Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001001557                                                           18    1935
NP_009089                                                              17    3301
NP_001007554                                                           17    3301
NP_001229820                                                           17    3301
NP_001123995                                                           17    3301
NP_001229822                                                           17    3301
NP_001229821                                                           17    3301
NP_004806                                                              17    4312
XP_006711111                                                           17    4312
NP_000446                                                              16    5631
NP_003480                                                              16    5631
XP_006724117                                                           16    5631
XP_005261123                                                           16    5631
XP_005261122                                                           16    5631
XP_005261120                                                           16    5631
XP_005259675                                                           16    5631
XP_005259674                                                           16    5631
XP_006712935                                                           16    5631
XP_006712933                                                           16    5631
NP_852118                                                              16    5631
NP_001706                                                              16    7355
NP_115532                                                              16    7355
NP_076414                                                              16    7355
NP_001002259                                                           16    7355
NP_001193785                                                           16    7355
NP_689707                                                              16    7355
NP_599152                                                              16    7355
NP_443166                                                              16    7355
NP_001265506                                                           16    7355
NP_001265507                                                           16    7355
NP_001265505                                                           16    7355
NP_001265504                                                           16    7355
NP_001137159                                                           16    7355
NP_775864                                                              16    7355
NP_001078869                                                           16    7355
NP_001078868                                                           16    7355
NP_001192202                                                           16    7355
XP_006719210                                                           16    7355
XP_006719209                                                           16    7355
XP_006719208                                                           16    7355
XP_006719207                                                           16    7355
XP_006719206                                                           16    7355
XP_006719205                                                           16    7355
XP_006719204                                                           16    7355
XP_006719203                                                           16    7355
XP_006719202                                                           16    7355
XP_006719201                                                           16    7355
XP_006719200                                                           16    7355
XP_005272447                                                           16    7355
XP_006716315                                                           16    7355
XP_006716314                                                           16    7355
XP_006716313                                                           16    7355
XP_006711207                                                           16    7355
NP_061881                                                              16    7355
NP_006556                                                              15    9605
NP_000544                                                              15    9605
NP_055453                                                              15    9605
NP_005024                                                              15    9605
NP_001029366                                                           15    9605
NP_079527                                                              15    9605
NP_055871                                                              15    9605
XP_006725014                                                           15    9605
XP_006725013                                                           15    9605
XP_006725012                                                           15    9605
XP_005255832                                                           15    9605
XP_006716724                                                           15    9605
XP_006711118                                                           15    9605
XP_006711117                                                           15    9605
NP_006733                                                              15    9605
>NP_001001557
          Length = 455

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KKSKLRC 9
           KKS+LRC
Sbjct: 348 KKSRLRC 354
>NP_009089
          Length = 767

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLKKSKLRC 9
           LLKK + RC
Sbjct: 147 LLKKKQARC 155
>NP_001007554
          Length = 798

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLKKSKLRC 9
           LLKK + RC
Sbjct: 178 LLKKKQARC 186
>NP_001229820
          Length = 844

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLKKSKLRC 9
           LLKK + RC
Sbjct: 224 LLKKKQARC 232
>NP_001123995
          Length = 813

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLKKSKLRC 9
           LLKK + RC
Sbjct: 193 LLKKKQARC 201
>NP_001229822
          Length = 767

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLKKSKLRC 9
           LLKK + RC
Sbjct: 147 LLKKKQARC 155
>NP_001229821
          Length = 798

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLKKSKLRC 9
           LLKK + RC
Sbjct: 178 LLKKKQARC 186
>NP_004806
          Length = 1261

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LKKSKLRC 9
           LKK+KL C
Sbjct: 325 LKKAKLLC 332
>XP_006711111
          Length = 1197

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LKKSKLRC 9
           LKK+KL C
Sbjct: 261 LKKAKLLC 268
>NP_000446
          Length = 433

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LLKKSKLR 8
          +LKK KLR
Sbjct: 79 ILKKKKLR 86
>NP_003480
          Length = 1158

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LLKKSKLR 8
           LLKKSK++
Sbjct: 188 LLKKSKVK 195
>XP_006724117
          Length = 1158

