Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              18    1935
XP_005271621                                                           18    1935
XP_006718907                                                           18    1935
XP_006718906                                                           18    1935
XP_005271619                                                           18    1935
XP_005271618                                                           18    1935
NP_998773                                                              17    3301
NP_001276627                                                           15    9605
NP_001122087                                                           15    9605
NP_062455                                                              15    9605
NP_001122088                                                           15    9605
NP_003715                                                              15    9605
NP_001070995                                                           15    9605
NP_001266281                                                           15    9605
NP_055568                                                              15    9605
NP_001104517                                                           15    9605
NP_001104516                                                           15    9605
NP_001104515                                                           15    9605
XP_005271906                                                           15    9605
XP_006718144                                                           15    9605
XP_005271905                                                           15    9605
XP_005271903                                                           15    9605
XP_006716742                                                           15    9605
XP_006716741                                                           15    9605
XP_006716740                                                           15    9605
XP_005265245                                                           15    9605
XP_005265244                                                           15    9605
XP_005265243                                                           15    9605
NP_003905                                                              15    9605
>NP_000042
          Length = 3056

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LMLIDSSRL 9
           LMLIDSS L
Sbjct: 928 LMLIDSSTL 936
>XP_005271621
          Length = 2708

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LMLIDSSRL 9
           LMLIDSS L
Sbjct: 580 LMLIDSSTL 588
>XP_006718907
          Length = 3050

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LMLIDSSRL 9
           LMLIDSS L
Sbjct: 928 LMLIDSSTL 936
>XP_006718906
          Length = 3056

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LMLIDSSRL 9
           LMLIDSS L
Sbjct: 928 LMLIDSSTL 936
>XP_005271619
          Length = 3056

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LMLIDSSRL 9
           LMLIDSS L
Sbjct: 928 LMLIDSSTL 936
>XP_005271618
          Length = 3056

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LMLIDSSRL 9
           LMLIDSS L
Sbjct: 928 LMLIDSSTL 936
>NP_998773
          Length = 117

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2 MLIDSSRL 9
         M+IDSSR+
Sbjct: 1 MIIDSSRI 8
>NP_001276627
          Length = 532

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LIDSSRL 9
           LIDSSR+
Sbjct: 334 LIDSSRV 340
>NP_001122087
          Length = 558

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LIDSSRL 9
           LIDSSR+
Sbjct: 360 LIDSSRV 366
>NP_062455
          Length = 526

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LIDSSRL 9
           LIDSSR+
Sbjct: 328 LIDSSRV 334
>NP_001122088
          Length = 532

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LIDSSRL 9
           LIDSSR+
Sbjct: 334 LIDSSRV 340
>NP_003715
          Length = 568

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LMLIDSSR 8
           ++L+DSSR
Sbjct: 295 VLLLDSSR 302
>NP_001070995
          Length = 556

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LMLIDSSR 8
           ++L+DSSR
Sbjct: 295 VLLLDSSR 302
>NP_001266281
          Length = 556

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LMLIDSSR 8
           ++L+DSSR
Sbjct: 295 VLLLDSSR 302
>NP_055568
          Length = 1282

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LMLIDSS 7
           LMLID+S
Sbjct: 151 LMLIDAS 157
>NP_001104517
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   MLIDSSRL 9
           ML+DSS L
Sbjct: 141 MLVDSSLL 148
>NP_001104516
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   MLIDSSRL 9
           ML+DSS L
Sbjct: 141 MLVDSSLL 148
>NP_001104515
          Length = 464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   MLIDSSRL 9
           ML+DSS L
Sbjct: 184 MLVDSSLL 191
>XP_005271906
          Length = 879

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LMLIDSS 7
           LMLID+S
Sbjct: 151 LMLIDAS 157
>XP_006718144
          Length = 886

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LMLIDSS 7
           LMLID+S
Sbjct: 151 LMLIDAS 157
>XP_005271905
          Length = 1219

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LMLIDSS 7
           LMLID+S
Sbjct: 151 LMLIDAS 157
>XP_005271903
          Length = 1282

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LMLIDSS 7
           LMLID+S
Sbjct: 151 LMLIDAS 157
>XP_006716742
          Length = 556

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LMLIDSSR 8
           ++L+DSSR
Sbjct: 295 VLLLDSSR 302
>XP_006716741
          Length = 568

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LMLIDSSR 8
           ++L+DSSR
Sbjct: 295 VLLLDSSR 302
>XP_006716740
          Length = 568

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LMLIDSSR 8
           ++L+DSSR
Sbjct: 295 VLLLDSSR 302
>XP_005265245
          Length = 538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LIDSSRL 9
           LIDSSR+
Sbjct: 340 LIDSSRV 346
>XP_005265244
          Length = 558

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LIDSSRL 9
           LIDSSR+
Sbjct: 360 LIDSSRV 366
>XP_005265243
          Length = 558

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LIDSSRL 9
           LIDSSR+
Sbjct: 360 LIDSSRV 366
>NP_003905
          Length = 465

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   MLIDSSRL 9
           ML+DSS L
Sbjct: 185 MLVDSSLL 192
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.333    0.145    0.347 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 293,414
Number of extensions: 198
Number of successful extensions: 29
Number of sequences better than 10000.0: 29
Number of HSP's gapped: 29
Number of HSP's successfully gapped: 29
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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