Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000236                                                              18    1482
NP_001120972                                                           18    1482
XP_006716052                                                           18    1482
XP_006716051                                                           18    1482
NP_056121                                                              17    4312
XP_006710574                                                           17    4312
XP_005270746                                                           17    4312
NP_001243657                                                           16    5631
NP_001243656                                                           16    5631
NP_001243655                                                           16    5631
NP_001243654                                                           16    5631
NP_006581                                                              16    5631
NP_001120650                                                           16    7355
NP_001275980                                                           16    7355
NP_060203                                                              16    7355
NP_001275981                                                           16    7355
XP_006713955                                                           16    7355
XP_005272341                                                           16    7355
XP_005272340                                                           16    7355
NP_115655                                                              15    9605
NP_001094299                                                           15    9605
XP_005247886                                                           15    9605
XP_006713849                                                           15    9605
XP_006711986                                                           15    9605
XP_006711985                                                           15    9605
>NP_000236
          Length = 1390

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  LLFILVQRS 9
          LLF LVQRS
Sbjct: 14 LLFTLVQRS 22
>NP_001120972
          Length = 1408

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  LLFILVQRS 9
          LLF LVQRS
Sbjct: 14 LLFTLVQRS 22
>XP_006716052
          Length = 1409

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  LLFILVQRS 9
          LLF LVQRS
Sbjct: 33 LLFTLVQRS 41
>XP_006716051
          Length = 1427

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  LLFILVQRS 9
          LLF LVQRS
Sbjct: 33 LLFTLVQRS 41
>NP_056121
          Length = 2620

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LFILVQRS 9
           LF+L+Q+S
Sbjct: 512 LFVLIQKS 519
>XP_006710574
          Length = 2445

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LFILVQRS 9
           LF+L+Q+S
Sbjct: 337 LFVLIQKS 344
>XP_005270746
          Length = 2443

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LFILVQRS 9
           LF+L+Q+S
Sbjct: 337 LFVLIQKS 344
>NP_001243657
          Length = 462

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LLFILVQR 8
           ++F+LVQR
Sbjct: 166 IMFLLVQR 173
>NP_001243656
          Length = 487

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LLFILVQR 8
           ++F+LVQR
Sbjct: 191 IMFLLVQR 198
>NP_001243655
          Length = 488

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LLFILVQR 8
           ++F+LVQR
Sbjct: 269 IMFLLVQR 276
>NP_001243654
          Length = 565

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LLFILVQR 8
           ++F+LVQR
Sbjct: 269 IMFLLVQR 276
>NP_006581
          Length = 565

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LLFILVQR 8
           ++F+LVQR
Sbjct: 269 IMFLLVQR 276
>NP_001120650
          Length = 983

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LLFILVQR 8
           ++F+LVQR
Sbjct: 707 VVFVLVQR 714
>NP_001275980
          Length = 894

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LLFILVQR 8
           ++F+LVQR
Sbjct: 618 VVFVLVQR 625
>NP_060203
          Length = 975

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LLFILVQR 8
           ++F+LVQR
Sbjct: 699 VVFVLVQR 706
>NP_001275981
          Length = 850

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LLFILVQR 8
           ++F+LVQR
Sbjct: 574 VVFVLVQR 581
>XP_006713955
          Length = 861

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LLFILVQR 8
           ++F+LVQR
Sbjct: 585 VVFVLVQR 592
>XP_005272341
          Length = 894

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LLFILVQR 8
           ++F+LVQR
Sbjct: 618 VVFVLVQR 625
>XP_005272340
          Length = 913

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LLFILVQR 8
           ++F+LVQR
Sbjct: 637 VVFVLVQR 644
>NP_115655
          Length = 1196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FILVQR 8
           FILVQR
Sbjct: 990 FILVQR 995
>NP_001094299
          Length = 132

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  LLFILVQR 8
          L+F+++QR
Sbjct: 56 LMFVMLQR 63
>XP_005247886
          Length = 1127

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FILVQR 8
           FILVQR
Sbjct: 990 FILVQR 995
>XP_006713849
          Length = 1147

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FILVQR 8
           FILVQR
Sbjct: 941 FILVQR 946
>XP_006711986
          Length = 296

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2 LFILVQR 8
         +F+LVQR
Sbjct: 1 MFLLVQR 7
>XP_006711985
          Length = 296

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2 LFILVQR 8
         +F+LVQR
Sbjct: 1 MFLLVQR 7
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.352    0.162    0.409 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 343,665
Number of extensions: 468
Number of successful extensions: 25
Number of sequences better than 10000.0: 25
Number of HSP's gapped: 25
Number of HSP's successfully gapped: 25
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.8 bits)
S2: 28 (15.4 bits)

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