Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              19     665
NP_671714                                                              19     665
XP_006715890                                                           19     665
XP_005250160                                                           19     665
XP_005250159                                                           19     665
NP_001265321                                                           18    1935
NP_078874                                                              17    3301
NP_001182231                                                           17    3301
NP_006513                                                              17    3301
XP_005256201                                                           17    3301
NP_001186930                                                           17    4312
NP_077719                                                              17    4312
NP_653267                                                              17    4312
XP_005270959                                                           17    4312
XP_005270958                                                           17    4312
XP_006710730                                                           17    4312
NP_079350                                                              16    5631
NP_001159605                                                           16    5631
NP_689479                                                              16    5631
NP_000500                                                              16    5631
NP_068656                                                              16    5631
NP_055892                                                              16    5631
XP_006723916                                                           16    5631
XP_005259451                                                           16    5631
XP_005259450                                                           16    5631
XP_006719124                                                           16    5631
XP_005253405                                                           16    5631
XP_006714380                                                           16    5631
XP_006714379                                                           16    5631
XP_006714378                                                           16    5631
XP_006714377                                                           16    5631
NP_777601                                                              16    5631
NP_001077430                                                           16    7355
NP_775907                                                              16    7355
NP_683515                                                              16    7355
NP_001128649                                                           16    7355
NP_001128647                                                           16    7355
NP_690869                                                              16    7355
XP_005258866                                                           16    7355
XP_006719300                                                           16    7355
XP_006719299                                                           16    7355
XP_005268701                                                           16    7355
NP_001128648                                                           16    7355
NP_000126                                                              15    9605
NP_056327                                                              15    9605
NP_005899                                                              15    9605
NP_001018122                                                           15    9605
NP_001273096                                                           15    9605
NP_055833                                                              15    9605
NP_057195                                                              15    9605
NP_001186871                                                           15    9605
NP_742013                                                              15    9605
NP_659419                                                              15    9605
NP_612152                                                              15    9605
NP_115597                                                              15    9605
NP_067076                                                              15    9605
NP_001186048                                                           15    9605
XP_005276688                                                           15    9605
XP_005260633                                                           15    9605
XP_005260632                                                           15    9605
XP_005260631                                                           15    9605
XP_005260630                                                           15    9605
XP_005256351                                                           15    9605
XP_006721230                                                           15    9605
XP_006721056                                                           15    9605
XP_006715715                                                           15    9605
XP_006715463                                                           15    9605
XP_006715462                                                           15    9605
XP_006715461                                                           15    9605
XP_006715460                                                           15    9605
XP_006715459                                                           15    9605
XP_006715458                                                           15    9605
XP_006715457                                                           15    9605
XP_006715456                                                           15    9605
XP_006713163                                                           15    9605
>NP_005742
          Length = 3907

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LQMEAQCIC 9
            LQMEAQ IC
Sbjct: 1111 LQMEAQRIC 1119
>NP_671714
          Length = 3899

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LQMEAQCIC 9
            LQMEAQ IC
Sbjct: 1111 LQMEAQRIC 1119
>XP_006715890
          Length = 3860

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LQMEAQCIC 9
            LQMEAQ IC
Sbjct: 1111 LQMEAQRIC 1119
>XP_005250160
          Length = 3939

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LQMEAQCIC 9
            LQMEAQ IC
Sbjct: 1111 LQMEAQRIC 1119
>XP_005250159
          Length = 3952

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LQMEAQCIC 9
            LQMEAQ IC
Sbjct: 1111 LQMEAQRIC 1119
>NP_001265321
          Length = 374

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QMEAQCIC 9
           Q+E +CIC
Sbjct: 250 QVEMECIC 257
>NP_078874
          Length = 265

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LQMEAQCI 8
           LQ+E QC+
Sbjct: 220 LQLEGQCL 227
>NP_001182231
          Length = 247

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LQMEAQCI 8
           LQ+E QC+
Sbjct: 202 LQLEGQCL 209
>NP_006513
          Length = 365

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   LQMEAQCIC 9
           +Q+E  C+C
Sbjct: 334 VQLEENCLC 342
>XP_005256201
          Length = 214

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LQMEAQCI 8
           LQ+E QC+
Sbjct: 169 LQLEGQCL 176
>NP_001186930
          Length = 1235

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4    EAQCIC 9
            E+QC+C
Sbjct: 1084 ESQCLC 1089
>NP_077719
          Length = 2471

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4    EAQCIC 9
            E+QC+C
Sbjct: 1084 ESQCLC 1089
>NP_653267
          Length = 4753

