Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              22     134
NP_001075109                                                           22     134
NP_775873                                                              18    1935
XP_006719585                                                           18    1935
XP_006719584                                                           18    1935
XP_005269101                                                           18    1935
XP_006719583                                                           18    1935
NP_000543                                                              17    4312
NP_062815                                                              16    5631
NP_079128                                                              16    5631
NP_001258875                                                           16    5631
NP_003053                                                              16    5631
NP_002799                                                              16    5631
NP_001265637                                                           16    5631
NP_001265638                                                           16    5631
NP_803171                                                              16    5631
XP_005270633                                                           16    5631
XP_006710467                                                           16    5631
XP_005270632                                                           16    5631
NP_277052                                                              16    7355
NP_055935                                                              16    7355
NP_056083                                                              16    7355
XP_006716621                                                           16    7355
XP_005250973                                                           16    7355
XP_005250972                                                           16    7355
XP_006716620                                                           16    7355
XP_006716619                                                           16    7355
XP_005247302                                                           16    7355
NP_976324                                                              16    7355
NP_001275582                                                           15    9605
NP_055507                                                              15    9605
NP_004850                                                              15    9605
NP_056019                                                              15    9605
NP_001364                                                              15    9605
NP_056377                                                              15    9605
NP_005079                                                              15    9605
NP_079216                                                              15    9605
XP_005257069                                                           15    9605
XP_005271598                                                           15    9605
XP_005273708                                                           15    9605
XP_006716465                                                           15    9605
XP_005273707                                                           15    9605
XP_006715725                                                           15    9605
XP_006715724                                                           15    9605
XP_006715723                                                           15    9605
XP_006715722                                                           15    9605
XP_006711798                                                           15    9605
XP_005270437                                                           15    9605
NP_006408                                                              15    9605
>NP_008835
          Length = 4128

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LMYKGSNRT 9
            LMYKG+NRT
Sbjct: 3857 LMYKGANRT 3865
>NP_001075109
          Length = 4097

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LMYKGSNRT 9
            LMYKG+NRT
Sbjct: 3826 LMYKGANRT 3834
>NP_775873
          Length = 1576

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   MYKGSNRT 9
           M+KGSNR+
Sbjct: 251 MHKGSNRS 258
>XP_006719585
          Length = 1459

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   MYKGSNRT 9
           M+KGSNR+
Sbjct: 133 MHKGSNRS 140
>XP_006719584
          Length = 1515

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   MYKGSNRT 9
           M+KGSNR+
Sbjct: 190 MHKGSNRS 197
>XP_005269101
          Length = 1577

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   MYKGSNRT 9
           M+KGSNR+
Sbjct: 251 MHKGSNRS 258
>XP_006719583
          Length = 1586

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   MYKGSNRT 9
           M+KGSNR+
Sbjct: 261 MHKGSNRS 268
>NP_000543
          Length = 2813

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LMYKGSNRT 9
            + Y+G NRT
Sbjct: 1568 IRYQGGNRT 1576
>NP_062815
          Length = 729

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LMYKGSNRT 9
           L ++G NRT
Sbjct: 352 LKFRGGNRT 360
>NP_079128
          Length = 860

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LMYKGSNRT 9
           L Y G NRT
Sbjct: 419 LQYGGRNRT 427
>NP_001258875
          Length = 1530

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    LMYKGSN 7
            L+YKG N
Sbjct: 1202 LLYKGDN 1208
>NP_003053
          Length = 1523

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    LMYKGSN 7
            L+YKG N
Sbjct: 1195 LLYKGDN 1201
>NP_002799
          Length = 908

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LMYKGSNR 8
           L Y GSNR
Sbjct: 487 LAYAGSNR 494
>NP_001265637
          Length = 778

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LMYKGSNR 8
           L Y GSNR
Sbjct: 357 LAYAGSNR 364
>NP_001265638
          Length = 749

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LMYKGSNR 8
           L Y GSNR
Sbjct: 328 LAYAGSNR 335
>NP_803171
          Length = 626

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LMYKGSNRT 9
           L Y G NRT
Sbjct: 185 LQYGGRNRT 193
>XP_005270633
          Length = 585

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LMYKGSNRT 9
           L Y G NRT
Sbjct: 144 LQYGGRNRT 152
>XP_006710467
          Length = 626

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LMYKGSNRT 9
           L Y G NRT
Sbjct: 185 LQYGGRNRT 193
>XP_005270632
          Length = 860

