Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001030                                                              18    1135
XP_005255526                                                           18    1135
NP_065997                                                              17    4312
NP_079096                                                              17    4312
NP_001032852                                                           17    4312
XP_006719137                                                           17    4312
XP_005252170                                                           17    4312
XP_005252168                                                           17    4312
XP_006717258                                                           17    4312
XP_005252166                                                           17    4312
NP_001121650                                                           16    5631
NP_997064                                                              16    5631
NP_000263                                                              16    5631
NP_001121651                                                           16    5631
NP_997244                                                              16    5631
NP_001029                                                              16    5631
NP_001153048                                                           16    5631
NP_001153047                                                           16    5631
NP_001157887                                                           16    5631
NP_057237                                                              16    5631
NP_001193988                                                           16    5631
NP_001193987                                                           16    5631
NP_001230967                                                           16    5631
XP_006720774                                                           16    5631
XP_006720773                                                           16    5631
XP_006720772                                                           16    5631
XP_006720771                                                           16    5631
XP_005263736                                                           16    5631
XP_005263735                                                           16    5631
XP_005263734                                                           16    5631
XP_005263733                                                           16    5631
XP_005263732                                                           16    5631
XP_006712614                                                           16    5631
NP_570138                                                              16    5631
NP_037536                                                              16    7355
NP_062824                                                              16    7355
NP_001107562                                                           16    7355
NP_005814                                                              16    7355
NP_001170826                                                           16    7355
NP_060139                                                              16    7355
NP_056386                                                              16    7355
NP_115800                                                              16    7355
NP_060164                                                              16    7355
XP_005255091                                                           16    7355
XP_006720900                                                           16    7355
XP_006720899                                                           16    7355
XP_005271758                                                           16    7355
XP_005271756                                                           16    7355
XP_005271757                                                           16    7355
XP_005271755                                                           16    7355
XP_005271754                                                           16    7355
XP_006715520                                                           16    7355
XP_005246713                                                           16    7355
XP_005246712                                                           16    7355
XP_005246711                                                           16    7355
NP_001093879                                                           16    7355
NP_001017415                                                           16    7355
NP_003359                                                              16    7355
NP_001017416                                                           16    7355
NP_000483                                                              15    9605
NP_056344                                                              15    9605
NP_775853                                                              15    9605
NP_775790                                                              15    9605
NP_079145                                                              15    9605
XP_005251234                                                           15    9605
XP_005251233                                                           15    9605
XP_006715905                                                           15    9605
XP_006715519                                                           15    9605
XP_005246059                                                           15    9605
YP_003024035                                                           15    9605
>NP_001030
          Length = 649

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LIFYKQLN 8
           LIFYK LN
Sbjct: 505 LIFYKDLN 512
>XP_005255526
          Length = 616

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LIFYKQLN 8
           LIFYK LN
Sbjct: 472 LIFYKDLN 479
>NP_065997
          Length = 1009

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IFYKQLNL 9
           +FYK LN+
Sbjct: 108 VFYKLLNI 115
>NP_079096
          Length = 559

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IFYKQLNL 9
           +FYK LN+
Sbjct: 108 VFYKLLNI 115
>NP_001032852
          Length = 1125

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   IFYKQLNL 9
           IF+K++NL
Sbjct: 944 IFHKEMNL 951
>XP_006719137
          Length = 353

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   LIFYKQLNL 9
           ++FYK+++L
Sbjct: 293 IVFYKKIHL 301
>XP_005252170
          Length = 574

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IFYKQLNL 9
           +FYK LN+
Sbjct: 123 VFYKLLNI 130
>XP_005252168
          Length = 1024

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IFYKQLNL 9
           +FYK LN+
Sbjct: 123 VFYKLLNI 130
>XP_006717258
          Length = 1067

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IFYKQLNL 9
           +FYK LN+
Sbjct: 123 VFYKLLNI 130
>XP_005252166
          Length = 1070

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IFYKQLNL 9
           +FYK LN+
Sbjct: 108 VFYKLLNI 115
>NP_001121650
          Length = 677

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LIFYKQL 7
           LIFY+Q+
Sbjct: 526 LIFYRQI 532
>NP_997064
          Length = 732