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    QMEAQCI 8
            Q+EAQC+
Sbjct: 1716 QIEAQCL 1722
>XP_005270959
          Length = 2432

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4    EAQCIC 9
            E+QC+C
Sbjct: 1045 ESQCLC 1050
>XP_005270958
          Length = 2432

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4    EAQCIC 9
            E+QC+C
Sbjct: 1045 ESQCLC 1050
>XP_006710730
          Length = 2432

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4    EAQCIC 9
            E+QC+C
Sbjct: 1045 ESQCLC 1050
>NP_079350
          Length = 4012

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LQMEAQCI 8
            L +EAQC+
Sbjct: 1026 LLLEAQCV 1033
>NP_001159605
          Length = 1976

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LQMEAQCI 8
            L +EAQC+
Sbjct: 1026 LLLEAQCV 1033
>NP_689479
          Length = 215

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   QMEAQCI 8
           QMEA C+
Sbjct: 122 QMEASCL 128
>NP_000500
          Length = 437

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   QMEAQC 7
           Q+EAQC
Sbjct: 156 QLEAQC 161
>NP_068656
          Length = 453

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   QMEAQC 7
           Q+EAQC
Sbjct: 156 QLEAQC 161
>NP_055892
          Length = 724

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   QMEAQCI 8
           ++EAQCI
Sbjct: 338 RLEAQCI 344
>XP_006723916
          Length = 456

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2  QMEAQCIC 9
          Q+E  C+C
Sbjct: 19 QVEPPCVC 26
>XP_005259451
          Length = 120

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  QMEAQCI 8
          QMEA C+
Sbjct: 27 QMEASCL 33
>XP_005259450
          Length = 172

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  QMEAQCI 8
          QMEA C+
Sbjct: 79 QMEASCL 85
>XP_006719124
          Length = 1047

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LQMEAQCIC 9
           L MEA  IC
Sbjct: 791 LNMEASLIC 799
>XP_005253405
          Length = 1463

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LQMEAQCIC 9
           L MEA  IC
Sbjct: 791 LNMEASLIC 799
>XP_006714380
          Length = 3897

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LQMEAQCI 8
            L +EAQC+
Sbjct: 1026 LLLEAQCV 1033
>XP_006714379
          Length = 3936

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LQMEAQCI 8
            L +EAQC+
Sbjct: 1026 LLLEAQCV 1033
>XP_006714378
          Length = 3965

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LQMEAQCI 8
           L +EAQC+
Sbjct: 979 LLLEAQCV 986
>XP_006714377
          Length = 4010

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LQMEAQCI 8
            L +EAQC+
Sbjct: 1026 LLLEAQCV 1033
>NP_777601
          Length = 1453

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LQMEAQCIC 9
           L MEA  IC
Sbjct: 781 LNMEASLIC 789
>NP_001077430
          Length = 1523

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2    QMEAQCI 8
            Q+EA+C+
Sbjct: 1465 QLEAECL 1471
>NP_775907
          Length = 1518

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2    QMEAQCI 8
            Q+EA+C+
Sbjct: 1460 QLEAECL 1466
>NP_683515
          Length = 1235

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LQMEAQCI 8
           L +E+QCI
Sbjct: 742 LNIESQCI 749
>NP_001128649
          Length = 571

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QMEAQCIC 9
           ++EAQ IC
Sbjct: 445 EIEAQLIC 452
>NP_001128647
          Length = 667

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QMEAQCIC 9
           ++EAQ IC
Sbjct: 541 EIEAQLIC 548
>NP_690869
          Length = 660

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QMEAQCIC 9
           ++EAQ IC
Sbjct: 534 EIEAQLIC 541
>XP_005258866
          Length = 1486

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2    QMEAQCI 8
            Q+EA+C+
Sbjct: 1428 QLEAECL 1434
>XP_006719300
          Length = 571

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QMEAQCIC 9
           ++EAQ IC
Sbjct: 445 EIEAQLIC 452
>XP_006719299
          Length = 660

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QMEAQCIC 9
           ++EAQ IC
Sbjct: 534 EIEAQLIC 541
>XP_005268701
          Length = 667

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QMEAQCIC 9
           ++EAQ IC
Sbjct: 541 EIEAQLIC 548
>NP_001128648
          Length = 660

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QMEAQCIC 9
           ++EAQ IC
Sbjct: 534 EIEAQLIC 541
>NP_000126
          Length = 1455

