Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_009224                                                              17    3301
NP_001239133                                                           17    3301
NP_001138473                                                           17    3301
NP_001159643                                                           17    3301
NP_001002029                                                           17    3301
NP_001159639                                                           17    3301
NP_001159641                                                           17    3301
NP_001229752                                                           17    3301
XP_006716998                                                           17    3301
XP_006716997                                                           17    3301
NP_036423                                                              17    4312
NP_001159371                                                           17    4312
XP_006719768                                                           17    4312
XP_006719760                                                           17    4312
XP_006719759                                                           17    4312
XP_006719758                                                           17    4312
XP_005254048                                                           17    4312
XP_006719757                                                           17    4312
NP_997194                                                              17    4312
NP_078891                                                              16    5631
NP_001171526                                                           16    5631
NP_001171527                                                           16    5631
NP_001128504                                                           16    5631
XP_005248653                                                           16    5631
NP_115557                                                              16    5631
NP_001367                                                              16    7355
NP_065871                                                              16    7355
NP_079446                                                              16    7355
NP_079146                                                              16    7355
NP_001189386                                                           16    7355
NP_001189385                                                           16    7355
NP_001026835                                                           16    7355
XP_006723584                                                           16    7355
XP_006723583                                                           16    7355
XP_006723582                                                           16    7355
XP_005273584                                                           16    7355
NP_057324                                                              16    7355
NP_878185                                                              16    7355
NP_001243197                                                           15    9605
NP_001243196                                                           15    9605
NP_115967                                                              15    9605
NP_001136095                                                           15    9605
NP_001136094                                                           15    9605
NP_775733                                                              15    9605
NP_705900                                                              15    9605
NP_055242                                                              15    9605
NP_115873                                                              15    9605
NP_001159580                                                           15    9605
NP_003892                                                              15    9605
NP_057165                                                              15    9605
NP_001159582                                                           15    9605
NP_001159581                                                           15    9605
NP_982288                                                              15    9605
XP_006721239                                                           15    9605
XP_005268242                                                           15    9605
XP_005268241                                                           15    9605
XP_006718116                                                           15    9605
XP_006718115                                                           15    9605
XP_005270320                                                           15    9605
XP_006718107                                                           15    9605
XP_006718106                                                           15    9605
XP_005262923                                                           15    9605
XP_005262922                                                           15    9605
XP_005262921                                                           15    9605
XP_005262920                                                           15    9605
XP_005262919                                                           15    9605
XP_005262918                                                           15    9605
XP_005246497                                                           15    9605
XP_005270390                                                           15    9605
XP_006711823                                                           15    9605
NP_733843                                                              15    9605
NP_001004477                                                           15    9605
NP_001243055                                                           15    9605
>NP_009224
          Length = 1744

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    IVRLSCRL 9
            +VR SCRL
Sbjct: 1668 LVRASCRL 1675
>NP_001239133
          Length = 1698

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    IVRLSCRL 9
            +VR SCRL
Sbjct: 1622 LVRASCRL 1629
>NP_001138473
          Length = 347

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  IVRLSCRL 9
          +VRL+CR+
Sbjct: 28 LVRLACRM 35
>NP_001159643
          Length = 347

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  IVRLSCRL 9
          +VRL+CR+
Sbjct: 28 LVRLACRM 35
>NP_001002029
          Length = 1744

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    IVRLSCRL 9
            +VR SCRL
Sbjct: 1668 LVRASCRL 1675
>NP_001159639
          Length = 331

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  IVRLSCRL 9
          +VRL+CR+
Sbjct: 12 LVRLACRM 19
>NP_001159641
          Length = 338

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  IVRLSCRL 9
          +VRL+CR+
Sbjct: 19 LVRLACRM 26
>NP_001229752
          Length = 1744

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    IVRLSCRL 9
            +VR SCRL
Sbjct: 1668 LVRASCRL 1675
>XP_006716998
          Length = 357

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  IVRLSCRL 9
          +VRL+CR+
Sbjct: 38 LVRLACRM 45
>XP_006716997
          Length = 371

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  IVRLSCRL 9
          +VRL+CR+
Sbjct: 52 LVRLACRM 59
>NP_036423
          Length = 2120

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    IVRLSCR 8
            ++RLSCR
Sbjct: 2015 VLRLSCR 2021
>NP_001159371
          Length = 748

