Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000258                                                              18    1135
NP_001035957                                                           18    1135
XP_006721991                                                           18    1135
XP_006721990                                                           18    1135
XP_006721989                                                           18    1135
XP_005258041                                                           18    1135
XP_006721988                                                           18    1135
XP_006721987                                                           18    1135
XP_006721986                                                           18    1135
XP_005258040                                                           18    1135
XP_006721985                                                           18    1135
NP_001269973                                                           17    2528
NP_055805                                                              17    2528
NP_001269972                                                           17    2528
NP_919277                                                              17    2528
XP_006720167                                                           17    2528
XP_006720166                                                           17    2528
XP_005267550                                                           17    2528
XP_005267549                                                           17    2528
XP_005267548                                                           17    2528
XP_006720165                                                           17    2528
XP_006720164                                                           17    2528
XP_006720163                                                           17    2528
XP_006720162                                                           17    2528
XP_006720161                                                           17    2528
NP_114477                                                              17    4312
NP_054723                                                              17    4312
XP_005261256                                                           16    5631
XP_005261255                                                           16    5631
XP_005261253                                                           16    5631
XP_005261252                                                           16    5631
NP_003672                                                              16    5631
NP_005236                                                              16    7355
NP_001964                                                              16    7355
NP_061740                                                              16    7355
NP_114442                                                              16    7355
XP_006714202                                                           16    7355
XP_005262892                                                           16    7355
XP_005262891                                                           16    7355
XP_005245008                                                           16    7355
XP_005245007                                                           16    7355
NP_068567                                                              16    7355
NP_115824                                                              15    9605
NP_001273308                                                           15    9605
NP_001008781                                                           15    9605
NP_001273309                                                           15    9605
XP_006725079                                                           15    9605
XP_006725078                                                           15    9605
XP_006718827                                                           15    9605
XP_006715643                                                           15    9605
XP_006715642                                                           15    9605
>NP_000258
          Length = 2818

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LQIVITSSD 9
            L+IVITSSD
Sbjct: 1305 LRIVITSSD 1313
>NP_001035957
          Length = 2839

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LQIVITSSD 9
            L+IVITSSD
Sbjct: 1305 LRIVITSSD 1313
>XP_006721991
          Length = 1632

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LQIVITSSD 9
            L+IVITSSD
Sbjct: 1315 LRIVITSSD 1323
>XP_006721990
          Length = 2823

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LQIVITSSD 9
            L+IVITSSD
Sbjct: 1315 LRIVITSSD 1323
>XP_006721989
          Length = 2823

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LQIVITSSD 9
            L+IVITSSD
Sbjct: 1315 LRIVITSSD 1323
>XP_005258041
          Length = 2836

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LQIVITSSD 9
            L+IVITSSD
Sbjct: 1305 LRIVITSSD 1313
>XP_006721988
          Length = 2846

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LQIVITSSD 9
            L+IVITSSD
Sbjct: 1315 LRIVITSSD 1323
>XP_006721987
          Length = 2849

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LQIVITSSD 9
            L+IVITSSD
Sbjct: 1315 LRIVITSSD 1323
>XP_006721986
          Length = 2854

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LQIVITSSD 9
            L+IVITSSD
Sbjct: 1302 LRIVITSSD 1310
>XP_005258040
          Length = 2857

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LQIVITSSD 9
            L+IVITSSD
Sbjct: 1305 LRIVITSSD 1313
>XP_006721985
          Length = 2867

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LQIVITSSD 9
            L+IVITSSD
Sbjct: 1315 LRIVITSSD 1323
>NP_001269973
          Length = 2083

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   QIVITSSD 9
           +IVITSSD
Sbjct: 454 EIVITSSD 461
>NP_055805
          Length = 2036

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   QIVITSSD 9
           +IVITSSD
Sbjct: 454 EIVITSSD 461
>NP_001269972
          Length = 2049

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   QIVITSSD 9
           +IVITSSD
Sbjct: 454 EIVITSSD 461
>NP_919277
          Length = 2083

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   QIVITSSD 9
           +IVITSSD
Sbjct: 454 EIVITSSD 461
>XP_006720167
          Length = 1607

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   QIVITSSD 9
           +IVITSSD
Sbjct: 454 EIVITSSD 461
>XP_006720166
          Length = 2083

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   QIVITSSD 9
           +IVITSSD
Sbjct: 454 EIVITSSD 461
>XP_005267550
          Length = 2084

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   QIVITSSD 9
           +IVITSSD
Sbjct: 454 EIVITSSD 461
>XP_005267549
          Length = 2130

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   QIVITSSD 9
           +IVITSSD
Sbjct: 454 EIVITSSD 461
>XP_005267548
          Length = 2131

