Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000236                                                              20     509
NP_001120972                                                           20     509
XP_006716054                                                           20     509
XP_006716053                                                           20     509
XP_006716052                                                           20     509
XP_006716051                                                           20     509
NP_004597                                                              18    1935
NP_001273003                                                           18    1935
NP_620278                                                              18    1935
XP_005262357                                                           18    1935
XP_006724745                                                           18    1935
XP_006724744                                                           18    1935
XP_005262354                                                           18    1935
XP_006724743                                                           18    1935
XP_005262353                                                           18    1935
XP_005262352                                                           18    1935
NP_722516                                                              18    1935
NP_116764                                                              17    4312
NP_116765                                                              17    4312
NP_001215                                                              17    4312
NP_116107                                                              17    4312
NP_060206                                                              17    4312
XP_005255481                                                           17    4312
XP_005255479                                                           17    4312
XP_005264089                                                           17    4312
NP_001189472                                                           16    5631
NP_853530                                                              16    5631
XP_006715919                                                           16    5631
XP_006715917                                                           16    5631
XP_005250208                                                           16    5631
XP_005250207                                                           16    5631
NP_079232                                                              16    7355
NP_057726                                                              15    9605
NP_056082                                                              15    9605
NP_001073379                                                           15    9605
NP_523352                                                              15    9605
NP_056073                                                              15    9605
NP_001106853                                                           15    9605
NP_114118                                                              15    9605
NP_852660                                                              15    9605
XP_005254495                                                           15    9605
XP_006719698                                                           15    9605
XP_005269240                                                           15    9605
XP_006719697                                                           15    9605
XP_006719696                                                           15    9605
XP_006719695                                                           15    9605
XP_005269238                                                           15    9605
XP_006719362                                                           15    9605
XP_006718161                                                           15    9605
XP_006718160                                                           15    9605
XP_006718159                                                           15    9605
XP_006718158                                                           15    9605
XP_006718157                                                           15    9605
XP_006718156                                                           15    9605
XP_006718075                                                           15    9605
XP_006718074                                                           15    9605
XP_006718073                                                           15    9605
XP_006718072                                                           15    9605
XP_006718071                                                           15    9605
XP_006718070                                                           15    9605
XP_005277720                                                           15    9605
XP_005277718                                                           15    9605
XP_006717082                                                           15    9605
XP_006717081                                                           15    9605
XP_006712889                                                           15    9605
NP_067016                                                              15    9605
>NP_000236
          Length = 1390

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LKKTRVVLG 9
           LKKTRV+LG
Sbjct: 598 LKKTRVLLG 606
>NP_001120972
          Length = 1408

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LKKTRVVLG 9
           LKKTRV+LG
Sbjct: 598 LKKTRVLLG 606
>XP_006716054
          Length = 960

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LKKTRVVLG 9
           LKKTRV+LG
Sbjct: 168 LKKTRVLLG 176
>XP_006716053
          Length = 960

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LKKTRVVLG 9
           LKKTRV+LG
Sbjct: 168 LKKTRVLLG 176
>XP_006716052
          Length = 1409

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LKKTRVVLG 9
           LKKTRV+LG
Sbjct: 617 LKKTRVLLG 625
>XP_006716051
          Length = 1427

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LKKTRVVLG 9
           LKKTRV+LG
Sbjct: 617 LKKTRVLLG 625
>NP_004597
          Length = 1893

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LKKTRVVLG 9
           LKK+R++LG
Sbjct: 556 LKKSRILLG 564
>NP_001273003
          Length = 1895

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LKKTRVVLG 9
           LKK+R++LG
Sbjct: 556 LKKSRILLG 564
>NP_620278
          Length = 1872

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LKKTRVVLG 9
           LKK+R++LG
Sbjct: 535 LKKSRILLG 543
>XP_005262357
          Length = 999

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LKKTRVVLG 9
           LKK+R++LG
Sbjct: 556 LKKSRILLG 564
>XP_006724745
          Length = 1800