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LIVRLSCR 8
          L+ RLSCR
Sbjct: 37 LVRRLSCR 44
>XP_006719768
          Length = 2120

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    IVRLSCR 8
            ++RLSCR
Sbjct: 2015 VLRLSCR 2021
>XP_006719760
          Length = 504

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VRLSCR 8
           VRLSCR
Sbjct: 318 VRLSCR 323
>XP_006719759
          Length = 577

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VRLSCR 8
           VRLSCR
Sbjct: 318 VRLSCR 323
>XP_006719758
          Length = 578

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VRLSCR 8
           VRLSCR
Sbjct: 318 VRLSCR 323
>XP_005254048
          Length = 621

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VRLSCR 8
           VRLSCR
Sbjct: 314 VRLSCR 319
>XP_006719757
          Length = 625

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VRLSCR 8
           VRLSCR
Sbjct: 318 VRLSCR 323
>NP_997194
          Length = 573

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   VRLSCR 8
           VRLSCR
Sbjct: 314 VRLSCR 319
>NP_078891
          Length = 854

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LIVRLSCRL 9
           +IVRL C L
Sbjct: 208 IIVRLHCSL 216
>NP_001171526
          Length = 854

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LIVRLSCRL 9
           +IVRL C L
Sbjct: 208 IIVRLHCSL 216
>NP_001171527
          Length = 812

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LIVRLSCRL 9
           +IVRL C L
Sbjct: 208 IIVRLHCSL 216
>NP_001128504
          Length = 152

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  LIVRLSC 7
          L++R+SC
Sbjct: 53 LVIRISC 59
>XP_005248653
          Length = 895

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LIVRLSCRL 9
           +IVRL C L
Sbjct: 249 IIVRLHCSL 257
>NP_115557
          Length = 152

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  LIVRLSC 7
          L++R+SC
Sbjct: 53 LVIRISC 59
>NP_001367
          Length = 4646

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    IVRLSC 7
            +VRLSC
Sbjct: 3935 VVRLSC 3940
>NP_065871
          Length = 1659

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VRLSCRL 9
           VRL CRL
Sbjct: 515 VRLYCRL 521
>NP_079446
          Length = 979

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VRLSCRL 9
           VRL CRL
Sbjct: 483 VRLYCRL 489
>NP_079146
          Length = 1606

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VRLSCRL 9
           VRL CRL
Sbjct: 483 VRLYCRL 489
>NP_001189386
          Length = 651

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RLSCRL 9
           R+SCRL
Sbjct: 194 RISCRL 199
>NP_001189385
          Length = 651

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RLSCRL 9
           R+SCRL
Sbjct: 194 RISCRL 199
>NP_001026835
          Length = 651

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RLSCRL 9
           R+SCRL
Sbjct: 194 RISCRL 199
>XP_006723584
          Length = 641

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RLSCRL 9
           R+SCRL
Sbjct: 195 RISCRL 200
>XP_006723583
          Length = 641

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RLSCRL 9
           R+SCRL
Sbjct: 195 RISCRL 200
>XP_006723582
          Length = 641

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RLSCRL 9
           R+SCRL
Sbjct: 195 RISCRL 200
>XP_005273584
          Length = 606

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VRLSCRL 9
           VRLSC L
Sbjct: 381 VRLSCTL 387
>NP_057324
          Length = 606

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VRLSCRL 9
           VRLSC L
Sbjct: 381 VRLSCTL 387
>NP_878185
          Length = 466

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VRLSCRL 9
           VRLSC L
Sbjct: 381 VRLSCTL 387
>NP_001243197
          Length = 1026

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VRLSCRL 9
           VRL CR+
Sbjct: 895 VRLECRV 901
>NP_001243196
          Length = 1320

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    VRLSCRL 9
            VRL CR+
Sbjct: 1189 VRLECRV 1195
>NP_115967
          Length = 1320

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    VRLSCRL 9
            VRL CR+
Sbjct: 1189 VRLECRV 1195
>NP_001136095
          Length = 474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   IVRLSCRL 9
           +VR  CRL
Sbjct: 379 VVRFICRL 386
>NP_001136094
          Length = 491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   IVRLSCRL 9
           +VR  CRL
Sbjct: 340 VVRFICRL 347
>NP_775733
          Length = 1251

