sbjct: 461 LRAHIACR 468
>NP_079152
          Length = 544

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LRARAACR 8
           LRA  ACR
Sbjct: 502 LRAHIACR 509
>NP_003459
          Length = 585

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   RARAACRP 9
           RA+A C P
Sbjct: 111 RAKAGCSP 118
>XP_005259331
          Length = 544

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LRARAACR 8
           LRA  ACR
Sbjct: 502 LRAHIACR 509
>XP_006723457
          Length = 544

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LRARAACR 8
           LRA  ACR
Sbjct: 502 LRAHIACR 509
>XP_006723456
          Length = 544

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LRARAACR 8
           LRA  ACR
Sbjct: 502 LRAHIACR 509
>XP_006723455
          Length = 544

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LRARAACR 8
           LRA  ACR
Sbjct: 502 LRAHIACR 509
>XP_005259330
          Length = 544

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LRARAACR 8
           LRA  ACR
Sbjct: 502 LRAHIACR 509
>XP_005259328
          Length = 544

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LRARAACR 8
           LRA  ACR
Sbjct: 502 LRAHIACR 509
>XP_005259329
          Length = 544

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LRARAACR 8
           LRA  ACR
Sbjct: 502 LRAHIACR 509
>XP_005259327
          Length = 628

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LRARAACR 8
           LRA  ACR
Sbjct: 586 LRAHIACR 593
>XP_006722922
          Length = 658

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   RARAACRP 9
           RAR  C+P
Sbjct: 474 RARTRCQP 481
>NP_000264
          Length = 404

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  LRARAAC 7
          LRA AAC
Sbjct: 71 LRAAAAC 77
>NP_001454
          Length = 325

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   RARAACRP 9
           RAR  C P
Sbjct: 114 RARQGCEP 121
>NP_001273758
          Length = 525

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  ARAACRP 9
          ARAA RP
Sbjct: 9  ARAAARP 15
>NP_660202
          Length = 538

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  ARAACRP 9
          ARAA RP
Sbjct: 9  ARAAARP 15
>XP_006726824
          Length = 216

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LRARAACR 8
          LRA +ACR
Sbjct: 83 LRAFSACR 90
>XP_005274599
          Length = 380

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  LRARAAC 7
          LRA AAC
Sbjct: 71 LRAAAAC 77
>XP_005274598
          Length = 386

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  LRARAAC 7
          LRA AAC
Sbjct: 71 LRAAAAC 77
>XP_006722739
          Length = 1181

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LRARAACR 8
          +RAR+ CR
Sbjct: 49 VRARSPCR 56
>XP_006722738
          Length = 1181

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LRARAACR 8
          +RAR+ CR
Sbjct: 49 VRARSPCR 56
>XP_005259567
          Length = 1217

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LRARAACR 8
          +RAR+ CR
Sbjct: 85 VRARSPCR 92
>XP_006722329
          Length = 216

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LRARAACR 8
          LRA +ACR
Sbjct: 83 LRAFSACR 90
>XP_006710154
          Length = 426

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LRARAACR 8
          LRA AAC+
Sbjct: 32 LRAPAACQ 39
>XP_006710096
          Length = 216

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LRARAACR 8
          LRA +ACR
Sbjct: 83 LRAFSACR 90
>NP_000398
          Length = 206

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   RAACRP 9
           RAAC P
Sbjct: 138 RAACAP 143
>NP_001025035
          Length = 1200

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   RARAACRP 9
           R+R AC P
Sbjct: 575 RSRIACLP 582
>NP_114088
          Length = 818

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  RARAAC 7
          RA+AAC
Sbjct: 88 RAKAAC 93
>NP_061721
          Length = 963

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  RARAAC 7
          RA+AAC
Sbjct: 88 RAKAAC 93
>NP_660281
          Length = 1043

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LRARAACR 8
           +RARAA R
Sbjct: 569 MRARAAVR 576
>NP_115894
          Length = 601

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   LRARAACR 8
           LRAR  C+
Sbjct: 377 LRARIGCK 384
>NP_003117
          Length = 2419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LRARAACR 8
           LRARAA R
Sbjct: 884 LRARAARR 891
>NP_002481
          Length = 154

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  ARAACR 8
          ARAAC+
Sbjct: 10 ARAACK 15
>NP_061130
          Length = 513

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ARAACRP 9
           +RAAC P
Sbjct: 196 SRAACDP 202
>NP_001730
          Length = 305

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ARAACRP 9
           ARAA RP
Sbjct: 208 ARAAMRP 214
>XP_006726620
          Length = 106

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  RARAACRP 9
          +ARA C P
Sbjct: 92 QARALCSP 99
>XP_005276276
          Length = 302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RARAACRP 9
           RARA  RP
Sbjct: 176 RARAPLRP 183
>XP_006720857
          Length = 106

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  RARAACRP 9
          +ARA C P
Sbjct: 92 QARALCSP 99
>XP_006720422
          Length = 106

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  RARAACRP 9
          +ARA C P
Sbjct: 92 QARALCSP 99
>XP_005264828
          Length = 524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   LRARAACR 8
           LRAR  C+
Sbjct: 300 LRARIGCK 307
>XP_005263905
          Length = 302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RARAACRP 9
           RARA  RP
Sbjct: 176 RARAPLRP 183
>XP_006710939
          Length = 989

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LRARAACR 8
           +RARAA R
Sbjct: 515 MRARAAVR 522
>XP_005271228
          Length = 1042

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LRARAACR 8
           +RARAA R
Sbjct: 568 MRARAAVR 575
>XP_006710938
          Length = 1043

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LRARAACR 8
           +RARAA R
Sbjct: 569 MRARAAVR 576
>XP_006710937
          Length = 1043

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LRARAACR 8
           +RARAA R
Sbjct: 569 MRARAAVR 576
>XP_005275986
          Length = 302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RARAACRP 9
           RARA  RP
Sbjct: 176 RARAPLRP 183
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.340    0.137    0.472 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 527,963
Number of extensions: 686
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.6 bits)
S2: 28 (15.4 bits)

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