Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004295                                                              20     509
NP_000095                                                              17    4312
NP_848563                                                              17    4312
NP_653081                                                              17    4312
NP_055650                                                              17    4312
NP_060500                                                              17    4312
NP_001229437                                                           17    4312
NP_542164                                                              17    4312
NP_001265578                                                           17    4312
XP_006722445                                                           17    4312
XP_006722443                                                           17    4312
NP_862829                                                              16    5631
NP_848552                                                              16    5631
XP_005260332                                                           16    5631
XP_005260331                                                           16    5631
XP_005260330                                                           16    5631
XP_006723761                                                           16    5631
XP_005260329                                                           16    5631
XP_006723255                                                           16    5631
XP_006723254                                                           16    5631
XP_006723253                                                           16    5631
NP_005480                                                              16    7355
NP_001239263                                                           16    7355
NP_001136004                                                           16    7355
NP_001136005                                                           16    7355
NP_733745                                                              16    7355
NP_001136003                                                           16    7355
NP_001136006                                                           16    7355
NP_001164638                                                           16    7355
NP_055670                                                              16    7355
XP_005251694                                                           16    7355
XP_005251696                                                           16    7355
NP_659440                                                              15    9605
NP_001177369                                                           15    9605
NP_006302                                                              15    9605
NP_079368                                                              15    9605
NP_001013725                                                           15    9605
NP_114147                                                              15    9605
XP_005260150                                                           15    9605
XP_005256932                                                           15    9605
XP_006721667                                                           15    9605
XP_005256931                                                           15    9605
XP_005256930                                                           15    9605
XP_006721666                                                           15    9605
XP_005256929                                                           15    9605
XP_005256928                                                           15    9605
XP_006721665                                                           15    9605
XP_005256925                                                           15    9605
XP_005256924                                                           15    9605
XP_006721664                                                           15    9605
XP_005256923                                                           15    9605
XP_005254450                                                           15    9605
XP_005254449                                                           15    9605
XP_006718399                                                           15    9605
XP_006718398                                                           15    9605
XP_006718397                                                           15    9605
XP_006718396                                                           15    9605
XP_006718395                                                           15    9605
XP_006718394                                                           15    9605
XP_006718393                                                           15    9605
>NP_004295
          Length = 1620

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LLSHNEAAR 9
           LL HNEAAR
Sbjct: 365 LLPHNEAAR 373
>NP_000095
          Length = 543

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LLSHNE 6
           LLSHNE
Sbjct: 224 LLSHNE 229
>NP_848563
          Length = 747

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LLSHNEAAR 9
          +L H+EAAR
Sbjct: 38 VLRHSEAAR 46
>NP_653081
          Length = 480

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LLSHNEA 7
           LL HNEA
Sbjct: 223 LLKHNEA 229
>NP_055650
          Length = 468

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LLSHNEA 7
           LL HNEA
Sbjct: 211 LLKHNEA 217
>NP_060500
          Length = 437

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LLSHNEA 7
           LL HNEA
Sbjct: 183 LLEHNEA 189
>NP_001229437
          Length = 568

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LLSHNEA 7
           LL HNEA
Sbjct: 314 LLEHNEA 320
>NP_542164
          Length = 950

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LLSHNEA 7
           LL HNEA
Sbjct: 696 LLEHNEA 702
>NP_001265578
          Length = 370

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LLSHNEA 7
           LL HNEA
Sbjct: 131 LLKHNEA 137
>XP_006722445
          Length = 905

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LLSHNEA 7
           LL HNEA
Sbjct: 651 LLEHNEA 657
>XP_006722443
          Length = 925

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LLSHNEA 7
           LL HNEA
Sbjct: 671 LLEHNEA 677
>NP_862829
          Length = 491

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  LSHNEAAR 9
          ++H+EAAR
Sbjct: 42 IAHSEAAR 49
>NP_848552
          Length = 1677

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LLSHNEA 7
           L+SHN+A
Sbjct: 411 LISHNQA 417
>XP_005260332
          Length = 1256

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LLSHNEA 7
           L+SHN+A
Sbjct: 411 LISHNQA 417
>XP_005260331
          Length = 1677

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LLSHNEA 7
           L+SHN+A
Sbjct: 411 LISHNQA 417
>XP_005260330
          Length = 1677

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LLSHNEA 7
           L+SHN+A
Sbjct: 411 LISHNQA 417
>XP_006723761
          Length = 1677

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LLSHNEA 7
           L+SHN+A
Sbjct: 411 LISHNQA 417
>XP_005260329
          Length = 1677

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LLSHNEA 7
           L+SHN+A
Sbjct: 411 LISHNQA 417
>XP_006723255
          Length = 491

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  LSHNEAAR 9
          ++H+EAAR
Sbjct: 42 IAHSEAAR 49
>XP_006723254
          Length = 491

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  LSHNEAAR 9
          ++H+EAAR
Sbjct: 42 IAHSEAAR 49
>XP_006723253
          Length = 491

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  LSHNEAAR 9
          ++H+EAAR
Sbjct: 42 IAHSEAAR 49
>NP_005480
          Length = 703

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LLSHNEAAR 9
           +L+H EAAR
Sbjct: 619 VLAHLEAAR 627
>NP_001239263
          Length = 792

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LLSHNEAAR 9
           +L+H EAAR
Sbjct: 708 VLAHLEAAR 716
>NP_001136004
          Length = 506