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   IVRLSC 7
           +VRLSC
Sbjct: 899 LVRLSC 904
>NP_705900
          Length = 558

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  VRLSCR 8
          +RLSCR
Sbjct: 26 LRLSCR 31
>NP_055242
          Length = 633

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  VRLSCR 8
          +RLSCR
Sbjct: 26 LRLSCR 31
>NP_115873
          Length = 530

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   IVRLSCRL 9
           +VR  CRL
Sbjct: 379 VVRFICRL 386
>NP_001159580
          Length = 1123

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    VRLSCRL 9
            VRL CR+
Sbjct: 1044 VRLECRV 1050
>NP_003892
          Length = 568

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IVRLSCRL 9
           IVR++C L
Sbjct: 188 IVRIACSL 195
>NP_057165
          Length = 1106

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    VRLSCRL 9
            VRL CR+
Sbjct: 1027 VRLECRV 1033
>NP_001159582
          Length = 672

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VRLSCRL 9
           VRL CR+
Sbjct: 540 VRLECRV 546
>NP_001159581
          Length = 777

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VRLSCRL 9
           VRL CR+
Sbjct: 645 VRLECRV 651
>NP_982288
          Length = 384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   LIVRLSCR 8
           LIV+++C+
Sbjct: 321 LIVKIACK 328
>XP_006721239
          Length = 556

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  VRLSCR 8
          +RLSCR
Sbjct: 26 LRLSCR 31
>XP_005268242
          Length = 1285

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   IVRLSC 7
           +VRLSC
Sbjct: 933 LVRLSC 938
>XP_005268241
          Length = 1300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   IVRLSC 7
           +VRLSC
Sbjct: 948 LVRLSC 953
>XP_006718116
          Length = 488

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IVRLSCRL 9
           IVR++C L
Sbjct: 108 IVRIACSL 115
>XP_006718115
          Length = 567

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IVRLSCRL 9
           IVR++C L
Sbjct: 187 IVRIACSL 194
>XP_005270320
          Length = 568

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IVRLSCRL 9
           IVR++C L
Sbjct: 188 IVRIACSL 195
>XP_006718107
          Length = 1330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    VRLSCRL 9
            VRL CR+
Sbjct: 1199 VRLECRV 1205
>XP_006718106
          Length = 1338

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    VRLSCRL 9
            VRL CR+
Sbjct: 1207 VRLECRV 1213
>XP_005262923
          Length = 1018

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VRLSCRL 9
           VRL CR+
Sbjct: 886 VRLECRV 892
>XP_005262922
          Length = 1276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    VRLSCRL 9
            VRL CR+
Sbjct: 1144 VRLECRV 1150
>XP_005262921
          Length = 1309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    VRLSCRL 9
            VRL CR+
Sbjct: 1177 VRLECRV 1183
>XP_005262920
          Length = 1347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    VRLSCRL 9
            VRL CR+
Sbjct: 1268 VRLECRV 1274
>XP_005262919
          Length = 1383

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    VRLSCRL 9
            VRL CR+
Sbjct: 1251 VRLECRV 1257
>XP_005262918
          Length = 1400

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    VRLSCRL 9
            VRL CR+
Sbjct: 1268 VRLECRV 1274
>XP_005246497
          Length = 200

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   LIVRLSCR 8
           LIV+++C+
Sbjct: 129 LIVKIACK 136
>XP_005270390
          Length = 589

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   LIVRLSC 7
           LI+R++C
Sbjct: 245 LIIRMNC 251
>XP_006711823
          Length = 592

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   LIVRLSC 7
           LI+R++C
Sbjct: 248 LIIRMNC 254
>NP_733843
          Length = 592

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   LIVRLSC 7
           LI+R++C
Sbjct: 248 LIIRMNC 254
>NP_001004477
          Length = 326

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   IVRLSC 7
           ++RLSC
Sbjct: 200 VIRLSC 205
>NP_001243055
          Length = 392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   LIVRLSCR 8
           LIV+++C+
Sbjct: 321 LIVKIACK 328
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.353    0.158    0.484 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 603,098
Number of extensions: 805
Number of successful extensions: 73
Number of sequences better than 10000.0: 73
Number of HSP's gapped: 73
Number of HSP's successfully gapped: 73
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.9 bits)
S2: 28 (15.4 bits)

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