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LIFYKQL 7
           LIFY+Q+
Sbjct: 581 LIFYRQI 587
>NP_000263
          Length = 733

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LIFYKQL 7
           LIFY+Q+
Sbjct: 582 LIFYRQI 588
>NP_001121651
          Length = 614

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LIFYKQL 7
           LIFY+Q+
Sbjct: 463 LIFYRQI 469
>NP_997244
          Length = 3169

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LIFYKQLNL 9
            L FY+ LNL
Sbjct: 2624 LRFYRNLNL 2632
>NP_001029
          Length = 669

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IFYKQLN 8
           IF+K+LN
Sbjct: 526 IFFKELN 532
>NP_001153048
          Length = 728

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IFYKQLN 8
           IF+K+LN
Sbjct: 585 IFFKELN 591
>NP_001153047
          Length = 692

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IFYKQLN 8
           IF+K+LN
Sbjct: 549 IFFKELN 555
>NP_001157887
          Length = 423

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FYKQLNL 9
           F++QLNL
Sbjct: 153 FFRQLNL 159
>NP_057237
          Length = 423

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FYKQLNL 9
           F++QLNL
Sbjct: 153 FFRQLNL 159
>NP_001193988
          Length = 461

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   FYKQLN 8
           FYK+LN
Sbjct: 376 FYKELN 381
>NP_001193987
          Length = 500

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   FYKQLN 8
           FYK+LN
Sbjct: 415 FYKELN 420
>NP_001230967
          Length = 616

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IFYKQLNL 9
           +FYK +NL
Sbjct: 153 VFYKFINL 160
>XP_006720774
          Length = 439

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   FYKQLN 8
           FYK+LN
Sbjct: 354 FYKELN 359
>XP_006720773
          Length = 439

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   FYKQLN 8
           FYK+LN
Sbjct: 354 FYKELN 359
>XP_006720772
          Length = 439

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   FYKQLN 8
           FYK+LN
Sbjct: 354 FYKELN 359
>XP_006720771
          Length = 550

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   FYKQLN 8
           FYK+LN
Sbjct: 465 FYKELN 470
>XP_005263736
          Length = 676

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LIFYKQL 7
           LIFY+Q+
Sbjct: 525 LIFYRQI 531
>XP_005263735
          Length = 686

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LIFYKQL 7
           LIFY+Q+
Sbjct: 582 LIFYRQI 588
>XP_005263734
          Length = 711

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LIFYKQL 7
           LIFY+Q+
Sbjct: 525 LIFYRQI 531
>XP_005263733
          Length = 712

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LIFYKQL 7
           LIFY+Q+
Sbjct: 526 LIFYRQI 532
>XP_005263732
          Length = 767

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LIFYKQL 7
           LIFY+Q+
Sbjct: 581 LIFYRQI 587
>XP_006712614
          Length = 768

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LIFYKQL 7
           LIFY+Q+
Sbjct: 582 LIFYRQI 588
>NP_570138
          Length = 235

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  LIFYKQLNL 9
          L+F+ Q+N+
Sbjct: 5  LLFFSQINM 13
>NP_037536
          Length = 630

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LIFYKQLNL 9
           LIFYK+  L
Sbjct: 315 LIFYKKWEL 323
>NP_062824
          Length = 710

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   FYKQLNL 9
           +YK LNL
Sbjct: 288 YYKSLNL 294
>NP_001107562
          Length = 618

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   FYKQLNL 9
           +YK LNL
Sbjct: 196 YYKSLNL 202
>NP_005814
          Length = 622

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LIFYKQLNL 9
           LIFYK+  L
Sbjct: 315 LIFYKKWEL 323
>NP_001170826
          Length = 622

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LIFYKQLNL 9
           LIFYK+  L
Sbjct: 315 LIFYKKWEL 323
>NP_060139
          Length = 1250

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    LIFYKQLN 8
            L  YKQLN
Sbjct: 1241 LSLYKQLN 1248
>NP_056386
          Length = 1112

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   FYKQLN 8
           FYK+LN
Sbjct: 714 FYKRLN 719
>NP_115800
          Length = 345

