Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_056141                                                              17    2528
NP_001164108                                                           17    2528
NP_065813                                                              17    2528
NP_722576                                                              17    2528
XP_005269099                                                           17    2528
XP_005277479                                                           17    2528
XP_005277478                                                           17    2528
XP_005277477                                                           17    2528
XP_005277476                                                           17    2528
XP_005277572                                                           17    2528
XP_005277571                                                           17    2528
XP_006711310                                                           17    2528
XP_005277570                                                           17    2528
XP_005277569                                                           17    2528
XP_006711309                                                           17    2528
XP_005277568                                                           17    2528
XP_005277567                                                           17    2528
XP_005277387                                                           17    2528
XP_005277386                                                           17    2528
XP_005277556                                                           17    2528
XP_005277555                                                           17    2528
XP_005277554                                                           17    2528
NP_001258816                                                           17    2528
NP_001258799                                                           17    2528
NP_001258801                                                           17    2528
NP_061836                                                              17    4312
NP_387505                                                              17    4312
XP_005261051                                                           17    4312
NP_001171134                                                           16    5631
NP_060621                                                              16    5631
NP_001171136                                                           16    5631
NP_055665                                                              16    5631
NP_001028289                                                           16    5631
XP_005265679                                                           16    5631
XP_006712674                                                           16    5631
XP_006712673                                                           16    5631
XP_006712672                                                           16    5631
XP_005246722                                                           16    5631
NP_001171135                                                           16    5631
NP_056493                                                              16    7355
XP_006719869                                                           16    7355
XP_006719868                                                           16    7355
XP_005266408                                                           16    7355
XP_005266407                                                           16    7355
XP_005266403                                                           16    7355
XP_006719867                                                           16    7355
XP_006719866                                                           16    7355
XP_005266405                                                           16    7355
XP_005266404                                                           16    7355
NP_001258604                                                           15    9605
NP_055642                                                              15    9605
NP_116020                                                              15    9605
NP_001264                                                              15    9605
XP_006719025                                                           15    9605
XP_005253725                                                           15    9605
XP_006719024                                                           15    9605
XP_006719023                                                           15    9605
XP_006719022                                                           15    9605
XP_006719021                                                           15    9605
XP_006711736                                                           15    9605
XP_005245701                                                           15    9605
XP_005245700                                                           15    9605
NP_001001520                                                           15    9605
>NP_056141
          Length = 1071

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKIESSEVK 9
           LKIE+ EVK
Sbjct: 380 LKIENEEVK 388
>NP_001164108
          Length = 1070

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKIESSEVK 9
           LKIE+ EVK
Sbjct: 379 LKIENEEVK 387
>NP_065813
          Length = 1085

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKIESSEVK 9
           LKIE+ EVK
Sbjct: 369 LKIENEEVK 377
>NP_722576
          Length = 3080

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LKIESSEVK 9
           LK ESSEVK
Sbjct: 164 LKNESSEVK 172
>XP_005269099
          Length = 1062

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKIESSEVK 9
           LKIE+ EVK
Sbjct: 369 LKIENEEVK 377
>XP_005277479
          Length = 306

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKIESSEVK 9
           LKIE+ EVK
Sbjct: 227 LKIENEEVK 235
>XP_005277478
          Length = 306

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKIESSEVK 9
           LKIE+ EVK
Sbjct: 227 LKIENEEVK 235
>XP_005277477
          Length = 458

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKIESSEVK 9
           LKIE+ EVK
Sbjct: 379 LKIENEEVK 387
>XP_005277476
          Length = 459

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKIESSEVK 9
           LKIE+ EVK
Sbjct: 380 LKIENEEVK 388
>XP_005277572
          Length = 789

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKIESSEVK 9
           LKIE+ EVK
Sbjct: 379 LKIENEEVK 387
>XP_005277571
          Length = 790

