Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_036433                                                              16    5631
XP_005250782                                                           16    5631
NP_009128                                                              16    5631
NP_689846                                                              16    7355
NP_001018123                                                           16    7355
NP_071926                                                              16    7355
NP_689603                                                              16    7355
NP_001182207                                                           16    7355
XP_005268557                                                           16    7355
XP_006714856                                                           16    7355
XP_005268556                                                           16    7355
XP_006714855                                                           16    7355
XP_006714854                                                           16    7355
XP_005268555                                                           16    7355
XP_005268554                                                           16    7355
XP_006714215                                                           16    7355
XP_006714214                                                           16    7355
XP_005262915                                                           16    7355
XP_006712843                                                           16    7355
XP_005264079                                                           16    7355
NP_055806                                                              16    7355
NP_001073908                                                           15    9605
NP_001073883                                                           15    9605
NP_008922                                                              15    9605
NP_001041677                                                           15    9605
XP_005267748                                                           15    9605
XP_006712978                                                           15    9605
XP_005264840                                                           15    9605
NP_848591                                                              15    9605

>NP_036433
          Length = 1455

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   IHLRRM 7
           +HLRRM
Sbjct: 779 VHLRRM 784



>XP_005250782
          Length = 1441

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   IHLRRM 7
           +HLRRM
Sbjct: 765 VHLRRM 770



>NP_009128
          Length = 581

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LIHLRRMM 8
           L H+RR+M
Sbjct: 420 LFHIRRVM 427



>NP_689846
          Length = 859

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  LIHLRRMM 8
          ++H+RRM+
Sbjct: 42 ILHVRRMV 49



>NP_001018123
          Length = 859

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  LIHLRRMM 8
          ++H+RRM+
Sbjct: 42 ILHVRRMV 49



>NP_071926
          Length = 1544

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   LIHLRRM 7
           ++HLRR+
Sbjct: 848 MVHLRRL 854



>NP_689603
          Length = 297

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LIHLRRM 7
           L+HLRR+
Sbjct: 170 LLHLRRI 176



>NP_001182207
          Length = 294

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   IHLRRM 7
           +HLRRM
Sbjct: 165 LHLRRM 170



>XP_005268557
          Length = 934

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   LIHLRRM 7
           ++HLRR+
Sbjct: 848 MVHLRRL 854



>XP_006714856
          Length = 1346

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   LIHLRRM 7
           ++HLRR+
Sbjct: 650 MVHLRRL 656



>XP_005268556
          Length = 1466

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   LIHLRRM 7
           ++HLRR+
Sbjct: 770 MVHLRRL 776



>XP_006714855
          Length = 1473

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   LIHLRRM 7
           ++HLRR+
Sbjct: 848 MVHLRRL 854



>XP_006714854
          Length = 1486

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   LIHLRRM 7
           ++HLRR+
Sbjct: 790 MVHLRRL 796



>XP_005268555
          Length = 1524

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   LIHLRRM 7
           ++HLRR+
Sbjct: 848 MVHLRRL 854



>XP_005268554
          Length = 1531

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   LIHLRRM 7
           ++HLRR+
Sbjct: 848 MVHLRRL 854



>XP_006714215
          Length = 3544

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  LIHLRRM 7
          L+HLRR+
Sbjct: 25 LMHLRRL 31



>XP_006714214
          Length = 3544

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  LIHLRRM 7
          L+HLRR+
Sbjct: 25 LMHLRRL 31



>XP_005262915
          Length = 3544

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  LIHLRRM 7
          L+HLRR+
Sbjct: 25 LMHLRRL 31



>XP_006712843
          Length = 891

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   HLRRMM 8
           HLR+MM
Sbjct: 197 HLRKMM 202



>XP_005264079
          Length = 893

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   HLRRMM 8
           HLR+MM
Sbjct: 192 HLRKMM 197



>NP_055806
          Length = 3526

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  LIHLRRM 7
          L+HLRR+
Sbjct: 25 LMHLRRL 31



>NP_001073908
          Length = 596

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   LIHLRRM 7
           L+HL+R+
Sbjct: 124 LVHLKRL 130



>NP_001073883
          Length = 2028

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   LIHLRRMM 8
           ++HLRR++
Sbjct: 193 VLHLRRLI 200



>NP_008922
          Length = 1029

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LIHLRR 6
           +IHLRR
Sbjct: 470 IIHLRR 475



>NP_001041677
          Length = 247

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  IHLRRMM 8
          IH+RR++
Sbjct: 77 IHIRRLL 83



>XP_005267748
          Length = 1535

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   LIHLRRMM 8
           ++HLRR++
Sbjct: 193 VLHLRRLI 200



>XP_006712978
          Length = 826

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LIHLRR 6
           +IHLRR
Sbjct: 267 IIHLRR 272



>XP_005264840
          Length = 1029

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LIHLRR 6
           +IHLRR
Sbjct: 470 IIHLRR 475



>NP_848591
          Length = 491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   HLRRMMM 9
           HLR MM+
Sbjct: 331 HLRSMML 337



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.368    0.155    0.463 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 527,370
Number of extensions: 716
Number of successful extensions: 29
Number of sequences better than 10000.0: 29
Number of HSP's gapped: 29
Number of HSP's successfully gapped: 29
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (17.5 bits)
S2: 28 (15.4 bits)