Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000213                                                              18    1482
NP_001087241                                                           18    1482
XP_005265799                                                           18    1482
XP_005265798                                                           18    1482
XP_005265797                                                           18    1482
NP_005202                                                              17    3301
NP_002600                                                              17    3301
NP_001275634                                                           17    3301
XP_005268521                                                           17    3301
NP_002011                                                              16    5631
NP_891555                                                              16    5631
NP_002244                                                              16    5631
NP_079003                                                              16    5631
NP_001264056                                                           16    5631
NP_005859                                                              16    5631
NP_006197                                                              16    7355
NP_056054                                                              16    7355
NP_057646                                                              16    7355
NP_001012977                                                           16    7355
NP_001012975                                                           16    7355
NP_001158016                                                           16    7355
NP_001158014                                                           16    7355
NP_001158013                                                           16    7355
NP_001158012                                                           16    7355
NP_001158011                                                           16    7355
NP_001158010                                                           16    7355
NP_061132                                                              16    7355
NP_001158009                                                           16    7355
XP_005251905                                                           16    7355
XP_005251904                                                           16    7355
XP_006714104                                                           16    7355
XP_005265800                                                           16    7355
XP_006714103                                                           16    7355
XP_006714102                                                           16    7355
NP_061735                                                              16    7355
NP_114382                                                              16    7355
NP_002733                                                              15    9605
NP_002431                                                              15    9605
XP_005267916                                                           15    9605
XP_006718567                                                           15    9605
NP_001032302                                                           15    9605
>NP_000213
          Length = 976

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LMSKLKVLS 9
           LMS+LKVLS
Sbjct: 637 LMSELKVLS 645
>NP_001087241
          Length = 972

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LMSKLKVLS 9
           LMS+LKVLS
Sbjct: 633 LMSELKVLS 641
>XP_005265799
          Length = 973

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LMSKLKVLS 9
           LMS+LKVLS
Sbjct: 634 LMSELKVLS 642
>XP_005265798
          Length = 976

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LMSKLKVLS 9
           LMS+LKVLS
Sbjct: 638 LMSELKVLS 646
>XP_005265797
          Length = 977

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LMSKLKVLS 9
           LMS+LKVLS
Sbjct: 638 LMSELKVLS 646
>NP_005202
          Length = 972

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LMSKLKVLS 9
           LMS+LK++S
Sbjct: 630 LMSELKIMS 638
>NP_002600
          Length = 1106

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LMSKLKVLS 9
           LMS+LK++S
Sbjct: 648 LMSELKIMS 656
>NP_001275634
          Length = 972

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LMSKLKVLS 9
           LMS+LK++S
Sbjct: 630 LMSELKIMS 638
>XP_005268521
          Length = 1042

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LMSKLKVLS 9
           LMS+LK++S
Sbjct: 584 LMSELKIMS 592
>NP_002011
          Length = 1298

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LMSKLKVL 8
           LMS+LK+L
Sbjct: 893 LMSELKIL 900
>NP_891555
          Length = 1363

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LMSKLKVL 8
           LMS+LK+L
Sbjct: 893 LMSELKIL 900
>NP_002244
          Length = 1356

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LMSKLKVL 8
           LMS+LK+L
Sbjct: 882 LMSELKIL 889
>NP_079003
          Length = 552

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LMSKLKVL 8
           L+SKLK+L
Sbjct: 140 LVSKLKIL 147
>NP_001264056
          Length = 443

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LMSKLKVL 8
           L+SKLK+L
Sbjct: 140 LVSKLKIL 147
>NP_005859
          Length = 118

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  MSKLKVLS 9
          M KLK+LS
Sbjct: 82 MGKLKILS 89
>NP_006197
          Length = 1089

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LMSKLKVLS 9
           LMS+LK+++
Sbjct: 641 LMSELKIMT 649
>NP_056054
          Length = 1186

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2 MSKLKVL 8
         MSKLKV+
Sbjct: 1 MSKLKVI 7
>NP_057646
          Length = 1049

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   MSKLKVLS 9
           ++KLKVLS
Sbjct: 203 LTKLKVLS 210
>NP_001012977
          Length = 678

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LMSKLKVLS 9
           L+SKL VLS
Sbjct: 624 LLSKLLVLS 632
>NP_001012975
          Length = 832

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LMSKLKVLS 9
           L+SKL VLS
Sbjct: 624 LLSKLLVLS 632
>NP_001158016
          Length = 662

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LMSKLKVLS 9
           L+SKL VLS
Sbjct: 624 LLSKLLVLS 632
>NP_001158014
          Length = 681

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LMSKLKVLS 9
           L+SKL VLS
Sbjct: 624 LLSKLLVLS 632
>NP_001158013
          Length = 695

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LMSKLKVLS 9
           L+SKL VLS
Sbjct: 624 LLSKLLVLS 632
>NP_001158012
          Length = 732

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LMSKLKVLS 9
           L+SKL VLS
Sbjct: 502 LLSKLLVLS 510
>NP_001158011
          Length = 755

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LMSKLKVLS 9
           L+SKL VLS
Sbjct: 624 LLSKLLVLS 632
>NP_001158010
          Length = 803

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LMSKLKVLS 9
           L+SKL VLS
Sbjct: 624 LLSKLLVLS 632
>NP_061132
          Length = 854

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LMSKLKVLS 9
           L+SKL VLS
Sbjct: 624 LLSKLLVLS 632
>NP_001158009
          Length = 886

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LMSKLKVLS 9
           L+SKL VLS
Sbjct: 656 LLSKLLVLS 664
>XP_005251905
          Length = 1226

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2 MSKLKVL 8
         MSKLKV+
Sbjct: 1 MSKLKVI 7
>XP_005251904
          Length = 1226

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2 MSKLKVL 8
         MSKLKV+
Sbjct: 1 MSKLKVI 7
>XP_006714104
          Length = 832

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LMSKLKVLS 9
           LMS+LK+++
Sbjct: 666 LMSELKIMT 674
>XP_005265800
          Length = 1089

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LMSKLKVLS 9
           LMS+LK+++
Sbjct: 641 LMSELKIMT 649
>XP_006714103
          Length = 1111

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LMSKLKVLS 9
           LMS+LK+++
Sbjct: 663 LMSELKIMT 671
>XP_006714102
          Length = 1114

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LMSKLKVLS 9
           LMS+LK+++
Sbjct: 666 LMSELKIMT 674
>NP_061735
          Length = 931

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LMSKLKVL 8
           LM+K+KVL
Sbjct: 327 LMAKVKVL 334
>NP_114382
          Length = 823

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LMSKLKVL 8
           LM+K+KVL
Sbjct: 327 LMAKVKVL 334
>NP_002733
          Length = 912

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LMSKLKV 7
           LMSK+KV
Sbjct: 263 LMSKVKV 269
>NP_002431
          Length = 936

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LMSKLKVLS 9
           +++KLK+LS
Sbjct: 197 VITKLKILS 205
>XP_005267916
          Length = 920

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LMSKLKV 7
           LMSK+KV
Sbjct: 271 LMSKVKV 277
>XP_006718567
          Length = 255

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LMSKLKVLS 9
           LMS+ K+LS
Sbjct: 216 LMSRNKILS 224
>NP_001032302
          Length = 216

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LMSKLKVLS 9
           LMS+ K+LS
Sbjct: 177 LMSRNKILS 185
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.320    0.130    0.286 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 268,859
Number of extensions: 375
Number of successful extensions: 41
Number of sequences better than 10000.0: 41
Number of HSP's gapped: 41
Number of HSP's successfully gapped: 41
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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