Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_057666                                                              17    2528
NP_060016                                                              17    3301
NP_001275936                                                           17    4312
NP_001275937                                                           17    4312
NP_004450                                                              17    4312
NP_872579                                                              17    4312
NP_699185                                                              17    4312
XP_005257218                                                           17    4312
XP_005257217                                                           17    4312
XP_005257216                                                           17    4312
XP_005257215                                                           17    4312
XP_005257214                                                           17    4312
XP_005257213                                                           17    4312
XP_005257212                                                           17    4312
XP_006721834                                                           17    4312
XP_005257211                                                           17    4312
XP_005257210                                                           17    4312
XP_005257209                                                           17    4312
XP_005257208                                                           17    4312
XP_006721833                                                           17    4312
XP_005257207                                                           17    4312
XP_006714620                                                           17    4312
XP_006714619                                                           17    4312
XP_006714618                                                           17    4312
XP_006714617                                                           17    4312
NP_037450                                                              16    5631
NP_689775                                                              16    5631
XP_005277007                                                           16    5631
XP_005277005                                                           16    5631
XP_005258778                                                           16    5631
XP_005258776                                                           16    5631
XP_006716359                                                           16    5631
XP_006716358                                                           16    5631
XP_006716357                                                           16    5631
NP_001107565                                                           16    5631
NP_056393                                                              16    5631
NP_003592                                                              16    7355
NP_001136028                                                           16    7355
NP_036616                                                              16    7355
NP_036617                                                              16    7355
NP_056169                                                              16    7355
XP_005269123                                                           16    7355
XP_005269118                                                           16    7355
XP_006719607                                                           16    7355
XP_005269117                                                           16    7355
XP_006719606                                                           16    7355
XP_006719605                                                           16    7355
XP_005269116                                                           16    7355
XP_006719604                                                           16    7355
NP_002889                                                              16    7355
NP_056030                                                              15    9605
NP_001364                                                              15    9605
NP_055523                                                              15    9605
NP_694539                                                              15    9605
NP_001273336                                                           15    9605
NP_001180404                                                           15    9605
NP_001803                                                              15    9605
NP_689473                                                              15    9605
NP_001129101                                                           15    9605
XP_005267442                                                           15    9605
XP_006719769                                                           15    9605
XP_006714127                                                           15    9605
XP_006711798                                                           15    9605
XP_006710546                                                           15    9605
XP_006710545                                                           15    9605
>NP_057666
          Length = 581

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LPSAAQKM 8
           LPSA QKM
Sbjct: 404 LPSALQKM 411
>NP_060016
          Length = 510

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LPSAAQKM 8
           LPSAAQ++
Sbjct: 118 LPSAAQRL 125
>NP_001275936
          Length = 502

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LPSAAQKMK 9
           LPSA  KMK
Sbjct: 425 LPSAEGKMK 433
>NP_001275937
          Length = 476

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LPSAAQKMK 9
           LPSA  KMK
Sbjct: 414 LPSAEGKMK 422
>NP_004450
          Length = 2903

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LPSAAQKMK 9
            LP+A+QK K
Sbjct: 2687 LPAASQKRK 2695
>NP_872579
          Length = 2920

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LPSAAQKMK 9
            LP+A+QK K
Sbjct: 2704 LPAASQKRK 2712
>NP_699185
          Length = 487

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LPSAAQKMK 9
           LPSA  KMK
Sbjct: 425 LPSAEGKMK 433
>XP_005257218
          Length = 2957

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LPSAAQKMK 9
            LP+A+QK K
Sbjct: 2741 LPAASQKRK 2749
>XP_005257217
          Length = 2961

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LPSAAQKMK 9
            LP+A+QK K
Sbjct: 2687 LPAASQKRK 2695
>XP_005257216
          Length = 3015

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LPSAAQKMK 9
            LP+A+QK K
Sbjct: 2741 LPAASQKRK 2749
>XP_005257215
          Length = 3032