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LLKKSKLR 8
           LLKKSK++
Sbjct: 188 LLKKSKVK 195
>XP_005261123
          Length = 1158

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LLKKSKLR 8
           LLKKSK++
Sbjct: 188 LLKKSKVK 195
>XP_005261122
          Length = 1158

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LLKKSKLR 8
           LLKKSK++
Sbjct: 188 LLKKSKVK 195
>XP_005261120
          Length = 1158

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LLKKSKLR 8
           LLKKSK++
Sbjct: 188 LLKKSKVK 195
>XP_005259675
          Length = 404

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LLKKSKLR 8
          +LKK KLR
Sbjct: 79 ILKKKKLR 86
>XP_005259674
          Length = 600

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LLKKSKLR 8
          +LKK KLR
Sbjct: 79 ILKKKKLR 86
>XP_006712935
          Length = 977

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  LLKKSKLRC 9
          L++K+K RC
Sbjct: 43 LIQKAKSRC 51
>XP_006712933
          Length = 1687

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  LLKKSKLRC 9
          L++K+K RC
Sbjct: 43 LIQKAKSRC 51
>NP_852118
          Length = 1684

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  LLKKSKLRC 9
          L++K+K RC
Sbjct: 40 LIQKAKSRC 48
>NP_001706
          Length = 505

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LLKKSKLRC 9
           L+K  K+RC
Sbjct: 173 LIKHYKIRC 181
>NP_115532
          Length = 960

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLKKSKLRC 9
           L+K SKL C
Sbjct: 254 LIKFSKLTC 262
>NP_076414
          Length = 1077

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLKKSKLRC 9
           L+K SKL C
Sbjct: 254 LIKFSKLTC 262
>NP_001002259
          Length = 1127

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLKKSKLRC 9
           L+K SKL C
Sbjct: 254 LIKFSKLTC 262
>NP_001193785
          Length = 905

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLKKSKLRC 9
           L+K SKL C
Sbjct: 254 LIKFSKLTC 262
>NP_689707
          Length = 706

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   KSKLRC 9
           K+KLRC
Sbjct: 243 KTKLRC 248
>NP_599152
          Length = 887

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLKKSKLRC 9
           L +KSKL C
Sbjct: 455 LWRKSKLDC 463
>NP_443166
          Length = 791

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLKKSKLRC 9
           L +KSKL C
Sbjct: 455 LWRKSKLDC 463
>NP_001265506
          Length = 140

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LLKKSKLR 8
           LLKKSK R
Sbjct: 123 LLKKSKHR 130
>NP_001265507
          Length = 140

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LLKKSKLR 8
           LLKKSK R
Sbjct: 123 LLKKSKHR 130
>NP_001265505
          Length = 140

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LLKKSKLR 8
           LLKKSK R
Sbjct: 123 LLKKSKHR 130
>NP_001265504
          Length = 140

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LLKKSKLR 8
           LLKKSK R
Sbjct: 123 LLKKSKHR 130
>NP_001137159
          Length = 681

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   KSKLRC 9
           K+KLRC
Sbjct: 218 KTKLRC 223
>NP_775864
          Length = 998

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LKKSKLR 8
           LK+SKLR
Sbjct: 838 LKRSKLR 844
>NP_001078869
          Length = 271

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  LLKKSKLRC 9
          LLKK   RC
Sbjct: 80 LLKKKGYRC 88
>NP_001078868
          Length = 271

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  LLKKSKLRC 9
          LLKK   RC
Sbjct: 80 LLKKKGYRC 88
>NP_001192202
          Length = 148

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LLKKSKLR 8
           LLKKSK R
Sbjct: 131 LLKKSKHR 138
>XP_006719210
          Length = 940

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLKKSKLRC 9
           L+K SKL C
Sbjct: 254 LIKFSKLTC 262
>XP_006719209
          Length = 941

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLKKSKLRC 9
           L+K SKL C
Sbjct: 254 LIKFSKLTC 262
>XP_006719208
          Length = 961

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLKKSKLRC 9
           L+K SKL C
Sbjct: 254 LIKFSKLTC 262
>XP_006719207
          Length = 1043

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLKKSKLRC 9
           L+K SKL C
Sbjct: 254 LIKFSKLTC 262
>XP_006719206
          Length = 1046

