Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001093890                                                           19     869
NP_059143                                                              19     869
NP_001093891                                                           19     869
NP_061184                                                              17    4312
NP_003692                                                              16    5631
NP_001124382                                                           16    5631
NP_001229269                                                           16    7355
NP_776168                                                              16    7355
NP_001124429                                                           16    7355
NP_149353                                                              16    7355
NP_149355                                                              16    7355
NP_149354                                                              16    7355
NP_006110                                                              16    7355
NP_001193318                                                           16    7355
NP_001138341                                                           16    7355
NP_055439                                                              16    7355
XP_006718228                                                           16    7355
XP_005252866                                                           16    7355
XP_005252781                                                           16    7355
XP_006718181                                                           16    7355
XP_005252779                                                           16    7355
XP_006711820                                                           16    7355
XP_005273147                                                           16    7355
XP_006711819                                                           16    7355
NP_005697                                                              16    7355
NP_001053                                                              16    7355
NP_001193985                                                           15    9605
NP_065988                                                              15    9605
NP_958443                                                              15    9605
NP_001243496                                                           15    9605
NP_839955                                                              15    9605
NP_001073996                                                           15    9605
NP_001020095                                                           15    9605
NP_001533                                                              15    9605
NP_061903                                                              15    9605
NP_001007238                                                           15    9605
XP_006726889                                                           15    9605
XP_006726880                                                           15    9605
XP_006725000                                                           15    9605
XP_005262050                                                           15    9605
XP_005262049                                                           15    9605
XP_006724468                                                           15    9605
XP_006724454                                                           15    9605
XP_005267986                                                           15    9605
XP_006714716                                                           15    9605
XP_005265807                                                           15    9605
XP_006714105                                                           15    9605
XP_005265805                                                           15    9605
XP_005265804                                                           15    9605
XP_006712602                                                           15    9605
XP_005270851                                                           15    9605
XP_005270850                                                           15    9605
XP_006710656                                                           15    9605
NP_060731                                                              15    9605
>NP_001093890
          Length = 297

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1  LIYTKSLRG 9
          L++TKSLRG
Sbjct: 49 LLHTKSLRG 57
>NP_059143
          Length = 296

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1  LIYTKSLRG 9
          L++TKSLRG
Sbjct: 49 LLHTKSLRG 57
>NP_001093891
          Length = 221

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1  LIYTKSLRG 9
          L++TKSLRG
Sbjct: 49 LLHTKSLRG 57
>NP_061184
          Length = 980

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LIYTKSLRG 9
           L+Y KS++G
Sbjct: 370 LMYVKSMKG 378
>NP_003692
          Length = 317

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  YTKSLRG 9
          YTK LRG
Sbjct: 8  YTKYLRG 14
>NP_001124382
          Length = 356

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1 LIYTKSLRG 9
         +IYT+ L+G
Sbjct: 1 MIYTRFLKG 9
>NP_001229269
          Length = 800

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LIYTKSLRG 9
           ++Y KS RG
Sbjct: 153 VLYIKSFRG 161
>NP_776168
          Length = 832

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LIYTKSLRG 9
           ++Y KS RG
Sbjct: 304 VLYIKSFRG 312
>NP_001124429
          Length = 951

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LIYTKSLRG 9
           ++Y KS RG
Sbjct: 304 VLYIKSFRG 312
>NP_149353
          Length = 244

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YTKSLRG 9
           +T+SLRG
Sbjct: 228 FTRSLRG 234
>NP_149355
          Length = 204

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YTKSLRG 9
           +T+SLRG
Sbjct: 188 FTRSLRG 194
>NP_149354
          Length = 233

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YTKSLRG 9
           +T+SLRG
Sbjct: 217 FTRSLRG 223
>NP_006110
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YTKSLRG 9
           +T+SLRG
Sbjct: 199 FTRSLRG 205
>NP_001193318
          Length = 140

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YTKSLRG 9
           +T+SLRG
Sbjct: 124 FTRSLRG 130
>NP_001138341
          Length = 231

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  IYTKSLRG 9
          +YT  LRG
Sbjct: 56 VYTAGLRG 63
>NP_055439
          Length = 90

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  LIYTKSLRG 9
          LIY ++L+G
Sbjct: 82 LIYNEALKG 90
>XP_006718228
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IYTKSLRG 9
           IY K++RG
Sbjct: 142 IYPKNIRG 149
>XP_005252866
          Length = 279

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IYTKSLRG 9
           IY K++RG
Sbjct: 206 IYPKNIRG 213
>XP_005252781
          Length = 265

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LIYTKSLRG 9
           +I+TK +RG
Sbjct: 149 VIFTKPVRG 157
>XP_006718181
          Length = 329

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LIYTKSLRG 9
           +I+TK +RG
Sbjct: 213 VIFTKPVRG 221
>XP_005252779
          Length = 329

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LIYTKSLRG 9
           +I+TK +RG
Sbjct: 213 VIFTKPVRG 221
>XP_006711820
          Length = 809

