Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443099                                                              16    5631
XP_006720008                                                           16    5631
XP_006720006                                                           16    5631
NP_005742                                                              16    7355
NP_671714                                                              16    7355
NP_004789                                                              16    7355
NP_997698                                                              16    7355
NP_004835                                                              16    7355
NP_085148                                                              16    7355
NP_001018009                                                           16    7355
NP_001597                                                              16    7355
NP_940931                                                              16    7355
XP_006721943                                                           16    7355
XP_006721942                                                           16    7355
XP_006717059                                                           16    7355
XP_006715890                                                           16    7355
XP_005250160                                                           16    7355
XP_005250159                                                           16    7355
XP_006713483                                                           16    7355
XP_006712581                                                           16    7355
XP_005246132                                                           16    7355
NP_001073973                                                           16    7355
NP_004612                                                              15    9605
NP_872603                                                              15    9605
NP_056372                                                              15    9605
NP_001273612                                                           15    9605
NP_001432                                                              15    9605
NP_079003                                                              15    9605
NP_001264057                                                           15    9605
NP_954863                                                              15    9605
NP_065122                                                              15    9605
NP_001161048                                                           15    9605
NP_001264056                                                           15    9605
XP_006718961                                                           15    9605
XP_005272093                                                           15    9605
XP_006714294                                                           15    9605
NP_001161049                                                           15    9605
NP_570141                                                              15    9605
NP_001135440                                                           15    9605
NP_057312                                                              15    9605
NP_001273611                                                           15    9605
>NP_443099
          Length = 1738

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LQKMMKRAV 9
           LQKMM+ +V
Sbjct: 377 LQKMMRSSV 385
>XP_006720008
          Length = 1645

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LQKMMKRAV 9
           LQKMM+ +V
Sbjct: 377 LQKMMRSSV 385
>XP_006720006
          Length = 1713

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LQKMMKRAV 9
           LQKMM+ +V
Sbjct: 377 LQKMMRSSV 385
>NP_005742
          Length = 3907

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LQKMMKRA 8
            LQK +KRA
Sbjct: 3662 LQKSLKRA 3669
>NP_671714
          Length = 3899

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LQKMMKRA 8
            LQK +KRA
Sbjct: 3654 LQKSLKRA 3661
>NP_004789
          Length = 747

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QKMMKRAV 9
           Q+MMKR V
Sbjct: 623 QQMMKRPV 630
>NP_997698
          Length = 2466

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LQKMMKRAV 9
           +Q MM+RA+
Sbjct: 693 IQDMMERAI 701
>NP_004835
          Length = 455

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LQKMMKRAV 9
           L+K +KRA+
Sbjct: 197 LEKKLKRAI 205
>NP_085148
          Length = 393

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LQKMMKRAV 9
           LQK ++RA+
Sbjct: 211 LQKTLRRAI 219
>NP_001018009
          Length = 298

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  LQKMMKRAV 9
          L+K +KRA+
Sbjct: 40 LEKKLKRAI 48
>NP_001597
          Length = 2436

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LQKMMKRAV 9
           +Q MM+RA+
Sbjct: 663 IQDMMERAI 671
>NP_940931
          Length = 1503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LQKMMK 6
            LQKMMK
Sbjct: 1284 LQKMMK 1289
>XP_006721943
          Length = 1456

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LQKMMK 6
            LQKMMK
Sbjct: 1284 LQKMMK 1289
>XP_006721942
          Length = 1503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LQKMMK 6
            LQKMMK
Sbjct: 1284 LQKMMK 1289
>XP_006717059
          Length = 2435

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LQKMMKRAV 9
           +Q MM+RA+
Sbjct: 662 IQDMMERAI 670
>XP_006715890
          Length = 3860

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LQKMMKRA 8
            LQK +KRA
Sbjct: 3615 LQKSLKRA 3622
>XP_005250160
          Length = 3939

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LQKMMKRA 8
            LQK +KRA
Sbjct: 3694 LQKSLKRA 3701
>XP_005250159
          Length = 3952

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LQKMMKRA 8
            LQK +KRA
Sbjct: 3707 LQKSLKRA 3714
>XP_006713483
          Length = 298

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  LQKMMKRAV 9
          L+K +KRA+
Sbjct: 40 LEKKLKRAI 48
>XP_006712581
          Length = 1047

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QKMMKRAV 9
           QK+M+RA+
Sbjct: 598 QKIMQRAI 605
>XP_005246132
          Length = 1047

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QKMMKRAV 9
           QK+M+RA+
Sbjct: 598 QKIMQRAI 605
>NP_001073973
          Length = 1052

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QKMMKRAV 9
           QK+M+RA+
Sbjct: 598 QKIMQRAI 605
>NP_004612
          Length = 931

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QKMMKRAV 9
           QK+MKR +
Sbjct: 856 QKIMKRLI 863
>NP_872603
          Length = 425

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  QKMMKRAV 9
          ++MMKRA+
Sbjct: 65 EEMMKRAL 72
>NP_056372
          Length = 1954

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    LQKMMKR 7
            LQKM+K+
Sbjct: 1029 LQKMLKK 1035
>NP_001273612
          Length = 425

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  QKMMKRAV 9
          ++MMKRA+
Sbjct: 65 EEMMKRAL 72
>NP_001432
          Length = 579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LQKMMKRAV 9
           LQK MK++V
Sbjct: 535 LQKGMKKSV 543
>NP_079003
          Length = 552

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LQKMMKRAV 9
          LQK+ K+AV
Sbjct: 79 LQKLGKKAV 87
>NP_001264057
          Length = 496

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LQKMMKRAV 9
          LQK+ K+AV
Sbjct: 79 LQKLGKKAV 87
>NP_954863
          Length = 522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LQKMMKRAV 9
           L+K+M+R V
Sbjct: 197 LEKLMRRLV 205
>NP_065122
          Length = 862

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QKMMKRAV 9
           QK+MKR +
Sbjct: 781 QKIMKRLI 788
>NP_001161048
          Length = 746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QKMMKRAV 9
           QK+MKR +
Sbjct: 665 QKIMKRLI 672
>NP_001264056
          Length = 443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LQKMMKRAV 9
          LQK+ K+AV
Sbjct: 79 LQKLGKKAV 87
>XP_006718961
          Length = 906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QKMMKRAV 9
           QK+MKR +
Sbjct: 831 QKIMKRLI 838
>XP_005272093
          Length = 477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QKMMKRAV 9
           QK+MKR +
Sbjct: 396 QKIMKRLI 403
>XP_006714294
          Length = 464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QKMMKRAV 9
           ++MMKRA+
Sbjct: 104 EEMMKRAL 111
>NP_001161049
          Length = 801

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QKMMKRAV 9
           QK+MKR +
Sbjct: 720 QKIMKRLI 727
>NP_570141
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LQKMMKRAV 9
           L+K+M+R V
Sbjct: 120 LEKLMRRLV 128
>NP_001135440
          Length = 411

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  LQKMMKRAV 9
          L+K+M+R V
Sbjct: 86 LEKLMRRLV 94
>NP_057312
          Length = 425

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  QKMMKRAV 9
          ++MMKRA+
Sbjct: 65 EEMMKRAL 72
>NP_001273611
          Length = 429

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  QKMMKRAV 9
          ++MMKRA+
Sbjct: 69 EEMMKRAL 76
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.336    0.130    0.312 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 323,706
Number of extensions: 504
Number of successful extensions: 41
Number of sequences better than 10000.0: 41
Number of HSP's gapped: 41
Number of HSP's successfully gapped: 41
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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