Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000258                                                              20     509
NP_001035957                                                           20     509
XP_006721990                                                           20     509
XP_006721989                                                           20     509
XP_005258041                                                           20     509
XP_006721988                                                           20     509
XP_006721987                                                           20     509
XP_006721986                                                           20     509
XP_005258040                                                           20     509
XP_006721985                                                           20     509
NP_002909                                                              17    4312
XP_006722894                                                           17    4312
XP_006722893                                                           17    4312
XP_006722892                                                           17    4312
NP_001180464                                                           16    5631
NP_036293                                                              16    5631
NP_001180463                                                           16    5631
XP_006714023                                                           16    5631
XP_006714022                                                           16    5631
NP_076947                                                              16    5631
NP_604391                                                              16    7355
NP_004370                                                              16    7355
NP_005521                                                              16    7355
NP_001185708                                                           16    7355
NP_073620                                                              16    7355
NP_003582                                                              16    7355
NP_001269941                                                           16    7355
NP_473362                                                              16    7355
NP_001185707                                                           16    7355
NP_060116                                                              16    7355
NP_001185706                                                           16    7355
XP_005257785                                                           16    7355
XP_005255358                                                           16    7355
XP_005255357                                                           16    7355
XP_005255356                                                           16    7355
XP_005255355                                                           16    7355
XP_005254394                                                           16    7355
XP_005254393                                                           16    7355
XP_005254391                                                           16    7355
XP_006710769                                                           16    7355
XP_005271011                                                           16    7355
NP_001138483                                                           16    7355
NP_115510                                                              16    7355
NP_001001674                                                           16    7355
NP_001420                                                              15    9605
NP_004371                                                              15    9605
NP_001073315                                                           15    9605
NP_000350                                                              15    9605
NP_055798                                                              15    9605
NP_006150                                                              15    9605
NP_060634                                                              15    9605
NP_919288                                                              15    9605
NP_001138582                                                           15    9605
NP_001138581                                                           15    9605
NP_001138580                                                           15    9605
NP_001138579                                                           15    9605
XP_006724228                                                           15    9605
XP_005255182                                                           15    9605
XP_006720911                                                           15    9605
XP_005255181                                                           15    9605
XP_005268962                                                           15    9605
XP_006719170                                                           15    9605
XP_005253479                                                           15    9605
XP_006719169                                                           15    9605
XP_006714830                                                           15    9605
XP_006714829                                                           15    9605
XP_006714828                                                           15    9605
XP_006712548                                                           15    9605
XP_005246130                                                           15    9605
>NP_000258
          Length = 2818

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    IHGIVQSV 9
            IHGIVQSV
Sbjct: 2660 IHGIVQSV 2667
>NP_001035957
          Length = 2839

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    IHGIVQSV 9
            IHGIVQSV
Sbjct: 2681 IHGIVQSV 2688
>XP_006721990
          Length = 2823

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    IHGIVQSV 9
            IHGIVQSV
Sbjct: 2691 IHGIVQSV 2698
>XP_006721989
          Length = 2823

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    IHGIVQSV 9
            IHGIVQSV
Sbjct: 2691 IHGIVQSV 2698
>XP_005258041
          Length = 2836

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    IHGIVQSV 9
            IHGIVQSV
Sbjct: 2660 IHGIVQSV 2667
>XP_006721988
          Length = 2846

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    IHGIVQSV 9
            IHGIVQSV
Sbjct: 2670 IHGIVQSV 2677
>XP_006721987
          Length = 2849

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    IHGIVQSV 9
            IHGIVQSV
Sbjct: 2691 IHGIVQSV 2698
>XP_006721986
          Length = 2854

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    IHGIVQSV 9
            IHGIVQSV
Sbjct: 2678 IHGIVQSV 2685
>XP_005258040
          Length = 2857

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    IHGIVQSV 9
            IHGIVQSV
Sbjct: 2681 IHGIVQSV 2688
>XP_006721985
          Length = 2867

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    IHGIVQSV 9
            IHGIVQSV
Sbjct: 2691 IHGIVQSV 2698
>NP_002909
          Length = 979

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IHGIVQSV 9
           +HG+ QSV
Sbjct: 234 VHGVQQSV 241
>XP_006722894
          Length = 870

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IHGIVQSV 9
           +HG+ QSV
Sbjct: 125 VHGVQQSV 132
>XP_006722893
          Length = 870

