Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_733751                                                              20     390
XP_006716142                                                           20     390
XP_005250088                                                           20     390
XP_006716141                                                           20     390
XP_005250085                                                           20     390
XP_006716140                                                           20     390
XP_005250084                                                           20     390
XP_005250083                                                           20     390
XP_005250082                                                           20     390
NP_742093                                                              18    1935
NP_001269238                                                           18    1935
NP_001269239                                                           18    1935
NP_473361                                                              18    1935
NP_001004298                                                           17    2528
NP_542389                                                              17    2528
XP_005269549                                                           17    2528
XP_005269548                                                           17    2528
NP_001610                                                              17    3301
NP_001193731                                                           17    4312
NP_004872                                                              17    4312
NP_671713                                                              17    4312
NP_005151                                                              17    4312
XP_006724221                                                           17    4312
XP_006712213                                                           17    4312
NP_003981                                                              16    5631
NP_003980                                                              16    5631
NP_000269                                                              16    5631
NP_003978                                                              16    5631
NP_003979                                                              16    5631
NP_065777                                                              16    7355
NP_689648                                                              16    7355
XP_006714724                                                           16    7355
XP_005248616                                                           16    7355
NP_775321                                                              15    9605
NP_001106649                                                           15    9605
NP_619728                                                              15    9605
NP_006590                                                              15    9605
NP_619727                                                              15    9605
NP_775322                                                              15    9605
NP_008860                                                              15    9605
NP_005473                                                              15    9605
XP_006725560                                                           15    9605
XP_005255834                                                           15    9605
XP_006721188                                                           15    9605
XP_006715231                                                           15    9605
>NP_733751
          Length = 4911

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    RADVFQRQ 9
            RADVFQRQ
Sbjct: 2013 RADVFQRQ 2020
>XP_006716142
          Length = 4927

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    RADVFQRQ 9
            RADVFQRQ
Sbjct: 2030 RADVFQRQ 2037
>XP_005250088
          Length = 4928

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    RADVFQRQ 9
            RADVFQRQ
Sbjct: 2030 RADVFQRQ 2037
>XP_006716141
          Length = 4959

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    RADVFQRQ 9
            RADVFQRQ
Sbjct: 2030 RADVFQRQ 2037
>XP_005250085
          Length = 4979

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    RADVFQRQ 9
            RADVFQRQ
Sbjct: 2030 RADVFQRQ 2037
>XP_006716140
          Length = 4982

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    RADVFQRQ 9
            RADVFQRQ
Sbjct: 2030 RADVFQRQ 2037
>XP_005250084
          Length = 4982

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    RADVFQRQ 9
            RADVFQRQ
Sbjct: 2030 RADVFQRQ 2037
>XP_005250083
          Length = 4982

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    RADVFQRQ 9
            RADVFQRQ
Sbjct: 2029 RADVFQRQ 2036
>XP_005250082
          Length = 4983

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    RADVFQRQ 9
            RADVFQRQ
Sbjct: 2030 RADVFQRQ 2037
>NP_742093
          Length = 530

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LRADVFQRQ 9
           L+AD+F+RQ
Sbjct: 362 LKADMFKRQ 370
>NP_001269238
          Length = 528

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LRADVFQRQ 9
           L+AD+F+RQ
Sbjct: 362 LKADMFKRQ 370
>NP_001269239
          Length = 534

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LRADVFQRQ 9
           L+AD+F+RQ
Sbjct: 368 LKADMFKRQ 376
>NP_473361
          Length = 528

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LRADVFQRQ 9
           L+AD+F+RQ
Sbjct: 362 LKADMFKRQ 370
>NP_001004298
          Length = 699

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LRADVFQRQ 9
           LRA+VF++Q
Sbjct: 680 LRAEVFKKQ 688
>NP_542389
          Length = 319

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LRADVFQR 8
           LRAD+F R
Sbjct: 187 LRADIFSR 194
>XP_005269549
          Length = 292

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LRADVFQRQ 9
           LRA+VF++Q
Sbjct: 273 LRAEVFKKQ 281
>XP_005269548
          Length = 738

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LRADVFQRQ 9
           LRA+VF++Q
Sbjct: 719 LRAEVFKKQ 727
>NP_001610
          Length = 689

