Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              18    1482
NP_001075109                                                           18    1482
NP_001171886                                                           17    2528
NP_115513                                                              17    2528
NP_001171887                                                           17    2528
XP_006713407                                                           17    2528
XP_006713406                                                           17    2528
XP_006713405                                                           17    2528
XP_006713404                                                           17    2528
NP_003679                                                              17    3301
NP_001119526                                                           17    3301
NP_001119527                                                           17    3301
XP_006724629                                                           17    3301
XP_006724628                                                           17    3301
XP_005272743                                                           17    3301
NP_001121797                                                           16    5631
NP_036577                                                              16    5631
NP_079032                                                              16    5631
NP_001185950                                                           16    5631
XP_006721915                                                           16    5631
XP_005270210                                                           16    5631
XP_006718033                                                           16    5631
NP_055418                                                              16    5631
NP_001129111                                                           16    7355
NP_001288                                                              16    7355
NP_004466                                                              16    7355
NP_001273059                                                           16    7355
NP_055898                                                              16    7355
NP_057591                                                              16    7355
NP_671725                                                              16    7355
NP_757379                                                              16    7355
NP_001240841                                                           16    7355
NP_055988                                                              16    7355
NP_055833                                                              16    7355
NP_001186871                                                           16    7355
NP_699197                                                              16    7355
XP_005257515                                                           16    7355
XP_005257513                                                           16    7355
XP_005258010                                                           16    7355
XP_005258009                                                           16    7355
XP_005258007                                                           16    7355
XP_006721197                                                           16    7355
XP_006715463                                                           16    7355
XP_006715462                                                           16    7355
XP_006715461                                                           16    7355
XP_006715460                                                           16    7355
XP_006715459                                                           16    7355
XP_006715458                                                           16    7355
XP_006715457                                                           16    7355
XP_006715456                                                           16    7355
XP_005262708                                                           16    7355
XP_005262706                                                           16    7355
XP_006714063                                                           16    7355
XP_005262705                                                           16    7355
XP_006714062                                                           16    7355
XP_005262704                                                           16    7355
XP_005262703                                                           16    7355
XP_006710418                                                           16    7355
NP_000287                                                              15    9605
NP_001009944                                                           15    9605
XP_006720958                                                           15    9605
XP_006720957                                                           15    9605
XP_005255427                                                           15    9605
XP_006720956                                                           15    9605
XP_006720955                                                           15    9605
XP_006720954                                                           15    9605
XP_006720953                                                           15    9605
XP_006720952                                                           15    9605
>NP_008835
          Length = 4128

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LQSVHALTE 9
            LQSV ALTE
Sbjct: 3129 LQSVQALTE 3137
>NP_001075109
          Length = 4097

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LQSVHALTE 9
            LQSV ALTE
Sbjct: 3129 LQSVQALTE 3137
>NP_001171886
          Length = 782

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  QSVHALTE 9
          QS+H LTE
Sbjct: 18 QSIHLLTE 25
>NP_115513
          Length = 904

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QSVHALTE 9
           QS+H LTE
Sbjct: 140 QSIHLLTE 147
>NP_001171887
          Length = 782

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  QSVHALTE 9
          QS+H LTE
Sbjct: 18 QSIHLLTE 25
>XP_006713407
          Length = 648

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QSVHALTE 9
           QS+H LTE
Sbjct: 140 QSIHLLTE 147
>XP_006713406
          Length = 669

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QSVHALTE 9
           QS+H LTE
Sbjct: 140 QSIHLLTE 147
>XP_006713405
          Length = 947

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QSVHALTE 9
           QS+H LTE
Sbjct: 140 QSIHLLTE 147
>XP_006713404
          Length = 947

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QSVHALTE 9
           QS+H LTE
Sbjct: 140 QSIHLLTE 147
>NP_003679
          Length = 921

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LQSVHALTE 9
           L+ +HALT+
Sbjct: 354 LEEIHALTD 362
>NP_001119526
          Length = 898

