Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001185761                                                           19     665
NP_001185763                                                           19     665
NP_055459                                                              19     665
XP_006726410                                                           19     665
XP_006711719                                                           19     665
XP_006711718                                                           19     665
XP_006711717                                                           19     665
XP_006711716                                                           19     665
XP_006711715                                                           19     665
XP_006711714                                                           19     665
XP_006711713                                                           19     665
XP_006711711                                                           19     665
XP_006711710                                                           19     665
XP_006711709                                                           19     665
XP_005277503                                                           19     665
XP_005273038                                                           19     665
XP_005277500                                                           19     665
XP_006711707                                                           19     665
XP_005277499                                                           19     665
XP_006711706                                                           19     665
XP_006711705                                                           19     665
XP_006711164                                                           19     665
XP_006726412                                                           18    1935
XP_006711760                                                           18    1935
XP_005276153                                                           17    2528
XP_003846805                                                           17    2528
NP_054784                                                              17    3301
NP_001275879                                                           17    3301
XP_006713672                                                           17    3301
NP_149120                                                              16    5631
NP_000827                                                              16    5631
NP_085126                                                              16    7355
NP_001136116                                                           16    7355
NP_001269777                                                           16    7355
NP_690608                                                              16    7355
NP_004674                                                              16    7355
XP_005246927                                                           16    7355
XP_005246925                                                           16    7355
XP_006712841                                                           16    7355
XP_005246924                                                           16    7355
XP_006712840                                                           16    7355
NP_001269365                                                           15    9605
NP_001269366                                                           15    9605
NP_776170                                                              15    9605
NP_001269367                                                           15    9605
NP_001001342                                                           15    9605
NP_001269368                                                           15    9605
NP_001539                                                              15    9605
NP_001257856                                                           15    9605
NP_001273587                                                           15    9605
NP_001138626                                                           15    9605
NP_001273588                                                           15    9605
NP_055647                                                              15    9605
NP_001364                                                              15    9605
NP_001240841                                                           15    9605
NP_055988                                                              15    9605
NP_001257859                                                           15    9605
NP_001257857                                                           15    9605
NP_001257858                                                           15    9605
XP_005266662                                                           15    9605
XP_006719966                                                           15    9605
XP_006719965                                                           15    9605
XP_005266660                                                           15    9605
XP_006714064                                                           15    9605
XP_005262708                                                           15    9605
XP_005262706                                                           15    9605
XP_006714063                                                           15    9605
XP_005262705                                                           15    9605
XP_006714062                                                           15    9605
XP_005262704                                                           15    9605
XP_005262703                                                           15    9605
XP_006711798                                                           15    9605
>NP_001185761
          Length = 2240

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LKAYSLDA 8
            LKAYSLDA
Sbjct: 1921 LKAYSLDA 1928
>NP_001185763
          Length = 2362

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LKAYSLDA 8
            LKAYSLDA
Sbjct: 2027 LKAYSLDA 2034
>NP_055459
          Length = 2346

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LKAYSLDA 8
            LKAYSLDA
Sbjct: 2027 LKAYSLDA 2034
>XP_006726410
          Length = 2087

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LKAYSLDA 8
            LKAYSLDA
Sbjct: 1768 LKAYSLDA 1775
>XP_006711719
          Length = 2302

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LKAYSLDA 8
            LKAYSLDA
Sbjct: 1983 LKAYSLDA 1990
>XP_006711718
          Length = 1436

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LKAYSLDA 8
            LKAYSLDA
Sbjct: 1034 LKAYSLDA 1041
>XP_006711717
          Length = 2385

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LKAYSLDA 8
            LKAYSLDA
Sbjct: 1983 LKAYSLDA 1990
>XP_006711716
          Length = 2411

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LKAYSLDA 8
            LKAYSLDA
Sbjct: 2092 LKAYSLDA 2099
>XP_006711715
          Length = 2428

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LKAYSLDA 8
            LKAYSLDA
Sbjct: 2026 LKAYSLDA 2033
>XP_006711714
          Length = 2429

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LKAYSLDA 8
            LKAYSLDA
Sbjct: 2027 LKAYSLDA 2034
>XP_006711713
          Length = 2432

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LKAYSLDA 8
            LKAYSLDA
Sbjct: 2030 LKAYSLDA 2037
>XP_006711711
          Length = 2482

