Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001013433                                                           20     299
NP_060785                                                              20     299
NP_361014                                                              20     299
NP_060149                                                              17    3301
NP_001092902                                                           17    3301
XP_005257534                                                           17    3301
XP_005257533                                                           17    3301
XP_005257532                                                           17    3301
XP_005257531                                                           17    3301
XP_005257530                                                           17    3301
XP_005257529                                                           17    3301
NP_872311                                                              17    4312
NP_001494                                                              17    4312
NP_848593                                                              17    4312
NP_001273385                                                           17    4312
XP_006718220                                                           17    4312
XP_006718219                                                           17    4312
XP_006718218                                                           17    4312
XP_005249342                                                           17    4312
XP_005249075                                                           17    4312
NP_056297                                                              17    4312
NP_001006619                                                           16    5631
NP_001006618                                                           16    5631
NP_001006620                                                           16    5631
NP_077022                                                              16    5631
NP_005779                                                              16    5631
NP_075067                                                              16    5631
NP_001138639                                                           16    5631
NP_001138638                                                           16    5631
XP_005252787                                                           16    5631
NP_005474                                                              16    7355
NP_004563                                                              16    7355
NP_001005242                                                           16    7355
NP_031374                                                              16    7355
NP_001276077                                                           16    7355
NP_001276078                                                           16    7355
NP_061138                                                              16    7355
XP_005254945                                                           16    7355
XP_005254944                                                           16    7355
XP_006711287                                                           16    7355
NP_079023                                                              15    9605
NP_001783                                                              15    9605
NP_000785                                                              15    9605
NP_001248762                                                           15    9605
NP_003763                                                              15    9605
NP_003646                                                              15    9605
NP_001078823                                                           15    9605
NP_001106853                                                           15    9605
NP_078933                                                              15    9605
NP_003326                                                              15    9605
NP_060687                                                              15    9605
NP_001363                                                              15    9605
NP_001075                                                              15    9605
NP_001157968                                                           15    9605
XP_006724755                                                           15    9605
XP_006724754                                                           15    9605
XP_005262247                                                           15    9605
XP_005258239                                                           15    9605
XP_005258238                                                           15    9605
XP_006721530                                                           15    9605
XP_006721529                                                           15    9605
XP_006721528                                                           15    9605
XP_005247674                                                           15    9605
XP_006713762                                                           15    9605
XP_006713761                                                           15    9605
XP_006713760                                                           15    9605
XP_006713759                                                           15    9605
XP_005265487                                                           15    9605
XP_006713384                                                           15    9605
XP_006712889                                                           15    9605
NP_001138497                                                           15    9605
NP_699207                                                              15    9605
>NP_001013433
          Length = 589

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LLLLDFDVD 9
           LL+LDFDVD
Sbjct: 579 LLVLDFDVD 587
>NP_060785
          Length = 627

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LLLLDFDVD 9
           LL+LDFDVD
Sbjct: 617 LLVLDFDVD 625
>NP_361014
          Length = 707

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LLLLDFDVD 9
           LL+LDFDVD
Sbjct: 697 LLVLDFDVD 705
>NP_060149
          Length = 913

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LLDFDVD 9
           LLDFD D
Sbjct: 762 LLDFDTD 768
>NP_001092902
          Length = 928

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LLDFDVD 9
           LLDFD D
Sbjct: 777 LLDFDTD 783
>XP_005257534
          Length = 831

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LLDFDVD 9
           LLDFD D
Sbjct: 777 LLDFDTD 783
>XP_005257533
          Length = 835

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LLDFDVD 9
           LLDFD D
Sbjct: 777 LLDFDTD 783
>XP_005257532
          Length = 928

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LLDFDVD 9
           LLDFD D
Sbjct: 762 LLDFDTD 768
>XP_005257531
          Length = 935

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LLDFDVD 9
           LLDFD D
Sbjct: 762 LLDFDTD 768
>XP_005257530
          Length = 943

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LLDFDVD 9
           LLDFD D
Sbjct: 777 LLDFDTD 783
>XP_005257529
          Length = 950

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LLDFDVD 9
           LLDFD D
Sbjct: 777 LLDFDTD 783
>NP_872311
          Length = 157

