Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006209                                                              19     665
XP_006713721                                                           19     665
NP_006210                                                              19     869
NP_001242974                                                           19     869
XP_005247589                                                           19     869
XP_006713722                                                           19     869
XP_005247588                                                           19     869
XP_005247587                                                           19     869
NP_000565                                                              16    5631
NP_001108224                                                           16    5631
XP_005273134                                                           16    5631
NP_114115                                                              16    5631
NP_005624                                                              16    7355
NP_001152869                                                           16    7355
NP_001152870                                                           16    7355
NP_443170                                                              16    7355
NP_940912                                                              16    7355
XP_005264572                                                           16    7355
XP_005244926                                                           16    7355
XP_005244924                                                           16    7355
XP_005244923                                                           16    7355
XP_005245939                                                           16    7355
NP_109590                                                              15    9605
NP_008821                                                              15    9605
NP_001278414                                                           15    9605
NP_001274182                                                           15    9605
NP_001274181                                                           15    9605
NP_001034869                                                           15    9605
NP_612449                                                              15    9605
NP_003135                                                              15    9605
NP_002738                                                              15    9605
NP_002548                                                              15    9605
XP_005258487                                                           15    9605
XP_005258356                                                           15    9605
XP_005254596                                                           15    9605
XP_005254595                                                           15    9605
XP_005254594                                                           15    9605
XP_005254593                                                           15    9605
XP_006712096                                                           15    9605
XP_006712095                                                           15    9605
XP_005264430                                                           15    9605
XP_006712094                                                           15    9605
XP_006712093                                                           15    9605
XP_005264429                                                           15    9605
XP_006710047                                                           15    9605
NP_002739                                                              15    9605
NP_001457                                                              15    9605
NP_001004469                                                           15    9605
NP_060022                                                              15    9605
NP_001229267                                                           15    9605
>NP_006209
          Length = 1068

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LPRLLLSVK 9
           LP+LLLSVK
Sbjct: 565 LPKLLLSVK 573
>XP_006713721
          Length = 1068

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LPRLLLSVK 9
           LP+LLLSVK
Sbjct: 565 LPKLLLSVK 573
>NP_006210
          Length = 1070

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   LPRLLLSVK 9
           LP+LLLS+K
Sbjct: 573 LPKLLLSIK 581
>NP_001242974
          Length = 582

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1  LPRLLLSVK 9
          LP+LLLS+K
Sbjct: 85 LPKLLLSIK 93
>XP_005247589
          Length = 1053

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   LPRLLLSVK 9
           LP+LLLS+K
Sbjct: 556 LPKLLLSIK 564
>XP_006713722
          Length = 1070

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   LPRLLLSVK 9
           LP+LLLS+K
Sbjct: 573 LPKLLLSIK 581
>XP_005247588
          Length = 1070

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   LPRLLLSVK 9
           LP+LLLS+K
Sbjct: 573 LPKLLLSIK 581
>XP_005247587
          Length = 1070

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   LPRLLLSVK 9
           LP+LLLS+K
Sbjct: 573 LPKLLLSIK 581
>NP_000565
          Length = 381

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  LPRLLLSV 8
          LPRLLL V
Sbjct: 18 LPRLLLLV 25
>NP_001108224
          Length = 440

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  LPRLLLSV 8
          LPRLLL V
Sbjct: 18 LPRLLLLV 25
>XP_005273134
          Length = 444

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  LPRLLLSV 8
          LPRLLL V
Sbjct: 18 LPRLLLLV 25
>NP_114115
          Length = 329

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LPRLLLSVK 9
           LPR  LSVK
Sbjct: 238 LPRKTLSVK 246
>NP_005624
          Length = 1333

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LPRLLLS 7
           LPRLLL+
Sbjct: 339 LPRLLLA 345
>NP_001152869
          Length = 366

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1 LPRLLLSV 8
         LPRLLL +
Sbjct: 2 LPRLLLLI 9
>NP_001152870
          Length = 428

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1 LPRLLLSV 8
         LPRLLL +
Sbjct: 2 LPRLLLLI 9
>NP_443170
          Length = 429

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1 LPRLLLSV 8
         LPRLLL +
Sbjct: 2 LPRLLLLI 9
>NP_940912
          Length = 1313

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   PRLLLSVK 9
           P++LLS+K
Sbjct: 850 PKILLSLK 857
>XP_005264572
          Length = 1318

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LPRLLLS 7
           LPRLLL+
Sbjct: 339 LPRLLLA 345
>XP_005244926
          Length = 333

