Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000258                                                              18    1935
NP_001035957                                                           18    1935
XP_006721990                                                           18    1935
XP_006721989                                                           18    1935
XP_005258041                                                           18    1935
XP_006721988                                                           18    1935
XP_006721987                                                           18    1935
XP_006721986                                                           18    1935
XP_005258040                                                           18    1935
XP_006721985                                                           18    1935
XP_006717971                                                           17    3301
NP_065883                                                              17    4312
NP_036325                                                              17    4312
NP_776152                                                              17    4312
XP_005245423                                                           17    4312
XP_005245425                                                           17    4312
NP_002652                                                              16    7355
NP_068775                                                              16    7355
NP_056175                                                              16    7355
NP_001269065                                                           16    7355
NP_001916                                                              16    7355
NP_001138587                                                           16    7355
XP_006722562                                                           16    7355
XP_006722561                                                           16    7355
XP_006722560                                                           16    7355
XP_006722559                                                           16    7355
XP_005266781                                                           16    7355
XP_006722558                                                           16    7355
XP_005266780                                                           16    7355
XP_005266779                                                           16    7355
XP_005267003                                                           16    7355
XP_005267002                                                           16    7355
XP_005248831                                                           16    7355
XP_005248830                                                           16    7355
XP_006715361                                                           16    7355
NP_060651                                                              16    7355
NP_036547                                                              15    9605
NP_001192192                                                           15    9605
NP_001156597                                                           15    9605
NP_001156596                                                           15    9605
NP_001156592                                                           15    9605
NP_001156602                                                           15    9605
NP_001030008                                                           15    9605
NP_663629                                                              15    9605
NP_001156593                                                           15    9605
NP_001156594                                                           15    9605
NP_003310                                                              15    9605
NP_597676                                                              15    9605
NP_001243779                                                           15    9605
NP_596869                                                              15    9605
NP_789792                                                              15    9605
NP_009114                                                              15    9605
NP_079384                                                              15    9605
NP_001004301                                                           15    9605
NP_055445                                                              15    9605
NP_079335                                                              15    9605
XP_006723069                                                           15    9605
XP_006721018                                                           15    9605
XP_005255053                                                           15    9605
XP_006720074                                                           15    9605
XP_006718281                                                           15    9605
XP_005252817                                                           15    9605
XP_006715631                                                           15    9605
XP_005246888                                                           15    9605
XP_006712788                                                           15    9605
XP_006712787                                                           15    9605
XP_006712786                                                           15    9605
NP_803875                                                              15    9605
NP_001254479                                                           15    9605
NP_597681                                                              15    9605
>NP_000258
          Length = 2818

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LKCSKRLVF 9
            LK SKRLVF
Sbjct: 1679 LKGSKRLVF 1687
>NP_001035957
          Length = 2839

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LKCSKRLVF 9
            LK SKRLVF
Sbjct: 1700 LKGSKRLVF 1708
>XP_006721990
          Length = 2823

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LKCSKRLVF 9
            LK SKRLVF
Sbjct: 1710 LKGSKRLVF 1718
>XP_006721989
          Length = 2823

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LKCSKRLVF 9
            LK SKRLVF
Sbjct: 1710 LKGSKRLVF 1718
>XP_005258041
          Length = 2836

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LKCSKRLVF 9
            LK SKRLVF
Sbjct: 1679 LKGSKRLVF 1687
>XP_006721988
          Length = 2846

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LKCSKRLVF 9
            LK SKRLVF
Sbjct: 1689 LKGSKRLVF 1697
>XP_006721987
          Length = 2849

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LKCSKRLVF 9
            LK SKRLVF
Sbjct: 1710 LKGSKRLVF 1718
>XP_006721986
          Length = 2854

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LKCSKRLVF 9
            LK SKRLVF
Sbjct: 1697 LKGSKRLVF 1705
>XP_005258040
          Length = 2857

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LKCSKRLVF 9
            LK SKRLVF
Sbjct: 1700 LKGSKRLVF 1708
>XP_006721985
          Length = 2867

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LKCSKRLVF 9
            LK SKRLVF
Sbjct: 1710 LKGSKRLVF 1718
>XP_006717971
          Length = 559