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IHGIVQSV 9
           +HG+ QSV
Sbjct: 125 VHGVQQSV 132
>XP_006722892
          Length = 979

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IHGIVQSV 9
           +HG+ QSV
Sbjct: 234 VHGVQQSV 241
>NP_001180464
          Length = 674

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LIHGIVQSV 9
           L+HG++ +V
Sbjct: 299 LLHGLIHNV 307
>NP_036293
          Length = 691

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LIHGIVQSV 9
           L+HG++ +V
Sbjct: 316 LLHGLIHNV 324
>NP_001180463
          Length = 690

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LIHGIVQSV 9
           L+HG++ +V
Sbjct: 315 LLHGLIHNV 323
>XP_006714023
          Length = 636

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LIHGIVQSV 9
           L+HG++ +V
Sbjct: 261 LLHGLIHNV 269
>XP_006714022
          Length = 672

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LIHGIVQSV 9
           L+HG++ +V
Sbjct: 297 LLHGLIHNV 305
>NP_076947
          Length = 293

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LIHGIVQSV 9
           +IHGI+  V
Sbjct: 189 VIHGIIHGV 197
>NP_604391
          Length = 341

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/7 (42%), Positives = 7/7 (100%)

Query: 2  IHGIVQS 8
          +HG++Q+
Sbjct: 66 VHGVIQA 72
>NP_004370
          Length = 327

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/7 (42%), Positives = 7/7 (100%)

Query: 2  IHGIVQS 8
          +HG++Q+
Sbjct: 66 VHGVIQA 72
>NP_005521
          Length = 366

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LIHGIVQSV 9
           ++ G+VQS+
Sbjct: 160 IVDGVVQSI 168
>NP_001185708
          Length = 758

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   LIHGIVQS 8
           +IHG++ S
Sbjct: 193 VIHGVINS 200
>NP_073620
          Length = 409

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   HGIVQSV 9
           HGI+Q V
Sbjct: 196 HGIIQHV 202
>NP_003582
          Length = 745

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   LIHGIVQS 8
           +IHG++ S
Sbjct: 180 VIHGVINS 187
>NP_001269941
          Length = 308

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   HGIVQSV 9
           HGI+Q V
Sbjct: 95  HGIIQHV 101
>NP_473362
          Length = 508

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LIHGIVQS 8
          L HGI++S
Sbjct: 28 LAHGIIRS 35
>NP_001185707
          Length = 764

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   LIHGIVQS 8
           +IHG++ S
Sbjct: 199 VIHGVINS 206
>NP_060116
          Length = 467

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   HGIVQSV 9
           HGI QS+
Sbjct: 277 HGIFQSI 283
>NP_001185706
          Length = 745

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   LIHGIVQS 8
           +IHG++ S
Sbjct: 180 VIHGVINS 187
>XP_005257785
          Length = 1887

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   HGIVQS 8
           HG+VQS
Sbjct: 708 HGLVQS 713
>XP_005255358
          Length = 1086

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  LIHGIVQSV 9
          L+HGI++ +
Sbjct: 29 LLHGILEHI 37
>XP_005255357
          Length = 1112

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  LIHGIVQSV 9
          L+HGI++ +
Sbjct: 29 LLHGILEHI 37
>XP_005255356
          Length = 1114

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  LIHGIVQSV 9
          L+HGI++ +
Sbjct: 29 LLHGILEHI 37
>XP_005255355
          Length = 1121

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  LIHGIVQSV 9
          L+HGI++ +
Sbjct: 29 LLHGILEHI 37
>XP_005254394
          Length = 257

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  LIHGIVQSV 9
          ++ G+VQS+
Sbjct: 51 IVDGVVQSI 59
>XP_005254393
          Length = 257

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  LIHGIVQSV 9
          ++ G+VQS+
Sbjct: 51 IVDGVVQSI 59
>XP_005254391
          Length = 316

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LIHGIVQSV 9
           ++ G+VQS+
Sbjct: 110 IVDGVVQSI 118
>XP_006710769
          Length = 326

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   HGIVQSV 9
           HGI QS+
Sbjct: 136 HGIFQSI 142
>XP_005271011
          Length = 386

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   HGIVQSV 9
           HGI QS+
Sbjct: 196 HGIFQSI 202
>NP_001138483
          Length = 1141