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLKKSKLRC 9
           L+K SKL C
Sbjct: 173 LIKFSKLTC 181
>XP_006719205
          Length = 1057

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLKKSKLRC 9
           L+K SKL C
Sbjct: 254 LIKFSKLTC 262
>XP_006719204
          Length = 1078

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLKKSKLRC 9
           L+K SKL C
Sbjct: 254 LIKFSKLTC 262
>XP_006719203
          Length = 1091

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLKKSKLRC 9
           L+K SKL C
Sbjct: 254 LIKFSKLTC 262
>XP_006719202
          Length = 1092

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLKKSKLRC 9
           L+K SKL C
Sbjct: 254 LIKFSKLTC 262
>XP_006719201
          Length = 1106

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLKKSKLRC 9
           L+K SKL C
Sbjct: 254 LIKFSKLTC 262
>XP_006719200
          Length = 1126

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLKKSKLRC 9
           L+K SKL C
Sbjct: 254 LIKFSKLTC 262
>XP_005272447
          Length = 434

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LLKKSKLRC 9
           L+K  K+RC
Sbjct: 102 LIKHYKIRC 110
>XP_006716315
          Length = 442

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LLKKSKLRC 9
           L+K  K+RC
Sbjct: 173 LIKHYKIRC 181
>XP_006716314
          Length = 505

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LLKKSKLRC 9
           L+K  K+RC
Sbjct: 173 LIKHYKIRC 181
>XP_006716313
          Length = 505

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LLKKSKLRC 9
           L+K  K+RC
Sbjct: 173 LIKHYKIRC 181
>XP_006711207
          Length = 791

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLKKSKLRC 9
           L +KSKL C
Sbjct: 455 LWRKSKLDC 463
>NP_061881
          Length = 463

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LKKSKLR 8
           LKKS+LR
Sbjct: 126 LKKSRLR 132
>NP_006556
          Length = 727

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   KKSKLR 8
           KKSKLR
Sbjct: 208 KKSKLR 213
>NP_000544
          Length = 1432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   LLKKSKLRC 9
           LLK   +RC
Sbjct: 189 LLKDKSIRC 197
>NP_055453
          Length = 1416

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LLKKSKLR 8
           L+K+SK+R
Sbjct: 524 LIKESKIR 531
>NP_005024
          Length = 439

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LLKKSKLRC 9
           LLK   LRC
Sbjct: 242 LLKDQVLRC 250
>NP_001029366
          Length = 456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LLKKSKLRC 9
           LLK   LRC
Sbjct: 242 LLKDQVLRC 250
>NP_079527
          Length = 1114

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   KKSKLR 8
           KKSKLR
Sbjct: 855 KKSKLR 860
>NP_055871
          Length = 758

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LKKSKLR 8
           LKK KLR
Sbjct: 631 LKKQKLR 637
>XP_006725014
          Length = 1129

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LLKKSKLR 8
           L+K+SK+R
Sbjct: 497 LIKESKIR 504
>XP_006725013
          Length = 1389

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LLKKSKLR 8
           L+K+SK+R
Sbjct: 497 LIKESKIR 504
>XP_006725012
          Length = 1388

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LLKKSKLR 8
           L+K+SK+R
Sbjct: 497 LIKESKIR 504
>XP_005255832
          Length = 725

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   KKSKLR 8
           KKSKLR
Sbjct: 208 KKSKLR 213
>XP_006716724
          Length = 970

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   KKSKLR 8
           KKSKLR
Sbjct: 711 KKSKLR 716
>XP_006711118
          Length = 1129

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LLKKSKLR 8
           L+K+SK+R
Sbjct: 497 LIKESKIR 504
>XP_006711117
          Length = 1413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LLKKSKLR 8
           L+K+SK+R
Sbjct: 521 LIKESKIR 528
>NP_006733
          Length = 424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LLKKSKLRC 9
           LLK++  RC
Sbjct: 375 LLKRASSRC 383
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.330    0.139    0.406 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 526,801
Number of extensions: 1045
Number of successful extensions: 69
Number of sequences better than 10000.0: 69
Number of HSP's gapped: 69
Number of HSP's successfully gapped: 69
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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