Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000360                                                              17    4312
XP_005268094                                                           17    4312
NP_115943                                                              16    5631
NP_001137300                                                           16    7355
NP_001153638                                                           16    7355
NP_067637                                                              16    7355
XP_006716681                                                           16    7355
NP_795370                                                              16    7355
NP_795368                                                              16    7355
NP_001034201                                                           16    7355
NP_004942                                                              15    9605
NP_001091112                                                           15    9605
NP_001248383                                                           15    9605
NP_001248381                                                           15    9605
NP_001248384                                                           15    9605
NP_001248382                                                           15    9605
NP_005270                                                              15    9605
NP_001091669                                                           15    9605
NP_001166932                                                           15    9605
NP_001166933                                                           15    9605
NP_997269                                                              15    9605
NP_001166245                                                           15    9605
XP_006723108                                                           15    9605
XP_005258618                                                           15    9605
XP_005246528                                                           15    9605
XP_006712500                                                           15    9605
NP_997208                                                              15    9605

>NP_000360
          Length = 764

 Score = 16.5 bits (31), Expect =  4312
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LIIVAFVIV 9
           L IVAFVIV
Sbjct: 589 LNIVAFVIV 597



>XP_005268094
          Length = 764

 Score = 16.5 bits (31), Expect =  4312
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LIIVAFVIV 9
           L IVAFVIV
Sbjct: 589 LNIVAFVIV 597



>NP_115943
          Length = 346

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  LIIVAFVI 8
          L+IVAFV+
Sbjct: 21 LLIVAFVL 28



>NP_001137300
          Length = 302

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LIIVAFVI 8
          L+I+AFV+
Sbjct: 35 LVILAFVV 42



>NP_001153638
          Length = 67

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LIIVAFVI 8
          L+I+AFV+
Sbjct: 35 LVILAFVV 42



>NP_067637
          Length = 390

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LIIVAFVI 8
          L+I+AFV+
Sbjct: 35 LVILAFVV 42



>XP_006716681
          Length = 1867

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IIVAFVIV 9
            II+AF+++
Sbjct: 1835 IIIAFILI 1842



>NP_795370
          Length = 309

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  LIIVAFVI 8
          L++VAF++
Sbjct: 12 LVVVAFIL 19



>NP_795368
          Length = 309

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LIIVAFVI 8
          LI+V FVI
Sbjct: 12 LIVVTFVI 19



>NP_001034201
          Length = 1857

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    IIVAFVIV 9
            II+AF+++
Sbjct: 1825 IIIAFILI 1832



>NP_004942
          Length = 361

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LIIVAFVI 8
           LIIV FV+
Sbjct: 248 LIIVVFVL 255



>NP_001091112
          Length = 319

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LIIVAFVI 8
          LI+V FVI
Sbjct: 12 LIVVIFVI 19



>NP_001248383
          Length = 355

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   LIIVAFVI 8
           +++VAFV+
Sbjct: 250 VVVVAFVV 257



>NP_001248381
          Length = 355

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   LIIVAFVI 8
           +++VAFV+
Sbjct: 250 VVVVAFVV 257



>NP_001248384
          Length = 355

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   LIIVAFVI 8
           +++VAFV+
Sbjct: 250 VVVVAFVV 257



>NP_001248382
          Length = 355

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   LIIVAFVI 8
           +++VAFV+
Sbjct: 250 VVVVAFVV 257



>NP_005270
          Length = 355

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   LIIVAFVI 8
           +++VAFV+
Sbjct: 250 VVVVAFVV 257



>NP_001091669
          Length = 355

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   LIIVAFVI 8
           +++VAFV+
Sbjct: 250 VVVVAFVV 257



>NP_001166932
          Length = 500

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IVAFVIV 9
           ++AFVIV
Sbjct: 184 VIAFVIV 190



>NP_001166933
          Length = 532

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IVAFVIV 9
           ++AFVIV
Sbjct: 184 VIAFVIV 190



>NP_997269
          Length = 551

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IVAFVIV 9
           ++AFVIV
Sbjct: 184 VIAFVIV 190



>NP_001166245
          Length = 716

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IIVAFVI 8
           +IVAFV+
Sbjct: 429 VIVAFVV 435



>XP_006723108
          Length = 520

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IIVAFVI 8
           +IVAFV+
Sbjct: 233 VIVAFVV 239



>XP_005258618
          Length = 682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IIVAFVI 8
           +IVAFV+
Sbjct: 395 VIVAFVV 401



>XP_005246528
          Length = 355

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   LIIVAFVI 8
           +++VAFV+
Sbjct: 250 VVVVAFVV 257



>XP_006712500
          Length = 355

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   LIIVAFVI 8
           +++VAFV+
Sbjct: 250 VVVVAFVV 257



>NP_997208
          Length = 716

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IIVAFVI 8
           +IVAFV+
Sbjct: 429 VIVAFVV 435



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.365    0.178    0.440 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 226,572
Number of extensions: 406
Number of successful extensions: 27
Number of sequences better than 10000.0: 27
Number of HSP's gapped: 27
Number of HSP's successfully gapped: 27
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (17.2 bits)
S2: 28 (15.4 bits)