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LPSAAQKMK 9
            LP+A+QK K
Sbjct: 2758 LPAASQKRK 2766
>XP_005257214
          Length = 3094

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LPSAAQKMK 9
            LP+A+QK K
Sbjct: 2820 LPAASQKRK 2828
>XP_005257213
          Length = 3095

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LPSAAQKMK 9
            LP+A+QK K
Sbjct: 2821 LPAASQKRK 2829
>XP_005257212
          Length = 3095

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LPSAAQKMK 9
            LP+A+QK K
Sbjct: 2821 LPAASQKRK 2829
>XP_006721834
          Length = 3100

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LPSAAQKMK 9
            LP+A+QK K
Sbjct: 2884 LPAASQKRK 2892
>XP_005257211
          Length = 3100

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LPSAAQKMK 9
            LP+A+QK K
Sbjct: 2884 LPAASQKRK 2892
>XP_005257210
          Length = 3104

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LPSAAQKMK 9
            LP+A+QK K
Sbjct: 2830 LPAASQKRK 2838
>XP_005257209
          Length = 3148

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LPSAAQKMK 9
            LP+A+QK K
Sbjct: 2884 LPAASQKRK 2892
>XP_005257208
          Length = 3157

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LPSAAQKMK 9
            LP+A+QK K
Sbjct: 2883 LPAASQKRK 2891
>XP_006721833
          Length = 3158

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LPSAAQKMK 9
            LP+A+QK K
Sbjct: 2884 LPAASQKRK 2892
>XP_005257207
          Length = 3158

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LPSAAQKMK 9
            LP+A+QK K
Sbjct: 2884 LPAASQKRK 2892
>XP_006714620
          Length = 305

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LPSAAQKMK 9
           LPSA  KMK
Sbjct: 243 LPSAEGKMK 251
>XP_006714619
          Length = 360

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LPSAAQKMK 9
           LPSA  KMK
Sbjct: 298 LPSAEGKMK 306
>XP_006714618
          Length = 360

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LPSAAQKMK 9
           LPSA  KMK
Sbjct: 298 LPSAEGKMK 306
>XP_006714617
          Length = 360

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LPSAAQKMK 9
           LPSA  KMK
Sbjct: 298 LPSAEGKMK 306
>NP_037450
          Length = 2229

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    PSAAQKMK 9
            PSAA +MK
Sbjct: 2205 PSAASQMK 2212
>NP_689775
          Length = 1023

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LPSAAQKMK 9
           LPS +QK K
Sbjct: 912 LPSTSQKAK 920
>XP_005277007
          Length = 426

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LPSAAQK 7
           LPSA+QK
Sbjct: 223 LPSASQK 229
>XP_005277005
          Length = 487

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LPSAAQK 7
           LPSA+QK
Sbjct: 223 LPSASQK 229
>XP_005258778
          Length = 426

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LPSAAQK 7
           LPSA+QK
Sbjct: 223 LPSASQK 229
>XP_005258776
          Length = 487

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LPSAAQK 7
           LPSA+QK
Sbjct: 223 LPSASQK 229
>XP_006716359
          Length = 1028

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LPSAAQKMK 9
           LPS +QK K
Sbjct: 917 LPSTSQKAK 925
>XP_006716358
          Length = 1028

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LPSAAQKMK 9
           LPS +QK K
Sbjct: 917 LPSTSQKAK 925
>XP_006716357
          Length = 1028

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LPSAAQKMK 9
           LPS +QK K
Sbjct: 917 LPSTSQKAK 925
>NP_001107565
          Length = 463

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LPSAAQK 7
           LPSA+QK
Sbjct: 223 LPSASQK 229
>NP_056393
          Length = 463

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LPSAAQK 7
           LPSA+QK
Sbjct: 223 LPSASQK 229
>NP_003592
          Length = 1052

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LPSAAQKMK 9
           LP+AAQ  K
Sbjct: 806 LPNAAQAQK 814
>NP_001136028
          Length = 725

