Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              21     175
XP_005271621                                                           21     175
XP_006718907                                                           21     175
XP_006718906                                                           21     175
XP_005271619                                                           21     175
XP_005271618                                                           21     175
NP_079279                                                              18    1935
NP_065920                                                              18    1935
NP_036335                                                              17    4312
XP_005251688                                                           17    4312
NP_036423                                                              16    5631
NP_001258652                                                           16    5631
NP_110420                                                              16    5631
XP_006719768                                                           16    5631
XP_006714860                                                           16    5631
XP_006714859                                                           16    5631
XP_005268570                                                           16    5631
NP_579875                                                              16    7355
NP_758847                                                              16    7355
NP_036415                                                              16    7355
NP_775871                                                              16    7355
NP_001121636                                                           15    9605
NP_000323                                                              15    9605
NP_000748                                                              15    9605
NP_757350                                                              15    9605
NP_757351                                                              15    9605
NP_757349                                                              15    9605
NP_001095139                                                           15    9605
NP_003857                                                              15    9605
XP_006726395                                                           15    9605
XP_005263382                                                           15    9605
XP_005263381                                                           15    9605
XP_006714466                                                           15    9605
XP_005263380                                                           15    9605
XP_006714465                                                           15    9605
XP_005263379                                                           15    9605
XP_006714464                                                           15    9605
XP_006714463                                                           15    9605
>NP_000042
          Length = 3056

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LLSLTMKNC 9
           L+SLTMKNC
Sbjct: 612 LVSLTMKNC 620
>XP_005271621
          Length = 2708

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LLSLTMKNC 9
           L+SLTMKNC
Sbjct: 264 LVSLTMKNC 272
>XP_006718907
          Length = 3050

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LLSLTMKNC 9
           L+SLTMKNC
Sbjct: 612 LVSLTMKNC 620
>XP_006718906
          Length = 3056

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LLSLTMKNC 9
           L+SLTMKNC
Sbjct: 612 LVSLTMKNC 620
>XP_005271619
          Length = 3056

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LLSLTMKNC 9
           L+SLTMKNC
Sbjct: 612 LVSLTMKNC 620
>XP_005271618
          Length = 3056

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LLSLTMKNC 9
           L+SLTMKNC
Sbjct: 612 LVSLTMKNC 620
>NP_079279
          Length = 1910

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LSLTMKNC 9
            +SLT KNC
Sbjct: 1576 ISLTSKNC 1583
>NP_065920
          Length = 890

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LLSLTMKNC 9
           LLSL MK C
Sbjct: 494 LLSLRMKTC 502
>NP_036335
          Length = 328

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LTMKNC 9
           LT+KNC
Sbjct: 283 LTLKNC 288
>XP_005251688
          Length = 221

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LTMKNC 9
           LT+KNC
Sbjct: 176 LTLKNC 181
>NP_036423
          Length = 2120

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LLSLTMKNC 9
           LL LT+++C
Sbjct: 251 LLELTLEHC 259
>NP_001258652
          Length = 943

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LLSLTMKNC 9
           L+ +TM NC
Sbjct: 682 LVGVTMTNC 690
>NP_110420
          Length = 1113

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LLSLTMKNC 9
           L+ +TM NC
Sbjct: 852 LVGVTMTNC 860
>XP_006719768
          Length = 2120

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LLSLTMKNC 9
           LL LT+++C
Sbjct: 251 LLELTLEHC 259
>XP_006714860
          Length = 1146

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LLSLTMKNC 9
           L+ +TM NC
Sbjct: 885 LVGVTMTNC 893
>XP_006714859
          Length = 1188

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LLSLTMKNC 9
           L+ +TM NC
Sbjct: 927 LVGVTMTNC 935
>XP_005268570
          Length = 1188

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LLSLTMKNC 9
           L+ +TM NC
Sbjct: 927 LVGVTMTNC 935
>NP_579875
          Length = 436

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LSLTMKNC 9
           L LT+K C
Sbjct: 312 LGLTLKRC 319
>NP_758847
          Length = 425

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LSLTMKNC 9
           L LT+K C
Sbjct: 301 LGLTLKRC 308
>NP_036415
          Length = 466

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LSLTMKNC 9
           L LTM+ C
Sbjct: 311 LGLTMRRC 318
>NP_775871
          Length = 8384

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    LSLTMKNC 9
            + LT++NC
Sbjct: 1169 IDLTLQNC 1176
>NP_001121636
          Length = 815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LSLTMKN 8
           +SLT+KN
Sbjct: 683 ISLTLKN 689
>NP_000323
          Length = 815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LSLTMKN 8
           +SLT+KN
Sbjct: 683 ISLTLKN 689
>NP_000748
          Length = 554

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LSLTMKNC 9
           LSL +K+C
Sbjct: 115 LSLRLKSC 122
>NP_757350
          Length = 256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LSLTMKNC 9
           LSL +K+C
Sbjct: 115 LSLRLKSC 122
>NP_757351
          Length = 554

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LSLTMKNC 9
           LSL +K+C
Sbjct: 115 LSLRLKSC 122
>NP_757349
          Length = 438

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LSLTMKNC 9
           LSL +K+C
Sbjct: 115 LSLRLKSC 122
>NP_001095139
          Length = 924

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LSLTMKNC 9
           L LT+K+C
Sbjct: 583 LILTLKDC 590
>NP_003857
          Length = 924

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LSLTMKNC 9
           L LT+K+C
Sbjct: 583 LILTLKDC 590
>XP_006726395
          Length = 477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  LLSLTMKNC 9
          L +LT+K+C
Sbjct: 42 LETLTLKDC 50
>XP_005263382
          Length = 753

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LSLTMKNC 9
           L LT+K+C
Sbjct: 398 LILTLKDC 405
>XP_005263381
          Length = 762

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LSLTMKNC 9
           L LT+K+C
Sbjct: 407 LILTLKDC 414
>XP_006714466
          Length = 762

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LSLTMKNC 9
           L LT+K+C
Sbjct: 407 LILTLKDC 414
>XP_005263380
          Length = 809

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LSLTMKNC 9
           L LT+K+C
Sbjct: 454 LILTLKDC 461
>XP_006714465
          Length = 924

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LSLTMKNC 9
           L LT+K+C
Sbjct: 583 LILTLKDC 590
>XP_005263379
          Length = 933

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LSLTMKNC 9
           L LT+K+C
Sbjct: 592 LILTLKDC 599
>XP_006714464
          Length = 938

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LSLTMKNC 9
           L LT+K+C
Sbjct: 583 LILTLKDC 590
>XP_006714463
          Length = 947

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LSLTMKNC 9
           L LT+K+C
Sbjct: 592 LILTLKDC 599
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.329    0.132    0.394 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 383,520
Number of extensions: 473
Number of successful extensions: 38
Number of sequences better than 10000.0: 38
Number of HSP's gapped: 38
Number of HSP's successfully gapped: 38
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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