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LIFYKQLN 8
          +IF KQLN
Sbjct: 30 VIFSKQLN 37
>NP_060164
          Length = 791

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  IFYKQLNL 9
          ++YKQL +
Sbjct: 91 VYYKQLGM 98
>XP_005255091
          Length = 621

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LIFYKQLNL 9
           LIFYK+  L
Sbjct: 314 LIFYKKWEL 322
>XP_006720900
          Length = 622

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LIFYKQLNL 9
           LIFYK+  L
Sbjct: 315 LIFYKKWEL 323
>XP_006720899
          Length = 622

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LIFYKQLNL 9
           LIFYK+  L
Sbjct: 315 LIFYKKWEL 323
>XP_005271758
          Length = 345

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LIFYKQLN 8
          +IF KQLN
Sbjct: 30 VIFSKQLN 37
>XP_005271756
          Length = 345

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LIFYKQLN 8
          +IF KQLN
Sbjct: 30 VIFSKQLN 37
>XP_005271757
          Length = 345

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LIFYKQLN 8
          +IF KQLN
Sbjct: 30 VIFSKQLN 37
>XP_005271755
          Length = 345

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LIFYKQLN 8
          +IF KQLN
Sbjct: 30 VIFSKQLN 37
>XP_005271754
          Length = 345

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LIFYKQLN 8
          +IF KQLN
Sbjct: 30 VIFSKQLN 37
>XP_006715520
          Length = 1056

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   FYKQLN 8
           FYK+LN
Sbjct: 658 FYKRLN 663
>XP_005246713
          Length = 735

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  IFYKQLNL 9
          ++YKQL +
Sbjct: 91 VYYKQLGM 98
>XP_005246712
          Length = 791

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  IFYKQLNL 9
          ++YKQL +
Sbjct: 91 VYYKQLGM 98
>XP_005246711
          Length = 791

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  IFYKQLNL 9
          ++YKQL +
Sbjct: 91 VYYKQLGM 98
>NP_001093879
          Length = 1105

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   FYKQLN 8
           FYK+LN
Sbjct: 707 FYKRLN 712
>NP_001017415
          Length = 785

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LIFYKQL 7
           L+FYK+L
Sbjct: 779 LLFYKKL 785
>NP_003359
          Length = 785

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LIFYKQL 7
           L+FYK+L
Sbjct: 779 LLFYKKL 785
>NP_001017416
          Length = 785

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LIFYKQL 7
           L+FYK+L
Sbjct: 779 LLFYKKL 785
>NP_000483
          Length = 1480

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    IFYKQLNL 9
            +F+K LNL
Sbjct: 1077 LFHKALNL 1084
>NP_056344
          Length = 613

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LIFYKQLNL 9
           L++Y ++NL
Sbjct: 469 LLYYPRINL 477
>NP_775853
          Length = 622

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   LIFYKQLN 8
           + FY++LN
Sbjct: 246 ICFYRELN 253
>NP_775790
          Length = 354

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   YKQLNL 9
           Y+QLNL
Sbjct: 100 YRQLNL 105
>NP_079145
          Length = 271

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  LIFYKQ 6
          LIFY+Q
Sbjct: 84 LIFYRQ 89
>XP_005251234
          Length = 317

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   YKQLNL 9
           Y+QLNL
Sbjct: 100 YRQLNL 105
>XP_005251233
          Length = 354

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   YKQLNL 9
           Y+QLNL
Sbjct: 100 YRQLNL 105
>XP_006715905
          Length = 1588

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    IFYKQLNL 9
            +F+K LNL
Sbjct: 1185 LFHKALNL 1192
>XP_006715519
          Length = 603

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LIFYKQLNL 9
           L++Y ++NL
Sbjct: 459 LLYYPRINL 467
>XP_005246059
          Length = 271

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  LIFYKQ 6
          LIFY+Q
Sbjct: 84 LIFYRQ 89
>YP_003024035
          Length = 459

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  LIFYKQLN 8
          L+F+ Q+N
Sbjct: 39 LLFFNQIN 46
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.341    0.159    0.449 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 472,539
Number of extensions: 541
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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