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LKKTRVVLG 9
           LKK+R++LG
Sbjct: 429 LKKSRILLG 437
>XP_006724744
          Length = 1851

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LKKTRVVLG 9
           LKK+R++LG
Sbjct: 556 LKKSRILLG 564
>XP_005262354
          Length = 1906

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LKKTRVVLG 9
           LKK+R++LG
Sbjct: 535 LKKSRILLG 543
>XP_006724743
          Length = 1924

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LKKTRVVLG 9
           LKK+R++LG
Sbjct: 556 LKKSRILLG 564
>XP_005262353
          Length = 1926

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LKKTRVVLG 9
           LKK+R++LG
Sbjct: 556 LKKSRILLG 564
>XP_005262352
          Length = 1927

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LKKTRVVLG 9
           LKK+R++LG
Sbjct: 556 LKKSRILLG 564
>NP_722516
          Length = 1826

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LKKTRVVLG 9
           LKK+R++LG
Sbjct: 554 LKKSRILLG 562
>NP_116764
          Length = 452

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  LKKTRVVL 8
          LKK RVVL
Sbjct: 40 LKKNRVVL 47
>NP_116765
          Length = 108

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  LKKTRVVL 8
          LKK RVVL
Sbjct: 40 LKKNRVVL 47
>NP_001215
          Length = 312

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  LKKTRVVL 8
          LKK RVVL
Sbjct: 9  LKKNRVVL 16
>NP_116107
          Length = 474

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LKKTRVVLG 9
           L+KT V+LG
Sbjct: 234 LRKTHVLLG 242
>NP_060206
          Length = 353

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KKTRVVL 8
           KKTRV+L
Sbjct: 154 KKTRVIL 160
>XP_005255481
          Length = 439

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KKTRVVL 8
           KKTRV+L
Sbjct: 240 KKTRVIL 246
>XP_005255479
          Length = 439

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KKTRVVL 8
           KKTRV+L
Sbjct: 240 KKTRVIL 246
>XP_005264089
          Length = 413

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LKKTRVVLG 9
           L+KT V+LG
Sbjct: 173 LRKTHVLLG 181
>NP_001189472
          Length = 1516

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    LKKTRVVL 8
            LKK RVVL
Sbjct: 1255 LKKPRVVL 1262
>NP_853530
          Length = 1505

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    LKKTRVVL 8
            LKK RVVL
Sbjct: 1244 LKKPRVVL 1251
>XP_006715919
          Length = 1494

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    LKKTRVVL 8
            LKK RVVL
Sbjct: 1233 LKKPRVVL 1240
>XP_006715917
          Length = 1583

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    LKKTRVVL 8
            LKK RVVL
Sbjct: 1322 LKKPRVVL 1329
>XP_005250208
          Length = 1603

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    LKKTRVVL 8
            LKK RVVL
Sbjct: 1342 LKKPRVVL 1349
>XP_005250207
          Length = 1604

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    LKKTRVVL 8
            LKK RVVL
Sbjct: 1343 LKKPRVVL 1350
>NP_079232
          Length = 643

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LKKTRVV 7
           LKKTRV+
Sbjct: 125 LKKTRVM 131
>NP_057726
          Length = 3674

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    TRVVLG 9
            TRVVLG
Sbjct: 2949 TRVVLG 2954
>NP_056082
          Length = 1486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LKKTRVVL 8
            +KK RVVL
Sbjct: 1168 IKKPRVVL 1175
>NP_001073379
          Length = 1722

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   KKTRVVLG 9
           +KT+++LG
Sbjct: 551 QKTQIILG 558
>NP_523352
          Length = 416

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LKKTRVVLG 9
           L+K+R +LG
Sbjct: 388 LEKSRFILG 396
>NP_056073
          Length = 1219

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LKKTRV 6
           LKKTRV
Sbjct: 779 LKKTRV 784
>NP_001106853
          Length = 2093

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  KKTRVVLG 9
          K+TRVV G
Sbjct: 32 KRTRVVEG 39
>NP_114118
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   KKTRVVLG 9
           KKT  VLG
Sbjct: 332 KKTSAVLG 339
>NP_852660
          Length = 390

