Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001243398                                                           20     299
NP_036462                                                              20     299
NP_001243397                                                           20     299
XP_005269721                                                           20     299
NP_001120669                                                           16    7355
NP_001412                                                              16    7355
NP_001275705                                                           16    7355
NP_005424                                                              16    7355
NP_004415                                                              16    7355
XP_005262446                                                           16    7355
XP_006720920                                                           16    7355
XP_005255212                                                           16    7355
NP_001026                                                              15    9605
NP_000173                                                              15    9605
NP_064504                                                              15    9605
NP_443111                                                              15    9605
NP_078901                                                              15    9605
NP_954660                                                              15    9605
NP_001164274                                                           15    9605
XP_006719279                                                           15    9605
XP_006719278                                                           15    9605
XP_005250558                                                           15    9605
XP_006711873                                                           15    9605
XP_006711871                                                           15    9605
XP_006711870                                                           15    9605
XP_006711869                                                           15    9605
XP_006711868                                                           15    9605
XP_006711867                                                           15    9605
XP_006711866                                                           15    9605
XP_006711865                                                           15    9605
NP_001164275                                                           15    9605
NP_001164279                                                           15    9605

>NP_001243398
          Length = 1781

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LQTQVASKG 9
            LQTQ+ASKG
Sbjct: 1621 LQTQIASKG 1629



>NP_036462
          Length = 2073

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LQTQVASKG 9
            LQTQ+ASKG
Sbjct: 1913 LQTQIASKG 1921



>NP_001243397
          Length = 1890

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LQTQVASKG 9
            LQTQ+ASKG
Sbjct: 1730 LQTQIASKG 1738



>XP_005269721
          Length = 2073

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LQTQVASKG 9
            LQTQ+ASKG
Sbjct: 1913 LQTQIASKG 1921



>NP_001120669
          Length = 663

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LQTQVASKG 9
           L TQV S+G
Sbjct: 579 LPTQVVSRG 587



>NP_001412
          Length = 663

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LQTQVASKG 9
           L TQV S+G
Sbjct: 579 LPTQVVSRG 587



>NP_001275705
          Length = 654

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LQTQVASK 8
           L+TQVAS+
Sbjct: 420 LETQVASE 427



>NP_005424
          Length = 543

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LQTQVASKG 9
           LQT++ +KG
Sbjct: 461 LQTELVTKG 469



>NP_004415
          Length = 784

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LQTQVASK 8
           L+TQVAS+
Sbjct: 420 LETQVASE 427



>XP_005262446
          Length = 663

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LQTQVASKG 9
           L TQV S+G
Sbjct: 579 LPTQVVSRG 587



>XP_006720920
          Length = 785

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LQTQVASK 8
           L+TQVAS+
Sbjct: 421 LETQVASE 428



>XP_005255212
          Length = 837

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LQTQVASK 8
           L+TQVAS+
Sbjct: 473 LETQVASE 480



>NP_001026
          Length = 4967

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LQTQVASKG 9
            LQT  ASKG
Sbjct: 3741 LQTISASKG 3749



>NP_000173
          Length = 763

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LQTQVASKG 9
           L TQ+ SKG
Sbjct: 618 LLTQMVSKG 626



>NP_064504
          Length = 902

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LQTQVASK 8
           +QT +ASK
Sbjct: 667 IQTNIASK 674



>NP_443111
          Length = 724

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  QVASKG 9
          QVASKG
Sbjct: 7  QVASKG 12



>NP_078901
          Length = 699

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LQTQVASK 8
           +QT +ASK
Sbjct: 667 IQTNIASK 674



>NP_954660
          Length = 653

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  QVASKG 9
          QVASKG
Sbjct: 7  QVASKG 12



>NP_001164274
          Length = 582

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  QVASKG 9
          QVASKG
Sbjct: 7  QVASKG 12



>XP_006719279
          Length = 402

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  QVASKG 9
          QVASKG
Sbjct: 7  QVASKG 12



>XP_006719278
          Length = 670

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  QVASKG 9
          QVASKG
Sbjct: 7  QVASKG 12



>XP_005250558
          Length = 1024

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LQTQVASK 8
           +QT +ASK
Sbjct: 789 IQTNIASK 796



>XP_006711873
          Length = 4954

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LQTQVASKG 9
            LQT  ASKG
Sbjct: 3728 LQTISASKG 3736



>XP_006711871
          Length = 4906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LQTQVASKG 9
            LQT  ASKG
Sbjct: 3680 LQTISASKG 3688



>XP_006711870
          Length = 4965

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LQTQVASKG 9
            LQT  ASKG
Sbjct: 3739 LQTISASKG 3747



>XP_006711869
          Length = 4973

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LQTQVASKG 9
            LQT  ASKG
Sbjct: 3747 LQTISASKG 3755



>XP_006711868
          Length = 4975

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LQTQVASKG 9
            LQT  ASKG
Sbjct: 3749 LQTISASKG 3757



>XP_006711867
          Length = 4977

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LQTQVASKG 9
            LQT  ASKG
Sbjct: 3751 LQTISASKG 3759



>XP_006711866
          Length = 4984

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LQTQVASKG 9
            LQT  ASKG
Sbjct: 3758 LQTISASKG 3766



>XP_006711865
          Length = 4985

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LQTQVASKG 9
            LQT  ASKG
Sbjct: 3759 LQTISASKG 3767



>NP_001164275
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  QVASKG 9
          QVASKG
Sbjct: 7  QVASKG 12



>NP_001164279
          Length = 653

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  QVASKG 9
          QVASKG
Sbjct: 7  QVASKG 12



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.301    0.114    0.271 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 308,124
Number of extensions: 363
Number of successful extensions: 32
Number of sequences better than 10000.0: 32
Number of HSP's gapped: 32
Number of HSP's successfully gapped: 32
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)