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   QIVITSSD 9
           +IVITSSD
Sbjct: 454 EIVITSSD 461
>XP_006720165
          Length = 2542

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   QIVITSSD 9
           +IVITSSD
Sbjct: 454 EIVITSSD 461
>XP_006720164
          Length = 2542

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   QIVITSSD 9
           +IVITSSD
Sbjct: 454 EIVITSSD 461
>XP_006720163
          Length = 2543

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   QIVITSSD 9
           +IVITSSD
Sbjct: 454 EIVITSSD 461
>XP_006720162
          Length = 2589

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   QIVITSSD 9
           +IVITSSD
Sbjct: 454 EIVITSSD 461
>XP_006720161
          Length = 2590

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   QIVITSSD 9
           +IVITSSD
Sbjct: 454 EIVITSSD 461
>NP_114477
          Length = 932

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LQIVITSSD 9
           LQ+++T+SD
Sbjct: 528 LQLLVTASD 536
>NP_054723
          Length = 820

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LQIVITSSD 9
           LQ+++T+SD
Sbjct: 528 LQLLVTASD 536
>XP_005261256
          Length = 239

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   IVITSSD 9
           +VITSSD
Sbjct: 110 VVITSSD 116
>XP_005261255
          Length = 272

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   IVITSSD 9
           +VITSSD
Sbjct: 143 VVITSSD 149
>XP_005261253
          Length = 321

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   IVITSSD 9
           +VITSSD
Sbjct: 192 VVITSSD 198
>XP_005261252
          Length = 364

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   IVITSSD 9
           +VITSSD
Sbjct: 235 VVITSSD 241
>NP_003672
          Length = 312

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   IVITSSD 9
           +VITSSD
Sbjct: 183 VVITSSD 189
>NP_005236
          Length = 4588

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LQIVITSSD 9
            LQ+V+T  D
Sbjct: 3460 LQLVVTDED 3468
>NP_001964
          Length = 431

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   IVITSSD 9
           +VITSSD
Sbjct: 331 LVITSSD 337
>NP_061740
          Length = 962

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LQIVITSSD 9
           LQ+++T+SD
Sbjct: 559 LQLLMTASD 567
>NP_114442
          Length = 851

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LQIVITSSD 9
           LQ+++T+SD
Sbjct: 559 LQLLMTASD 567
>XP_006714202
          Length = 4588

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LQIVITSSD 9
            LQ+V+T  D
Sbjct: 3460 LQLVVTDED 3468
>XP_005262892
          Length = 4600

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LQIVITSSD 9
            LQ+V+T  D
Sbjct: 3460 LQLVVTDED 3468
>XP_005262891
          Length = 4600

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LQIVITSSD 9
            LQ+V+T  D
Sbjct: 3460 LQLVVTDED 3468
>XP_005245008
          Length = 431

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   IVITSSD 9
           +VITSSD
Sbjct: 331 LVITSSD 337
>XP_005245007
          Length = 431

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   IVITSSD 9
           +VITSSD
Sbjct: 331 LVITSSD 337
>NP_068567
          Length = 405

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   IVITSSD 9
           +VITSSD
Sbjct: 331 LVITSSD 337
>NP_115824
          Length = 910

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QIVITSSD 9
           Q++ TSSD
Sbjct: 327 QVISTSSD 334
>NP_001273308
          Length = 922

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QIVITSSD 9
           Q++ TSSD
Sbjct: 339 QVISTSSD 346
>NP_001008781
          Length = 4557

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LQIVITSSD 9
            LQ+V+T  D
Sbjct: 3466 LQLVVTDRD 3474
>NP_001273309
          Length = 933

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QIVITSSD 9
           Q++ TSSD
Sbjct: 350 QVISTSSD 357
>XP_006725079
          Length = 916

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QIVITSSD 9
           Q++ TSSD
Sbjct: 327 QVISTSSD 334
>XP_006725078
          Length = 916

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QIVITSSD 9
           Q++ TSSD
Sbjct: 327 QVISTSSD 334
>XP_006718827
          Length = 3479

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LQIVITSSD 9
            LQ+V+T  D
Sbjct: 2356 LQLVVTDRD 2364
>XP_006715643
          Length = 916

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QIVITSSD 9
           Q++ TSSD
Sbjct: 327 QVISTSSD 334
>XP_006715642
          Length = 916

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QIVITSSD 9
           Q++ TSSD
Sbjct: 327 QVISTSSD 334
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.315    0.129    0.297 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 305,773
Number of extensions: 352
Number of successful extensions: 51
Number of sequences better than 10000.0: 51
Number of HSP's gapped: 51
Number of HSP's successfully gapped: 51
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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