Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005645                                                              18    1935
NP_066285                                                              18    1935
NP_001138627                                                           18    1935
NP_001138628                                                           18    1935
NP_001138629                                                           18    1935
NP_001001956                                                           16    5631
NP_009149                                                              16    7355
NP_002982                                                              15    9605
NP_001153581                                                           15    9605
NP_001153583                                                           15    9605
NP_000594                                                              15    9605
NP_001153582                                                           15    9605
XP_006716065                                                           15    9605
XP_006716064                                                           15    9605
XP_006716063                                                           15    9605
>NP_005645
          Length = 423

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKATILFTS 9
           LKA +LFTS
Sbjct: 322 LKAIVLFTS 330
>NP_066285
          Length = 414

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKATILFTS 9
           LKA +LFTS
Sbjct: 315 LKAIVLFTS 323
>NP_001138627
          Length = 281

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKATILFTS 9
           LKA +LFTS
Sbjct: 182 LKAIVLFTS 190
>NP_001138628
          Length = 261

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKATILFTS 9
           LKA +LFTS
Sbjct: 162 LKAIVLFTS 170
>NP_001138629
          Length = 261

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LKATILFTS 9
           LKA +LFTS
Sbjct: 162 LKAIVLFTS 170
>NP_001001956
          Length = 318

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LKATILFT 8
           L ATILFT
Sbjct: 200 LVATILFT 207
>NP_009149
          Length = 664

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LKATILFTS 9
           ++ T+LFTS
Sbjct: 174 IRETLLFTS 182
>NP_002982
          Length = 119

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  LKATILFTS 9
          LKA ++FT+
Sbjct: 59 LKAGVIFTT 67
>NP_001153581
          Length = 596

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LKATILFTS 9
           +KATIL+ S
Sbjct: 518 VKATILYGS 526
>NP_001153583
          Length = 629

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LKATILFTS 9
           +KATIL+ S
Sbjct: 518 VKATILYGS 526
>NP_000594
          Length = 1203

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LKATILFTS 9
           +KATIL+ S
Sbjct: 518 VKATILYGS 526
>NP_001153582
          Length = 614

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LKATILFTS 9
           +KATIL+ S
Sbjct: 518 VKATILYGS 526
>XP_006716065
          Length = 705

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LKATILFTS 9
           +KATIL+ S
Sbjct: 518 VKATILYGS 526
>XP_006716064
          Length = 997

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LKATILFTS 9
           +KATIL+ S
Sbjct: 312 VKATILYGS 320
>XP_006716063
          Length = 1203

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LKATILFTS 9
           +KATIL+ S
Sbjct: 518 VKATILYGS 526
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.329    0.134    0.333 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 316,341
Number of extensions: 347
Number of successful extensions: 15
Number of sequences better than 10000.0: 15
Number of HSP's gapped: 15
Number of HSP's successfully gapped: 15
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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