Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_072088                                                              17    3301
NP_919255                                                              16    7355
XP_005255358                                                           16    7355
XP_005255357                                                           16    7355
XP_005255356                                                           16    7355
XP_005255355                                                           16    7355
NP_001138483                                                           16    7355
NP_002038                                                              15    9605
NP_001121361                                                           15    9605
NP_057714                                                              15    9605
NP_001121362                                                           15    9605
NP_060225                                                              15    9605
NP_079124                                                              15    9605
NP_001265723                                                           15    9605
NP_055426                                                              15    9605
NP_079229                                                              15    9605
NP_002635                                                              15    9605
NP_005963                                                              15    9605
NP_001265724                                                           15    9605
XP_006726481                                                           15    9605
XP_005254494                                                           15    9605
XP_005254493                                                           15    9605
XP_006720627                                                           15    9605
XP_005253995                                                           15    9605
XP_006719669                                                           15    9605
XP_005277701                                                           15    9605
XP_006717608                                                           15    9605
XP_006715749                                                           15    9605
XP_006715467                                                           15    9605
XP_006714573                                                           15    9605
XP_005273220                                                           15    9605
XP_005244856                                                           15    9605
XP_006710969                                                           15    9605
XP_005244855                                                           15    9605
NP_001180384                                                           15    9605

>NP_072088
          Length = 362

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LLEVSQG 7
           LLEVSQG
Sbjct: 180 LLEVSQG 186



>NP_919255
          Length = 154

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LLEVSQGS 8
          LLE+++GS
Sbjct: 60 LLEITEGS 67



>XP_005255358
          Length = 1086

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LLEVSQGS 8
           LLE SQG+
Sbjct: 107 LLEASQGT 114



>XP_005255357
          Length = 1112

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LLEVSQGS 8
           LLE SQG+
Sbjct: 107 LLEASQGT 114



>XP_005255356
          Length = 1114

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LLEVSQGS 8
           LLE SQG+
Sbjct: 107 LLEASQGT 114



>XP_005255355
          Length = 1121

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LLEVSQGS 8
           LLE SQG+
Sbjct: 107 LLEASQGT 114



>NP_001138483
          Length = 1141

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LLEVSQGS 8
           LLE SQG+
Sbjct: 107 LLEASQGT 114



>NP_002038
          Length = 739

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLEVSQGSL 9
           LLE +QG L
Sbjct: 311 LLEFNQGKL 319



>NP_001121361
          Length = 308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LEVSQGSL 9
           LEV +GSL
Sbjct: 294 LEVQKGSL 301



>NP_057714
          Length = 308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LEVSQGSL 9
           LEV +GSL
Sbjct: 294 LEVQKGSL 301



>NP_001121362
          Length = 281

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LEVSQGSL 9
           LEV +GSL
Sbjct: 267 LEVQKGSL 274



>NP_060225
          Length = 767

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LLEVSQGSL 9
           LLE S+G+L
Sbjct: 335 LLEKSEGAL 343



>NP_079124
          Length = 497

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LLEVSQGS 8
           ++EV+QGS
Sbjct: 224 VMEVAQGS 231



>NP_001265723
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EVSQGSL 9
           EVS+GSL
Sbjct: 360 EVSKGSL 366



>NP_055426
          Length = 5596

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LLEVSQGSL 9
           LLE S GSL
Sbjct: 852 LLEGSSGSL 860



>NP_079229
          Length = 972

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLEVSQGSL 9
           LLEV  G+L
Sbjct: 823 LLEVKDGNL 831



>NP_002635
          Length = 764

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LEVSQG 7
           LEVSQG
Sbjct: 125 LEVSQG 130



>NP_005963
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EVSQGSL 9
           EVS+GSL
Sbjct: 360 EVSKGSL 366



>NP_001265724
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EVSQGSL 9
           EVS+GSL
Sbjct: 360 EVSKGSL 366



>XP_006726481
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LEVSQGSL 9
          LE+S+G L
Sbjct: 43 LEISEGKL 50



>XP_005254494
          Length = 308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LEVSQGSL 9
           LEV +GSL
Sbjct: 294 LEVQKGSL 301



>XP_005254493
          Length = 308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LEVSQGSL 9
           LEV +GSL
Sbjct: 294 LEVQKGSL 301



>XP_006720627
          Length = 308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LEVSQGSL 9
           LEV +GSL
Sbjct: 294 LEVQKGSL 301



>XP_005253995
          Length = 836

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLEVSQGSL 9
           LLEV  G+L
Sbjct: 687 LLEVKDGNL 695



>XP_006719669
          Length = 944

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLEVSQGSL 9
           LLEV  G+L
Sbjct: 795 LLEVKDGNL 803



>XP_005277701
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EVSQGSL 9
           EVS+GSL
Sbjct: 360 EVSKGSL 366



>XP_006717608
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EVSQGSL 9
           EVS+GSL
Sbjct: 360 EVSKGSL 366



>XP_006715749
          Length = 616

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLEVSQGSL 9
           LLE +QG L
Sbjct: 188 LLEFNQGKL 196



>XP_006715467
          Length = 5550

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LLEVSQGSL 9
           LLE S GSL
Sbjct: 852 LLEGSSGSL 860



>XP_006714573
          Length = 342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LEVSQGSL 9
          LE+S+G L
Sbjct: 43 LEISEGKL 50



>XP_005273220
          Length = 773

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LEVSQG 7
           LEVSQG
Sbjct: 125 LEVSQG 130



>XP_005244856
          Length = 350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LLEVSQGS 8
           ++EV+QGS
Sbjct: 224 VMEVAQGS 231



>XP_006710969
          Length = 360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LLEVSQGS 8
           ++EV+QGS
Sbjct: 224 VMEVAQGS 231



>XP_005244855
          Length = 473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LLEVSQGS 8
           ++EV+QGS
Sbjct: 200 VMEVAQGS 207



>NP_001180384
          Length = 732

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LLEVSQGSL 9
           LLE S+G+L
Sbjct: 300 LLEKSEGAL 308



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.307    0.130    0.304 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 489,292
Number of extensions: 628
Number of successful extensions: 35
Number of sequences better than 10000.0: 35
Number of HSP's gapped: 35
Number of HSP's successfully gapped: 35
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)