Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              20     390
NP_001075109                                                           20     390
NP_001161842                                                           16    5631
NP_001189479                                                           16    5631
NP_055595                                                              16    5631
XP_006715498                                                           16    5631
XP_006715497                                                           16    5631
XP_006715496                                                           16    5631
XP_006715348                                                           16    5631
XP_005249560                                                           16    5631
NP_055022                                                              16    5631
NP_067640                                                              16    7355
NP_001258510                                                           16    7355
NP_061854                                                              16    7355
XP_005247748                                                           16    7355
XP_005247747                                                           16    7355
NP_008880                                                              15    9605
NP_001258963                                                           15    9605
NP_001120868                                                           15    9605
NP_055904                                                              15    9605
NP_689593                                                              15    9605
XP_006722914                                                           15    9605
XP_006715094                                                           15    9605
XP_006715093                                                           15    9605
XP_006715092                                                           15    9605
XP_005271219                                                           15    9605
XP_005271218                                                           15    9605
NP_001127925                                                           15    9605
>NP_008835
          Length = 4128

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LQAYPALMV 9
            LQAYPAL+V
Sbjct: 3439 LQAYPALVV 3447
>NP_001075109
          Length = 4097

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LQAYPALMV 9
            LQAYPAL+V
Sbjct: 3439 LQAYPALVV 3447
>NP_001161842
          Length = 1782

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   QAYPALM 8
           QAYP+L+
Sbjct: 661 QAYPSLL 667
>NP_001189479
          Length = 730

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LQAYPAL 7
           LQAYP L
Sbjct: 109 LQAYPLL 115
>NP_055595
          Length = 1698

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   QAYPALM 8
           QAYP+L+
Sbjct: 577 QAYPSLL 583
>XP_006715498
          Length = 378

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LQAYPAL 7
           LQAYP L
Sbjct: 109 LQAYPLL 115
>XP_006715497
          Length = 434

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LQAYPAL 7
           LQAYP L
Sbjct: 109 LQAYPLL 115
>XP_006715496
          Length = 497

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LQAYPAL 7
           LQAYP L
Sbjct: 109 LQAYPLL 115
>XP_006715348
          Length = 1734

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   QAYPALM 8
           QAYP+L+
Sbjct: 609 QAYPSLL 615
>XP_005249560
          Length = 1750

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   QAYPALM 8
           QAYP+L+
Sbjct: 629 QAYPSLL 635
>NP_055022
          Length = 495

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LQAYPAL 7
           L AYPAL
Sbjct: 462 LSAYPAL 468
>NP_067640
          Length = 589

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   QAYPALMV 9
           Q YPAL V
Sbjct: 430 QGYPALHV 437
>NP_001258510
          Length = 747

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LQAYPALMV 9
           +QAYP  +V
Sbjct: 474 IQAYPTTVV 482
>NP_061854
          Length = 793

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LQAYPALMV 9
           +QAYP  +V
Sbjct: 520 IQAYPTTVV 528
>XP_005247748
          Length = 474

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   QAYPALMV 9
           Q YPAL V
Sbjct: 315 QGYPALHV 322
>XP_005247747
          Length = 620

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   QAYPALMV 9
           Q YPAL V
Sbjct: 461 QGYPALHV 468
>NP_008880
          Length = 593

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   LQAYPAL 7
           LQ YPA+
Sbjct: 183 LQEYPAI 189
>NP_001258963
          Length = 604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   LQAYPAL 7
           LQ YPA+
Sbjct: 194 LQEYPAI 200
>NP_001120868
          Length = 590

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   LQAYPAL 7
           LQ YPA+
Sbjct: 180 LQEYPAI 186
>NP_055904
          Length = 2517

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  LQAYPALMV 9
          LQAYP  ++
Sbjct: 18 LQAYPEELI 26
>NP_689593
          Length = 496

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   LQAYPAL 7
           LQ+YP L
Sbjct: 304 LQSYPGL 310
>XP_006722914
          Length = 566

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   LQAYPAL 7
           LQ YPA+
Sbjct: 183 LQEYPAI 189
>XP_006715094
          Length = 2407

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  LQAYPALMV 9
          LQAYP  ++
Sbjct: 18 LQAYPEELI 26
>XP_006715093
          Length = 2459

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  LQAYPALMV 9
          LQAYP  ++
Sbjct: 18 LQAYPEELI 26
>XP_006715092
          Length = 2490

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  LQAYPALMV 9
          LQAYP  ++
Sbjct: 18 LQAYPEELI 26
>XP_005271219
          Length = 602

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   LQAYPAL 7
           LQ+YP L
Sbjct: 410 LQSYPGL 416
>XP_005271218
          Length = 635

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   LQAYPAL 7
           LQ+YP L
Sbjct: 443 LQSYPGL 449
>NP_001127925
          Length = 1059

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LQAYPALM 8
           LQA PAL+
Sbjct: 717 LQATPALL 724
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.331    0.137    0.393 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 426,808
Number of extensions: 328
Number of successful extensions: 28
Number of sequences better than 10000.0: 28
Number of HSP's gapped: 28
Number of HSP's successfully gapped: 28
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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