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LQSVHALTE 9
           L+ +HALT+
Sbjct: 354 LEEIHALTD 362
>NP_001119527
          Length = 897

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LQSVHALTE 9
           L+ +HALT+
Sbjct: 348 LEEIHALTD 356
>XP_006724629
          Length = 885

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LQSVHALTE 9
           L+ +HALT+
Sbjct: 348 LEEIHALTD 356
>XP_006724628
          Length = 908

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LQSVHALTE 9
           L+ +HALT+
Sbjct: 348 LEEIHALTD 356
>XP_005272743
          Length = 920

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LQSVHALTE 9
           L+ +HALT+
Sbjct: 348 LEEIHALTD 356
>NP_001121797
          Length = 331

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LQSVHAL 7
           LQSVHA+
Sbjct: 117 LQSVHAV 123
>NP_036577
          Length = 331

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LQSVHAL 7
           LQSVHA+
Sbjct: 117 LQSVHAV 123
>NP_079032
          Length = 949

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QSVHALTE 9
           QS+H+LT+
Sbjct: 250 QSLHSLTQ 257
>NP_001185950
          Length = 331

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LQSVHAL 7
           LQSVHA+
Sbjct: 117 LQSVHAV 123
>XP_006721915
          Length = 456

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   QSVHALTE 9
           Q +H LTE
Sbjct: 110 QKIHGLTE 117
>XP_005270210
          Length = 888

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QSVHALTE 9
           QS+H+LT+
Sbjct: 189 QSLHSLTQ 196
>XP_006718033
          Length = 888

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QSVHALTE 9
           QS+H+LT+
Sbjct: 189 QSLHSLTQ 196
>NP_055418
          Length = 465

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   QSVHALTE 9
           Q +H LTE
Sbjct: 110 QKIHGLTE 117
>NP_001129111
          Length = 299

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QSVHALTE 9
           Q VH++TE
Sbjct: 116 QPVHSITE 123
>NP_001288
          Length = 1251

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QSVHALTE 9
           Q VH++TE
Sbjct: 116 QPVHSITE 123
>NP_004466
          Length = 428

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SVHALT 8
           SVHALT
Sbjct: 405 SVHALT 410
>NP_001273059
          Length = 1245

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QSVHALTE 9
           Q VH++TE
Sbjct: 116 QPVHSITE 123
>NP_055898
          Length = 1481

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    QSVHALTE 9
            QS+ ALTE
Sbjct: 1155 QSISALTE 1162
>NP_057591
          Length = 1490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    QSVHALTE 9
            QS+ ALTE
Sbjct: 1155 QSISALTE 1162
>NP_671725
          Length = 382

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  SVHALT 8
          SVHALT
Sbjct: 40 SVHALT 45
>NP_757379
          Length = 377

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  SVHALT 8
          SVHALT
Sbjct: 40 SVHALT 45
>NP_001240841
          Length = 1159

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LQSVHALTE 9
           LQS+H L E
Sbjct: 392 LQSLHKLCE 400
>NP_055988
          Length = 1168

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LQSVHALTE 9
           LQS+H L E
Sbjct: 392 LQSLHKLCE 400
>NP_055833
          Length = 2465

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    SVHALT 8
            SVHALT
Sbjct: 2034 SVHALT 2039
>NP_001186871
          Length = 2476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    SVHALT 8
            SVHALT
Sbjct: 2025 SVHALT 2030
>NP_699197
          Length = 3571

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LQSVHALT 8
            L S+HALT
Sbjct: 1445 LPSLHALT 1452
>XP_005257515
          Length = 1256

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    QSVHALTE 9
            QS+ ALTE
Sbjct: 1155 QSISALTE 1162
>XP_005257513
          Length = 1489

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    QSVHALTE 9
            QS+ ALTE
Sbjct: 1154 QSISALTE 1161
>XP_005258010
          Length = 351

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SVHALT 8
           SVHALT
Sbjct: 328 SVHALT 333
>XP_005258009
          Length = 379

