Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              18    1135
NP_671714                                                              18    1135
XP_006715890                                                           18    1135
XP_005250160                                                           18    1135
XP_005250159                                                           18    1135
NP_036562                                                              17    4312
NP_620482                                                              16    5631
NP_001077084                                                           16    5631
NP_060883                                                              16    5631
XP_006726609                                                           16    5631
XP_006719787                                                           16    5631
XP_006712362                                                           16    5631
XP_006710027                                                           16    5631
NP_001167453                                                           16    5631
NP_877963                                                              16    7355
NP_002651                                                              16    7355
NP_002652                                                              16    7355
NP_877949                                                              16    7355
NP_000924                                                              16    7355
NP_001166117                                                           16    7355
NP_588614                                                              16    7355
NP_001730                                                              16    7355
NP_149114                                                              16    7355
XP_005260495                                                           16    7355
XP_005260785                                                           16    7355
XP_006723635                                                           16    7355
XP_006723634                                                           16    7355
XP_006723633                                                           16    7355
XP_005260781                                                           16    7355
XP_006723632                                                           16    7355
XP_006723631                                                           16    7355
XP_005253583                                                           16    7355
XP_005253581                                                           16    7355
XP_005253580                                                           16    7355
XP_006719225                                                           16    7355
XP_005253579                                                           16    7355
XP_005253578                                                           16    7355
XP_005253577                                                           16    7355
XP_005253576                                                           16    7355
NP_001188326                                                           15    9605
NP_001159751                                                           15    9605
NP_055686                                                              15    9605
NP_001120932                                                           15    9605
NP_078966                                                              15    9605
NP_006085                                                              15    9605
NP_006216                                                              15    9605
NP_001157743                                                           15    9605
NP_872584                                                              15    9605
NP_001124436                                                           15    9605
NP_001186758                                                           15    9605
NP_001028774                                                           15    9605
NP_001002926                                                           15    9605
NP_705833                                                              15    9605
XP_005266332                                                           15    9605
XP_005273432                                                           15    9605
XP_005273431                                                           15    9605
XP_005247174                                                           15    9605
XP_006711632                                                           15    9605
NP_115508                                                              15    9605
>NP_005742
          Length = 3907

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LKISSSHQT 9
            LKISSS+QT
Sbjct: 2786 LKISSSNQT 2794
>NP_671714
          Length = 3899

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LKISSSHQT 9
            LKISSS+QT
Sbjct: 2778 LKISSSNQT 2786
>XP_006715890
          Length = 3860

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LKISSSHQT 9
            LKISSS+QT
Sbjct: 2739 LKISSSNQT 2747
>XP_005250160
          Length = 3939

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LKISSSHQT 9
            LKISSS+QT
Sbjct: 2818 LKISSSNQT 2826
>XP_005250159
          Length = 3952

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LKISSSHQT 9
            LKISSS+QT
Sbjct: 2831 LKISSSNQT 2839
>NP_036562
          Length = 307

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KISSSHQ 8
           KISS+HQ
Sbjct: 177 KISSAHQ 183
>NP_620482
          Length = 1341

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ISSSHQT 9
           ISS HQT
Sbjct: 620 ISSQHQT 626
>NP_001077084
          Length = 1314

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ISSSHQT 9
           ISS HQT
Sbjct: 620 ISSQHQT 626
>NP_060883
          Length = 352

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ISSSHQT 9
           ISS HQT
Sbjct: 322 ISSEHQT 328
>XP_006726609
          Length = 2838

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LKISSSHQT 9
            L ISS HQT
Sbjct: 1962 LVISSYHQT 1970
>XP_006719787
          Length = 2838

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LKISSSHQT 9
            L ISS HQT
Sbjct: 1962 LVISSYHQT 1970
>XP_006712362
          Length = 1350

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ISSSHQT 9
           ISS HQT
Sbjct: 629 ISSQHQT 635
>XP_006710027
          Length = 2837

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LKISSSHQT 9
            L ISS HQT
Sbjct: 1961 LVISSYHQT 1969
>NP_001167453
          Length = 347

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ISSSHQT 9
           ISS HQT
Sbjct: 317 ISSEHQT 323
>NP_877963
          Length = 1290

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ISSSHQT 9
           ISSSH T
Sbjct: 331 ISSSHNT 337
>NP_002651
          Length = 1291

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ISSSHQT 9
           ISSSH T
Sbjct: 331 ISSSHNT 337
>NP_002652
          Length = 1265

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ISSSHQT 9
           ISSSH T
Sbjct: 323 ISSSHNT 329
>NP_877949
          Length = 1175

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ISSSHQT 9
           ISSSH T
Sbjct: 324 ISSSHNT 330
>NP_000924
          Length = 1194

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ISSSHQT 9
           ISSSH T
Sbjct: 324 ISSSHNT 330
>NP_001166117
          Length = 1187

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ISSSHQT 9
           ISSSH T
Sbjct: 324 ISSSHNT 330
>NP_588614
          Length = 789

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ISSSHQT 9
           ISSSH T
Sbjct: 348 ISSSHNT 354
>NP_001730
          Length = 305

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LKISSSHQT 9
           LK+ + HQT
Sbjct: 184 LKLGAHHQT 192
>NP_149114
          Length = 608

