Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000537                                                              18    1482
NP_001263689                                                           18    1482
NP_001119584                                                           18    1482
NP_001119586                                                           18    1482
NP_001263625                                                           18    1482
NP_001119590                                                           18    1482
NP_001263690                                                           18    1482
NP_001119585                                                           18    1482
NP_001263624                                                           18    1482
NP_001119588                                                           18    1482
NP_001119587                                                           18    1482
NP_001119589                                                           18    1482
NP_001263627                                                           18    1482
NP_001263628                                                           18    1482
NP_001263626                                                           18    1482
NP_001240658                                                           17    4312
NP_001240657                                                           17    4312
NP_001240656                                                           17    4312
NP_001240659                                                           17    4312
NP_001240662                                                           17    4312
NP_001240661                                                           17    4312
NP_067647                                                              17    4312
NP_112208                                                              17    4312
NP_000224                                                              16    5631
NP_001159530                                                           16    5631
NP_775924                                                              16    5631
NP_000360                                                              16    5631
NP_570718                                                              16    5631
XP_005268094                                                           16    5631
XP_005264366                                                           16    5631
XP_006712078                                                           16    5631
NP_062873                                                              15    9605
NP_062874                                                              15    9605
NP_000863                                                              15    9605
>NP_000537
          Length = 393

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ILTIITLE 9
           ILTIITLE
Sbjct: 251 ILTIITLE 258
>NP_001263689
          Length = 354

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ILTIITLE 9
           ILTIITLE
Sbjct: 212 ILTIITLE 219
>NP_001119584
          Length = 393

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ILTIITLE 9
           ILTIITLE
Sbjct: 251 ILTIITLE 258
>NP_001119586
          Length = 341

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ILTIITLE 9
           ILTIITLE
Sbjct: 251 ILTIITLE 258
>NP_001263625
          Length = 302

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ILTIITLE 9
           ILTIITLE
Sbjct: 212 ILTIITLE 219
>NP_001119590
          Length = 354

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ILTIITLE 9
           ILTIITLE
Sbjct: 212 ILTIITLE 219
>NP_001263690
          Length = 354

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ILTIITLE 9
           ILTIITLE
Sbjct: 212 ILTIITLE 219
>NP_001119585
          Length = 346

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ILTIITLE 9
           ILTIITLE
Sbjct: 251 ILTIITLE 258
>NP_001263624
          Length = 307

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ILTIITLE 9
           ILTIITLE
Sbjct: 212 ILTIITLE 219
>NP_001119588
          Length = 209

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ILTIITLE 9
           ILTIITLE
Sbjct: 119 ILTIITLE 126
>NP_001119587
          Length = 261

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ILTIITLE 9
           ILTIITLE
Sbjct: 119 ILTIITLE 126
>NP_001119589
          Length = 214

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ILTIITLE 9
           ILTIITLE
Sbjct: 119 ILTIITLE 126
>NP_001263627
          Length = 182

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2  ILTIITLE 9
          ILTIITLE
Sbjct: 92 ILTIITLE 99
>NP_001263628
          Length = 187

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2  ILTIITLE 9
          ILTIITLE
Sbjct: 92 ILTIITLE 99
>NP_001263626
          Length = 234

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2  ILTIITLE 9
          ILTIITLE
Sbjct: 92 ILTIITLE 99
>NP_001240658
          Length = 709

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LILTIITLE 9
           L+LT +TLE
Sbjct: 453 LLLTFLTLE 461
>NP_001240657
          Length = 724

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LILTIITLE 9
           L+LT +TLE
Sbjct: 468 LLLTFLTLE 476
>NP_001240656
          Length = 784

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LILTIITLE 9
           L+LT +TLE
Sbjct: 528 LLLTFLTLE 536
>NP_001240659
          Length = 626

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LILTIITLE 9
           L+LT +TLE
Sbjct: 370 LLLTFLTLE 378
>NP_001240662
          Length = 601

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LILTIITLE 9
           L+LT +TLE
Sbjct: 345 LLLTFLTLE 353
>NP_001240661
          Length = 625

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LILTIITLE 9
           L+LT +TLE
Sbjct: 369 LLLTFLTLE 377
>NP_067647
          Length = 757

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LILTIITLE 9
           L+LT +TLE
Sbjct: 501 LLLTFLTLE 509
>NP_112208
          Length = 321

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  LILTIITLE 9
          LI+TIIT++
Sbjct: 42 LIITIITVD 50
>NP_000224
          Length = 699

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LTIITLE 9
           LT+ITLE
Sbjct: 457 LTVITLE 463
>NP_001159530
          Length = 730

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LILTIITLE 9
           L+LT +TLE
Sbjct: 487 LLLTYLTLE 495
>NP_775924
          Length = 645

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  LILTIITL 8
          LILTI+T+
Sbjct: 31 LILTILTI 38
>NP_000360
          Length = 764

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LTIITLE 9
           LT+ITLE
Sbjct: 512 LTVITLE 518
>NP_570718
          Length = 754

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LILTIITLE 9
           L+LT +TLE
Sbjct: 511 LLLTYLTLE 519
>XP_005268094
          Length = 764

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LTIITLE 9
           LT+ITLE
Sbjct: 512 LTVITLE 518
>XP_005264366
          Length = 380

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LTIITLE 9
           LT+ITLE
Sbjct: 138 LTVITLE 144
>XP_006712078
          Length = 389

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LTIITLE 9
           LT+ITLE
Sbjct: 147 LTVITLE 153
>NP_062873
          Length = 479

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  ILTIITL 8
          ILT+ITL
Sbjct: 87 ILTLITL 93
>NP_062874
          Length = 432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  ILTIITL 8
          ILT+ITL
Sbjct: 87 ILTLITL 93
>NP_000863
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  ILTIITL 8
          ILT+ITL
Sbjct: 87 ILTLITL 93
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.336    0.158    0.372 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 371,017
Number of extensions: 582
Number of successful extensions: 34
Number of sequences better than 10000.0: 34
Number of HSP's gapped: 34
Number of HSP's successfully gapped: 34
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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