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LKAYSLDA 8
            LKAYSLDA
Sbjct: 2080 LKAYSLDA 2087
>XP_006711710
          Length = 2494

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LKAYSLDA 8
            LKAYSLDA
Sbjct: 2092 LKAYSLDA 2099
>XP_006711709
          Length = 2495

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LKAYSLDA 8
            LKAYSLDA
Sbjct: 2093 LKAYSLDA 2100
>XP_005277503
          Length = 2498

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LKAYSLDA 8
            LKAYSLDA
Sbjct: 2190 LKAYSLDA 2197
>XP_005273038
          Length = 2509

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LKAYSLDA 8
            LKAYSLDA
Sbjct: 2190 LKAYSLDA 2197
>XP_005277500
          Length = 2525

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LKAYSLDA 8
            LKAYSLDA
Sbjct: 2190 LKAYSLDA 2197
>XP_006711707
          Length = 2553

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LKAYSLDA 8
            LKAYSLDA
Sbjct: 2190 LKAYSLDA 2197
>XP_005277499
          Length = 2561

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LKAYSLDA 8
            LKAYSLDA
Sbjct: 2190 LKAYSLDA 2197
>XP_006711706
          Length = 2591

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LKAYSLDA 8
            LKAYSLDA
Sbjct: 2189 LKAYSLDA 2196
>XP_006711705
          Length = 2592

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LKAYSLDA 8
            LKAYSLDA
Sbjct: 2190 LKAYSLDA 2197
>XP_006711164
          Length = 2087

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LKAYSLDA 8
            LKAYSLDA
Sbjct: 1768 LKAYSLDA 1775
>XP_006726412
          Length = 140

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LKAYSLD 7
           LKAYSLD
Sbjct: 99  LKAYSLD 105
>XP_006711760
          Length = 140

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LKAYSLD 7
           LKAYSLD
Sbjct: 99  LKAYSLD 105
>XP_005276153
          Length = 267

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  LKAYSLDA 8
          L AYSLDA
Sbjct: 23 LSAYSLDA 30
>XP_003846805
          Length = 306

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  LKAYSLDA 8
          L AYSLDA
Sbjct: 23 LSAYSLDA 30
>NP_054784
          Length = 679

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KAYSLDAF 9
           K +SLDAF
Sbjct: 196 KCFSLDAF 203
>NP_001275879
          Length = 704

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KAYSLDAF 9
           K +SLDAF
Sbjct: 196 KCFSLDAF 203
>XP_006713672
          Length = 452

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KAYSLDAF 9
           K +SLDAF
Sbjct: 196 KCFSLDAF 203
>NP_149120
          Length = 307

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AYSLDAF 9
           +YS+DAF
Sbjct: 105 SYSMDAF 111
>NP_000827
          Length = 1336

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LKAYSLDAF 9
           LKA  LDAF
Sbjct: 748 LKAGKLDAF 756
>NP_085126
          Length = 1671

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LKAYSLDAF 9
            +KA SLD F
Sbjct: 1255 IKANSLDGF 1263
>NP_001136116
          Length = 1700

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LKAYSLDAF 9
            +KA SLD F
Sbjct: 1255 IKANSLDGF 1263
>NP_001269777
          Length = 246

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AYSLDAF 9
           +YS+DAF
Sbjct: 119 SYSVDAF 125
>NP_690608
          Length = 299

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AYSLDAF 9
           +YS+DAF
Sbjct: 172 SYSVDAF 178
>NP_004674
          Length = 299

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AYSLDAF 9
           +YS+DAF
Sbjct: 172 SYSVDAF 178
>XP_005246927
          Length = 1683

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LKAYSLDAF 9
            +KA SLD F
Sbjct: 1238 IKANSLDGF 1246
>XP_005246925
          Length = 1696

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LKAYSLDAF 9
            +KA SLD F
Sbjct: 1251 IKANSLDGF 1259
>XP_006712841
          Length = 1696

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LKAYSLDAF 9
            +KA SLD F
Sbjct: 1280 IKANSLDGF 1288
>XP_005246924
          Length = 1713

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LKAYSLDAF 9
            +KA SLD F
Sbjct: 1268 IKANSLDGF 1276
>XP_006712840
          Length = 1725

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LKAYSLDAF 9
            +KA SLD F
Sbjct: 1280 IKANSLDGF 1288
>NP_001269365
          Length = 95