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LRADVFQR 8
           LR DVFQ+
Sbjct: 157 LRGDVFQK 164
>NP_001193731
          Length = 248

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  RADVFQRQ 9
          RAD+ QRQ
Sbjct: 41 RADLMQRQ 48
>NP_004872
          Length = 332

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  RADVFQRQ 9
          RAD+ QRQ
Sbjct: 41 RADLMQRQ 48
>NP_671713
          Length = 332

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  RADVFQRQ 9
          RAD+ QRQ
Sbjct: 41 RADLMQRQ 48
>NP_005151
          Length = 688

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LRADVFQR 8
           LR D+FQ+
Sbjct: 157 LRGDIFQK 164
>XP_006724221
          Length = 575

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LRADVFQR 8
          LR D+FQ+
Sbjct: 44 LRGDIFQK 51
>XP_006712213
          Length = 248

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  RADVFQRQ 9
          RAD+ QRQ
Sbjct: 41 RADLMQRQ 48
>NP_003981
          Length = 431

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LRADVFQRQ 9
           LRAD F +Q
Sbjct: 251 LRADTFTQQ 259
>NP_003980
          Length = 408

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LRADVFQRQ 9
           LRAD F +Q
Sbjct: 228 LRADTFTQQ 236
>NP_000269
          Length = 393

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LRADVFQRQ 9
           LRAD F +Q
Sbjct: 228 LRADTFTQQ 236
>NP_003978
          Length = 416

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LRADVFQRQ 9
           LRAD F +Q
Sbjct: 251 LRADTFTQQ 259
>NP_003979
          Length = 396

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LRADVFQRQ 9
           LRAD F +Q
Sbjct: 228 LRADTFTQQ 236
>NP_065777
          Length = 704

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   LRADVFQR 8
           +R D+F+R
Sbjct: 138 MRGDIFER 145
>NP_689648
          Length = 426

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  ADVFQRQ 9
          ADV QRQ
Sbjct: 56 ADVIQRQ 62
>XP_006714724
          Length = 681

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   LRADVFQR 8
           +R D+F+R
Sbjct: 115 MRGDIFER 122
>XP_005248616
          Length = 686

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   LRADVFQR 8
           +R D+F+R
Sbjct: 138 MRGDIFER 145
>NP_775321
          Length = 1455

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LRADVFQR 8
           L AD+FQ+
Sbjct: 750 LSADIFQQ 757
>NP_001106649
          Length = 1548

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LRADVFQR 8
           L AD+FQ+
Sbjct: 843 LSADIFQQ 850
>NP_619728
          Length = 1455

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LRADVFQR 8
           L AD+FQ+
Sbjct: 750 LSADIFQQ 757
>NP_006590
          Length = 1531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LRADVFQR 8
           L AD+FQ+
Sbjct: 826 LSADIFQQ 833
>NP_619727
          Length = 1549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LRADVFQR 8
           L AD+FQ+
Sbjct: 844 LSADIFQQ 851
>NP_775322
          Length = 1455

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LRADVFQR 8
           L AD+FQ+
Sbjct: 750 LSADIFQQ 757
>NP_008860
          Length = 1246

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   DVFQRQ 9
           DVFQ+Q
Sbjct: 312 DVFQKQ 317
>NP_005473
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RADVFQR 8
           R D+FQR
Sbjct: 287 RTDLFQR 293
>XP_006725560
          Length = 1031

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   DVFQRQ 9
           DVFQ+Q
Sbjct: 312 DVFQKQ 317
>XP_005255834
          Length = 1264

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LRADVFQR 8
           L AD+FQ+
Sbjct: 559 LSADIFQQ 566
>XP_006721188
          Length = 1484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LRADVFQR 8
           L AD+FQ+
Sbjct: 779 LSADIFQQ 786
>XP_006715231
          Length = 1031

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   DVFQRQ 9
           DVFQ+Q
Sbjct: 312 DVFQKQ 317
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.341    0.144    0.396 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 414,719
Number of extensions: 704
Number of successful extensions: 45
Number of sequences better than 10000.0: 45
Number of HSP's gapped: 45
Number of HSP's successfully gapped: 45
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.6 bits)
S2: 28 (15.4 bits)

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