Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001277144                                                           20     390
NP_001277143                                                           20     390
NP_001077383                                                           20     390
NP_001320                                                              20     390
NP_073713                                                              20     390
XP_005269629                                                           20     390
XP_005269628                                                           20     390
XP_005269627                                                           20     390
XP_005269626                                                           20     390
XP_006717706                                                           20     390
XP_005269625                                                           20     390
XP_005269624                                                           20     390
XP_006717705                                                           20     390
XP_005269622                                                           20     390
XP_005269621                                                           20     390
XP_006717704                                                           20     390
XP_005269619                                                           20     390
XP_005269618                                                           20     390
NP_001319                                                              20     509
NP_001012632                                                           20     509
XP_005272320                                                           20     509
XP_005272319                                                           20     509
XP_005272318                                                           20     509
NP_001263280                                                           18    1135
NP_005600                                                              17    4312
NP_001158188                                                           17    4312
NP_694996                                                              17    4312
NP_116182                                                              17    4312
NP_001265227                                                           17    4312
NP_001129965                                                           17    4312
NP_001274738                                                           17    4312
NP_001274737                                                           17    4312
XP_005271342                                                           17    4312
NP_710156                                                              16    5631
NP_001156372                                                           16    5631
NP_001273330                                                           16    5631
NP_115635                                                              16    5631
NP_001035282                                                           16    5631
NP_060303                                                              16    5631
XP_006725461                                                           16    5631
XP_006724090                                                           16    5631
NP_660359                                                              16    5631
NP_055712                                                              16    7355
NP_001138837                                                           16    7355
NP_660149                                                              16    7355
NP_056330                                                              16    7355
NP_777550                                                              16    7355
NP_001121796                                                           16    7355
NP_001269835                                                           16    7355
NP_001269834                                                           16    7355
NP_002057                                                              16    7355
NP_001269362                                                           16    7355
XP_005277848                                                           16    7355
XP_005257257                                                           16    7355
XP_005257223                                                           16    7355
XP_006721837                                                           16    7355
XP_005271897                                                           16    7355
XP_005265639                                                           16    7355
XP_006713478                                                           16    7355
NP_112597                                                              15    9605
NP_005827                                                              15    9605
NP_001008781                                                           15    9605
XP_005271745                                                           15    9605
XP_005271744                                                           15    9605
XP_005248355                                                           15    9605
NP_114417                                                              15    9605
NP_443732                                                              15    9605
NP_659486                                                              15    9605
NP_872438                                                              15    9605
>NP_001277144
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LINDFNIKQ 9
           LINDF IKQ
Sbjct: 252 LINDFTIKQ 260
>NP_001277143
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LINDFNIKQ 9
           LINDF IKQ
Sbjct: 252 LINDFTIKQ 260
>NP_001077383
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LINDFNIKQ 9
           LINDF IKQ
Sbjct: 252 LINDFTIKQ 260
>NP_001320
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LINDFNIKQ 9
           LINDF IKQ
Sbjct: 252 LINDFTIKQ 260
>NP_073713
          Length = 985

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LINDFNIKQ 9
           LINDF IKQ
Sbjct: 792 LINDFTIKQ 800
>XP_005269629
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LINDFNIKQ 9
           LINDF IKQ
Sbjct: 252 LINDFTIKQ 260
>XP_005269628
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LINDFNIKQ 9
           LINDF IKQ
Sbjct: 252 LINDFTIKQ 260
>XP_005269627
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LINDFNIKQ 9
           LINDF IKQ
Sbjct: 252 LINDFTIKQ 260
>XP_005269626
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LINDFNIKQ 9
           LINDF IKQ
Sbjct: 252 LINDFTIKQ 260
>XP_006717706
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LINDFNIKQ 9
           LINDF IKQ
Sbjct: 252 LINDFTIKQ 260
>XP_005269625
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LINDFNIKQ 9
           LINDF IKQ
Sbjct: 252 LINDFTIKQ 260
>XP_005269624
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LINDFNIKQ 9
           LINDF IKQ
Sbjct: 252 LINDFTIKQ 260
>XP_006717705
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LINDFNIKQ 9
           LINDF IKQ
Sbjct: 252 LINDFTIKQ 260
>XP_005269622
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LINDFNIKQ 9
           LINDF IKQ
Sbjct: 252 LINDFTIKQ 260
>XP_005269621
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LINDFNIKQ 9
           LINDF IKQ
Sbjct: 252 LINDFTIKQ 260
>XP_006717704
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LINDFNIKQ 9
           LINDF IKQ
Sbjct: 252 LINDFTIKQ 260
>XP_005269619
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LINDFNIKQ 9
           LINDF IKQ
Sbjct: 252 LINDFTIKQ 260
>XP_005269618
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LINDFNIKQ 9
           LINDF IKQ
Sbjct: 252 LINDFTIKQ 260
>NP_001319
          Length = 440