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKIESSEVK 9
           LKIE+ EVK
Sbjct: 380 LKIENEEVK 388
>XP_006711310
          Length = 849

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKIESSEVK 9
           LKIE+ EVK
Sbjct: 380 LKIENEEVK 388
>XP_005277570
          Length = 918

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKIESSEVK 9
           LKIE+ EVK
Sbjct: 227 LKIENEEVK 235
>XP_005277569
          Length = 918

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKIESSEVK 9
           LKIE+ EVK
Sbjct: 227 LKIENEEVK 235
>XP_006711309
          Length = 973

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKIESSEVK 9
           LKIE+ EVK
Sbjct: 380 LKIENEEVK 388
>XP_005277568
          Length = 1070

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKIESSEVK 9
           LKIE+ EVK
Sbjct: 379 LKIENEEVK 387
>XP_005277567
          Length = 1071

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKIESSEVK 9
           LKIE+ EVK
Sbjct: 380 LKIENEEVK 388
>XP_005277387
          Length = 305

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKIESSEVK 9
           LKIE+ EVK
Sbjct: 226 LKIENEEVK 234
>XP_005277386
          Length = 306

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKIESSEVK 9
           LKIE+ EVK
Sbjct: 227 LKIENEEVK 235
>XP_005277556
          Length = 306

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKIESSEVK 9
           LKIE+ EVK
Sbjct: 227 LKIENEEVK 235
>XP_005277555
          Length = 306

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKIESSEVK 9
           LKIE+ EVK
Sbjct: 227 LKIENEEVK 235
>XP_005277554
          Length = 459

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKIESSEVK 9
           LKIE+ EVK
Sbjct: 380 LKIENEEVK 388
>NP_001258816
          Length = 305

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKIESSEVK 9
           LKIE+ EVK
Sbjct: 226 LKIENEEVK 234
>NP_001258799
          Length = 458

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKIESSEVK 9
           LKIE+ EVK
Sbjct: 379 LKIENEEVK 387
>NP_001258801
          Length = 458

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKIESSEVK 9
           LKIE+ EVK
Sbjct: 379 LKIENEEVK 387
>NP_061836
          Length = 2320

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1    LKIESSE 7
            LKIESSE
Sbjct: 1751 LKIESSE 1757
>NP_387505
          Length = 2269

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1    LKIESSE 7
            LKIESSE
Sbjct: 1751 LKIESSE 1757
>XP_005261051
          Length = 2242

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1    LKIESSE 7
            LKIESSE
Sbjct: 1673 LKIESSE 1679
>NP_001171134
          Length = 2446

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LKIESSEVK 9
            LK+ESS +K
Sbjct: 1026 LKLESSSLK 1034
>NP_060621
          Length = 2472

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LKIESSEVK 9
            LK+ESS +K
Sbjct: 1026 LKLESSSLK 1034
>NP_001171136
          Length = 2446

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LKIESSEVK 9
            LK+ESS +K
Sbjct: 1026 LKLESSSLK 1034
>NP_055665
          Length = 1099

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LKIESSEVK 9
           LKIE+ EV+
Sbjct: 369 LKIENEEVR 377
>NP_001028289
          Length = 1075

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LKIESSEVK 9
           LKIE+ EV+
Sbjct: 369 LKIENEEVR 377
>XP_005265679
          Length = 858

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LKIESSEVK 9
           LKIE+ EV+
Sbjct: 369 LKIENEEVR 377
>XP_006712674
          Length = 2436

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LKIESSEVK 9
           LK+ESS +K
Sbjct: 990 LKLESSSLK 998
>XP_006712673
          Length = 2441

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LKIESSEVK 9
            LK+ESS +K
Sbjct: 995  LKLESSSLK 1003
>XP_006712672
          Length = 2443

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LKIESSEVK 9
            LK+ESS +K
Sbjct: 997  LKLESSSLK 1005
>XP_005246722
          Length = 2472

