Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_002430                                                              20     509
NP_068591                                                              17    4312
NP_001793                                                              16    7355
NP_061124                                                              16    7355
XP_005276559                                                           16    7355
XP_005253478                                                           16    7355
NP_542194                                                              15    9605
NP_001276018                                                           15    9605
NP_079048                                                              15    9605
NP_001276019                                                           15    9605
NP_001276017                                                           15    9605
NP_001276020                                                           15    9605
NP_997698                                                              15    9605
NP_057506                                                              15    9605
NP_570123                                                              15    9605
NP_001597                                                              15    9605
XP_006721915                                                           15    9605
XP_006717059                                                           15    9605
XP_006714595                                                           15    9605
XP_006714594                                                           15    9605
XP_005271279                                                           15    9605
XP_005271277                                                           15    9605
XP_005271276                                                           15    9605
XP_005271275                                                           15    9605
XP_005271273                                                           15    9605
NP_055418                                                              15    9605
>NP_002430
          Length = 1137

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LNEQTAKVG 9
           LNEQ AKVG
Sbjct: 689 LNEQAAKVG 697
>NP_068591
          Length = 526

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LNEQTAKVG 9
           LN+ +AKVG
Sbjct: 375 LNKDSAKVG 383
>NP_001793
          Length = 454

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LNEQTAKV 8
          +NEQ AKV
Sbjct: 76 MNEQHAKV 83
>NP_061124
          Length = 345

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LNEQTAKV 8
          LN+QTA V
Sbjct: 84 LNQQTAPV 91
>XP_005276559
          Length = 454

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LNEQTAKV 8
          +NEQ AKV
Sbjct: 76 MNEQHAKV 83
>XP_005253478
          Length = 345

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LNEQTAKV 8
          LN+QTA V
Sbjct: 84 LNQQTAPV 91
>NP_542194
          Length = 1661

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    LNEQTAKVG 9
            LN++ AK+G
Sbjct: 1572 LNKKAAKLG 1580
>NP_001276018
          Length = 1123

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LNEQTAK 7
           LNE TAK
Sbjct: 986 LNETTAK 992
>NP_079048
          Length = 1142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    LNEQTAK 7
            LNE TAK
Sbjct: 1005 LNETTAK 1011
>NP_001276019
          Length = 1142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    LNEQTAK 7
            LNE TAK
Sbjct: 1005 LNETTAK 1011
>NP_001276017
          Length = 1142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    LNEQTAK 7
            LNE TAK
Sbjct: 1005 LNETTAK 1011
>NP_001276020
          Length = 782

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LNEQTAK 7
           LNE TAK
Sbjct: 645 LNETTAK 651
>NP_997698
          Length = 2466

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LNEQTAKVG 9
            +NE  AK+G
Sbjct: 1997 INEYYAKIG 2005
>NP_057506
          Length = 230

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LNEQTAKV 8
          LN+ TAKV
Sbjct: 45 LNDVTAKV 52
>NP_570123
          Length = 555

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  EQTAKVG 9
          E+TA+VG
Sbjct: 62 EETARVG 68
>NP_001597
          Length = 2436

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LNEQTAKVG 9
            +NE  AK+G
Sbjct: 1967 INEYYAKIG 1975
>XP_006721915
          Length = 456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LNEQTAKV 8
          +NEQ AKV
Sbjct: 76 VNEQHAKV 83
>XP_006717059
          Length = 2435

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LNEQTAKVG 9
            +NE  AK+G
Sbjct: 1966 INEYYAKIG 1974
>XP_006714595
          Length = 378

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  EQTAKVG 9
          E+TA+VG
Sbjct: 62 EETARVG 68
>XP_006714594
          Length = 527

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  EQTAKVG 9
          E+TA+VG
Sbjct: 62 EETARVG 68
>XP_005271279
          Length = 782

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LNEQTAK 7
           LNE TAK
Sbjct: 645 LNETTAK 651
>XP_005271277
          Length = 951

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LNEQTAK 7
           LNE TAK
Sbjct: 814 LNETTAK 820
>XP_005271276
          Length = 1067

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LNEQTAK 7
           LNE TAK
Sbjct: 930 LNETTAK 936
>XP_005271275
          Length = 1067

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LNEQTAK 7
           LNE TAK
Sbjct: 930 LNETTAK 936
>XP_005271273
          Length = 1130

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LNEQTAK 7
           LNE TAK
Sbjct: 993 LNETTAK 999
>NP_055418
          Length = 465

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LNEQTAKV 8
          +NEQ AKV
Sbjct: 76 VNEQHAKV 83
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.299    0.119    0.295 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 355,985
Number of extensions: 538
Number of successful extensions: 26
Number of sequences better than 10000.0: 26
Number of HSP's gapped: 26
Number of HSP's successfully gapped: 26
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package