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  AYSLDAF 9
          AY LDA+
Sbjct: 75 AYKLDAY 81
>NP_001269366
          Length = 99

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  AYSLDAF 9
          AY LDA+
Sbjct: 79 AYKLDAY 85
>NP_776170
          Length = 142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   AYSLDAF 9
           AY LDA+
Sbjct: 122 AYKLDAY 128
>NP_001269367
          Length = 99

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  AYSLDAF 9
          AY LDA+
Sbjct: 79 AYKLDAY 85
>NP_001001342
          Length = 99

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  AYSLDAF 9
          AY LDA+
Sbjct: 79 AYKLDAY 85
>NP_001269368
          Length = 141

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   AYSLDAF 9
           AY LDA+
Sbjct: 122 AYKLDAY 128
>NP_001539
          Length = 478

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   LKAYSLDAF 9
           + AY LD F
Sbjct: 183 ISAYRLDGF 191
>NP_001257856
          Length = 478

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   LKAYSLDAF 9
           + AY LD F
Sbjct: 183 ISAYRLDGF 191
>NP_001273587
          Length = 1290

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LKAYSL 6
           LKAYSL
Sbjct: 987 LKAYSL 992
>NP_001138626
          Length = 453

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KAYSLDAF 9
           + YSLD F
Sbjct: 330 RTYSLDEF 337
>NP_001273588
          Length = 1235

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LKAYSL 6
           LKAYSL
Sbjct: 932 LKAYSL 937
>NP_055647
          Length = 1298

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LKAYSL 6
            LKAYSL
Sbjct: 995  LKAYSL 1000
>NP_001364
          Length = 4515

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KAYSLDAF 9
           + YSLD F
Sbjct: 330 RTYSLDEF 337
>NP_001240841
          Length = 1159

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LKAYSL 6
           LKAYSL
Sbjct: 971 LKAYSL 976
>NP_055988
          Length = 1168

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LKAYSL 6
           LKAYSL
Sbjct: 877 LKAYSL 882
>NP_001257859
          Length = 447

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   LKAYSLDAF 9
           + AY LD F
Sbjct: 152 ISAYRLDGF 160
>NP_001257857
          Length = 447

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   LKAYSLDAF 9
           + AY LD F
Sbjct: 152 ISAYRLDGF 160
>NP_001257858
          Length = 447

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   LKAYSLDAF 9
           + AY LD F
Sbjct: 152 ISAYRLDGF 160
>XP_005266662
          Length = 1117

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LKAYSL 6
           LKAYSL
Sbjct: 814 LKAYSL 819
>XP_006719966
          Length = 1140

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LKAYSL 6
           LKAYSL
Sbjct: 837 LKAYSL 842
>XP_006719965
          Length = 1243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LKAYSL 6
           LKAYSL
Sbjct: 940 LKAYSL 945
>XP_005266660
          Length = 1273

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LKAYSL 6
           LKAYSL
Sbjct: 970 LKAYSL 975
>XP_006714064
          Length = 546

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LKAYSL 6
           LKAYSL
Sbjct: 255 LKAYSL 260
>XP_005262708
          Length = 1039

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LKAYSL 6
           LKAYSL
Sbjct: 748 LKAYSL 753
>XP_005262706
          Length = 1146

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LKAYSL 6
           LKAYSL
Sbjct: 855 LKAYSL 860
>XP_006714063
          Length = 1168

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LKAYSL 6
           LKAYSL
Sbjct: 877 LKAYSL 882
>XP_005262705
          Length = 1181

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LKAYSL 6
           LKAYSL
Sbjct: 890 LKAYSL 895
>XP_006714062
          Length = 1262

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LKAYSL 6
           LKAYSL
Sbjct: 971 LKAYSL 976
>XP_005262704
          Length = 1262

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LKAYSL 6
           LKAYSL
Sbjct: 971 LKAYSL 976
>XP_005262703
          Length = 1275

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LKAYSL 6
           LKAYSL
Sbjct: 984 LKAYSL 989
>XP_006711798
          Length = 4586

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KAYSLDAF 9
           + YSLD F
Sbjct: 330 RTYSLDEF 337
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.327    0.138    0.378 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 512,123
Number of extensions: 785
Number of successful extensions: 72
Number of sequences better than 10000.0: 72
Number of HSP's gapped: 72
Number of HSP's successfully gapped: 72
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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