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  LIHGIVQSV 9
          L+HGI++ +
Sbjct: 29 LLHGILEHI 37
>NP_115510
          Length = 1663

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   HGIVQS 8
           HG+VQS
Sbjct: 542 HGLVQS 547
>NP_001001674
          Length = 312

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LIHGIVQSV 9
           LIH +VQ V
Sbjct: 153 LIHSLVQLV 161
>NP_001420
          Length = 2414

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LIHGIVQSV 9
           L+H +VQ++
Sbjct: 583 LVHKLVQAI 591
>NP_004371
          Length = 2442

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LIHGIVQSV 9
           L+H +VQ++
Sbjct: 604 LVHKLVQAI 612
>NP_001073315
          Length = 2404

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LIHGIVQSV 9
           L+H +VQ++
Sbjct: 566 LVHKLVQAI 574
>NP_000350
          Length = 817

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/6 (50%), Positives = 6/6 (100%)

Query: 2   IHGIVQ 7
           +HG++Q
Sbjct: 778 VHGVIQ 783
>NP_055798
          Length = 1292

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    IHGIVQS 8
            IH IVQS
Sbjct: 1248 IHDIVQS 1254
>NP_006150
          Length = 816

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   HGIVQSV 9
           HG+VQ +
Sbjct: 235 HGLVQKI 241
>NP_060634
          Length = 706

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LIHGIVQSV 9
           ++HG+V +V
Sbjct: 122 ILHGLVAAV 130
>NP_919288
          Length = 1005

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   IHGIVQ 7
           +HG+VQ
Sbjct: 610 VHGLVQ 615
>NP_001138582
          Length = 839

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   HGIVQSV 9
           HG+VQ +
Sbjct: 258 HGLVQKI 264
>NP_001138581
          Length = 815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   HGIVQSV 9
           HG+VQ +
Sbjct: 234 HGLVQKI 240
>NP_001138580
          Length = 816

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   HGIVQSV 9
           HG+VQ +
Sbjct: 235 HGLVQKI 241
>NP_001138579
          Length = 866

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   HGIVQSV 9
           HG+VQ +
Sbjct: 285 HGLVQKI 291
>XP_006724228
          Length = 2388

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LIHGIVQSV 9
           L+H +VQ++
Sbjct: 583 LVHKLVQAI 591
>XP_005255182
          Length = 2303

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LIHGIVQSV 9
           L+H +VQ++
Sbjct: 604 LVHKLVQAI 612
>XP_006720911
          Length = 2355

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LIHGIVQSV 9
           L+H +VQ++
Sbjct: 604 LVHKLVQAI 612
>XP_005255181
          Length = 2427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LIHGIVQSV 9
           L+H +VQ++
Sbjct: 604 LVHKLVQAI 612
>XP_005268962
          Length = 816

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   HGIVQSV 9
           HG+VQ +
Sbjct: 235 HGLVQKI 241
>XP_006719170
          Length = 631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LIHGIVQSV 9
           ++HG+V +V
Sbjct: 122 ILHGLVAAV 130
>XP_005253479
          Length = 649

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LIHGIVQSV 9
           ++HG+V +V
Sbjct: 122 ILHGLVAAV 130
>XP_006719169
          Length = 706

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LIHGIVQSV 9
           ++HG+V +V
Sbjct: 122 ILHGLVAAV 130
>XP_006714830
          Length = 1007

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   IHGIVQS 8
           IH IVQS
Sbjct: 963 IHDIVQS 969
>XP_006714829
          Length = 1093

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    IHGIVQS 8
            IH IVQS
Sbjct: 1049 IHDIVQS 1055
>XP_006714828
          Length = 1126

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    IHGIVQS 8
            IH IVQS
Sbjct: 1082 IHDIVQS 1088
>XP_006712548
          Length = 637

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   IHGIVQ 7
           +HG+VQ
Sbjct: 242 VHGLVQ 247
>XP_005246130
          Length = 637

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   IHGIVQ 7
           +HG+VQ
Sbjct: 242 VHGLVQ 247
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.331    0.148    0.407 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 455,737
Number of extensions: 562
Number of successful extensions: 69
Number of sequences better than 10000.0: 69
Number of HSP's gapped: 69
Number of HSP's successfully gapped: 69
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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