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   CSKRLVF 9
           CS RLVF
Sbjct: 546 CSSRLVF 552
>NP_065883
          Length = 1237

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   CSKRLVF 9
           C++RLVF
Sbjct: 566 CARRLVF 572
>NP_036325
          Length = 537

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   KCSKRLV 8
           KCS RLV
Sbjct: 506 KCSNRLV 512
>NP_776152
          Length = 1154

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LKCSKRLVF 9
           L+CS+ L+F
Sbjct: 328 LECSRLLIF 336
>XP_005245423
          Length = 1246

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   CSKRLVF 9
           C++RLVF
Sbjct: 575 CARRLVF 581
>XP_005245425
          Length = 1299

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   CSKRLVF 9
           C++RLVF
Sbjct: 628 CARRLVF 634
>NP_002652
          Length = 1265

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    KCSKRL 7
            KC+KRL
Sbjct: 1248 KCNKRL 1253
>NP_068775
          Length = 908

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   LKCSKRL 7
           LKC +RL
Sbjct: 869 LKCQRRL 875
>NP_056175
          Length = 1042

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LKCSKRLV 8
           LKC KR++
Sbjct: 851 LKCRKRVL 858
>NP_001269065
          Length = 385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   KCSKRL 7
           KCSK+L
Sbjct: 232 KCSKKL 237
>NP_001916
          Length = 97

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  CSKRLVF 9
          CS RLVF
Sbjct: 65 CSCRLVF 71
>NP_001138587
          Length = 358

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KCSKRLVF 9
           KC KR+ F
Sbjct: 127 KCKKRVQF 134
>XP_006722562
          Length = 1060

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   CSKRLVF 9
           C+K LVF
Sbjct: 649 CTKNLVF 655
>XP_006722561
          Length = 1094

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   CSKRLVF 9
           C+K LVF
Sbjct: 649 CTKNLVF 655
>XP_006722560
          Length = 1295

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   CSKRLVF 9
           C+K LVF
Sbjct: 649 CTKNLVF 655
>XP_006722559
          Length = 1297

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   CSKRLVF 9
           C+K LVF
Sbjct: 649 CTKNLVF 655
>XP_005266781
          Length = 1301

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   CSKRLVF 9
           C+K LVF
Sbjct: 649 CTKNLVF 655
>XP_006722558
          Length = 1301

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   CSKRLVF 9
           C+K LVF
Sbjct: 649 CTKNLVF 655
>XP_005266780
          Length = 1301

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   CSKRLVF 9
           C+K LVF
Sbjct: 649 CTKNLVF 655
>XP_005266779
          Length = 1301

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   CSKRLVF 9
           C+K LVF
Sbjct: 649 CTKNLVF 655
>XP_005267003
          Length = 859

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   LKCSKRL 7
           LKC +RL
Sbjct: 820 LKCQRRL 826
>XP_005267002
          Length = 908

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   LKCSKRL 7
           LKC +RL
Sbjct: 869 LKCQRRL 875
>XP_005248831
          Length = 287

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   KCSKRL 7
           KCSK+L
Sbjct: 134 KCSKKL 139
>XP_005248830
          Length = 385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   KCSKRL 7
           KCSK+L
Sbjct: 232 KCSKKL 237
>XP_006715361
          Length = 385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   KCSKRL 7
           KCSK+L
Sbjct: 232 KCSKKL 237
>NP_060651
          Length = 1301

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   CSKRLVF 9
           C+K LVF
Sbjct: 649 CTKNLVF 655
>NP_036547
          Length = 910

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1   LKCSKRLV 8
           L C KR++
Sbjct: 450 LSCEKRII 457
>NP_001192192
          Length = 726

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1   LKCSKRLV 8
           L C KR++
Sbjct: 266 LSCEKRII 273
>NP_001156597
          Length = 116

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   CSKRLV 8
           CSKR++
Sbjct: 104 CSKRII 109
>NP_001156596
          Length = 143

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   CSKRLV 8
           CSKR++
Sbjct: 104 CSKRII 109
>NP_001156592
          Length = 166