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LIYTKSLRG 9
           ++Y KS RG
Sbjct: 162 VLYIKSFRG 170
>XP_005273147
          Length = 809

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LIYTKSLRG 9
           ++Y KS RG
Sbjct: 162 VLYIKSFRG 170
>XP_006711819
          Length = 884

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LIYTKSLRG 9
           ++Y KS RG
Sbjct: 237 VLYIKSFRG 245
>NP_005697
          Length = 329

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LIYTKSLRG 9
           +I+TK +RG
Sbjct: 213 VIFTKPVRG 221
>NP_001053
          Length = 433

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   IYTKSL 7
           IYTKSL
Sbjct: 219 IYTKSL 224
>NP_001193985
          Length = 694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LIYTKSLR 8
          L YT+SLR
Sbjct: 64 LSYTQSLR 71
>NP_065988
          Length = 2048

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    IYTKSLR 8
            IY KSLR
Sbjct: 1564 IYMKSLR 1570
>NP_958443
          Length = 711

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   IYTKSLRG 9
           +YT  LRG
Sbjct: 357 VYTVGLRG 364
>NP_001243496
          Length = 231

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LIYTKSLR 8
           ++Y KSLR
Sbjct: 116 VLYNKSLR 123
>NP_839955
          Length = 879

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YTKSLRG 9
           YTK +RG
Sbjct: 687 YTKLIRG 693
>NP_001073996
          Length = 2116

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LIYTKSLRG 9
            LIY + LRG
Sbjct: 1305 LIYRQVLRG 1313
>NP_001020095
          Length = 894

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YTKSLRG 9
           YTK +RG
Sbjct: 702 YTKLIRG 708
>NP_001533
          Length = 1214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  IYTKSLRG 9
          IYT+ +RG
Sbjct: 83 IYTQRVRG 90
>NP_061903
          Length = 1369

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    LIYTKSL 7
            +IYTKS+
Sbjct: 1231 IIYTKSV 1237
>NP_001007238
          Length = 1194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  IYTKSLRG 9
          IYT+ +RG
Sbjct: 83 IYTQRVRG 90
>XP_006726889
          Length = 137

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  IYTKSLRG 9
          IYT+ +RG
Sbjct: 88 IYTQRVRG 95
>XP_006726880
          Length = 137

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  IYTKSLRG 9
          IYT+ +RG
Sbjct: 88 IYTQRVRG 95
>XP_006725000
          Length = 285

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IYTKSLRG 9
           IYT+ +RG
Sbjct: 236 IYTQRVRG 243
>XP_005262050
          Length = 470

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   IYTKSLRG 9
           +YT  LRG
Sbjct: 116 VYTVGLRG 123
>XP_005262049
          Length = 711

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   IYTKSLRG 9
           +YT  LRG
Sbjct: 357 VYTVGLRG 364
>XP_006724468
          Length = 137

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  IYTKSLRG 9
          IYT+ +RG
Sbjct: 88 IYTQRVRG 95
>XP_006724454
          Length = 137

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  IYTKSLRG 9
          IYT+ +RG
Sbjct: 88 IYTQRVRG 95
>XP_005267986
          Length = 2022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    IYTKSLR 8
            IY KSLR
Sbjct: 1538 IYMKSLR 1544
>XP_006714716
          Length = 1318

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    LIYTKSL 7
            +IYTKS+
Sbjct: 1180 IIYTKSV 1186
>XP_005265807
          Length = 879

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YTKSLRG 9
           YTK +RG
Sbjct: 687 YTKLIRG 693
>XP_006714105
          Length = 897

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YTKSLRG 9
           YTK +RG
Sbjct: 705 YTKLIRG 711
>XP_005265805
          Length = 912

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YTKSLRG 9
           YTK +RG
Sbjct: 720 YTKLIRG 726
>XP_005265804
          Length = 912

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YTKSLRG 9
           YTK +RG
Sbjct: 720 YTKLIRG 726
>XP_006712602
          Length = 2142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LIYTKSLRG 9
            LIY + LRG
Sbjct: 1331 LIYRQVLRG 1339
>XP_005270851
          Length = 1199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  IYTKSLRG 9
          IYT+ +RG
Sbjct: 88 IYTQRVRG 95
>XP_005270850
          Length = 1214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  IYTKSLRG 9
          IYT+ +RG
Sbjct: 83 IYTQRVRG 90
>XP_006710656
          Length = 1219

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  IYTKSLRG 9
          IYT+ +RG
Sbjct: 88 IYTQRVRG 95
>NP_060731
          Length = 894

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YTKSLRG 9
           YTK +RG
Sbjct: 702 YTKLIRG 708
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.325    0.144    0.394 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 402,151
Number of extensions: 480
Number of successful extensions: 54
Number of sequences better than 10000.0: 54
Number of HSP's gapped: 54
Number of HSP's successfully gapped: 54
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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