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SVHALT 8
           SVHALT
Sbjct: 356 SVHALT 361
>XP_005258007
          Length = 428

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SVHALT 8
           SVHALT
Sbjct: 405 SVHALT 410
>XP_006721197
          Length = 1251

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QSVHALTE 9
           Q VH++TE
Sbjct: 116 QPVHSITE 123
>XP_006715463
          Length = 2434

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    SVHALT 8
            SVHALT
Sbjct: 2034 SVHALT 2039
>XP_006715462
          Length = 2452

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    SVHALT 8
            SVHALT
Sbjct: 2001 SVHALT 2006
>XP_006715461
          Length = 2456

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    SVHALT 8
            SVHALT
Sbjct: 2025 SVHALT 2030
>XP_006715460
          Length = 2465

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    SVHALT 8
            SVHALT
Sbjct: 2034 SVHALT 2039
>XP_006715459
          Length = 2475

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    SVHALT 8
            SVHALT
Sbjct: 2024 SVHALT 2029
>XP_006715458
          Length = 2476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    SVHALT 8
            SVHALT
Sbjct: 2025 SVHALT 2030
>XP_006715457
          Length = 2485

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    SVHALT 8
            SVHALT
Sbjct: 2034 SVHALT 2039
>XP_006715456
          Length = 2485

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    SVHALT 8
            SVHALT
Sbjct: 2034 SVHALT 2039
>XP_005262708
          Length = 1039

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LQSVHALTE 9
           LQS+H L E
Sbjct: 263 LQSLHKLCE 271
>XP_005262706
          Length = 1146

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LQSVHALTE 9
           LQS+H L E
Sbjct: 263 LQSLHKLCE 271
>XP_006714063
          Length = 1168

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LQSVHALTE 9
           LQS+H L E
Sbjct: 392 LQSLHKLCE 400
>XP_005262705
          Length = 1181

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LQSVHALTE 9
           LQS+H L E
Sbjct: 392 LQSLHKLCE 400
>XP_006714062
          Length = 1262

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LQSVHALTE 9
           LQS+H L E
Sbjct: 392 LQSLHKLCE 400
>XP_005262704
          Length = 1262

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LQSVHALTE 9
           LQS+H L E
Sbjct: 392 LQSLHKLCE 400
>XP_005262703
          Length = 1275

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LQSVHALTE 9
           LQS+H L E
Sbjct: 392 LQSLHKLCE 400
>XP_006710418
          Length = 377

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  SVHALT 8
          SVHALT
Sbjct: 40 SVHALT 45
>NP_000287
          Length = 4302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LQSVHALT 8
            L +VHALT
Sbjct: 2481 LGAVHALT 2488
>NP_001009944
          Length = 4303

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LQSVHALT 8
            L +VHALT
Sbjct: 2481 LGAVHALT 2488
>XP_006720958
          Length = 2675

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LQSVHALT 8
            L +VHALT
Sbjct: 2518 LGAVHALT 2525
>XP_006720957
          Length = 2688

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LQSVHALT 8
            L +VHALT
Sbjct: 2518 LGAVHALT 2525
>XP_005255427
          Length = 3288

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LQSVHALT 8
            L +VHALT
Sbjct: 1466 LGAVHALT 1473
>XP_006720956
          Length = 3895

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LQSVHALT 8
            L +VHALT
Sbjct: 2073 LGAVHALT 2080
>XP_006720955
          Length = 4279

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LQSVHALT 8
            L +VHALT
Sbjct: 2457 LGAVHALT 2464
>XP_006720954
          Length = 4334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LQSVHALT 8
            L +VHALT
Sbjct: 2518 LGAVHALT 2525
>XP_006720953
          Length = 4339

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LQSVHALT 8
            L +VHALT
Sbjct: 2518 LGAVHALT 2525
>XP_006720952
          Length = 4340

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LQSVHALT 8
            L +VHALT
Sbjct: 2518 LGAVHALT 2525
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.311    0.119    0.298 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 482,243
Number of extensions: 584
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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