Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004351                                                              20     390
NP_817089                                                              17    3301
NP_115267                                                              17    3301
NP_061746                                                              17    3301
NP_689804                                                              17    4312
NP_001273173                                                           17    4312
NP_001273172                                                           17    4312
XP_006719326                                                           17    4312
XP_006719325                                                           17    4312
NP_005430                                                              16    5631
NP_061885                                                              16    7355
NP_001171809                                                           16    7355
NP_116564                                                              16    7355
NP_001098713                                                           16    7355
NP_065817                                                              16    7355
NP_001398                                                              16    7355
NP_001243716                                                           16    7355
NP_001243399                                                           16    7355
NP_001137293                                                           16    7355
NP_689963                                                              16    7355
NP_001784                                                              16    7355
NP_060127                                                              16    7355
XP_005262224                                                           16    7355
XP_005262223                                                           16    7355
XP_005262222                                                           16    7355
XP_006719159                                                           16    7355
XP_006719158                                                           16    7355
XP_006719157                                                           16    7355
XP_006719156                                                           16    7355
XP_006719155                                                           16    7355
XP_005253457                                                           16    7355
XP_006719154                                                           16    7355
XP_005253456                                                           16    7355
XP_005253455                                                           16    7355
XP_006719153                                                           16    7355
XP_006719152                                                           16    7355
XP_005250282                                                           16    7355
XP_006715968                                                           16    7355
XP_005250281                                                           16    7355
XP_005250280                                                           16    7355
XP_005264437                                                           16    7355
NP_982261                                                              16    7355
NP_001002243                                                           16    7355
NP_115266                                                              16    7355
NP_061745                                                              16    7355
NP_004412                                                              15    9605
NP_079150                                                              15    9605
NP_000364                                                              15    9605
NP_001243497                                                           15    9605
NP_775901                                                              15    9605
NP_003612                                                              15    9605
NP_001243498                                                           15    9605
XP_005266736                                                           15    9605
XP_006722498                                                           15    9605
XP_006722497                                                           15    9605
XP_006718416                                                           15    9605
XP_006718415                                                           15    9605
XP_006718414                                                           15    9605
XP_006718413                                                           15    9605
XP_005253234                                                           15    9605
XP_006718412                                                           15    9605
XP_005253233                                                           15    9605
XP_005253232                                                           15    9605
XP_005253231                                                           15    9605
XP_006710974                                                           15    9605
XP_006710973                                                           15    9605
XP_006710972                                                           15    9605
XP_006710971                                                           15    9605
XP_006710970                                                           15    9605
XP_005244790                                                           15    9605
XP_005244789                                                           15    9605
XP_005244788                                                           15    9605
>NP_004351
          Length = 882

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LKVTDANAP 9
           LKVTDA+AP
Sbjct: 396 LKVTDADAP 404
>NP_817089
          Length = 832

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LKVTDANAP 9
           ++VTDAN P
Sbjct: 385 VQVTDANDP 393
>NP_115267
          Length = 811

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LKVTDAN 7
           +KVTDAN
Sbjct: 230 IKVTDAN 236
>NP_061746
          Length = 931

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LKVTDAN 7
           +KVTDAN
Sbjct: 230 IKVTDAN 236
>NP_689804
          Length = 563

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   KVTDANAP 9
           KVTD N P
Sbjct: 437 KVTDINLP 444
>NP_001273173
          Length = 484

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   KVTDANAP 9
           KVTD N P
Sbjct: 358 KVTDINLP 365
>NP_001273172
          Length = 523

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   KVTDANAP 9
           KVTD N P
Sbjct: 397 KVTDINLP 404
>XP_006719326
          Length = 539

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   KVTDANAP 9
           KVTD N P
Sbjct: 437 KVTDINLP 444
>XP_006719325
          Length = 563

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   KVTDANAP 9
           KVTD N P
Sbjct: 437 KVTDINLP 444
>NP_005430
          Length = 248

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  LKVTDANAP 9
          L +TD N P
Sbjct: 41 LSITDGNMP 49
>NP_061885
          Length = 1116

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KVTDANAP 9
           K+T  NAP
Sbjct: 279 KITSENAP 286
>NP_001171809
          Length = 1148