 Score = 19.6 bits (39), Expect =   509
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LINDFNIKQ 9
           LINDF +KQ
Sbjct: 246 LINDFTVKQ 254
>NP_001012632
          Length = 429

 Score = 19.6 bits (39), Expect =   509
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LINDFNIKQ 9
           LINDF +KQ
Sbjct: 235 LINDFTVKQ 243
>XP_005272320
          Length = 430

 Score = 19.6 bits (39), Expect =   509
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LINDFNIKQ 9
           LINDF +KQ
Sbjct: 235 LINDFTVKQ 243
>XP_005272319
          Length = 430

 Score = 19.6 bits (39), Expect =   509
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LINDFNIKQ 9
           LINDF +KQ
Sbjct: 235 LINDFTVKQ 243
>XP_005272318
          Length = 441

 Score = 19.6 bits (39), Expect =   509
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LINDFNIKQ 9
           LINDF +KQ
Sbjct: 246 LINDFTVKQ 254
>NP_001263280
          Length = 400

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   INDFNIKQ 9
           +NDFNIK+
Sbjct: 145 MNDFNIKE 152
>NP_005600
          Length = 842

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NDFNIK 8
           NDFN+K
Sbjct: 251 NDFNLK 256
>NP_001158188
          Length = 754

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NDFNIK 8
           NDFN+K
Sbjct: 163 NDFNLK 168
>NP_694996
          Length = 2526

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    LINDFNIKQ 9
            ++ND NI++
Sbjct: 1784 IVNDLNIRE 1792
>NP_116182
          Length = 530

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LINDFNIKQ 9
           +I+DF++KQ
Sbjct: 409 VIDDFHLKQ 417
>NP_001265227
          Length = 2614

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    LINDFNIKQ 9
            ++ND NI++
Sbjct: 1784 IVNDLNIRE 1792
>NP_001129965
          Length = 543

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LINDFNIKQ 9
           +I+DF++KQ
Sbjct: 422 VIDDFHLKQ 430
>NP_001274738
          Length = 491

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LINDFNIKQ 9
           +I+DF++KQ
Sbjct: 370 VIDDFHLKQ 378
>NP_001274737
          Length = 374

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LINDFNIKQ 9
           +I+DF++KQ
Sbjct: 253 VIDDFHLKQ 261
>XP_005271342
          Length = 528

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LINDFNIKQ 9
           +I+DF++KQ
Sbjct: 407 VIDDFHLKQ 415
>NP_710156
          Length = 385

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LINDFNIKQ 9
           L+N FN+ Q
Sbjct: 191 LVNAFNLSQ 199
>NP_001156372
          Length = 202

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NDFNIKQ 9
           NDF+IK+
Sbjct: 117 NDFDIKE 123
>NP_001273330
          Length = 211

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NDFNIKQ 9
           NDF+IK+
Sbjct: 117 NDFDIKE 123
>NP_115635
          Length = 790

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LINDFNIK 8
           L+N FN+K
Sbjct: 481 LMNSFNLK 488
>NP_001035282
          Length = 388

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   INDFNI 7
           INDFN+
Sbjct: 311 INDFNL 316
>NP_060303
          Length = 388

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   INDFNI 7
           INDFN+
Sbjct: 311 INDFNL 316
>XP_006725461
          Length = 388

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   INDFNI 7
           INDFN+
Sbjct: 311 INDFNL 316
>XP_006724090
          Length = 388