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ISSSHQT 9
           ISSSH T
Sbjct: 166 ISSSHNT 172
>XP_005260495
          Length = 1330

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ISSSHQT 9
           ISSSH T
Sbjct: 331 ISSSHNT 337
>XP_005260785
          Length = 938

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  ISSSHQT 9
          ISSSH T
Sbjct: 56 ISSSHNT 62
>XP_006723635
          Length = 1175

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ISSSHQT 9
           ISSSH T
Sbjct: 324 ISSSHNT 330
>XP_006723634
          Length = 1187

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ISSSHQT 9
           ISSSH T
Sbjct: 324 ISSSHNT 330
>XP_006723633
          Length = 1194

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ISSSHQT 9
           ISSSH T
Sbjct: 324 ISSSHNT 330
>XP_005260781
          Length = 1206

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ISSSHQT 9
           ISSSH T
Sbjct: 324 ISSSHNT 330
>XP_006723632
          Length = 1206

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ISSSHQT 9
           ISSSH T
Sbjct: 324 ISSSHNT 330
>XP_006723631
          Length = 1206

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ISSSHQT 9
           ISSSH T
Sbjct: 324 ISSSHNT 330
>XP_005253583
          Length = 545

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  ISSSHQT 9
          ISSSH T
Sbjct: 62 ISSSHNT 68
>XP_005253581
          Length = 521

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  ISSSHQT 9
          ISSSH T
Sbjct: 38 ISSSHNT 44
>XP_005253580
          Length = 545

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  ISSSHQT 9
          ISSSH T
Sbjct: 62 ISSSHNT 68
>XP_006719225
          Length = 545

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  ISSSHQT 9
          ISSSH T
Sbjct: 62 ISSSHNT 68
>XP_005253579
          Length = 610

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ISSSHQT 9
           ISSSH T
Sbjct: 166 ISSSHNT 172
>XP_005253578
          Length = 632

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ISSSHQT 9
           ISSSH T
Sbjct: 166 ISSSHNT 172
>XP_005253577
          Length = 649

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ISSSHQT 9
           ISSSH T
Sbjct: 166 ISSSHNT 172
>XP_005253576
          Length = 649

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ISSSHQT 9
           ISSSH T
Sbjct: 166 ISSSHNT 172
>NP_001188326
          Length = 532

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  LKISSSHQT 9
          LK+ S H+T
Sbjct: 75 LKLRSGHRT 83
>NP_001159751
          Length = 1201

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    KISSSHQT 9
            KISS H T
Sbjct: 1052 KISSKHLT 1059
>NP_055686
          Length = 1198

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    KISSSHQT 9
            KISS H T
Sbjct: 1049 KISSKHLT 1056
>NP_001120932
          Length = 1202

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    KISSSHQT 9
            KISS H T
Sbjct: 1053 KISSKHLT 1060
>NP_078966
          Length = 14507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KISSSHQT 9
           ++SSSH T
Sbjct: 473 QVSSSHPT 480
>NP_006085
          Length = 1091

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LKISSSHQT 9
           LK+ SSH +
Sbjct: 237 LKLKSSHHS 245
>NP_006216
          Length = 756

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ISSSHQT 9
           +SSSH T
Sbjct: 307 VSSSHNT 313
>NP_001157743
          Length = 1017

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LKISSSHQT 9
           LK+ SSH +
Sbjct: 163 LKLKSSHHS 171
>NP_872584
          Length = 1528

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LKISSSHQT 9
           LK+ SSH +
Sbjct: 674 LKLKSSHHS 682
>NP_001124436
          Length = 777

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ISSSHQT 9
           +SSSH T
Sbjct: 328 VSSSHNT 334
>NP_001186758
          Length = 387

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KISSSHQT 9
          KIS+ HQ+
Sbjct: 19 KISTEHQS 26
>NP_001028774
          Length = 1379

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  LKISSSH 7
          L++SSSH
Sbjct: 52 LEVSSSH 58
>NP_001002926
          Length = 338

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   KISSSH 7
           K+SSSH
Sbjct: 137 KVSSSH 142
>NP_705833
          Length = 2970

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    LKISSSHQT 9
            LK+  +H+T
Sbjct: 1806 LKVKEAHET 1814
>XP_005266332
          Length = 426

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  LKISSSHQT 9
          LK+ S H+T
Sbjct: 75 LKLRSGHRT 83
>XP_005273432
          Length = 1125

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LKISSSHQT 9
           LK+ SSH +
Sbjct: 271 LKLKSSHHS 279
>XP_005273431
          Length = 1528

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LKISSSHQT 9
           LK+ SSH +
Sbjct: 674 LKLKSSHHS 682
>XP_005247174
          Length = 2679

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    LKISSSHQT 9
            LK+  +H+T
Sbjct: 1515 LKVKEAHET 1523
>XP_006711632
          Length = 374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KISSSHQT 9
          KIS+ HQ+
Sbjct: 19 KISTEHQS 26
>NP_115508
          Length = 394

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KISSSHQT 9
          KIS+ HQ+
Sbjct: 19 KISTEHQS 26
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.300    0.107    0.256 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 607,023
Number of extensions: 714
Number of successful extensions: 59
Number of sequences better than 10000.0: 59
Number of HSP's gapped: 59
Number of HSP's successfully gapped: 59
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package