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   KKTRVVLG 9
           KKT  VLG
Sbjct: 332 KKTSAVLG 339
>XP_005254495
          Length = 3694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    TRVVLG 9
            TRVVLG
Sbjct: 2969 TRVVLG 2974
>XP_006719698
          Length = 899

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   KKTRVVLG 9
           +KT+++LG
Sbjct: 551 QKTQIILG 558
>XP_005269240
          Length = 908

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   KKTRVVLG 9
           +KT+++LG
Sbjct: 551 QKTQIILG 558
>XP_006719697
          Length = 1658

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   KKTRVVLG 9
           +KT+++LG
Sbjct: 551 QKTQIILG 558
>XP_006719696
          Length = 1696

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   KKTRVVLG 9
           +KT+++LG
Sbjct: 551 QKTQIILG 558
>XP_006719695
          Length = 1696

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   KKTRVVLG 9
           +KT+++LG
Sbjct: 551 QKTQIILG 558
>XP_005269238
          Length = 1696

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   KKTRVVLG 9
           +KT+++LG
Sbjct: 551 QKTQIILG 558
>XP_006719362
          Length = 1546

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LKKTRVVL 8
            +KK RVVL
Sbjct: 1228 IKKPRVVL 1235
>XP_006718161
          Length = 305

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   KKTRVVLG 9
           KKT  VLG
Sbjct: 216 KKTSAVLG 223
>XP_006718160
          Length = 390

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   KKTRVVLG 9
           KKT  VLG
Sbjct: 332 KKTSAVLG 339
>XP_006718159
          Length = 411

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   KKTRVVLG 9
           KKT  VLG
Sbjct: 322 KKTSAVLG 329
>XP_006718158
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   KKTRVVLG 9
           KKT  VLG
Sbjct: 332 KKTSAVLG 339
>XP_006718157
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   KKTRVVLG 9
           KKT  VLG
Sbjct: 339 KKTSAVLG 346
>XP_006718156
          Length = 474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   KKTRVVLG 9
           KKT  VLG
Sbjct: 385 KKTSAVLG 392
>XP_006718075
          Length = 305

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   KKTRVVLG 9
           KKT  VLG
Sbjct: 216 KKTSAVLG 223
>XP_006718074
          Length = 390

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   KKTRVVLG 9
           KKT  VLG
Sbjct: 332 KKTSAVLG 339
>XP_006718073
          Length = 397

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   KKTRVVLG 9
           KKT  VLG
Sbjct: 339 KKTSAVLG 346
>XP_006718072
          Length = 397

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   KKTRVVLG 9
           KKT  VLG
Sbjct: 339 KKTSAVLG 346
>XP_006718071
          Length = 397

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   KKTRVVLG 9
           KKT  VLG
Sbjct: 339 KKTSAVLG 346
>XP_006718070
          Length = 411

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   KKTRVVLG 9
           KKT  VLG
Sbjct: 322 KKTSAVLG 329
>XP_005277720
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   KKTRVVLG 9
           KKT  VLG
Sbjct: 339 KKTSAVLG 346
>XP_005277718
          Length = 474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   KKTRVVLG 9
           KKT  VLG
Sbjct: 385 KKTSAVLG 392
>XP_006717082
          Length = 1151

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LKKTRV 6
           LKKTRV
Sbjct: 711 LKKTRV 716
>XP_006717081
          Length = 1209

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LKKTRV 6
           LKKTRV
Sbjct: 769 LKKTRV 774
>XP_006712889
          Length = 2069

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  KKTRVVLG 9
          K+TRVV G
Sbjct: 32 KRTRVVEG 39
>NP_067016
          Length = 270

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LKKTRVVL 8
           +KK RVVL
Sbjct: 255 MKKKRVVL 262
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.325    0.144    0.371 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 404,101
Number of extensions: 709
Number of successful extensions: 66
Number of sequences better than 10000.0: 66
Number of HSP's gapped: 66
Number of HSP's successfully gapped: 66
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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