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1 LPRLLLSV 8
         LPRLLL +
Sbjct: 2 LPRLLLLI 9
>XP_005244924
          Length = 390

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1 LPRLLLSV 8
         LPRLLL +
Sbjct: 2 LPRLLLLI 9
>XP_005244923
          Length = 405

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1 LPRLLLSV 8
         LPRLLL +
Sbjct: 2 LPRLLLLI 9
>XP_005245939
          Length = 343

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LPRLLLS 7
           LPRLLL+
Sbjct: 333 LPRLLLN 339
>NP_109590
          Length = 1906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   PRLLLS 7
           PRLLLS
Sbjct: 595 PRLLLS 600
>NP_008821
          Length = 265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   PRLLLS 7
           PRLLLS
Sbjct: 190 PRLLLS 195
>NP_001278414
          Length = 265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   PRLLLS 7
           PRLLLS
Sbjct: 190 PRLLLS 195
>NP_001274182
          Length = 370

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RLLLSVK 9
           RLL+SVK
Sbjct: 181 RLLISVK 187
>NP_001274181
          Length = 385

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RLLLSVK 9
           RLL+SVK
Sbjct: 180 RLLISVK 186
>NP_001034869
          Length = 369

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RLLLSVK 9
           RLL+SVK
Sbjct: 180 RLLISVK 186
>NP_612449
          Length = 673

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LPRLLL 6
           LPRLLL
Sbjct: 168 LPRLLL 173
>NP_003135
          Length = 286

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1 LPRLLL 6
         LPRLLL
Sbjct: 4 LPRLLL 9
>NP_002738
          Length = 587

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   PRLLLS 7
           PRLLLS
Sbjct: 197 PRLLLS 202
>NP_002548
          Length = 678

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   PRLLLS 7
           PRLLLS
Sbjct: 177 PRLLLS 182
>XP_005258487
          Length = 244

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   PRLLLS 7
           PRLLLS
Sbjct: 169 PRLLLS 174
>XP_005258356
          Length = 587

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   PRLLLS 7
           PRLLLS
Sbjct: 197 PRLLLS 202
>XP_005254596
          Length = 721

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   PRLLLS 7
           PRLLLS
Sbjct: 200 PRLLLS 205
>XP_005254595
          Length = 721

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   PRLLLS 7
           PRLLLS
Sbjct: 200 PRLLLS 205
>XP_005254594
          Length = 721

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   PRLLLS 7
           PRLLLS
Sbjct: 200 PRLLLS 205
>XP_005254593
          Length = 721

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   PRLLLS 7
           PRLLLS
Sbjct: 200 PRLLLS 205
>XP_006712096
          Length = 802

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   PRLLLS 7
           PRLLLS
Sbjct: 111 PRLLLS 116
>XP_006712095
          Length = 849

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   PRLLLS 7
           PRLLLS
Sbjct: 781 PRLLLS 786
>XP_005264430
          Length = 1044

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   PRLLLS 7
           PRLLLS
Sbjct: 353 PRLLLS 358
>XP_006712094
          Length = 1067

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   PRLLLS 7
           PRLLLS
Sbjct: 781 PRLLLS 786
>XP_006712093
          Length = 1460

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   PRLLLS 7
           PRLLLS
Sbjct: 781 PRLLLS 786
>XP_005264429
          Length = 1472

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   PRLLLS 7
           PRLLLS
Sbjct: 781 PRLLLS 786
>XP_006710047
          Length = 267

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   PRLLLS 7
           PRLLLS
Sbjct: 195 PRLLLS 200
>NP_002739
          Length = 721

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   PRLLLS 7
           PRLLLS
Sbjct: 200 PRLLLS 205
>NP_001457
          Length = 565

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  LPRLLL 6
          LPRLLL
Sbjct: 7  LPRLLL 12
>NP_001004469
          Length = 309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LPRLLLSV 8
          +PR+LLS+
Sbjct: 78 VPRMLLSL 85
>NP_060022
          Length = 1458

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   PRLLLS 7
           PRLLLS
Sbjct: 767 PRLLLS 772
>NP_001229267
          Length = 1453

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   PRLLLS 7
           PRLLLS
Sbjct: 767 PRLLLS 772
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.331    0.150    0.399 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 464,469
Number of extensions: 680
Number of successful extensions: 50
Number of sequences better than 10000.0: 50
Number of HSP's gapped: 50
Number of HSP's successfully gapped: 50
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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