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   CSKRLV 8
           CSKR++
Sbjct: 127 CSKRII 132
>NP_001156602
          Length = 261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   CSKRLV 8
           CSKR++
Sbjct: 104 CSKRII 109
>NP_001030008
          Length = 236

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   CSKRLV 8
           CSKR++
Sbjct: 127 CSKRII 132
>NP_663629
          Length = 284

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   CSKRLV 8
           CSKR++
Sbjct: 127 CSKRII 132
>NP_001156593
          Length = 251

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   CSKRLV 8
           CSKR++
Sbjct: 127 CSKRII 132
>NP_001156594
          Length = 228

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   CSKRLV 8
           CSKR++
Sbjct: 104 CSKRII 109
>NP_003310
          Length = 26926

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1     LKCSKRLV 8
             +KC+KR +
Sbjct: 17369 IKCNKRRI 17376
>NP_597676
          Length = 27051

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1     LKCSKRLV 8
             +KC+KR +
Sbjct: 17494 IKCNKRRI 17501
>NP_001243779
          Length = 34350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1     LKCSKRLV 8
             +KC+KR +
Sbjct: 24793 IKCNKRRI 24800
>NP_596869
          Length = 33423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1     LKCSKRLV 8
             +KC+KR +
Sbjct: 23866 IKCNKRRI 23873
>NP_789792
          Length = 1093

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LKCSKRLV 8
            L C+KRL+
Sbjct: 1010 LICNKRLI 1017
>NP_009114
          Length = 797

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   LKCSKRL 7
           L CS+RL
Sbjct: 127 LSCSRRL 133
>NP_079384
          Length = 433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  CSKRLV 8
          CS+RLV
Sbjct: 6  CSRRLV 11
>NP_001004301
          Length = 617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   LKCSKRL 7
           LKC +RL
Sbjct: 398 LKCHRRL 404
>NP_055445
          Length = 1267

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   CSKRLVF 9
           CSK L+F
Sbjct: 620 CSKTLLF 626
>NP_079335
          Length = 715

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LKCSKRLV 8
           +KC +RLV
Sbjct: 676 IKCLERLV 683
>XP_006723069
          Length = 533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   LKCSKRL 7
           LKC +RL
Sbjct: 398 LKCHRRL 404
>XP_006721018
          Length = 406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  CSKRLV 8
          CS+RLV
Sbjct: 6  CSRRLV 11
>XP_005255053
          Length = 1267

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   CSKRLVF 9
           CSK L+F
Sbjct: 620 CSKTLLF 626
>XP_006720074
          Length = 1051

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  LKCSKRL 7
          L CS+RL
Sbjct: 19 LSCSRRL 25
>XP_006718281
          Length = 983

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LKCSKRLV 8
           L C+KRL+
Sbjct: 900 LICNKRLI 907
>XP_005252817
          Length = 812

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   LKCSKRL 7
           L CS+RL
Sbjct: 142 LSCSRRL 148
>XP_006715631
          Length = 648

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LKCSKRLV 8
           +KC +RLV
Sbjct: 609 IKCLERLV 616
>XP_005246888
          Length = 22663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1     LKCSKRLV 8
             +KC+KR +
Sbjct: 13106 IKCNKRRI 13113
>XP_006712788
          Length = 24022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1     LKCSKRLV 8
             +KC+KR +
Sbjct: 14465 IKCNKRRI 14472
>XP_006712787
          Length = 33978

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1     LKCSKRLV 8
             +KC+KR +
Sbjct: 24421 IKCNKRRI 24428
>XP_006712786
          Length = 35484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1     LKCSKRLV 8
             +KC+KR +
Sbjct: 25927 IKCNKRRI 25934
>NP_803875
          Length = 4243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LKCSKRLVF 9
            +K SKRL+F
Sbjct: 1550 VKNSKRLLF 1558
>NP_001254479
          Length = 35991

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1     LKCSKRLV 8
             +KC+KR +
Sbjct: 26434 IKCNKRRI 26441
>NP_597681
          Length = 27118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1     LKCSKRLV 8
             +KC+KR +
Sbjct: 17561 IKCNKRRI 17568
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.343    0.147    0.466 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 724,901
Number of extensions: 1396
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.6 bits)
S2: 28 (15.4 bits)

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