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LMYKGSNRT 9
           L Y G NRT
Sbjct: 419 LQYGGRNRT 427
>NP_277052
          Length = 1731

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   LMYKGSNR 8
           L+++G+NR
Sbjct: 302 LLFRGANR 309
>NP_055935
          Length = 4169

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   LMYKGSNRT 9
           ++Y+G++RT
Sbjct: 121 IVYQGNSRT 129
>NP_056083
          Length = 2243

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    LMYKGSN 7
            +MY GSN
Sbjct: 1129 MMYTGSN 1135
>XP_006716621
          Length = 1001

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   MYKGSNRT 9
           +YK  NRT
Sbjct: 317 LYKDENRT 324
>XP_005250973
          Length = 1001

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   MYKGSNRT 9
           +YK  NRT
Sbjct: 317 LYKDENRT 324
>XP_005250972
          Length = 1001

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   MYKGSNRT 9
           +YK  NRT
Sbjct: 317 LYKDENRT 324
>XP_006716620
          Length = 1001

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   MYKGSNRT 9
           +YK  NRT
Sbjct: 317 LYKDENRT 324
>XP_006716619
          Length = 1001

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   MYKGSNRT 9
           +YK  NRT
Sbjct: 317 LYKDENRT 324
>XP_005247302
          Length = 2248

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    LMYKGSN 7
            +MY GSN
Sbjct: 1134 MMYTGSN 1140
>NP_976324
          Length = 1001

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   MYKGSNRT 9
           +YK  NRT
Sbjct: 317 LYKDENRT 324
>NP_001275582
          Length = 1679

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2    MYKGSNR 8
            ++KG+NR
Sbjct: 1518 LFKGNNR 1524
>NP_055507
          Length = 696

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   LMYKGSN 7
           L+Y GSN
Sbjct: 448 LIYSGSN 454
>NP_004850
          Length = 1675

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2    MYKGSNR 8
            ++KG+NR
Sbjct: 1514 LFKGNNR 1520
>NP_056019
          Length = 1657

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    YKGSNRT 9
            +KGS+RT
Sbjct: 1484 WKGSSRT 1490
>NP_001364
          Length = 4515

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3    YKGSN 7
            YKGSN
Sbjct: 3817 YKGSN 3821
>NP_056377
          Length = 489

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LMYKGSNRT 9
           LM+KGS  T
Sbjct: 148 LMHKGSFET 156
>NP_005079
          Length = 695

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   LMYKGSN 7
           LMYKG +
Sbjct: 239 LMYKGED 245
>NP_079216
          Length = 1870

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   LMYKGSNR 8
           ++YKG N+
Sbjct: 570 VVYKGDNK 577
>XP_005257069
          Length = 1682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2    MYKGSNR 8
            ++KG+NR
Sbjct: 1514 LFKGNNR 1520
>XP_005271598
          Length = 224

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YKGSNRT 9
           +KG NRT
Sbjct: 188 WKGMNRT 194
>XP_005273708
          Length = 1032

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   LMYKGSNR 8
           ++YKG N+
Sbjct: 284 VVYKGDNK 291
>XP_006716465
          Length = 1826

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   LMYKGSNR 8
           ++YKG N+
Sbjct: 570 VVYKGDNK 577
>XP_005273707
          Length = 1847

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   LMYKGSNR 8
           ++YKG N+
Sbjct: 570 VVYKGDNK 577
>XP_006715725
          Length = 1516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    YKGSNRT 9
            +KGS+RT
Sbjct: 1484 WKGSSRT 1490
>XP_006715724
          Length = 1533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    YKGSNRT 9
            +KGS+RT
Sbjct: 1484 WKGSSRT 1490
>XP_006715723
          Length = 1559

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    YKGSNRT 9
            +KGS+RT
Sbjct: 1484 WKGSSRT 1490
>XP_006715722
          Length = 1614

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    YKGSNRT 9
            +KGS+RT
Sbjct: 1484 WKGSSRT 1490
>XP_006711798
          Length = 4586

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3    YKGSN 7
            YKGSN
Sbjct: 3879 YKGSN 3883
>XP_005270437
          Length = 352

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  LMYKGS 6
          L+YKGS
Sbjct: 26 LLYKGS 31
>NP_006408
          Length = 444

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  LMYKGS 6
          L+YKGS
Sbjct: 26 LLYKGS 31
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.315    0.128    0.357 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 585,571
Number of extensions: 981
Number of successful extensions: 49
Number of sequences better than 10000.0: 49
Number of HSP's gapped: 49
Number of HSP's successfully gapped: 49
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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