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   INDFNI 7
           INDFN+
Sbjct: 311 INDFNL 316
>NP_660359
          Length = 229

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NDFNIKQ 9
           NDF+IK+
Sbjct: 117 NDFDIKE 123
>NP_055712
          Length = 606

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   DFNIKQ 9
           DFN+KQ
Sbjct: 421 DFNMKQ 426
>NP_001138837
          Length = 606

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   DFNIKQ 9
           DFN+KQ
Sbjct: 421 DFNMKQ 426
>NP_660149
          Length = 747

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   DFNIKQ 9
           DFN+KQ
Sbjct: 612 DFNMKQ 617
>NP_056330
          Length = 422

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   INDFNIK 8
           ++DFN+K
Sbjct: 154 VDDFNLK 160
>NP_777550
          Length = 727

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  INDFNIKQ 9
          +ND+NI +
Sbjct: 83 LNDYNISE 90
>NP_001121796
          Length = 727

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  INDFNIKQ 9
          +ND+NI +
Sbjct: 83 LNDYNISE 90
>NP_001269835
          Length = 653

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  INDFNIKQ 9
          +ND+NI +
Sbjct: 9  LNDYNISE 16
>NP_001269834
          Length = 653

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  INDFNIKQ 9
          +ND+NI +
Sbjct: 9  LNDYNISE 16
>NP_002057
          Length = 158

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  LINDFN 6
          +INDFN
Sbjct: 36 VINDFN 41
>NP_001269362
          Length = 285

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  INDFNIK 8
          ++DFN+K
Sbjct: 17 VDDFNLK 23
>XP_005277848
          Length = 285

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  INDFNIK 8
          ++DFN+K
Sbjct: 17 VDDFNLK 23
>XP_005257257
          Length = 285

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  INDFNIK 8
          ++DFN+K
Sbjct: 17 VDDFNLK 23
>XP_005257223
          Length = 426

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   DFNIKQ 9
           DFN+KQ
Sbjct: 241 DFNMKQ 246
>XP_006721837
          Length = 537

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   DFNIKQ 9
           DFN+KQ
Sbjct: 421 DFNMKQ 426
>XP_005271897
          Length = 634

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  INDFNIKQ 9
          +ND+NI +
Sbjct: 83 LNDYNISE 90
>XP_005265639
          Length = 775

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   DFNIKQ 9
           DFN+KQ
Sbjct: 640 DFNMKQ 645
>XP_006713478
          Length = 807

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   DFNIKQ 9
           DFN+KQ
Sbjct: 672 DFNMKQ 677
>NP_112597
          Length = 481

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   DFNIKQ 9
           DFN+K+
Sbjct: 144 DFNVKE 149
>NP_005827
          Length = 137

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2  INDFN 6
          INDFN
Sbjct: 86 INDFN 90
>NP_001008781
          Length = 4557

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   LINDFN 6
           L+ND+N
Sbjct: 975 LVNDYN 980
>XP_005271745
          Length = 176

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   DFNIKQ 9
           DFN+K+
Sbjct: 144 DFNVKE 149
>XP_005271744
          Length = 382

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4  DFNIKQ 9
          DFN+K+
Sbjct: 45 DFNVKE 50
>XP_005248355
          Length = 433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LINDFNIKQ 9
           LINDF+  +
Sbjct: 135 LINDFDFPE 143
>NP_114417
          Length = 367

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LINDFNIK 8
           L  DFNIK
Sbjct: 144 LDKDFNIK 151
>NP_443732
          Length = 358

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LINDFNIK 8
           L  DFNIK
Sbjct: 144 LDKDFNIK 151
>NP_659486
          Length = 318

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   LINDFNIK 8
           ++NDF+I+
Sbjct: 95  VVNDFDIE 102
>NP_872438
          Length = 628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LINDFNIKQ 9
           LINDF+  +
Sbjct: 330 LINDFDFPE 338
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.327    0.148    0.408 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 479,495
Number of extensions: 764
Number of successful extensions: 69
Number of sequences better than 10000.0: 69
Number of HSP's gapped: 69
Number of HSP's successfully gapped: 69
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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