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LKVTDAN 7
           +KVTD+N
Sbjct: 226 IKVTDSN 232
>NP_116564
          Length = 365

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LKVTDANAP 9
           LK+T+ N P
Sbjct: 151 LKITERNFP 159
>NP_001098713
          Length = 1101

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LKVTDAN 7
           +KVTD+N
Sbjct: 226 IKVTDSN 232
>NP_065817
          Length = 1100

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LKVTDAN 7
           +KVTD+N
Sbjct: 226 IKVTDSN 232
>NP_001398
          Length = 3312

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LKVTDANAP 9
           L+ TD +AP
Sbjct: 455 LRATDGDAP 463
>NP_001243716
          Length = 1098

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KVTDANAP 9
           K+T  NAP
Sbjct: 171 KITSENAP 178
>NP_001243399
          Length = 1282

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KVTDANAP 9
           K+T  NAP
Sbjct: 285 KITSENAP 292
>NP_001137293
          Length = 1174

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KVTDANAP 9
           K+T  NAP
Sbjct: 279 KITSENAP 286
>NP_689963
          Length = 885

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LKVTDANAP 9
           ++VTD N P
Sbjct: 121 VQVTDVNEP 129
>NP_001784
          Length = 829

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LKVTDANAP 9
           L VTD +AP
Sbjct: 349 LTVTDLDAP 357
>NP_060127
          Length = 909

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LKVTDANA 8
           LKVTDA A
Sbjct: 839 LKVTDAFA 846
>XP_005262224
          Length = 302

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  LKVTDANAP 9
          LK+T+ N P
Sbjct: 88 LKITERNFP 96
>XP_005262223
          Length = 305

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  LKVTDANAP 9
          LK+T+ N P
Sbjct: 88 LKITERNFP 96
>XP_005262222
          Length = 368

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LKVTDANAP 9
           LK+T+ N P
Sbjct: 151 LKITERNFP 159
>XP_006719159
          Length = 1276

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KVTDANAP 9
           K+T  NAP
Sbjct: 279 KITSENAP 286
>XP_006719158
          Length = 663

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KVTDANAP 9
           K+T  NAP
Sbjct: 279 KITSENAP 286
>XP_006719157
          Length = 1128

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KVTDANAP 9
           K+T  NAP
Sbjct: 171 KITSENAP 178
>XP_006719156
          Length = 1151

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KVTDANAP 9
           K+T  NAP
Sbjct: 279 KITSENAP 286
>XP_006719155
          Length = 1173

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KVTDANAP 9
           K+T  NAP
Sbjct: 279 KITSENAP 286
>XP_005253457
          Length = 1179

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KVTDANAP 9
           K+T  NAP
Sbjct: 279 KITSENAP 286
>XP_006719154
          Length = 1197

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KVTDANAP 9
           K+T  NAP
Sbjct: 279 KITSENAP 286
>XP_005253456
          Length = 1206

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KVTDANAP 9
           K+T  NAP
Sbjct: 279 KITSENAP 286
>XP_005253455
          Length = 1218

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KVTDANAP 9
           K+T  NAP
Sbjct: 279 KITSENAP 286
>XP_006719153
          Length = 1224

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KVTDANAP 9
           K+T  NAP
Sbjct: 279 KITSENAP 286
>XP_006719152
          Length = 1236

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KVTDANAP 9
           K+T  NAP
Sbjct: 279 KITSENAP 286
>XP_005250282
          Length = 693

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LKVTDANAP 9
           ++VTD N P
Sbjct: 121 VQVTDVNEP 129
>XP_006715968
          Length = 752

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LKVTDANAP 9
           ++VTD N P
Sbjct: 121 VQVTDVNEP 129
>XP_005250281
          Length = 797

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  LKVTDANAP 9
          ++VTD N P
Sbjct: 33 VQVTDVNEP 41
>XP_005250280
          Length = 797

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  LKVTDANAP 9
          ++VTD N P
Sbjct: 33 VQVTDVNEP 41
>XP_005264437
          Length = 937

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LKVTDANA 8
           LKVTDA A
Sbjct: 867 LKVTDAFA 874
>NP_982261
          Length = 936