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  LPSAAQKMK 9
          LP++A+K+K
Sbjct: 62 LPASARKVK 70
>NP_036616
          Length = 724

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  LPSAAQKMK 9
          LP++A+K+K
Sbjct: 62 LPASARKVK 70
>NP_036617
          Length = 709

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  LPSAAQKMK 9
          LP++A+K+K
Sbjct: 62 LPASARKVK 70
>NP_056169
          Length = 1749

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  PSAAQKMK 9
          PS+A+K+K
Sbjct: 55 PSSAEKVK 62
>XP_005269123
          Length = 214

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   PSAAQK 7
           PSAAQK
Sbjct: 107 PSAAQK 112
>XP_005269118
          Length = 388

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   PSAAQK 7
           PSAAQK
Sbjct: 107 PSAAQK 112
>XP_006719607
          Length = 407

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   PSAAQK 7
           PSAAQK
Sbjct: 107 PSAAQK 112
>XP_005269117
          Length = 419

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   PSAAQK 7
           PSAAQK
Sbjct: 107 PSAAQK 112
>XP_006719606
          Length = 429

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   PSAAQK 7
           PSAAQK
Sbjct: 107 PSAAQK 112
>XP_006719605
          Length = 448

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   PSAAQK 7
           PSAAQK
Sbjct: 107 PSAAQK 112
>XP_005269116
          Length = 448

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   PSAAQK 7
           PSAAQK
Sbjct: 107 PSAAQK 112
>XP_006719604
          Length = 477

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   PSAAQK 7
           PSAAQK
Sbjct: 107 PSAAQK 112
>NP_002889
          Length = 407

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   PSAAQK 7
           PSAAQK
Sbjct: 107 PSAAQK 112
>NP_056030
          Length = 1673

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LPSAAQ 6
            LPSAAQ
Sbjct: 1450 LPSAAQ 1455
>NP_001364
          Length = 4515

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LPSAAQKMK 9
            +PS +QK K
Sbjct: 4307 IPSTSQKCK 4315
>NP_055523
          Length = 2209

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LPSAAQ 6
            LPSAAQ
Sbjct: 1583 LPSAAQ 1588
>NP_694539
          Length = 769

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LPSAAQKM 8
           LP+A QK+
Sbjct: 455 LPTATQKL 462
>NP_001273336
          Length = 484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LPSAAQKMK 9
           L +AAQKM+
Sbjct: 396 LAAAAQKME 404
>NP_001180404
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LPSAAQKM 8
           LP+A QK+
Sbjct: 455 LPTATQKL 462
>NP_001803
          Length = 943

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LPSAAQK 7
           +PS+AQK
Sbjct: 174 IPSSAQK 180
>NP_689473
          Length = 545

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LPSAAQKMK 9
           L +AAQKM+
Sbjct: 457 LAAAAQKME 465
>NP_001129101
          Length = 780

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LPSAAQKM 8
           LP+A QK+
Sbjct: 455 LPTATQKL 462
>XP_005267442
          Length = 650

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LPSAAQK 7
           LPS AQK
Sbjct: 244 LPSEAQK 250
>XP_006719769
          Length = 2209

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LPSAAQ 6
            LPSAAQ
Sbjct: 1583 LPSAAQ 1588
>XP_006714127
          Length = 935

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LPSAAQK 7
           +PS+AQK
Sbjct: 174 IPSSAQK 180
>XP_006711798
          Length = 4586

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LPSAAQKMK 9
            +PS +QK K
Sbjct: 4378 IPSTSQKCK 4386
>XP_006710546
          Length = 704

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LPSAAQ 6
           LPSAAQ
Sbjct: 474 LPSAAQ 479
>XP_006710545
          Length = 704

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LPSAAQ 6
           LPSAAQ
Sbjct: 474 LPSAAQ 479
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.306    0.111    0.280 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 626,628
Number of extensions: 1173
Number of successful extensions: 65
Number of sequences better than 10000.0: 65
Number of HSP's gapped: 65
Number of HSP's successfully gapped: 65
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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