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   QMEAQC 7
           QMEA C
Sbjct: 220 QMEASC 225
>NP_056327
          Length = 4265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   QMEAQCI 8
           +ME QCI
Sbjct: 148 RMEQQCI 154
>NP_005899
          Length = 879

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   MEAQCI 8
           M+AQC+
Sbjct: 625 MQAQCV 630
>NP_001018122
          Length = 297

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   QMEAQC 7
           QMEA C
Sbjct: 220 QMEASC 225
>NP_001273096
          Length = 1424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   QMEAQC 7
           QMEA C
Sbjct: 220 QMEASC 225
>NP_055833
          Length = 2465

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2    QMEAQCI 8
            QM+A C+
Sbjct: 2122 QMDASCV 2128
>NP_057195
          Length = 837

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3   MEAQC 7
           MEAQC
Sbjct: 137 MEAQC 141
>NP_001186871
          Length = 2476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2    QMEAQCI 8
            QM+A C+
Sbjct: 2113 QMDASCV 2119
>NP_742013
          Length = 488

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  LQMEAQC 7
          LQ+EA C
Sbjct: 23 LQVEASC 29
>NP_659419
          Length = 1989

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   LQMEAQCI 8
           +Q+E +CI
Sbjct: 235 IQLELECI 242
>NP_612152
          Length = 2849

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   LQMEAQC 7
           L+MEA C
Sbjct: 186 LKMEASC 192
>NP_115597
          Length = 2715

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2    QMEAQCI 8
            Q+EA+C+
Sbjct: 1804 QLEAKCL 1810
>NP_067076
          Length = 518

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  LQMEAQC 7
          LQ+EA C
Sbjct: 23 LQVEASC 29
>NP_001186048
          Length = 503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  LQMEAQC 7
          LQ+EA C
Sbjct: 23 LQVEASC 29
>XP_005276688
          Length = 193

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   QMEAQCIC 9
           QM+  C+C
Sbjct: 134 QMDMGCMC 141
>XP_005260633
          Length = 1364

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   QMEAQCI 8
           Q+EA+C+
Sbjct: 453 QLEAKCL 459
>XP_005260632
          Length = 2377

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2    QMEAQCI 8
            Q+EA+C+
Sbjct: 1804 QLEAKCL 1810
>XP_005260631
          Length = 2667

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2    QMEAQCI 8
            Q+EA+C+
Sbjct: 1756 QLEAKCL 1762
>XP_005260630
          Length = 2693

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2    QMEAQCI 8
            Q+EA+C+
Sbjct: 1782 QLEAKCL 1788
>XP_005256351
          Length = 1463

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   QMEAQC 7
           QMEA C
Sbjct: 220 QMEASC 225
>XP_006721230
          Length = 1412

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   QMEAQC 7
           QMEA C
Sbjct: 220 QMEASC 225
>XP_006721056
          Length = 718

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3   MEAQC 7
           MEAQC
Sbjct: 137 MEAQC 141
>XP_006715715
          Length = 2023

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   LQMEAQC 7
           L+MEA C
Sbjct: 186 LKMEASC 192
>XP_006715463
          Length = 2434

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2    QMEAQCI 8
            QM+A C+
Sbjct: 2122 QMDASCV 2128
>XP_006715462
          Length = 2452

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2    QMEAQCI 8
            QM+A C+
Sbjct: 2089 QMDASCV 2095
>XP_006715461
          Length = 2456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2    QMEAQCI 8
            QM+A C+
Sbjct: 2113 QMDASCV 2119
>XP_006715460
          Length = 2465

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2    QMEAQCI 8
            QM+A C+
Sbjct: 2122 QMDASCV 2128
>XP_006715459
          Length = 2475

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2    QMEAQCI 8
            QM+A C+
Sbjct: 2112 QMDASCV 2118
>XP_006715458
          Length = 2476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2    QMEAQCI 8
            QM+A C+
Sbjct: 2113 QMDASCV 2119
>XP_006715457
          Length = 2485

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2    QMEAQCI 8
            QM+A C+
Sbjct: 2122 QMDASCV 2128
>XP_006715456
          Length = 2485

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2    QMEAQCI 8
            QM+A C+
Sbjct: 2122 QMDASCV 2128
>XP_006713163
          Length = 4265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   QMEAQCI 8
           +ME QCI
Sbjct: 148 RMEQQCI 154
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.339    0.135    0.482 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 621,920
Number of extensions: 767
Number of successful extensions: 75
Number of sequences better than 10000.0: 75
Number of HSP's gapped: 75
Number of HSP's successfully gapped: 75
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.6 bits)
S2: 28 (15.4 bits)

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