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LKIESSEVK 9
            LK+ESS +K
Sbjct: 1026 LKLESSSLK 1034
>NP_001171135
          Length = 2446

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LKIESSEVK 9
            LK+ESS +K
Sbjct: 1026 LKLESSSLK 1034
>NP_056493
          Length = 2946

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    KIESSEVK 9
            K+E++EVK
Sbjct: 1063 KVEATEVK 1070
>XP_006719869
          Length = 2943

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    KIESSEVK 9
            K+E++EVK
Sbjct: 1063 KVEATEVK 1070
>XP_006719868
          Length = 2938

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    KIESSEVK 9
            K+E++EVK
Sbjct: 1063 KVEATEVK 1070
>XP_005266408
          Length = 1934

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    KIESSEVK 9
            K+E++EVK
Sbjct: 1063 KVEATEVK 1070
>XP_005266407
          Length = 2641

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KIESSEVK 9
           K+E++EVK
Sbjct: 737 KVEATEVK 744
>XP_005266403
          Length = 2941

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    KIESSEVK 9
            K+E++EVK
Sbjct: 1063 KVEATEVK 1070
>XP_006719867
          Length = 2961

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    KIESSEVK 9
            K+E++EVK
Sbjct: 1063 KVEATEVK 1070
>XP_006719866
          Length = 2962

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    KIESSEVK 9
            K+E++EVK
Sbjct: 1063 KVEATEVK 1070
>XP_005266405
          Length = 2964

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    KIESSEVK 9
            K+E++EVK
Sbjct: 1063 KVEATEVK 1070
>XP_005266404
          Length = 2967

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    KIESSEVK 9
            K+E++EVK
Sbjct: 1063 KVEATEVK 1070
>NP_001258604
          Length = 805

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LKIESSE 7
           +K+ESSE
Sbjct: 139 MKVESSE 145
>NP_055642
          Length = 810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LKIESSE 7
           +K+ESSE
Sbjct: 139 MKVESSE 145
>NP_116020
          Length = 670

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LKIESSEVK 9
           LK++S +VK
Sbjct: 486 LKVDSPDVK 494
>NP_001264
          Length = 1912

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    KIESSEVK 9
            K+E +EVK
Sbjct: 1617 KVEKAEVK 1624
>XP_006719025
          Length = 1902

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    KIESSEVK 9
            K+E +EVK
Sbjct: 1604 KVEKAEVK 1611
>XP_005253725
          Length = 1905

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    KIESSEVK 9
            K+E +EVK
Sbjct: 1610 KVEKAEVK 1617
>XP_006719024
          Length = 1908

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    KIESSEVK 9
            K+E +EVK
Sbjct: 1610 KVEKAEVK 1617
>XP_006719023
          Length = 1914

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    KIESSEVK 9
            K+E +EVK
Sbjct: 1616 KVEKAEVK 1623
>XP_006719022
          Length = 1915

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    KIESSEVK 9
            K+E +EVK
Sbjct: 1617 KVEKAEVK 1624
>XP_006719021
          Length = 1940

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    KIESSEVK 9
            K+E +EVK
Sbjct: 1645 KVEKAEVK 1652
>XP_006711736
          Length = 810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LKIESSE 7
           +K+ESSE
Sbjct: 139 MKVESSE 145
>XP_005245701
          Length = 810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LKIESSE 7
           +K+ESSE
Sbjct: 139 MKVESSE 145
>XP_005245700
          Length = 810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LKIESSE 7
           +K+ESSE
Sbjct: 139 MKVESSE 145
>NP_001001520
          Length = 671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LKIESSEVK 9
           LK++S +VK
Sbjct: 486 LKVDSPDVK 494
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.291    0.115    0.244 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 301,981
Number of extensions: 446
Number of successful extensions: 63
Number of sequences better than 10000.0: 63
Number of HSP's gapped: 63
Number of HSP's successfully gapped: 63
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.9 bits)
S2: 28 (15.4 bits)

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