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LDFDVD 9
           LDFD+D
Sbjct: 141 LDFDID 146
>NP_001494
          Length = 840

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LLLLDFDVD 9
           L +LDF+VD
Sbjct: 454 LAVLDFNVD 462
>NP_848593
          Length = 618

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLLLDFDVD 9
           L + DFDVD
Sbjct: 223 LHIFDFDVD 231
>NP_001273385
          Length = 361

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  LLLLDFD 7
          LLLLD+D
Sbjct: 75 LLLLDYD 81
>XP_006718220
          Length = 391

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLLLDFDVD 9
           L + DFDVD
Sbjct: 223 LHIFDFDVD 231
>XP_006718219
          Length = 417

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLLLDFDVD 9
           L + DFDVD
Sbjct: 223 LHIFDFDVD 231
>XP_006718218
          Length = 507

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLLLDFDVD 9
           L + DFDVD
Sbjct: 112 LHIFDFDVD 120
>XP_005249342
          Length = 694

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  LLLLDFD 7
          LLLLD+D
Sbjct: 75 LLLLDYD 81
>XP_005249075
          Length = 677

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LLLLDFDVD 9
           L +LDF+VD
Sbjct: 291 LAVLDFNVD 299
>NP_056297
          Length = 686

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  LLLLDFD 7
          LLLLD+D
Sbjct: 75 LLLLDYD 81
>NP_001006619
          Length = 323

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  LLLLDFDVD 9
          ++L+D DVD
Sbjct: 29 MVLIDHDVD 37
>NP_001006618
          Length = 522

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  LLLLDFDVD 9
          ++L+D DVD
Sbjct: 29 MVLIDHDVD 37
>NP_001006620
          Length = 475

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  LLLLDFDVD 9
          ++L+D DVD
Sbjct: 29 MVLIDHDVD 37
>NP_077022
          Length = 486

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  LLLLDFDVD 9
          ++L+D DVD
Sbjct: 29 MVLIDHDVD 37
>NP_005779
          Length = 531

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LLLDFDVD 9
           LLL FDV+
Sbjct: 129 LLLQFDVE 136
>NP_075067
          Length = 596

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LLLLDFDVD 9
           LLLLD +VD
Sbjct: 227 LLLLDRNVD 235
>NP_001138639
          Length = 454

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  LLLDFDVD 9
          LLL FDV+
Sbjct: 52 LLLQFDVE 59
>NP_001138638
          Length = 469

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  LLLDFDVD 9
          LLL FDV+
Sbjct: 67 LLLQFDVE 74
>XP_005252787
          Length = 498

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LLLDFDVD 9
           LLL FDV+
Sbjct: 96  LLLQFDVE 103
>NP_005474
          Length = 956

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LLDFDVD 9
           LLD++VD
Sbjct: 593 LLDYEVD 599
>NP_004563
          Length = 881

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   LLDFDV 8
           LLDFD+
Sbjct: 549 LLDFDI 554
>NP_001005242
          Length = 837

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   LLDFDV 8
           LLDFD+
Sbjct: 505 LLDFDI 510
>NP_031374
          Length = 670

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  LDFDVD 9
          LDFD+D
Sbjct: 60 LDFDLD 65
>NP_001276077
          Length = 590

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLLLDFDVD 9
           + LLD DVD
Sbjct: 201 IFLLDRDVD 209
>NP_001276078
          Length = 526

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLLLDFDVD 9
           + LLD DVD
Sbjct: 137 IFLLDRDVD 145
>NP_061138
          Length = 617

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLLLDFDVD 9
           + LLD DVD
Sbjct: 228 IFLLDRDVD 236
>XP_005254945
          Length = 386

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLLLDFDVD 9
           + LLD DVD
Sbjct: 228 IFLLDRDVD 236
>XP_005254944
          Length = 526

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLLLDFDVD 9
           + LLD DVD
Sbjct: 137 IFLLDRDVD 145
>XP_006711287
          Length = 669

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  LDFDVD 9
          LDFD+D
Sbjct: 60 LDFDLD 65
>NP_079023
          Length = 775

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LLLLDF 6
           LLLLDF
Sbjct: 280 LLLLDF 285
>NP_001783
          Length = 906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   LDFDVD 9
           LD+D+D
Sbjct: 626 LDYDID 631
>NP_000785
          Length = 446