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LLSHNEAAR 9
           +L+H EAAR
Sbjct: 422 VLAHLEAAR 430
>NP_001136005
          Length = 702

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LLSHNEAAR 9
           +L+H EAAR
Sbjct: 618 VLAHLEAAR 626
>NP_733745
          Length = 860

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LLSHNEAAR 9
           +L+H EAAR
Sbjct: 776 VLAHLEAAR 784
>NP_001136003
          Length = 506

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LLSHNEAAR 9
           +L+H EAAR
Sbjct: 422 VLAHLEAAR 430
>NP_001136006
          Length = 700

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LLSHNEAAR 9
           +L+H EAAR
Sbjct: 616 VLAHLEAAR 624
>NP_001164638
          Length = 1241

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    LLSHNEA 7
            LLSH EA
Sbjct: 1181 LLSHQEA 1187
>NP_055670
          Length = 807

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LSHNEAA 8
           LSH EAA
Sbjct: 375 LSHGEAA 381
>XP_005251694
          Length = 822

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LLSHNEAAR 9
           +L+H EAAR
Sbjct: 738 VLAHLEAAR 746
>XP_005251696
          Length = 506

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LLSHNEAAR 9
           +L+H EAAR
Sbjct: 422 VLAHLEAAR 430
>NP_659440
          Length = 513

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SHNEAAR 9
           SH EAAR
Sbjct: 466 SHAEAAR 472
>NP_001177369
          Length = 2337

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LLSHNEAA 8
            L SHN+A+
Sbjct: 1082 LTSHNQAS 1089
>NP_006302
          Length = 2440

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LLSHNEAA 8
            L SHN+A+
Sbjct: 1066 LTSHNQAS 1073
>NP_079368
          Length = 737

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLSHNEAAR 9
           L+ H EAAR
Sbjct: 311 LMFHPEAAR 319
>NP_001013725
          Length = 1649

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    LLSHNEAA 8
            +  HNEAA
Sbjct: 1095 IYEHNEAA 1102
>NP_114147
          Length = 703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LSHNEA 7
           LSHN+A
Sbjct: 231 LSHNQA 236
>XP_005260150
          Length = 703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LSHNEA 7
           LSHN+A
Sbjct: 231 LSHNQA 236
>XP_005256932
          Length = 2448

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LLSHNEAA 8
            L SHN+A+
Sbjct: 1150 LTSHNQAS 1157
>XP_006721667
          Length = 2456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LLSHNEAA 8
            L SHN+A+
Sbjct: 1082 LTSHNQAS 1089
>XP_005256931
          Length = 2466

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LLSHNEAA 8
            L SHN+A+
Sbjct: 1092 LTSHNQAS 1099
>XP_005256930
          Length = 2508

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LLSHNEAA 8
            L SHN+A+
Sbjct: 1134 LTSHNQAS 1141
>XP_006721666
          Length = 2511

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LLSHNEAA 8
            L SHN+A+
Sbjct: 1150 LTSHNQAS 1157
>XP_005256929
          Length = 2514

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LLSHNEAA 8
            L SHN+A+
Sbjct: 1140 LTSHNQAS 1147
>XP_005256928
          Length = 2515

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LLSHNEAA 8
            L SHN+A+
Sbjct: 1141 LTSHNQAS 1148
>XP_006721665
          Length = 2523

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LLSHNEAA 8
            L SHN+A+
Sbjct: 1149 LTSHNQAS 1156
>XP_005256925
          Length = 2523

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LLSHNEAA 8
            L SHN+A+
Sbjct: 1149 LTSHNQAS 1156
>XP_005256924
          Length = 2524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LLSHNEAA 8
            L SHN+A+
Sbjct: 1150 LTSHNQAS 1157
>XP_006721664
          Length = 2524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LLSHNEAA 8
            L SHN+A+
Sbjct: 1150 LTSHNQAS 1157
>XP_005256923
          Length = 2524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LLSHNEAA 8
            L SHN+A+
Sbjct: 1150 LTSHNQAS 1157
>XP_005254450
          Length = 1505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    LLSHNEAA 8
            +  HNEAA
Sbjct: 1095 IYEHNEAA 1102
>XP_005254449
          Length = 1626

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    LLSHNEAA 8
            +  HNEAA
Sbjct: 1095 IYEHNEAA 1102
>XP_006718399
          Length = 487

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LLSHNEAAR 9
          L+ H EAAR
Sbjct: 6  LMFHPEAAR 14
>XP_006718398
          Length = 557

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLSHNEAAR 9
           L+ H EAAR
Sbjct: 311 LMFHPEAAR 319
>XP_006718397
          Length = 737

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLSHNEAAR 9
           L+ H EAAR
Sbjct: 311 LMFHPEAAR 319
>XP_006718396
          Length = 774

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLSHNEAAR 9
           L+ H EAAR
Sbjct: 311 LMFHPEAAR 319
>XP_006718395
          Length = 792

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLSHNEAAR 9
           L+ H EAAR
Sbjct: 311 LMFHPEAAR 319
>XP_006718394
          Length = 792

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLSHNEAAR 9
           L+ H EAAR
Sbjct: 311 LMFHPEAAR 319
>XP_006718393
          Length = 792

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLSHNEAAR 9
           L+ H EAAR
Sbjct: 311 LMFHPEAAR 319
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.313    0.120    0.315 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 498,501
Number of extensions: 404
Number of successful extensions: 60
Number of sequences better than 10000.0: 60
Number of HSP's gapped: 60
Number of HSP's successfully gapped: 60
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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