Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001275701                                                           21     229
NP_004561                                                              21     229
NP_001275703                                                           21     229
XP_005253450                                                           21     229
XP_006719151                                                           21     229
NP_001004692                                                           16    5631
NP_001004695                                                           16    5631
NP_077310                                                              16    7355
NP_659412                                                              16    7355
NP_078959                                                              15    9605
NP_001158238                                                           15    9605
NP_115605                                                              15    9605
NP_008816                                                              15    9605
NP_066580                                                              15    9605
XP_006722147                                                           15    9605
XP_005256014                                                           15    9605
XP_005253535                                                           15    9605
XP_005253534                                                           15    9605
XP_005253531                                                           15    9605
NP_602307                                                              15    9605
>NP_001275701
          Length = 1486

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LNLMEMMLY 9
            LNL+EMMLY
Sbjct: 1155 LNLLEMMLY 1163
>NP_004561
          Length = 1445

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LNLMEMMLY 9
            LNL+EMMLY
Sbjct: 1114 LNLLEMMLY 1122
>NP_001275703
          Length = 1264

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LNLMEMMLY 9
           LNL+EMMLY
Sbjct: 933 LNLLEMMLY 941
>XP_005253450
          Length = 1486

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LNLMEMMLY 9
            LNL+EMMLY
Sbjct: 1155 LNLLEMMLY 1163
>XP_006719151
          Length = 1486

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LNLMEMMLY 9
            LNL+EMMLY
Sbjct: 1155 LNLLEMMLY 1163
>NP_001004692
          Length = 320

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  LNLMEMML 8
          L+LM+MML
Sbjct: 64 LSLMDMML 71
>NP_001004695
          Length = 320

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  LNLMEMML 8
          L+LM+MML
Sbjct: 64 LSLMDMML 71
>NP_077310
          Length = 400

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LNLMEMMLY 9
           LNLM  +LY
Sbjct: 323 LNLMTRILY 331
>NP_659412
          Length = 891

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LNLMEMMLY 9
           LNL E+++Y
Sbjct: 764 LNLEEILIY 772
>NP_078959
          Length = 360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   NLMEMMLY 9
           ++ME MLY
Sbjct: 251 HIMEAMLY 258
>NP_001158238
          Length = 2789

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    LNLMEMMLY 9
            +NL EM+L+
Sbjct: 2581 VNLQEMVLH 2589
>NP_115605
          Length = 841

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LNLMEMMLY 9
           L LME ++Y
Sbjct: 797 LKLMETLMY 805
>NP_008816
          Length = 3703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    LNLMEMMLY 9
            +NL EM+L+
Sbjct: 3495 VNLQEMVLH 3503
>NP_066580
          Length = 670

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LNLMEMMLY 9
           L+L+E +LY
Sbjct: 394 LSLLEYLLY 402
>XP_006722147
          Length = 245

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   NLMEMMLY 9
           ++ME MLY
Sbjct: 136 HIMEAMLY 143
>XP_005256014
          Length = 3702

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    LNLMEMMLY 9
            +NL EM+L+
Sbjct: 3494 VNLQEMVLH 3502
>XP_005253535
          Length = 579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LNLMEMMLY 9
           L+L+E +LY
Sbjct: 392 LSLLEYLLY 400
>XP_005253534
          Length = 650

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LNLMEMMLY 9
           L+L+E +LY
Sbjct: 374 LSLLEYLLY 382
>XP_005253531
          Length = 670

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LNLMEMMLY 9
           L+L+E +LY
Sbjct: 394 LSLLEYLLY 402
>NP_602307
          Length = 670

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LNLMEMMLY 9
           L+L+E +LY
Sbjct: 394 LSLLEYLLY 402
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.340    0.145    0.390 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 316,559
Number of extensions: 488
Number of successful extensions: 20
Number of sequences better than 10000.0: 20
Number of HSP's gapped: 20
Number of HSP's successfully gapped: 20
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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