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   LLLDFDVD 9
           ++LD+D D
Sbjct: 422 VILDYDTD 429
>NP_001248762
          Length = 524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LDFDVD 9
           LDFDV+
Sbjct: 398 LDFDVE 403
>NP_003763
          Length = 524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LDFDVD 9
           LDFDV+
Sbjct: 398 LDFDVE 403
>NP_003646
          Length = 560

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LLLLDFDVD 9
           ++LLD D+D
Sbjct: 462 VILLDSDLD 470
>NP_001078823
          Length = 900

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   LDFDVD 9
           LDFD D
Sbjct: 233 LDFDTD 238
>NP_001106853
          Length = 2093

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LLLDFDVD 9
           LLLD D++
Sbjct: 838 LLLDIDIN 845
>NP_078933
          Length = 937

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   LDFDVD 9
           LDFD D
Sbjct: 233 LDFDTD 238
>NP_003326
          Length = 1012

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LLLDFDV 8
           LLLDF V
Sbjct: 115 LLLDFQV 121
>NP_060687
          Length = 578

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   LDFDVD 9
           +DFD+D
Sbjct: 105 VDFDID 110
>NP_001363
          Length = 4486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LLLDFDVD 9
            +LLD D+D
Sbjct: 2224 ILLDGDID 2231
>NP_001075
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLLLDFDVD 9
           LLLLD+  D
Sbjct: 318 LLLLDYPPD 326
>NP_001157968
          Length = 1854

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   DFDVD 9
           DFDVD
Sbjct: 979 DFDVD 983
>XP_006724755
          Length = 532

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   LDFDVD 9
           LDFD D
Sbjct: 233 LDFDTD 238
>XP_006724754
          Length = 815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   LDFDVD 9
           LDFD D
Sbjct: 111 LDFDTD 116
>XP_005262247
          Length = 845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   LDFDVD 9
           LDFD D
Sbjct: 141 LDFDTD 146
>XP_005258239
          Length = 875

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   LDFDVD 9
           LD+D+D
Sbjct: 595 LDYDID 600
>XP_005258238
          Length = 888

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   LDFDVD 9
           LD+D+D
Sbjct: 608 LDYDID 613
>XP_006721530
          Length = 2746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LLLDFDVD 9
            +LLD D+D
Sbjct: 2224 ILLDGDID 2231
>XP_006721529
          Length = 2817

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LLLDFDVD 9
            +LLD D+D
Sbjct: 2224 ILLDGDID 2231
>XP_006721528
          Length = 3869

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LLLDFDVD 9
            +LLD D+D
Sbjct: 2224 ILLDGDID 2231
>XP_005247674
          Length = 1089

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   DFDVD 9
           DFDVD
Sbjct: 214 DFDVD 218
>XP_006713762
          Length = 1197

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5    DFDVD 9
            DFDVD
Sbjct: 1023 DFDVD 1027
>XP_006713761
          Length = 1554

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   DFDVD 9
           DFDVD
Sbjct: 679 DFDVD 683
>XP_006713760
          Length = 1847

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   DFDVD 9
           DFDVD
Sbjct: 972 DFDVD 976
>XP_006713759
          Length = 1898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5    DFDVD 9
            DFDVD
Sbjct: 1023 DFDVD 1027
>XP_005265487
          Length = 987

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LLLDFDV 8
           LLLDF V
Sbjct: 115 LLLDFQV 121
>XP_006713384
          Length = 1005

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LLLDFDV 8
           LLLDF V
Sbjct: 115 LLLDFQV 121
>XP_006712889
          Length = 2069

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LLLDFDVD 9
           LLLD D++
Sbjct: 855 LLLDIDIN 862
>NP_001138497
          Length = 541

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4  LDFDVD 9
          +DFD+D
Sbjct: 68 VDFDID 73
>NP_699207
          Length = 555

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LLLLDFD 7
           LLL+DF+
Sbjct: 403 LLLIDFE 409
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.338    0.169    0.478 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 547,347
Number of extensions: 846
Number of successful extensions: 72
Number of sequences better than 10000.0: 72
Number of HSP's gapped: 72
Number of HSP's successfully gapped: 72
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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