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LKVTDANA 8
           LKVTDA A
Sbjct: 867 LKVTDAFA 874
>NP_001002243
          Length = 908

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LKVTDANA 8
           LKVTDA A
Sbjct: 839 LKVTDAFA 846
>NP_115266
          Length = 810

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LKVTDAN 7
           ++VTDAN
Sbjct: 227 IRVTDAN 233
>NP_061745
          Length = 927

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LKVTDAN 7
           ++VTDAN
Sbjct: 227 IRVTDAN 233
>NP_004412
          Length = 670

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LKVTDANA 8
           LK+T ANA
Sbjct: 412 LKITIANA 419
>NP_079150
          Length = 1049

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LKVTDA 6
           LKVTDA
Sbjct: 764 LKVTDA 769
>NP_000364
          Length = 480

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LKVTDA 6
           LKVTDA
Sbjct: 144 LKVTDA 149
>NP_001243497
          Length = 764

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TDANAP 9
           +DANAP
Sbjct: 437 SDANAP 442
>NP_775901
          Length = 2226

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LKVTDA 6
            LKVTDA
Sbjct: 1249 LKVTDA 1254
>NP_003612
          Length = 876

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TDANAP 9
           +DANAP
Sbjct: 549 SDANAP 554
>NP_001243498
          Length = 733

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TDANAP 9
           +DANAP
Sbjct: 406 SDANAP 411
>XP_005266736
          Length = 1314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LKVTDA 6
           LKVTDA
Sbjct: 337 LKVTDA 342
>XP_006722498
          Length = 2059

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LKVTDA 6
            LKVTDA
Sbjct: 1250 LKVTDA 1255
>XP_006722497
          Length = 2227

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LKVTDA 6
            LKVTDA
Sbjct: 1250 LKVTDA 1255
>XP_006718416
          Length = 784

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TDANAP 9
           +DANAP
Sbjct: 417 SDANAP 422
>XP_006718415
          Length = 839

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TDANAP 9
           +DANAP
Sbjct: 472 SDANAP 477
>XP_006718414
          Length = 850

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TDANAP 9
           +DANAP
Sbjct: 483 SDANAP 488
>XP_006718413
          Length = 887

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TDANAP 9
           +DANAP
Sbjct: 560 SDANAP 565
>XP_005253234
          Length = 916

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TDANAP 9
           +DANAP
Sbjct: 549 SDANAP 554
>XP_006718412
          Length = 927

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TDANAP 9
           +DANAP
Sbjct: 560 SDANAP 565
>XP_005253233
          Length = 937

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TDANAP 9
           +DANAP
Sbjct: 610 SDANAP 615
>XP_005253232
          Length = 948

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TDANAP 9
           +DANAP
Sbjct: 621 SDANAP 626
>XP_005253231
          Length = 977

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TDANAP 9
           +DANAP
Sbjct: 610 SDANAP 615
>XP_006710974
          Length = 691

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LKVTDA 6
           LKVTDA
Sbjct: 406 LKVTDA 411
>XP_006710973
          Length = 691

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LKVTDA 6
           LKVTDA
Sbjct: 406 LKVTDA 411
>XP_006710972
          Length = 1049

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LKVTDA 6
           LKVTDA
Sbjct: 764 LKVTDA 769
>XP_006710971
          Length = 1049

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LKVTDA 6
           LKVTDA
Sbjct: 764 LKVTDA 769
>XP_006710970
          Length = 1049

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LKVTDA 6
           LKVTDA
Sbjct: 764 LKVTDA 769
>XP_005244790
          Length = 549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LKVTDANA 8
           LK+T ANA
Sbjct: 412 LKITIANA 419
>XP_005244789
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LKVTDANA 8
           LK+T ANA
Sbjct: 437 LKITIANA 444
>XP_005244788
          Length = 695

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LKVTDANA 8
           LK+T ANA
Sbjct: 437 LKITIANA 444
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.305    0.121    0.331 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 511,715
Number of extensions: 1082
Number of successful extensions: 72
Number of sequences better than 10000.0: 72
Number of HSP's gapped: 72
Number of HSP's successfully gapped: 72
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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