Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_733751                                                              17    2528
NP_002310                                                              17    2528
NP_001276863                                                           17    2528
XP_006716142                                                           17    2528
XP_005250088                                                           17    2528
XP_006716141                                                           17    2528
XP_005250085                                                           17    2528
XP_006716140                                                           17    2528
XP_005250084                                                           17    2528
XP_005250083                                                           17    2528
XP_005250082                                                           17    2528
XP_005250403                                                           17    2528
NP_001120926                                                           16    7355
NP_001120925                                                           16    7355
NP_004394                                                              16    7355
XP_005256599                                                           16    7355
NP_877963                                                              15    9605
NP_002651                                                              15    9605
NP_821075                                                              15    9605
NP_443083                                                              15    9605
NP_821074                                                              15    9605
NP_001230405                                                           15    9605
NP_004163                                                              15    9605
NP_004161                                                              15    9605
NP_001160167                                                           15    9605
NP_001276868                                                           15    9605
NP_001276869                                                           15    9605
NP_064505                                                              15    9605
NP_071903                                                              15    9605
XP_005260495                                                           15    9605
XP_006719952                                                           15    9605
XP_006719951                                                           15    9605
XP_005266643                                                           15    9605
XP_005249615                                                           15    9605
XP_005249612                                                           15    9605
XP_006714551                                                           15    9605
XP_005248399                                                           15    9605
XP_006712699                                                           15    9605
XP_006712698                                                           15    9605
XP_006712697                                                           15    9605
>NP_733751
          Length = 4911

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LKSGIRAVV 9
           LKSGI AVV
Sbjct: 912 LKSGIGAVV 920
>NP_002310
          Length = 683

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKSGIRAVV 9
           LK G+RAVV
Sbjct: 434 LKPGLRAVV 442
>NP_001276863
          Length = 652

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKSGIRAVV 9
           LK G+RAVV
Sbjct: 434 LKPGLRAVV 442
>XP_006716142
          Length = 4927

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LKSGIRAVV 9
           LKSGI AVV
Sbjct: 913 LKSGIGAVV 921
>XP_005250088
          Length = 4928

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LKSGIRAVV 9
           LKSGI AVV
Sbjct: 913 LKSGIGAVV 921
>XP_006716141
          Length = 4959

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LKSGIRAVV 9
           LKSGI AVV
Sbjct: 913 LKSGIGAVV 921
>XP_005250085
          Length = 4979

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LKSGIRAVV 9
           LKSGI AVV
Sbjct: 913 LKSGIGAVV 921
>XP_006716140
          Length = 4982

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LKSGIRAVV 9
           LKSGI AVV
Sbjct: 913 LKSGIGAVV 921
>XP_005250084
          Length = 4982

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LKSGIRAVV 9
           LKSGI AVV
Sbjct: 913 LKSGIGAVV 921
>XP_005250083
          Length = 4982

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LKSGIRAVV 9
           LKSGI AVV
Sbjct: 912 LKSGIGAVV 920
>XP_005250082
          Length = 4983

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LKSGIRAVV 9
           LKSGI AVV
Sbjct: 913 LKSGIGAVV 921
>XP_005250403
          Length = 644

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKSGIRAVV 9
           LK G+RAVV
Sbjct: 395 LKPGLRAVV 403
>NP_001120926
          Length = 332

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LKSGIRAVV 9
           LKS ++AV+
Sbjct: 298 LKSSVKAVI 306
>NP_001120925
          Length = 496

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LKSGIRAVV 9
           LKS ++AV+
Sbjct: 462 LKSSVKAVI 470
>NP_004394
          Length = 496

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LKSGIRAVV 9
           LKS ++AV+
Sbjct: 462 LKSSVKAVI 470
>XP_005256599
          Length = 739

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  KSGIRAVV 9
          K+GIRA V
Sbjct: 12 KAGIRAAV 19
>NP_877963
          Length = 1290

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LKSGIRAV 8
            LK+G RAV
Sbjct: 1183 LKTGYRAV 1190
>NP_002651
          Length = 1291

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LKSGIRAV 8
            LK+G RAV
Sbjct: 1183 LKTGYRAV 1190
>NP_821075
          Length = 1105

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LKSGIRAVV 9
            L  G+RAVV
Sbjct: 1033 LLGGVRAVV 1041
>NP_443083
          Length = 995

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LKSGIRAVV 9
           L  G+RAVV
Sbjct: 923 LLGGVRAVV 931
>NP_821074
          Length = 1113

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LKSGIRAVV 9
            L  G+RAVV
Sbjct: 1041 LLGGVRAVV 1049
>NP_001230405
          Length = 1078

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LKSGIRAVV 9
            L  G+RAVV
Sbjct: 1006 LLGGVRAVV 1014
>NP_004163
          Length = 542

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KSGIRAVV 9
           K G+RAVV
Sbjct: 118 KMGMRAVV 125
>NP_004161
          Length = 524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  KSGIRAVV 9
          K G+RAVV
Sbjct: 89 KIGLRAVV 96
>NP_001160167
          Length = 497

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KSGIRAVV 9
           K G+RAVV
Sbjct: 118 KMGMRAVV 125
>NP_001276868
          Length = 496

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  KSGIRAVV 9
          K G+RAVV
Sbjct: 72 KMGMRAVV 79
>NP_001276869
          Length = 430

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KSGIRAVV 9
           K G+RAVV
Sbjct: 118 KMGMRAVV 125
>NP_064505
          Length = 1555

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LKSGIRAVV 9
           LK G RAV+
Sbjct: 886 LKKGQRAVI 894
>NP_071903
          Length = 490

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LKSGIRA 7
           LK GIRA
Sbjct: 139 LKKGIRA 145
>XP_005260495
          Length = 1330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LKSGIRAV 8
            LK+G RAV
Sbjct: 1222 LKTGYRAV 1229
>XP_006719952
          Length = 995

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LKSGIRAVV 9
           L  G+RAVV
Sbjct: 923 LLGGVRAVV 931
>XP_006719951
          Length = 995

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LKSGIRAVV 9
           L  G+RAVV
Sbjct: 923 LLGGVRAVV 931
>XP_005266643
          Length = 1098

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LKSGIRAVV 9
            L  G+RAVV
Sbjct: 1026 LLGGVRAVV 1034
>XP_005249615
          Length = 304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LKSGIRA 7
           LK GIRA
Sbjct: 139 LKKGIRA 145
>XP_005249612
          Length = 436

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LKSGIRA 7
           LK GIRA
Sbjct: 139 LKKGIRA 145
>XP_006714551
          Length = 542

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KSGIRAVV 9
           K G+RAVV
Sbjct: 118 KMGMRAVV 125
>XP_005248399
          Length = 542

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KSGIRAVV 9
           K G+RAVV
Sbjct: 118 KMGMRAVV 125
>XP_006712699
          Length = 1544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LKSGIRAVV 9
           LK G RAV+
Sbjct: 875 LKKGQRAVI 883
>XP_006712698
          Length = 1547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LKSGIRAVV 9
           LK G RAV+
Sbjct: 878 LKKGQRAVI 886
>XP_006712697
          Length = 1549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LKSGIRAVV 9
           LK G RAV+
Sbjct: 880 LKKGQRAVI 888
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.326    0.141    0.349 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 357,896
Number of extensions: 304
Number of successful extensions: 40
Number of sequences better than 10000.0: 40
Number of HSP's gapped: 40
Number of HSP's successfully gapped: 40
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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